{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:18:00Z","timestamp":1792289880415,"version":"4.4.0"},"reference-count":136,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Chronic intestinal failure (CIF) is a heterogeneous disease that affects pediatric and adult populations worldwide and requires complex multidisciplinary management. In recent years, many advances in intravenous supplementation support, surgical techniques, pharmacological management, and intestinal transplants have been published. Based on these advances, international societies have published multiple recommendations and guidelines for the management of these patients. The purpose of this paper is to show the differences that currently exist between the recommendations (ideal life) and the experiences published by different programs around the world. Methods: A review of the literature in PubMed from 1980 to 2024 was carried out using the following terms: intestinal failure, CIF, home parenteral nutrition, short bowel syndrome, chronic intestinal pseudo-obstruction, intestinal transplant, enterohormones, and glucagon-like peptide-2. Conclusions: There is a difference between what is recommended in the guidelines and consensus and what is applied in real life. Most of the world\u2019s countries are not able to offer all of the steps needed to treat this pathology. The development of cooperative networks between countries is necessary to ensure access to comprehensive treatment for most patients on all continents, but especially in low-income countries.<\/jats:p>","DOI":"10.3390\/nu16162648","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T08:54:08Z","timestamp":1723452848000},"page":"2648","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Current Status of Chronic Intestinal Failure Management in Adults"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8631-7073","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Solar","sequence":"first","affiliation":[{"name":"Nutritional Support, Intestinal Rehabilitation and Intestinal Transplant Unit, Hospital Universitario Fundaci\u00f3n Favaloro, Buenos Aires C1093AAS, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7709-8910","authenticated-orcid":false,"given":"Mariana L.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Nutritional Support, Intestinal Rehabilitation and Intestinal Transplant Unit, Hospital Universitario Fundaci\u00f3n Favaloro, Buenos Aires C1093AAS, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Gondolesi","sequence":"additional","affiliation":[{"name":"Nutritional Support, Intestinal Rehabilitation and Intestinal Transplant Unit, Hospital Universitario Fundaci\u00f3n Favaloro, Buenos Aires C1093AAS, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.clnu.2023.07.019","article-title":"ESPEN guideline on chronic intestinal failure in adults\u2014Update 2023","volume":"42","author":"Pironi","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_2","unstructured":"ICD-11 for Mortality and Morbidity Statistics (2022, August 17). DA96.05 Intestinal Failure. Available online: https:\/\/icd.who.int\/dev11\/l-m\/en#\/http%3a%2f%2fid.who.int%2ficd%2fentity%2f778202494."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clnu.2014.08.017","article-title":"ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults","volume":"34","author":"Pironi","year":"2015","journal-title":"Clin. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.clnu.2017.04.013","article-title":"Clinical classification of adult patients with chronic intestinal failure due to benign disease: An international multicenter cross-sectional survey","volume":"37","author":"Pironi","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1136\/gutjnl-2018-318172","article-title":"Intravenous supplementation type and volume are associated with 1 year outcome and major complications in patients with chronic intestinal failure","volume":"69","author":"Pironi","year":"2020","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/jpen.1686","article-title":"Results of Surgical and Medical Rehabilitation for Adult Patients with Type III Intestinal Failure in a Comprehensive Unit Today: Building a New Model to Predict Parenteral Nutrition Independency","volume":"44","author":"Gondolesi","year":"2020","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/SLA.0000000000003523","article-title":"Management of Five Hundred Patients with Gut Failure at a Single Center: Surgical Innovation Versus Transplantation with a Novel Predictive Model","volume":"270","author":"Armanyous","year":"2019","journal-title":"Ann. