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NANOSEAOMICS"],"award-info":[{"award-number":["Activity 3.6.B. NANOSEAOMICS"]}]},{"name":"Spanish Ministry of Universities from the UE NextGeneration fund","award":["PID2019-103845RB-C21"],"award-info":[{"award-number":["PID2019-103845RB-C21"]}]},{"name":"Spanish Ministry of Universities from the UE NextGeneration fund","award":["Activity 3.6.B. NANOSEAOMICS"],"award-info":[{"award-number":["Activity 3.6.B. NANOSEAOMICS"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Food allergy, referred to as the atypical physiological overreaction of the immune system after exposure to specific food components, is considered one of the major concerns in food safety. The prevalence of this emerging worldwide problem has been increasing during the last decades, especially in industrialized countries, being estimated to affect 6\u20138% of young children and about 2\u20134% of adults. Marine organisms are an important source of bioactive substances with the potential to functionally improve the immune system, reduce food allergy sensitization and development, and even have an anti-allergic action in food allergy. The present investigation aims to be a comprehensive report of marine bioactive compounds with verified actions to improve food allergy and identified mechanisms of actions rather than be an exhaustive compilation of all investigations searching beneficial effects of marine compounds in FA. Particularly, this research highlights the capacity of bioactive components extracted from marine microbial, animal, algae, and microalgae sources, such as n-3 long-chain polyunsaturated fatty acids (LC-PUFA), polysaccharide, oligosaccharide, chondroitin, vitamin D, peptides, pigments, and polyphenols, to regulate the immune system, epigenetic regulation, inflammation, and gut dysbiosis that are essential factors in the sensitization and effector phases of food allergy. In conclusion, the marine ecosystem is an excellent source to provide foods with the capacity to improve the hypersensitivity induced against specific food allergens and also bioactive compounds with a potential pharmacological aptitude to be applied as anti-allergenic in food allergy.<\/jats:p>","DOI":"10.3390\/nu16162592","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T15:24:16Z","timestamp":1722957856000},"page":"2592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Marine Bioactive Compounds with Functional Role in Immunity and Food Allergy"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9214-3273","authenticated-orcid":false,"given":"Ana G.","family":"Abril","sequence":"first","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Santiago de Compostela, 15898 Santiago de Compostela, Spain"},{"name":"Institute of Marine Research (IIM-CSIC), Spanish National Research Council (CSIC), 36208 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2973-449X","authenticated-orcid":false,"given":"M\u00f3nica","family":"Carrera","sequence":"additional","affiliation":[{"name":"Institute of Marine Research (IIM-CSIC), Spanish National Research Council (CSIC), 36208 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Pazos","sequence":"additional","affiliation":[{"name":"Institute of Marine Research (IIM-CSIC), Spanish National Research Council (CSIC), 36208 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s11882-012-0274-3","article-title":"Food Allergy: Temporal Trends and Determinants","volume":"12","author":"Turnbull","year":"2012","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-3083.1975.tb02618.x","article-title":"The Primary Structure of Allergen M from Cod","volume":"4","author":"Elsayed","year":"1975","journal-title":"Scand. J. Immunol."},{"key":"ref_3","first-page":"143","article-title":"Seafood Allergy: Tropomyosins and Beyond","volume":"32","author":"Leung","year":"1999","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Gou, J., Liang, R., Huang, H., and Ma, X. (2022). Maillard Reaction Induced Changes in Allergenicity of Food. Foods, 11.","DOI":"10.3390\/foods11040530"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"130308","DOI":"10.1016\/j.foodchem.2021.130308","article-title":"Fish Muscle Processing into Seafood Products Reduces \u03b2-Parvalbumin Allergenicity","volume":"364","author":"Moreno","year":"2021","journal-title":"Food Chem."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Carrera, M., Pazos, M., and Gasset, M. (2020). Proteomics-Based Methodologies for the Detection and Quantification of Seafood Allergens. Foods, 9.","DOI":"10.20944\/preprints202007.0523.v1"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12016-018-8680-5","article-title":"Mechanisms of Oral Tolerance","volume":"55","author":"Tordesillas","year":"2018","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"104251","DOI":"10.1016\/j.cellimm.2020.104251","article-title":"Role of Orally Induced Regulatory T Cells in Immunotherapy and Tolerance","volume":"359","author":"Bertolini","year":"2021","journal-title":"Cell Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2017.07.004","article-title":"Immunology of Food Allergy","volume":"47","author":"Tordesillas","year":"2017","journal-title":"Immunity"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Abril, A.G., Carrera, M., and Pazos, M. (2023). Immunomodulatory Effect of Marine Lipids on Food Allergy. