{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:57:36Z","timestamp":1790794656282,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shihezi University High-Level Talent Research Launch Project","award":["RCZK202367"],"award-info":[{"award-number":["RCZK202367"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: There is growing evidence indicating that environmental endocrine disruptors may influence the development of prostate cancer. Despite this, the connection between BPA and PSA levels is still not fully understood and appears intricate. In this study, we aimed to assess the link between BPA exposure and PSA levels using data from the NHANES database. Methods: We conducted a weighted linear regression, logistic regression analysis, natural cubic spline (NCS), subgroup analysis, and interaction analysis on 2768 participants. Urinary BPA was considered the independent variable, while PSA was the dependent variable. Results: In the study, the average age of the participants selected was 62.70 years (\u00b112.93). Age was negatively correlated with BPA, while PSA and BMI were positively correlated with BPA concentration (all of the p-value &lt; 0.05). In the fully adjusted model, the weighted linear and logistic regression results showed that BPA was positively correlated with PSA and prostate cancer. NCS analysis results show that BPA and PSA have a non-linear relationship. Sensitivity and subgroup analyses showed similar results. In addition, there were interactions between BPA and age, PIR, education, HbA1c, high-density lipoprotein, smoking status, and Diabetes. Conclusions: There was a positive correlation between urinary BPA and PSA in older American males, especially when the BPA concentration was higher than 4.46 ng\/mL. In future practical applications of prostate cancer screening, it is crucial to focus on individuals aged 75 years and older, as well as those with a PIR between 0 and 1, non-Hispanic black, and other risk groups to provide reference values for the primary and secondary prevention of prostate cancer.<\/jats:p>","DOI":"10.3390\/nu16162589","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T11:54:19Z","timestamp":1722945259000},"page":"2589","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between Bisphenol A and Prostate-Specific Antigen (PSA) among U.S. Older Males: National Health and Nutrition Examination Survey (NHANES), 2003\u20132012"],"prefix":"10.3390","volume":"16","author":[{"given":"Qingyuan","family":"Li","sequence":"first","affiliation":[{"name":"Medical School, Shihezi University, Shihezi 832003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipeng","family":"Gao","sequence":"additional","affiliation":[{"name":"Medical School, Shihezi University, Shihezi 832003, China"},{"name":"Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, Shihezi 832000, China"},{"name":"Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi 832000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youxian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical School, Shihezi University, Shihezi 832003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5719-6823","authenticated-orcid":false,"given":"Zhanpeng","family":"Xie","sequence":"additional","affiliation":[{"name":"Medical School, Shihezi University, Shihezi 832003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical School, Shihezi University, Shihezi 832003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Medical School, Shihezi University, Shihezi 832003, China"},{"name":"Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, Shihezi 832000, China"},{"name":"Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi 832000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3465-9789","authenticated-orcid":false,"given":"Qiang","family":"Niu","sequence":"additional","affiliation":[{"name":"Medical School, Shihezi University, Shihezi 832003, China"},{"name":"Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, Shihezi 832000, China"},{"name":"Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi 832000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7902-769X","authenticated-orcid":false,"given":"Haiyan","family":"Li","sequence":"additional","affiliation":[{"name":"Medical School, Shihezi University, Shihezi 832003, China"},{"name":"Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, Shihezi 832000, China"},{"name":"Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi 832000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Guo","sequence":"additional","affiliation":[{"name":"Medical School, Shihezi University, Shihezi 832003, China"},{"name":"Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, Shihezi 832000, China"},{"name":"Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi 832000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rulin","family":"Ma","sequence":"additional","affiliation":[{"name":"Medical School, Shihezi University, Shihezi 832003, China"},{"name":"Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, Shihezi 832000, China"},{"name":"Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi 832000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4631-4705","authenticated-orcid":false,"given":"Jia","family":"He","sequence":"additional","affiliation":[{"name":"Medical School, Shihezi University, Shihezi 832003, China"},{"name":"Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, Shihezi 832000, China"},{"name":"Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi 832000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.eururo.2020.09.042","article-title":"EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer\u20142020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent","volume":"79","author":"Mottet","year":"2021","journal-title":"Eur. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Zhang, T., Zhou, X., Ren, X., Zhang, X., Wu, J., Wang, S., and Wang, Z. (2021). Animal Toxicology Studies on the Male Reproductive Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin: Data Analysis and Health Effects Evaluation. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.696106"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Cimmino, I., Fiory, F., Perruolo, G., Miele, C., Beguinot, F., Formisano, P., and Oriente, F. (2020). Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165761"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Belluti, S., Imbriano, C., and Casarini, L. (2023). Nuclear Estrogen Receptors in Prostate Cancer: From Genes to Function. Cancers, 15.","DOI":"10.3390\/cancers15184653"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e23119","DOI":"10.1016\/j.heliyon.2023.e23119","article-title":"A novel ER\u03b2 high throughput microscopy platform for testing endocrine disrupting chemicals","volume":"10","author":"Abbott","year":"2023","journal-title":"Heliyon"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.21276\/ijre.2018.5.8.2","article-title":"Exploring the Therapeutic Effects of Bisphenol-A on Prostate Cancer","volume":"5","author":"Zhang","year":"2018","journal-title":"Int. J. Res. Eng."