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1053\/j.gastro.2012.09.007","article-title":"Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure","volume":"143","author":"Jeppesen","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.1038\/ctg.2015.69","article-title":"Long term teduglutide for the treatment of patients with intestinal failure associated with short bowel syndrome","volume":"7","author":"Schwartz","year":"2016","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ncp.10092","article-title":"Reduction of parenteral nutrition and hydration support and safety with long term teduglutide treatment in patients with short bowel syndrome-assocoiated intestinal failure. STEPS-3 study","volume":"33","author":"Seidner","year":"2018","journal-title":"Nutr. Clin. Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.cgh.2012.12.029","article-title":"Safety and Efficacy of Teduglutide After 52 Weeks of Treatment in Patients with Short Bowel Intestinal Failure","volume":"11","author":"Jeppesen","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrgastro.2013.18","article-title":"New perspectives in the diagnosis and management of enteric neuropathies","volume":"10","author":"Knowles","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11938-005-0046-4","article-title":"Chronic intestinal pseudo-obstruction","volume":"8","author":"Panganamamula","year":"2005","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1007\/s11605-010-1295-7","article-title":"Chronic intestinal pseudo -obstruction treated near small bowel resection: A 20 year of experience","volume":"14","author":"Lapointe","year":"2010","journal-title":"J. Gastrointest. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1002\/ncp.10991","article-title":"Anatomical and physiological considerations in short bowel syndrome. Emphasis in intestinal adaptation and the role of enterohormones","volume":"38","author":"Tappenden","year":"2023","journal-title":"Nutr. Clin. Pract."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/MCG.0000000000001047","article-title":"Pathopjysiology, Diagnosis, and Management of Chronic intestinal Pseudo Obstruction","volume":"52","author":"Downes","year":"2018","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/ncp.10926","article-title":"Characteristics of adult intestinal failure centers: An international multicenter survey","volume":"38","author":"Lakananurak","year":"2023","journal-title":"Nutr. Clin. Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/jpen.2387","article-title":"First registry of adult patients with chronic intestinal failure due to short bowel syndrome in Argentina: The RESTORE project","volume":"46","author":"Gondolesi","year":"2022","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/01.tp.0000945744.42089.70","article-title":"RESTORE \u201camendment\u201d: From Argentina to Latin America, new steps of the First prospective Intestinal Failure Registry due to short bowel syndrome","volume":"107","author":"Rumbo","year":"2023","journal-title":"Transplantation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1177\/0148607107031004306","article-title":"Home parenteral nutrition support in adults: Experience of medical center in Asia","volume":"31","author":"Wang","year":"2007","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/j.transproceed.2015.05.016","article-title":"Transition of Decade in Short Bowel Syndrome in China: Yesterday, Today, and Tomorrow","volume":"47","author":"Kong","year":"2015","journal-title":"Transplant. Proc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00595-022-02587-4","article-title":"Efficacy, safety and pharmacokinetics of teduglutide in adult Japanese patients with short bowel syndrome and intestinal failure: Two phase III studies with an extension","volume":"53","author":"Nakamura","year":"2023","journal-title":"Surg. Today"},{"key":"ref_23","first-page":"282","article-title":"Long term clinical outcome of home parenteral nutrition in Singapore","volume":"32","author":"Veena","year":"2023","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cgh.2012.10.027","article-title":"Effects of a multimodal management strategy for acute mesenteric ischemia on survival and intestinal failure","volume":"11","author":"Corcos","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1177\/0269215510367538","article-title":"Interprofessional teamwork in medical rehabilitation: A comparison of multidisciplinary and interdisciplinary team approach","volume":"24","year":"2010","journal-title":"Clin. Rehabil."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2147\/CEG.S122868","article-title":"Assessment and management of patients with intestinal failure: A multidisciplinary approach","volume":"11","author":"Grainger","year":"2018","journal-title":"Clin. Exp. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/codi.13321","article-title":"European Society of Coloproctology consensus on the surgical management of intestinal failure in adults. The Association of Coloproctology of Great Britain and Ireland","volume":"18","author":"Vaizey","year":"2016","journal-title":"Color. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1002\/ncp.10988","article-title":"Surgical considerations in the management of short bowel syndrome","volume":"38","author":"Mercer","year":"2023","journal-title":"Nutr. Clin. Pract."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clnesp.2023.01.017","article-title":"Survey of healthcare professionals\u2019 experiences of care delivery in patients with chronic intestinal failure: ATLAS of Variance","volume":"54","author":"Geransar","year":"2023","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/jpen.1983","article-title":"Postsurgical intestinal rehabilitation using semisynthetic glucagon-like peptide-2 analogue (sGLP-2) at a referral center: Can patients achieve parenteral nutrition and sGLP-2 independency?","volume":"45","author":"Solar","year":"2021","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"422","DOI":"10.34172\/aim.2020.38","article-title":"Guideline for Management of Mesenteric Ischemia: Shiraz Intestinal Failure Unit Protocol","volume":"23","author":"Nikoupoor","year":"2020","journal-title":"Arch. Iran. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.clnu.2012.02.013","article-title":"Guidelines recommendations on care of adult patients receiving home parenteral nutrition: A systemic review of global practices","volume":"31","author":"Dreesen","year":"2012","journal-title":"Clin. Nutr."},{"key":"ref_33","first-page":"345","article-title":"Reversal of parenteral nutrition-associated liver disease with a fish base lipid emulsion (Omegaven) in an adult dependent on home parenteral nutrition","volume":"24","author":"Burns","year":"2000","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.nut.2012.07.009","article-title":"Successful treatment of parenteral nutrition-associated liver disease in an adult by use of a fish oil -bases lipid source","volume":"29","author":"Hill","year":"2013","journal-title":"Nutrition"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.clnu.2020.07.014","article-title":"Influence of different intravenous lipid emulsion on fatty acid status and laboratory and clinical outcomes in adult patients receiving home parenteral nutrition: A systematic review","volume":"4","author":"Ahmed","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000365608","article-title":"Intravenous lipids in home parenteral nutrition","volume":"112","author":"Pironi","year":"2015","journal-title":"World Rev. Nutr. Diet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1177\/0884533612439896","article-title":"ASPEN Position paper: Clinical role for alternative intravenous fat emulsions","volume":"27","author":"Vanek","year":"2012","journal-title":"Nutr. Clin. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.clnu.2012.06.011","article-title":"Four-week parenteral nutrition using a third-generation lipid emulsion (SMOFlipid)-a. double blind, randomized, multicenter study in adults","volume":"32","author":"Klek","year":"2013","journal-title":"Clin. Nutr."},{"key":"ref_39","unstructured":"Cawley, C., Lal, S., Nightingale, J., and Small, M. (2023, December 15). Standardized Parenteral Support Catheter Guidelines Connecting a Parenteral Support (PC) Infusion. Principles of Care and Management of Central Venous Catheters. Available online: https:\/\/www.bapen.org.uk\/pdfs\/bifa\/standardised-parenteral-support-catheter-guidelines.pdf."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1213\/01.ANE.0000118101.94596.A0","article-title":"Colonization and bloodstream infection with single-versus multi-lumen central venous catheters: A quantitative systematic review","volume":"99","author":"Tramer","year":"2004","journal-title":"Anasth. Analg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.clnu.2009.03.015","article-title":"ESPEN guidelines on parenteral nutrition: Central venous catheters (access, care, diagnosis and therapy of complications)","volume":"28","author":"Pittiruti","year":"2009","journal-title":"Clin. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jhin.2017.08.010","article-title":"Controlling catheter-related bloodstream infections through a multi-center educational programme for intensive care units","volume":"97","author":"Musu","year":"2017","journal-title":"J. Hosp. Infect."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"857","DOI":"10.14740\/jocmr2314w","article-title":"The impact of implementation of bundle to reduce catheter-related bloodstream infection rates","volume":"7","author":"Menegueti","year":"2015","journal-title":"J. Clin. Med. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1177\/01486071060300S1S82","article-title":"Evidence-based practice in the management of vascular access devices for home parenteral nutrition therapy","volume":"30","author":"Ryder","year":"2006","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Liu, Y., Zhang, A.Q., Cao, L., Xia, H.T., and Ma, J.J. (2013). Taurolidine lock solutions for the prevention of catheter related bloodstream infections: A systematic review and met analysis of randomized controlled trials. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079417"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.clnu.2016.01.020","article-title":"ESPEN guidelines on chronic intestinal failure in adults","volume":"35","author":"Pironi","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/ejcn.2014.32","article-title":"Taurolidine locks significantly reduce the incidence of catheter-related blood stream infections in high-risk patients on home parenteral nutrition","volume":"69","author":"Saunders","year":"2015","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1093\/jac\/dku182","article-title":"Adverse effects associated with ethanol catheter lock solutions: A systemic review","volume":"69","author":"Mermel","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1016\/j.clnu.2021.07.002","article-title":"ESPEN practical guideline: Clinical nutrition in chronic intestinal failure","volume":"40","author":"Cuerda","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/ncp.10113","article-title":"Bacteria, bones and stones: Managing complications of short bowel syndrome","volume":"33","author":"Johnson","year":"2018","journal-title":"Nutr. Clin. Pract."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.clnu.2019.03.010","article-title":"Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey","volume":"39","author":"Pironi","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000515057","article-title":"Management of Home Parenteral Nutrition: Complications and Survival","volume":"77","author":"Reber","year":"2021","journal-title":"Ann. Nutr. Metab."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/aas.13477","article-title":"Cather related infections: A Scandinavian observational study on the impact of a simple hyfgiene insertion bundle","volume":"64","author":"Thorarinsdottir","year":"2020","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nut.2017.08.002","article-title":"Predictive factors of catheter-related bloodstream infection in patients receiving home parenteral nutrition","volume":"46","author":"Pichitchaipitak","year":"2018","journal-title":"Nutrition"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/j.1365-2036.2006.03106.x","article-title":"Survival and dependence on home parenteral nutrition: Experience over a 25 years period in a UK referral center","volume":"24","author":"Lloyd","year":"2006","journal-title":"Aliment. Pharm. Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1053\/j.gastro.2005.09.065","article-title":"Home parenteral nutrition: Survival, cost, and quality of life","volume":"130","author":"Howard","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4065\/74.3.217","article-title":"Survival of home parenteral nutrition-treated patients: 20 years of experience at the Mayo Clinic","volume":"74","author":"Scolapio","year":"1999","journal-title":"Mayo Clin. Proc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1016\/j.clnu.2022.09.010","article-title":"Standardized survival and excess Life Years Lost in patients with type 3 intestinal failure","volume":"41","author":"Kopczynska","year":"2022","journal-title":"Clin. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.clnu.2017.06.016","article-title":"Five-year survival and causes of death in patients on home parenteral nutrition for severe chronic and benign intestinal failure","volume":"37","author":"Joly","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/jpen.2231","article-title":"Experiences with intestinal failure from an intestinal rehabilitation unit in a country without home parenteral nutrition","volume":"46","author":"Nikoupour","year":"2022","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"793","DOI":"10.5152\/tjg.2022.21708","article-title":"Intestinal Transplantation in a Country Without Home Parenteral Nutrition: The Largest Report from the Middle East","volume":"33","author":"Nikoupour","year":"2022","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ajg.2014.183","article-title":"Long-term outcome of enterocutaneous fistula in patients with Crohn\u2019s disease treated with anti-TNF therapy: A cohort study from the GETAID","volume":"109","author":"Amiot","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/ibd.21860","article-title":"Infliximab does not affect postoperative complication rates in Crohn\u2019s patients undergoing abdominal surgery","volume":"18","author":"Kasparek","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/codi.13321","article-title":"ESCP consensus on the surgical management of intestinal failure in adults","volume":"18","author":"Vaizey","year":"2016","journal-title":"Color Dis."