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1254681"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2500\/aap.2019.40.4217","article-title":"Role of Innate Lymphoid Cells in Allergic Diseases","volume":"40","author":"Pasha","year":"2019","journal-title":"Allergy Asthma Proc."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zheng, H., Zhang, Y., Pan, J., Liu, N., Qin, Y., Qiu, L., Liu, M., and Wang, T. (2021). The Role of Type 2 Innate Lymphoid Cells in Allergic Diseases. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.586078"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Guo, Y., Liu, Y., Rui, B., Lei, Z., Ning, X., Liu, Y., and Li, M. (2023). Crosstalk between the Gut Microbiota and Innate Lymphoid Cells in Intestinal Mucosal Immunity. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1171680"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/cea.14277","article-title":"Epigenome Alterations in Food Allergy: A Systematic Review of Candidate Gene and epigenome-wide Association Studies","volume":"53","author":"Safar","year":"2023","journal-title":"Clin. Exp. Allergy"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2217\/epi-2016-0162","article-title":"Epigenetics and Allergy: From Basic Mechanisms to Clinical Applications","volume":"9","author":"Potaczek","year":"2017","journal-title":"Epigenomics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41577-022-00786-1","article-title":"Allergen Immunotherapy: Past, Present and Future","volume":"23","author":"Durham","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Chebar-Lozinsky, A., De Koker, C., Dziubak, R., Rolnik, D.L., Godwin, H., Dominguez-Ortega, G., Skrapac, A.-K., Gholmie, Y., Reeve, K., and Shah, N. (2024). Assessing Feeding Difficulties in Children Presenting with Non-IgE-Mediated Gastrointestinal Food Allergies\u2014A Commonly Reported Problem. Nutrients, 16.","DOI":"10.3390\/nu16111563"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ku\u017aniar, J., Kozubek, P., and Gomu\u0142ka, K. (2024). Differences in the Course, Diagnosis, and Treatment of Food Allergies Depending on Age\u2014Comparison of Children and Adults. Nutrients, 16.","DOI":"10.3390\/nu16091317"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Brasal-Prieto, M., Fern\u00e1ndez-Prades, L., Dakhaoui, H., Sobrino, F., L\u00f3pez-Enr\u00edquez, S., and Palomares, F. (2023). Update on In Vitro Diagnostic Tools and Treatments for Food Allergies. Nutrients, 15.","DOI":"10.3390\/nu15173744"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jaip.2019.08.020","article-title":"Food Protein-Induced Enterocolitis Syndrome","volume":"8","author":"Berin","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"100471","DOI":"10.1016\/j.waojou.2020.100471","article-title":"Food Protein-Induced Allergic Proctocolitis in Infants: Literature Review and Proposal of a Management Protocol","volume":"13","author":"Mennini","year":"2020","journal-title":"World Allergy Organ. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jaci.2022.11.002","article-title":"Recent Trends in Food Protein\u2013Induced Enterocolitis Syndrome (FPIES)","volume":"151","author":"Baker","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.iac.2021.07.011","article-title":"Eosinophilic Esophagitis","volume":"41","author":"Lehman","year":"2021","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.jaci.2019.10.019","article-title":"Food Allergy and the Microbiome: Current Understandings and Future Directions","volume":"144","author":"Bunyavanich","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Abril, A.G., Carrera, M., S\u00e1nchez-P\u00e9rez, \u00c1., and Villa, T.G. (2023). Gut Microbiome Proteomics in Food Allergies. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032234"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Abril, A.G., Villa, T.G., S\u00e1nchez-P\u00e9rez, \u00c1., Notario, V., and Carrera, M. (2022). The Role of the Gallbladder, the Intestinal Barrier and the Gut Microbiota in the Development of Food Allergies and Other Disorders. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232214333"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.coi.2019.06.001","article-title":"Regulation of Oral Immune Tolerance by the Microbiome in Food Allergy","volume":"60","author":"Chatila","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2023.06.002","article-title":"Role of Mesenchymal Stem Cells and Short Chain Fatty Acids in Allergy: A Prophylactic Therapy for Future","volume":"260","author":"Mohanan","year":"2023","journal-title":"Immunol. Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1111\/all.14254","article-title":"Butyrate Inhibits Human Mast Cell Activation via Epigenetic Regulation of Fc\u03b5RI-mediated Signaling","volume":"75","author":"Folkerts","year":"2020","journal-title":"Allergy"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bhaskaran, N., Quigley, C., Paw, C., Butala, S., Schneider, E., and Pandiyan, P. (2018). Role of Short Chain Fatty Acids in Controlling Tregs and Immunopathology During Mucosal Infection. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01995"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"112431","DOI":"10.1016\/j.celrep.2023.112431","article-title":"Gut Dysbiosis Promotes the Breakdown of Oral Tolerance Mediated through Dysfunction of Mucosal Dendritic Cells","volume":"42","author":"Fukaya","year":"2023","journal-title":"Cell Rep."},{"key":"ref_32","first-page":"1","article-title":"Gut Microbiome Modulation by Probiotics, Prebiotics, Synbiotics and Postbiotics: A Novel Strategy in Food Allergy Prevention and Treatment","volume":"64","author":"Shi","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1017\/S0029665117003950","article-title":"Very Long-Chain n-3 Fatty Acids and Human Health: Fact, Fiction and the Future","volume":"77","author":"Calder","year":"2018","journal-title":"Proc. Nutr. Soc."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Moreno, P.J., Jacobsen, C., S\u00f8rensen, A.-D.M., and Yesiltas, B. (2021). Chapter 1: Traditional and Novel Sources of Long-Chain Omega-3 Fatty Acids. Omega-3 Delivery Systems, Academic Press.","DOI":"10.1016\/B978-0-12-821391-9.00013-2"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.0954-6820.1976.tb08198.x","article-title":"The Composition of Food Consumed by Greenland Eskimos","volume":"200","author":"Bang","year":"1976","journal-title":"Acta Med. Scand."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0140-6736(71)91658-8","article-title":"Plasma Lipid and Lipoprotein Pattern in Greenlandic West-Coast Eskimos","volume":"1","author":"Bang","year":"1971","journal-title":"Lancet"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/mnfr.201100710","article-title":"The Role of Marine Omega-3 (n-3) Fatty Acids in Inflammatory Processes, Atherosclerosis and Plaque Stability","volume":"56","author":"Calder","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.foodchem.2016.03.020","article-title":"Lipidomics to Analyze the Influence of Diets with Different EPA:DHA Ratios in the Progression of Metabolic Syndrome Using SHROB Rats as a Model","volume":"205","author":"Dasilva","year":"2016","journal-title":"Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.jnutbio.2015.07.007","article-title":"Healthy Effect of Different Proportions of Marine Omega-3 PUFAs EPA and DHA Supplementation in Wistar Rats: Lipidomic Biomarkers of Oxidative Stress and Inflammation","volume":"26","author":"Dasilva","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/bs.acc.2017.12.006","article-title":"Distribution of Fatty Acids and Lipids During Pregnancy","volume":"84","author":"Rani","year":"2018","journal-title":"Adv. Clin. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.plipres.2010.07.005","article-title":"Old and New Generation Lipid Mediators in Acute Inflammation and Resolution","volume":"50","author":"Stables","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1753-4887.2010.00287.x","article-title":"Fatty Acids from Fish: The Anti-Inflammatory Potential of Long-Chain Omega-3 Fatty Acids","volume":"68","author":"Wall","year":"2010","journal-title":"Nutr. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jnutbio.2017.02.007","article-title":"A Lipidomic Study on the Regulation of Inflammation and Oxidative Stress Targeted by Marine \u03c9-3 PUFA and Polyphenols in High-Fat High-Sucrose Diets","volume":"43","author":"Dasilva","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.freeradbiomed.2012.11.004","article-title":"Reduced Protein Oxidation in Wistar Rats Supplemented with Marine \u03a93 PUFAs","volume":"55","author":"Pazos","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"11023","DOI":"10.3748\/wjg.v20.i32.11023","article-title":"Non-Pulmonary Allergic Diseases and Inflammatory Bowel Disease: A Qualitative Review","volume":"20","author":"Kotlyar","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1038\/s41396-020-0672-9","article-title":"Fish Oil Supplementation Reduces Maternal Defensive Inflammation and Predicts a Gut Bacteriome with Reduced Immune Priming Capacity in Infants","volume":"14","author":"Quin","year":"2020","journal-title":"ISME J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1039\/C8FO01404C","article-title":"DHA-Phospholipids (DHA-PL) and EPA-Phospholipids (EPA-PL) Prevent Intestinal Dysfunction Induced by Chronic Stress","volume":"10","author":"Cao","year":"2019","journal-title":"Food Funct."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"skaa086","DOI":"10.1093\/jas\/skaa086","article-title":"Effects of Dietary Fatty Acids on Gut Health and Function of Pigs Pre- and Post-Weaning","volume":"98","author":"Lauridsen","year":"2020","journal-title":"J. Anim. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kaliannan, K., Wang, B., Li, X.Y., Kim, K.J., and Kang, J.X. (2015). A Host-Microbiome Interaction Mediates the Opposing Effects of Omega-6 and Omega-3 Fatty Acids on Metabolic Endotoxemia. Sci. Rep., 5.","DOI":"10.1038\/srep11276"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3089303","DOI":"10.1155\/2016\/3089303","article-title":"Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota","volume":"2016","author":"Noriega","year":"2016","journal-title":"Case Rep. Med."