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"116469","DOI":"10.1016\/j.envpol.2021.116469","article-title":"Bioinformatics analysis and quantitative weight of evidence assessment to map the potential mode of actions of bisphenol A","volume":"273","author":"Li","year":"2021","journal-title":"Environ. Pollut."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Guan, T., Sun, Y., Wang, Y., Li, Z., Li, T., and Hou, L. (2019). Multi-Residue Method for the Analysis of Stilbene Estrogens in Milk. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030744"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/oem.2006.027706","article-title":"Occupational risk factors for prostate cancer and benign prostatic hyperplasia: A case-control study in Western Australia","volume":"64","author":"Fritschi","year":"2007","journal-title":"Occup. Environ. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2018.3710","article-title":"Screening for Prostate Cancer: US Preventive Services Task Force Recommendation Statement","volume":"319","author":"Grossman","year":"2018","journal-title":"JAMA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1001\/jama.2018.4914","article-title":"Prostate-Specific Antigen (PSA) Screening for Prostate Cancer","volume":"319","year":"2018","journal-title":"JAMA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"127097","DOI":"10.1016\/j.jhazmat.2021.127097","article-title":"The hazardous threat of Bisphenol A: Toxicity, detection and remediation","volume":"423","author":"Tarafdar","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mce.2017.02.045","article-title":"Recent advances on bisphenol-A and endocrine disruptor effects on human prostate cancer","volume":"457","author":"Cernera","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.15585\/mmwr.mm6941a1","article-title":"Prostate Cancer Incidence and Survival, by Stage and Race\/Ethnicity-United States, 2001\u20132017","volume":"69","author":"Siegel","year":"2020","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.gene.2018.01.016","article-title":"The molecular mechanisms of action of the endocrine disrupting chemical bisphenol A in the development of cancer","volume":"647","author":"Shafei","year":"2018","journal-title":"Gene"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11010-009-0275-2","article-title":"Role of genetic polymorphism of estrogen receptor-\u03b1 gene and risk of prostate cancer in north Indian population","volume":"335","author":"Gupta","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.21037\/tau-20-1151","article-title":"Biomarkers for detection of clinically significant prostate cancer: Contemporary clinical data and future directions","volume":"10","author":"Eyrich","year":"2021","journal-title":"Transl. Androl. Urol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.envint.2015.07.017","article-title":"Human exposure to endocrine disrupting chemicals and fertility: A case\u2013control study in male subfertility patients","volume":"84","author":"Hond","year":"2015","journal-title":"Environ. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.annonc.2020.06.011","article-title":"ESMO Guidelines Committee. Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"31","author":"Parker","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1093\/annonc\/mdr603","article-title":"Body mass index and incidence of localized and advanced prostate cancer\u2015A dose-response meta-analysis of prospective studies","volume":"23","author":"Discacciati","year":"2012","journal-title":"Ann. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.envres.2011.09.003","article-title":"Urinary concentrations of bisphenol A and triclosan and associations with demographic factors in the Korean population","volume":"111","author":"Kim","year":"2011","journal-title":"Environ. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/andr.12193","article-title":"Low-dose effects of bisphenol a on mammary gland development in rats","volume":"4","author":"Mandrup","year":"2016","journal-title":"Andrology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1210\/en.2013-1955","article-title":"Bisphenol A promotes human prostate stem-progenitor cell self-renewal and increases in vivo carcinogenesis in human prostate epithelium","volume":"155","author":"Prins","year":"2014","journal-title":"Endocrinology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/pros.24422","article-title":"New strategy for the identification of prostate cancer: The combination of Proclarix and the prostate health index","volume":"82","author":"Terracciano","year":"2022","journal-title":"Prostate"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e49652","DOI":"10.2196\/49652","article-title":"Association Between Urinary Bisphenols and Body Composition Among American Adults: Cross-Sectional National Health and Nutrition Examination Survey Study","volume":"9","author":"Li","year":"2023","journal-title":"JMIR Public Health Surveill."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Wei, C., Tian, L., Jia, B., Wang, M., Xiong, M., Hu, B., Deng, C., Hou, Y., Hou, T., and Yang, X. (2022). Association between Serum Triglycerides and Prostate Specific Antigen (PSA) among U.S. Males: National Health and Nutrition Examination Survey (NHANES), 2003\u20132010. Nutrients, 14.","DOI":"10.3390\/nu14071325"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.reprotox.2010.07.005","article-title":"Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic","volume":"30","author":"Meeker","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e406","DOI":"10.1016\/j.clgc.2022.04.013","article-title":"A Combinatorial Neural Network Analysis Reveals a Synergistic Behaviour of Multiparametric Magnetic Resonance and Prostate Health Index in the Identification of Clinically Significant Prostate Cancer","volume":"20","author":"Gentile","year":"2022","journal-title":"Clin. Genitourin. Cancer"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2589\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:30:52Z","timestamp":1760110252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,6]]},"references-count":29,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["nu16162589"],"URL":"https:\/\/doi.org\/10.3390\/nu16162589","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,6]]}}}