},{"key":"ref_65","unstructured":"Carlson, G.L., Gardiner, K., McKee, R., MacFie, J., and Vaizey, C. (2010). The Surgical Management of Patients with Intestinal Failure. Issues in Professional Practice, Association of Surgeons of Great Britain and Ireland."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.clnu.2016.04.009","article-title":"Management of acute intestinal failure: A position paper from the European Society for Clinical Nutrition and Metabolism (ESPEN) Special Interest Group","volume":"35","author":"Klek","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0016-5085(99)70388-4","article-title":"Long-term survival and parentral nutrition dependence in adult patients with the short bowel syndrome","volume":"117","author":"Messing","year":"1999","journal-title":"Gastroenterology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.clnu.2012.08.007","article-title":"Determinants of home parenteral nutrition dependence and survival of 268 patients with non-malignant short bowel syndrome","volume":"32","author":"Amiot","year":"2013","journal-title":"Clin. Nutr."},{"key":"ref_69","first-page":"145","article-title":"Intestinal loop lengthening\u2014A technique for increasing small intestinal length","volume":"15","author":"Bianchi","year":"1980","journal-title":"J. Peiatr. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1053\/jpsu.2003.50073","article-title":"Serial Transverse Enteroplasty (STEP): A novel bowel lengthening procedure","volume":"38","author":"Kim","year":"2003","journal-title":"J. Pediatr. Surg."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e680","DOI":"10.1111\/nmo.12191","article-title":"Non transplantation surgical approach for chronic intestinal pseudo-obstruction: Analysis of 63 adult consecutive cases","volume":"25","author":"Sabbagh","year":"2013","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_72","first-page":"198","article-title":"Intestinal failure after surgery for complicated radiation enteritis","volume":"82","author":"Girvent","year":"2000","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.dld.2012.10.003","article-title":"Long term outcome after extensive intestinal resection for chronic radiation enteritis","volume":"45","author":"Amiot","year":"2013","journal-title":"Dig. Liver. Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/MOT.0000000000000967","article-title":"Autologous gastrointestinal reconstruction surgery for short bowel syndrome: The cornerstone for intestinal rehabilitation","volume":"27","author":"Gondolesi","year":"2022","journal-title":"Curr. Opin. Organ. Transplant."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1136\/gut.29.11.1613","article-title":"Treatment of end stage chronic intestinal pseudo-obstruction by subtotal enterectomy and home parenteral nutrition","volume":"29","author":"Mughal","year":"1988","journal-title":"Gut"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/ajg.2009.58","article-title":"Long term Outcome of Chronic Intestinal Pseudo-Obstruction Adult Patients Requiring Home Parenteral Nutrition","volume":"104","author":"Amiot","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.cgh.2022.05.032","article-title":"AGA Clinical practice update on management of short bowel syndrome: Expert review","volume":"20","author":"Iyer","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_78","first-page":"600","article-title":"Managing the adult patient with short bowel syndrome","volume":"13","author":"Parrish","year":"2017","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1002\/ncp.10978","article-title":"Short bowel syndrome: Complications and management","volume":"38","author":"Bering","year":"2023","journal-title":"Nutr. Clin. Pract."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"197","DOI":"10.7326\/0003-4819-102-2-197","article-title":"Treatment of diabetic diarrhea with clonidine","volume":"102","author":"Fedorak","year":"1985","journal-title":"Ann. Intern. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0025-6196(12)60606-5","article-title":"Chronic diarrhea in diabetes mellitus: Mechanisms and an approach to diagnosis and treatment","volume":"68","author":"Valdovinos","year":"1993","journal-title":"Mayo Clin. Proc."