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Acevedo, N., Alashkar Alhamwe, B., Caraballo, L., Ding, M., Ferrante, A., Garn, H., Garssen, J., Hii, C.S., Irvine, J., and Llin\u00e1s-Caballero, K. (2021). Perinatal and Early-Life Nutrition, Epigenetics, and Allergy. Nutrients, 13.","DOI":"10.3390\/nu13030724"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3945\/jn.113.178178","article-title":"N3 PUFAs Reduce Mouse CD4+ T-Cell Ex Vivo Polarization into Th17 Cells","volume":"143","author":"Monk","year":"2013","journal-title":"J. Nutr."},{"key":"ref_53","first-page":"236564","article-title":"Dietary Supplementation with Omega-3-Pufa-Rich Fish Oil Reduces Signs of Food Allergy in Ovalbumin-Sensitized Mice","volume":"2012","author":"Amaral","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/cea.12111","article-title":"Dietary Long Chain N-3 Polyunsaturated Fatty Acids Prevent Allergic Sensitization to Cow\u2019s Milk Protein in Mice","volume":"43","author":"Hofman","year":"2013","journal-title":"Clin. Exp. Allergy"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.3945\/jn.114.198515","article-title":"DHA-Rich Tuna Oil Effectively Suppresses Allergic Symptoms in Mice Allergic to Whey or Peanut","volume":"144","author":"Hofman","year":"2014","journal-title":"J. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Vo, T.S., and Kim, S.K. (2014). Marine-Derived Polysaccharides for Regulation of Allergic Responses. Advances in Food and Nutrition Research, Academic Press.","DOI":"10.1016\/B978-0-12-800268-1.00001-9"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/mnfr.201400412","article-title":"The Beneficial Properties of Marine Polysaccharides in Alleviation of Allergic Responses","volume":"59","author":"Vo","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.copbio.2010.02.008","article-title":"Red Microalgal Cell-Wall Polysaccharides: Biotechnological Aspects","volume":"21","author":"Arad","year":"2010","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.3390\/md8051482","article-title":"Production of Chitooligosaccharides and Their Potential Applications in Medicine","volume":"8","author":"Aam","year":"2010","journal-title":"Marine Drugs"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/j.carres.2005.05.018","article-title":"Structure and Anticoagulant Activity of a Sulfated Galactan from the Red Alga, Gelidium crinale. Is There a Specific Structural Requirement for the Anticoagulant Action?","volume":"340","author":"Pereira","year":"2005","journal-title":"Carbohydr. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"S0008","DOI":"10.1016\/S0008-6215(99)00127-5","article-title":"Further Data on the Structure of Brown Seaweed Fucans: Relationships with Anticoagulant Activity","volume":"319","author":"Chevolot","year":"1999","journal-title":"Carbohydr. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.progpolymsci.2006.06.001","article-title":"Chitin and Chitosan: Properties and Applications","volume":"31","author":"Boeriu","year":"2006","journal-title":"Prog. Polym. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0008-6215(00)00222-6","article-title":"The Cytokine Stimulating Activity of (1\u21923)-\u03b2-D-Glucans Is Dependent on the Triple Helix Conformation","volume":"329","author":"Falch","year":"2000","journal-title":"Carbohydr. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0031-9422(01)00450-2","article-title":"Structural Features of Immunologically Active Polysaccharides from Ganoderma Lucidum","volume":"59","author":"Bao","year":"2002","journal-title":"Phytochemistry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.carbpol.2010.01.017","article-title":"Structural Characterization of Immunostimulating Polysaccharide from Cultured Mycelia of Cordyceps Militaris","volume":"80","author":"Lee","year":"2010","journal-title":"Carbohydr. Polym."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1021\/acs.jafc.6b01086","article-title":"Anti-Food Allergic Activity of Sulfated Polysaccharide from Gracilaria lemaneiformis Is Dependent on Immunosuppression and Inhibition of P38 MAPK","volume":"64","author":"Liu","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Khora, S.S., and Navya, P. (2020). Bioactive Polysaccharides from Marine Macroalgae, John Wiley & Sons Ltd.","DOI":"10.1002\/9781119143802.ch6"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"115567","DOI":"10.1016\/j.carbpol.2019.115567","article-title":"Sulfated Oligosaccharide of Gracilaria lemaneiformis protect against Food Allergic Response in Mice by Up-Regulating Immunosuppression","volume":"230","author":"Liu","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1271\/bbb.61.1030","article-title":"Inhibitory Effect of Alginic Acids on Hyaluronidase and on Histamine Release from Mast Cells","volume":"61","author":"Asada","year":"1997","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Xing, M., Qi, C., Yu, W., Han, X., Jiarui, Z., Qing, Z., Ji, A., and Song, S. (2020). Advances in Research on the Bioactivity of Alginate Oligosaccharides. Mar. Drugs, 