},{"key":"ref_82","first-page":"G76","article-title":"Enterocyte alpha 2-adrenergic receptors: Yohimbine and p-aminoclonidine binding relative to ion transport","volume":"244","author":"Chang","year":"1983","journal-title":"Am. J. Physiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1177\/0148607106030006487","article-title":"Clonidine reduces diarrhea and sodium loss in patients with proximal jejunostomy: A cotrolled study","volume":"30","author":"Buchman","year":"2006","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/0148607104028004265","article-title":"Use of clonidine to decrease intestinal fluid losses in patients with high output short bowel syndrome","volume":"28","author":"McDoniel","year":"2004","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1136\/gut.30.7.943","article-title":"Effect of a long-acting somatostatin analogue SMS 201-995 on jejunostomy effluents in patients with severe short bowel syndrome","volume":"30","author":"Ladefoged","year":"1989","journal-title":"Gut"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1097\/SLA.0b013e318260aa26","article-title":"A meta-analysis of outcomes following use of somatostatin and its analogues for the management of enterocutaneous fistulas","volume":"256","author":"Rahbour","year":"2012","journal-title":"Ann. Surg."},{"key":"ref_87","first-page":"1290","article-title":"Somatostin analogues in the prevention of pancreas related complications agates pancreatic resection","volume":"13","author":"Sarr","year":"2006","journal-title":"J. Hepatobiliary Pancreat. Surg."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/apt.14136","article-title":"Systematic review: Pharmacotherapy for high-output enterostomies or enteral fisulas","volume":"46","author":"Reeskamp","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_89","first-page":"28","article-title":"Short bowel syndrome in adults-part 4A. A guide to front line drugs used in the treatment of short bowel syndrome","volume":"39","author":"Chan","year":"2015","journal-title":"Pract. Gastroenterol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/14656566.2020.1724959","article-title":"Treating short bowel syndrome with pharmacotherapy","volume":"21","author":"Lee","year":"2020","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1111\/cts.13117","article-title":"Population pharmacokinetics and exposure-response analyses of teduglutide in adult and pediatric patients with short bowel syndrome","volume":"14","author":"Marier","year":"2021","journal-title":"Clin. Transl. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ncp.11015","article-title":"Use of teduglutide in adults with short bowel syndrome-associated intestinal failure","volume":"39","author":"Pironi","year":"2024","journal-title":"Nutr. Clin. Pract."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/jpen.2223","article-title":"Apraglutide, a novel glucagon-like peptide-2 analog, improves fluid absorption in patients with short bowel syndrome intestinal failure: Findings from a placebo-controlled, randomized phase 2 trial","volume":"46","author":"Eliasson","year":"2022","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S2468-1253(19)30077-9","article-title":"Glepaglutide, a novel long-acting glucagon-like peptide-2 analogue, for patients with short bowel syndrome: A randomized phase 2 trial","volume":"4","author":"Naimi","year":"2019","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"s59","DOI":"10.1002\/ncp.10951","article-title":"Navigating nutrition and hydration care in the adult patient with short bowel syndrome","volume":"38","author":"Roberts","year":"2023","journal-title":"Nutr. Clin. Pract."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/0148607112469818","article-title":"Nutrition and fluid optimization for patients with short bowel syndrome","volume":"37","author":"Matarese","year":"2013","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"876","DOI":"10.14309\/ajg.0000000000001763","article-title":"Short bowel syndrome in adults","volume":"117","author":"Bering","year":"2022","journal-title":"Am. J. Gastroenterol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s11938-022-00385-y","article-title":"Dietary Strategies for Managing Short Bowel Syndrome","volume":"20","author":"Limtrakun","year":"2022","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"ref_99","first-page":"14","article-title":"The management of patients with high output enterocutaneous gastrointestinal fistula: A European Survey","volume":"7","author":"Gabe","year":"2012","journal-title":"Clin. Nutr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/MOT.0000000000000512","article-title":"Management of intestinal failure in middle-income countries, for children and adults","volume":"23","author":"Gondolesi","year":"2018","journal-title":"Curr. Opin. Organ. Transplant."