18.","DOI":"10.3390\/md18030144"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/10408398.2021.1946008","article-title":"Process and Applications of Alginate Oligosaccharides with Emphasis on Health Beneficial Perspectives","volume":"63","author":"Zhang","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1365-2222.2006.02508.x","article-title":"Alginic Acid Has Anti-Anaphylactic Effects and Inhibits Inflammatory Cytokine Expression via Suppression of Nuclear Factor-\u039aB Activation","volume":"36","author":"Jeong","year":"2006","journal-title":"Clin. Exp. Allergy"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000076830","article-title":"Alginic Acid Oligosaccharide Suppresses Th2 Development and IgE Production by Inducing IL-12 Production","volume":"133","author":"Yoshida","year":"2004","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1271\/bbb.60391","article-title":"Oral Administration of Alginic Acid Oligosaccharide Suppresses IgE Production and Inhibits the Induction of Oral Tolerance","volume":"70","author":"Uno","year":"2006","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1021\/jf405633n","article-title":"Immunomodulatory Effects of Alginate Oligosaccharides on Murine Macrophage RAW264.7 Cells and Their Structure-Activity Relationships","volume":"62","author":"Xu","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.3390\/md13041798","article-title":"Morphological and Proteomic Analyses Reveal That Unsaturated Guluronate Oligosaccharide Modulates Multiple Functional Pathways in Murine Macrophage RAW264.7 Cells","volume":"13","author":"Xu","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_77","first-page":"1","article-title":"Identification and Activation of TLR4-Mediated Signalling Pathways by Alginate-Derived Guluronate Oligosaccharide in RAW264.7 Macrophages","volume":"7","author":"Fang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41589-022-00983-y","article-title":"Metabolism of a Hybrid Algal Galactan by Members of the Human Gut Microbiome","volume":"18","author":"Robb","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1271\/bbb.69.1824","article-title":"Inhibitory Effect of Porphyran, Prepared from Dried \u201cNori\u201d, on Contact Hypersensitivity in Mice","volume":"69","author":"Ishihara","year":"2005","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1271\/bbb.57.1862","article-title":"Activation of Murine Macrophages by Polysaccharide Fractions from Marine Algae (Porphyra yezoensis)","volume":"57","author":"Yoshizawa","year":"1993","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1271\/bbb.59.1933","article-title":"Macrophage Stimulation Activity of the Polysaccharide Fraction from a Marine Alga (Porphyra yezoensis): Structure-Function Relationships and Improved Solubility","volume":"59","author":"Yoshizawa","year":"1995","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijbiomac.2013.03.012","article-title":"Immuno-Modulation Effect of Sulphated Polysaccharide (Porphyran) from Porphyra Vietnamensis","volume":"57","author":"Bhatia","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2248419","DOI":"10.1080\/09540105.2023.2248419","article-title":"Influence of Porphyra derived polysaccharides and oligosaccharides on attenuating food allergy and modulating enteric microflora in mice","volume":"34","author":"Wei","year":"2023","journal-title":"Food Agric. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"104084","DOI":"10.1016\/j.jff.2020.104084","article-title":"Purification and Identification of Anti-Allergic Peptide from Atlantic Salmon (Salmo Salar) Byproduct Enzymatic Hydrolysates","volume":"72","author":"Wang","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"115811","DOI":"10.1016\/j.carbpol.2019.115811","article-title":"Inhibitory Effect of Porphyran on Lipopolysaccharide-Induced Activation of Human Immune Cells","volume":"232","author":"Wang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"103167","DOI":"10.1016\/j.algal.2023.103167","article-title":"Porphyran, Porphyran Oligosaccharides and Porphyranase: Source, Structure, Preparation Methods and Applications","volume":"73","author":"Wang","year":"2023","journal-title":"Algal Res."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Li, Y.T., Huo, Y.F., Wang, F., Wang, C., Zhu, Q., Wang, Y.B., Fu, L.L., and Zhou, T. (2020). Improved Antioxidant and Immunomodulatory Activities of Enzymatically Degraded Porphyra haitanensis Polysaccharides. J. Food Biochem., 44.","DOI":"10.1111\/jfbc.13189"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3390\/molecules13081671","article-title":"Fucoidan: Structure and Bioactivity","volume":"13","author":"Li","year":"2008","journal-title":"Molecules"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Lee, H.G., Liyanage, N.M., Yang, F., Kim, Y.S., Lee, S.H., Ko, S.C., Yang, H.W., and Jeon, Y.J. (2024). Investigation of Physical Characteristics and In Vitro Anti-Inflammatory Effects of Fucoidan from Padina arborescens: A Comprehensive Assessment against Lipopolysaccharide-Induced Inflammation. Mar. Drugs, 22.","DOI":"10.3390\/md22030109"},{"key":"ref_90","first-page":"190","article-title":"Fucoidan Prevents Concanavalin A-Induced Liver Injury through Induction of Endogenous IL-10 in Mice","volume":"35","author":"Saito","year":"2006","journal-title":"Hepatol. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000086422","article-title":"Suppression of Th2 Immune Responses by Mekabu Fucoidan from Undaria Pinnatifida Sporophylls","volume":"137","author":"Maruyama","year":"2005","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.bbrc.2009.07.031","article-title":"Peritoneal Injection of Fucoidan Suppresses the Increase of Plasma IgE Induced by OVA-Sensitization","volume":"387","author":"Yanase","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00403-010-1115-7","article-title":"Fucoidan Suppresses IgE Production in Peripheral Blood Mononuclear Cells from Patients with Atopic Dermatitis","volume":"303","author":"Iwamoto","year":"2011","journal-title":"Arch. Dermatol. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.bbrc.2006.08.009","article-title":"Fucoidan Prevents C\u03b5 Germline Transcription and NF\u03baB P52 Translocation for IgE Production in B Cells","volume":"350","author":"Oomizu","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.4049\/jimmunol.159.5.2462","article-title":"Chitin Particle-Induced Cell-Mediated Immunity Is Inhibited by Soluble Mannan: Mannose Receptor-Mediated Phagocytosis Initiates IL-12 Production","volume":"159","author":"Shibata","year":"1997","journal-title":"J. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1128\/iai.65.5.1734-1741.1997","article-title":"Alveolar Macrophage Priming by Intravenous Administration of Chitin Particles, Polymers of N-Acetyl-D-Glucosamine, in Mice","volume":"65","author":"Shibata","year":"1997","journal-title":"Infect. Immun."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.4049\/jimmunol.164.3.1314","article-title":"Oral Administration of Chitin Down-Regulates Serum IgE Levels and Lung Eosinophilia in the Allergic Mouse","volume":"164","author":"Shibata","year":"2000","journal-title":"J. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"6123","DOI":"10.1128\/IAI.69.10.6123-6130.2001","article-title":"Th1 Adjuvant N-Acetyl-D-Glucosamine Polymer up-Regulates Th1 Immunity but down-Regulates Th2 Immunity against a Mycobacterial Protein (MPB-59) in Interleukin-10-Knockout and Wild-Type Mice","volume":"69","author":"Shibata","year":"2001","journal-title":"Infect. Immun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3349\/ymj.2009.50.1.22","article-title":"Chitin, Chitinases and Chitinase-like Proteins in Allergic Inflammation and Tissue Remodeling","volume":"50","author":"Lee","year":"2009","journal-title":"Yonsei Med. J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1089\/088282403771926355","article-title":"Chitin Micro-Particles (CMP): A Useful Adjuvant for Inducing Viral Specific Immunity When Delivered Intranasally with an HIV-DNA Vaccine","volume":"16","author":"Hamajima","year":"2004","journal-title":"Viral Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1046\/j.1365-2222.2002.01551.x","article-title":"Intranasal Application of Chitin Microparticles Down-Regulates Symptoms of Allergic Hypersensitivity to Dermatophagoides pteronyssinus and Aspergillus Fumigatus in Murine Models of Allergy","volume":"32","author":"Strong","year":"2002","journal-title":"Clin. Exp. Allergy"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.carbpol.2005.08.012","article-title":"Enzymatic Production and Biological Activities of Chitosan Oligosaccharides (COS): A Review","volume":"62","author":"Kim","year":"2005","journal-title":"Carbohydr. Polym."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.3390\/md9061038","article-title":"Chitosan Nanoparticles Act as an Adjuvant to Promote Both Th1 and Th2 Immune Responses Induced by Ovalbumin in Mice","volume":"9","author":"Wen","year":"2011","journal-title":"Mar. Drugs"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.procbio.2011.10.036","article-title":"Protective Effect of Chitosan Oligosaccharides against Fc\u025bRI-Mediated RBL-2H3 Mast Cell Activation","volume":"47","author":"Vo","year":"2012","journal-title":"Process Biochem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.carbpol.2010.12.046","article-title":"Inhibitory Effects of Chitooligosaccharides on Degranulation and Cytokine Generation in Rat Basophilic Leukemia RBL-2H3 Cells","volume":"84","author":"Vo","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.intimp.2011.12.027","article-title":"Il Anti-Inflammatory Effects of Low-Molecular Weight Chitosan Oligosaccharides in IgE-Antigen Complex-Stimulated RBL-2H3 Cells and Asthma Model Mice","volume":"12","author":"Chung","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.tifs.2021.08.017","article-title":"Bioactive Peptides Derived from Marine Sources: Biological and Functional Properties","volume":"119","author":"Cunha","year":"2022","journal-title":"Trends Food Sci. Technol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Abril, A.G., Pazos, M., Villa, T.G., Calo-Mata, P., Barros-Vel\u00e1zquez, J., and Carrera, M. (2022). Proteomics Characterization of Food-Derived Bioactive Peptides with Anti-Allergic and Anti-Inflammatory Properties. Nutrients, 