},{"key":"ref_101","first-page":"54","article-title":"S\u00edndrome de intestino corto asociado a la falla intestinal","volume":"16","year":"2019","journal-title":"Cirujano"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s10620-019-5473-5","article-title":"Off-Label Teduglutide Therapy in Non-Intestinal Failure Patients with Chronic Malabsorption","volume":"64","author":"George","year":"2019","journal-title":"Dig. Diseeases Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/jpen.2221","article-title":"Characterization of American teduglutide consumers from 2015\u20132020: A large database study","volume":"46","author":"Loutfy","year":"2022","journal-title":"J. Pareneter. Enter. Nutr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1016\/j.clnu.2021.02.011","article-title":"Candidacy of adult patients with short bowel syndrome for treatment with glucagon-like peptide-2 analogues: A systemic analysis of a single centre cohort","volume":"40","author":"Pironi","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41430-018-0278-8","article-title":"Examining the pathophysiology of short bowel syndrome and glucagon-like peptide 2 analogue suitability in chronic intestinal failure: Experience from a national intestinal failure unit","volume":"73","author":"Bond","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"de Dreuille, B., Nuzzo, A., Bataille, J., Mailhat, C., Billiauws, L., Le Gall, M., and Joly, F. (2023). Post-Marketing Use of Teduglutide in a Large Cohort of Adults with Short Bowel Syndrome-Associated Chronic Intestinal Failure: Evolution and Outcomes. Nutrients, 15.","DOI":"10.3390\/nu15112448"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jpen.1011","article-title":"Sigle-Center Experience with use of Teduglutide in Adult Patients with Short Boewl Syndrome","volume":"42","author":"Lam","year":"2018","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"47","DOI":"10.52787\/agl.v52i1.168","article-title":"Teduglutida en pacientes adultos con falla intestinal cr\u00f3nica por s\u00edndrome de intestino corto: Protocolo de manejo con base en recomendaciones de expertos","volume":"52","author":"Solar","year":"2022","journal-title":"Acta Gastroenterol. Latinoam."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Bioletto, F., D\u2019Eusebio, C., Merlo, F.D., Aimasso, U., Ossola, M., Pellegrini, M., Ponzo, V., Chiarotto, A., De Francesco, A., and Ghigo, E. (2022). Efficacy of teduglutide for parenteral support reduction in patients with short bowel syndrome: A systematic review and meta-analysis. Nutrients, 14.","DOI":"10.3390\/nu14040796"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.clnesp.2021.03.011","article-title":"Predictors and timing of response to teduglutide in patients with short bowel syndrome dependent on parenteral support","volume":"43","author":"Chen","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.2147\/TCRM.S166081","article-title":"Identifying a subpopulation with higher likelihoods of early response to treatment in a heterogeneous rare disease: A post hoc study of response to teduglutide for short bowel syndrome","volume":"14","author":"Chen","year":"2018","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_112","first-page":"S44","article-title":"P25- a prospective multicenter registry for patients with short bowel syndrome (SBS Registry): Long-term effectiveness analysis in the context of teduglutide treatment","volume":"45","author":"Allard","year":"2021","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.clnu.2019.08.020","article-title":"Colon polyps in patients with short bowel syndrome before and after teduglutide: Post hoc analysis of the STEPS study series","volume":"39","author":"Armstrong","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1177\/0148607117718480","article-title":"De Novo Development of Hamartomatous Duodenal Polyps in a Patient With Short Bowel Syndrome During Teduglutide Therapy: A Case Report","volume":"42","author":"Ukleja","year":"2018","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.ajcnut.2023.02.015","article-title":"Unexpected upper gastrointestinal polyps in patients with short bowel syndrome treated with teduglutide: Need for close monitoring","volume":"117","author":"Ronot","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.clnu.2016.01.028","article-title":"Survival and nutritional dependence on home parenteral nutrition: Three decades of experience from a single referral centre","volume":"36","author":"Dibb","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/jpen.1838","article-title":"Long-Term Outcomes with Teduglutide From a Single Center","volume":"45","author":"Puello","year":"2021","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/jpen.2272","article-title":"Teduglutide in short bowel syndrome patients: A way back to normal life?","volume":"46","author":"Harpain","year":"2022","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1016\/j.clnu.2019.12.019","article-title":"Six-month outcomes of teduglutide treatment in adult patients with short bowel syndrome with chronic intestinal failure: A real-world French observational cohort