14.","DOI":"10.3390\/nu14204400"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.ijbiomac.2018.07.096","article-title":"Spirulina Maxima Peptides Suppress Mast Cell Degranulation via Inactivating Akt and MAPKs Phosphorylation in RBL-2H3 Cells","volume":"118","author":"Vo","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1002\/mnfr.201400329","article-title":"The Role of Peptides Derived from Spirulina Maxima in Downregulation of Fc\u03b5RI-Mediated Allergic Responses","volume":"58","author":"Vo","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.3390\/md13074006","article-title":"Marine Peptides: Bioactivities and Applications","volume":"13","author":"Cheung","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1006\/phrs.1998.0302","article-title":"Antiallergic\/Antiasthmatic Activity of Oligopeptide Related to IgE","volume":"37","author":"Singh","year":"1998","journal-title":"Pharmacol. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3892\/ijmm.2015.2420","article-title":"Anti-Allergic Effects of a Nonameric Peptide Isolated from the Intestine Gastrointestinal Digests of Abalone (Haliotis Discus Hannai) in Activated HMC-1 Human Mast Cells","volume":"37","author":"Ko","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.fsi.2020.09.019","article-title":"Gut Immune Functions and Health in Atlantic Salmon (Salmo Salar) from Late Freshwater Stage until One Year in Seawater and Effects of Functional Ingredients: A Case Study from a Commercial Sized Research Site in the Arctic Region","volume":"106","author":"Wang","year":"2020","journal-title":"Fish. Shellfish. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1080\/10408398.2019.1650716","article-title":"An Overview on Marine Anti-Allergic Active Substances for Alleviating Food-Induced Allergy","volume":"60","author":"Wang","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"446","DOI":"10.31989\/ffhd.v9i7.618","article-title":"Anti-inflammatory and anti-allergic activities of Skipjack tuna (Katsuwonus pelamis) dark muscle hydrolysates evaluated in cell culture model","volume":"9","author":"Chansuwan","year":"2019","journal-title":"Funct. Foods Health Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1111\/jcmm.13607","article-title":"(Brad) Cellular and Molecular Mechanisms of Vitamin D in Food Allergy","volume":"22","author":"Poole","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"6088","DOI":"10.3390\/nu7085271","article-title":"Immune Modulation by Vitamin D and Its Relevance to Food Allergy","volume":"7","author":"Suaini","year":"2015","journal-title":"Nutrients"},{"key":"ref_119","first-page":"15","article-title":"Vitamin D Increases Percentages of Interleukin-10 Secreting Regulatory T Cells in Children with Cow\u2019s Milk Allergy","volume":"26","author":"Mabrouk","year":"2019","journal-title":"Egypt. J. Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Fakhoury, H.M.A., Kvietys, P.R., AlKattan, W., Anouti, F.A., Elahi, M.A., Karras, S.N., and Grant, W.B. (2020). Vitamin D and Intestinal Homeostasis: Barrier, Microbiota, and Immune Modulation. J. Steroid Biochem. Mol. Biol., 200.","DOI":"10.1016\/j.jsbmb.2020.105663"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"White, J.H. (2022). Emerging Roles of Vitamin D-Induced Antimicrobial Peptides in Antiviral Innate Immunity. Nutrients, 14.","DOI":"10.3390\/nu14020284"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Giannetti, A., Bernardini, L., Cangemi, J., Gallucci, M., Masetti, R., and Ricci, G. (2020). Role of Vitamin D in Prevention of Food Allergy in Infants. Front. Pediatr., 8.","DOI":"10.3389\/fped.2020.00447"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.3390\/md12041773","article-title":"Peridinin from the Marine Symbiotic Dinoflagellate, Symbiodinium Sp., Regulates Eosinophilia in Mice","volume":"12","author":"Onodera","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/09629350220131926","article-title":"Role of Histamine in the Inhibitory Effects of Phycocyanin in Experimental Models of Allergic Inflammatory Response","volume":"11","author":"Remirez","year":"2002","journal-title":"Mediat. Inflamm."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/1389203033487216","article-title":"C-Phycocyanin: A Biliprotein with Antioxidant, Anti-Inflammatory and Neuroprotective Effects","volume":"4","author":"Romay","year":"2005","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.intimp.2015.02.032","article-title":"Anti-Allergic Activity of R-Phycocyanin from Porphyra haitanensis in Antigen-Sensitized Mice and Mast Cells","volume":"25","author":"Liu","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/S0024-3205(97)00668-1","article-title":"Spirulina Platensis Inhibits Anaphaylactic Reaction","volume":"61","author":"Yang","year":"1997","journal-title":"Life Sci."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Wu, T., Li, Z., Wu, Y., Yang, X., Li, L., Chen, S., Qi, B., Wang, Y., Li, C., and Zhao, Y. (2023). Exploring Plant Polyphenols as Anti-Allergic Functional Products to Manage the Growing Incidence of Food Allergy. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1102225"},{"key":"ref_129","first-page":"1934578X211060924","article-title":"The Anti-Allergic and Anti-Inflammatory Effects of Phlorotannins from the Edible Brown Algae, Ecklonia Sp. and Eisenia Sp.","volume":"16","author":"Sugiura","year":"2021","journal-title":"Nat. Prod. Commun."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Chen, N., Zhang, S., Javeed, A., Jian, C., Liu, Y., Sun, J., Wu, S., Fu, P., and Han, B. (2023). Structures and Anti-Allergic Activities of Natural Products from Marine Organisms. Mar. Drugs, 21.","DOI":"10.3390\/md21030152"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-04021-z","article-title":"Dysivillosins A\u2013D, Unusual Anti-Allergic Meroterpenoids from the Marine Sponge Dysidea villosa","volume":"7","author":"Jiao","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Hong, L.L., Yu, H.B., Wang, J., Jiao, W.H., Cheng, B.H., Yang, F., Zhou, Y.J., Gu, B.B., Song, S.J., and Lin, H.W. (2017). Unusual Anti-Allergic Diterpenoids from the Marine Sponge Hippospongia lachne. Sci. Rep., 7.","DOI":"10.1038\/srep43138"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/j.1476-5381.1995.tb16634.x","article-title":"Effects of IZP-94005 (Contignasterol) on Antigen-induced Bronchial Responsiveness in Ovalbumin-sensitized Guinea-pigs","volume":"115","author":"Bramley","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1021\/np50089a021","article-title":"Potent Inhibitors of Histamine Release, Two Novel Triterpenoids from the Okinawan Marine Sponge Penares incrustans","volume":"55","author":"Shoji","year":"1992","journal-title":"J. Nat. Prod."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF01989419","article-title":"Mechanism of Inhibition of IgE-Dependent Histamine Release from Rat Mast Cells by Xestobergsterol A from the Okinawan Marine Sponge Xestospongia Bergquistia","volume":"49","author":"Takei","year":"1993","journal-title":"Experientia"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1055\/s-0033-1351098","article-title":"Antiallergic Effects of Pigments Isolated from Green Sea Urchin (Strongylocentrotus droebachiensis) Shells","volume":"79","author":"Pozharitskaya","year":"2013","journal-title":"Planta Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/jps.2600830534","article-title":"Potent Inhibitors of Histamine Release: Polyhydroxylated Sterols from the Okinawan Soft Coral Sinularia Abrupta","volume":"83","author":"Shoji","year":"1994","journal-title":"J. Pharm. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/glycob\/cws137","article-title":"Highly Sulfated Hexasaccharide Sequences Isolated from Chondroitin Sulfate of Shark Fin Cartilage: Insights into the Sugar Sequences with Bioactivities","volume":"23","author":"Mizumoto","year":"2013","journal-title":"Glycobiology"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.carres.2016.02.006","article-title":"Facile Analysis of Contents and Compositions of the Chondroitin Sulfate\/Dermatan Sulfate Hybrid Chain in Shark and Ray Tissues","volume":"424","author":"Takeda","year":"2016","journal-title":"Carbohydr. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s10068-013-0264-9","article-title":"Anti-Inflammatory and Anti-Allergic Activities of Sea Cucumber (Stichopus japonicus) Extract","volume":"22","author":"Song","year":"2013","journal-title":"Food Sci. Biotechnol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3390\/md12010491","article-title":"Hyaluromycin, a New Hyaluronidase Inhibitor of Polyketide Origin from Marine Streptomyces Sp.","volume":"12","author":"Harunari","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1021\/acs.jafc.7b04383","article-title":"Polyketides from the Deep-Sea-Derived Fungus Graphostroma Sp. MCCC 3A00421 Showed Potent Antifood Allergic Activities","volume":"66","author":"Niu","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1021\/acs.orglett.9b04332","article-title":"Botryotins A-H, Tetracyclic Diterpenoids Representing Three Carbon Skeletons from a Deep-Sea-Derived Botryotinia Fuckeliana","volume":"22","author":"Niu","year":"2020","journal-title":"Org. Lett."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Shu, Z., Liu, Q., Xing, C., Zhang, Y., Zhou, Y., Zhang, J., Liu, H., Cao, M., Yang, X., and Liu, G. (2020). Viridicatol Isolated from Deep-Sea Penicillium Griseofulvum Alleviates Anaphylaxis and Repairs the Intestinal Barrier in Mice by Suppressing Mast Cell Activation. Mar. Drugs, 18.","DOI":"10.3390\/md18100517"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Uras, I.S., Ebada, S.S., Korinek, M., Albohy, A., Abdulrazik, B.S., Wang, Y.H., Chen, B.H., Horng, J.T., Lin, W., and Hwang, T.L. (2021). Anti-Inflammatory, Antiallergic, and COVID-19 Main Protease (MPRO) Inhibitory Activities of Butenolides from a Marine-Derived Fungus Aspergillus Terreus. Molecules, 26.","DOI":"10.3390\/molecules26113354"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2592\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:30:59Z","timestamp":1760110259000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,6]]},"references-count":145,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["nu16162592"],"URL":"https:\/\/doi.org\/10.3390\/nu16162592","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,6]]}}}