study","volume":"39","author":"Joly","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.clnu.2018.07.030","article-title":"Experience with teduglutide treatment for short bowel syndrome in clinical practice","volume":"38","author":"Pevny","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1756284818793343","DOI":"10.1177\/1756284818793343","article-title":"GLP-2 analog teduglutide significantly reduces need for parenteral nutrition and stool frequency in a real-life setting","volume":"11","author":"Schoeler","year":"2018","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Lakananurak, N., Wall, E., Catron, H., Delgado, A., Greif, S., Herlitz, J., Moccia, L., Mercer, D., Vanuytsel, T., and Kumpf, V. (2023). Real-World Management or High Stool Output in Patients with Short Bowel syndrome; An International Multicenter survey. Nutrients, 15.","DOI":"10.3390\/nu15122763"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/00000658-199808000-00007","article-title":"The role of interdigestive small bowel motility in the regulation of gut microflora, bacterial overgrowth, and bacterial translocation in rats","volume":"228","author":"Nieuwenhuijs","year":"1998","journal-title":"Ann. Surg."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1136\/gutjnl-2020-321631","article-title":"The management of adult patients with severe chronic small intestinal dysmotility","volume":"69","author":"Nightingale","year":"2020","journal-title":"Gut"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/1529-0131(199907)42:7<1545::AID-ANR30>3.0.CO;2-T","article-title":"Octreotide treatment of chronic intestinal pseudoobstruction secondary to connective tissue diseases","volume":"42","author":"Perlemuter","year":"1999","journal-title":"Arthritis Rheum"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/MCO.0000000000000775","article-title":"Nutritional considerations in severe primary chronic small intestinal dysmotility","volume":"24","author":"Conley","year":"2021","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1572-0241.2006.00438.x","article-title":"Role of home parenteral nutrition in chronic radiation enteritis","volume":"101","author":"Gavazzi","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_128","first-page":"117","article-title":"Radiation enteropathy","volume":"81","author":"Bozzetti","year":"1995","journal-title":"Tumori"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e12945","DOI":"10.1111\/nmo.12945","article-title":"Chronic intestinal pseudo- obstruction in children and adults: Diagnosis and therapeutic options","volume":"29","author":"Lauro","year":"2017","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.gtc.2011.09.005","article-title":"Chronic intestinal pseudo-obstruction: Clinical features, diagnosis, and therapy","volume":"40","author":"Cogliandro","year":"2011","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e13231","DOI":"10.1111\/nmo.13231","article-title":"Chronic intestinal psudo-obstruction: Progress in management?","volume":"29","author":"Karunaratne","year":"2017","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/j.1365-2036.2004.01900.x","article-title":"Erythromiycin for the treatment ofo chronic intestinal pseudo-obstruction: Description of six cases with a positive response","volume":"19","author":"Emmanuel","year":"2004","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e13937","DOI":"10.1111\/nmo.13937","article-title":"An international survey on clinicians\u00b4 perspectives on the diagnosis and management of chronic intestinal pseudo-obstruction and enteric dysmotility","volume":"32","author":"Vasant","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1586\/17474124.2014.940317","article-title":"Advancement in the clinical management of intestinal pseudo-obstruction","volume":"9","author":"Lauro","year":"2014","journal-title":"Expert. Rev. Gastroenterol. Hepatol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/SLA.0000000000006045","article-title":"Outcome After Intestinal Transplantation from Living Versus Deceased Donors: A Propensity-matched Cohort Analysis of the International Intestinal Transplant Registry","volume":"278","author":"Ceulemans","year":"2023","journal-title":"Ann. Surg."},{"key":"ref_136","unstructured":"(2023, December 15). Available online: https:\/\/www.transplant-observatory.org\/wp-content\/uploads\/2023\/11\/2022-data-global-report_VF_2.pdf."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2648\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:34:43Z","timestamp":1760110483000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,10]]},"references-count":136,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["nu16162648"],"URL":"https:\/\/doi.org\/10.3390\/nu16162648","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,10]]}}}