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Studies on the frequency of consumption of food products in this group show many irregularities, in particular too low consumption of vegetables and fruits, wholegrain cereal products and dairy products, and excessive consumption of meat products and sweets. It is necessary to correct eating habits. The diets of people with trisomy 21 should be consistent with the recommendations of rational nutrition for the general population and take into account specific dietary modifications related to the occurrence of diseases and health problems characteristic of this syndrome.<\/jats:p>","DOI":"10.3390\/nu16162656","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T08:54:08Z","timestamp":1723452848000},"page":"2656","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["General Dietary Recommendations for People with Down Syndrome"],"prefix":"10.3390","volume":"16","author":[{"given":"Joanna","family":"Gruszka","sequence":"first","affiliation":[{"name":"Dieta Plus Nutritional and Dietary Counseling, 45-072 Opole, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2554-9388","authenticated-orcid":false,"given":"Dariusz","family":"W\u0142odarek","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Institute of Human Nutrition Science, Warsaw University of Life Science (WULS-SGGW), 159C Nowoursynowska Street, 02-776 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,11]]},"reference":[{"key":"ref_1","unstructured":"Maatta, T. (2011). Down Syndrome, Health and Disability: A Population-Based Case Record and Follow-Up Study, Universitatis Ouluensis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1542\/neo.9-1-e29","article-title":"Common Dysmorphic Syndromes in the NICU","volume":"9","author":"Bishara","year":"2009","journal-title":"NeoReviews"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s00431-010-1253-0","article-title":"Clinical Practice: The Care of Children with Down Syndrome","volume":"169","author":"Weijerman","year":"2010","journal-title":"Eur. J. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/0194599811425156","article-title":"Identification of Hearing Loss in Pediatric Patients with Down Syndrome","volume":"146","author":"Park","year":"2012","journal-title":"Otolaryngol.\u2014Head Neck Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jpeds.2014.09.005","article-title":"The Prevalence of Congenital Hearing Loss in Neonates with Down Syndrome","volume":"166","author":"Tedeschi","year":"2015","journal-title":"J. Pediatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2788.2004.00616.x","article-title":"Obesity in Adults with Down Syndrome: A Case\u2014Control Study","volume":"49","author":"Melville","year":"2004","journal-title":"J. Intellect. Disabil. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/jir.12100","article-title":"Obesity and Associated Factors in Adults with Intellectual Disability","volume":"58","author":"Hsieh","year":"2014","journal-title":"J. Intellect. Disabil. Res."},{"key":"ref_8","first-page":"6","article-title":"Insulin Resistance in Adolescents with Down Syndrome: A Cross-Sectional Study. BMC Endocr","volume":"5","author":"Fonseca","year":"2005","journal-title":"Disord"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e1382","DOI":"10.1542\/peds.2011-1262","article-title":"Lipid Profiles of Children with Down Syndrome Compared with Their Siblings","volume":"129","author":"Adelekan","year":"2012","journal-title":"Pediatrics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0009-8981(84)90267-5","article-title":"Cholesterol Fractions and Triglycerides in Children and Adults with down\u2019s Syndrome","volume":"142","author":"Gaethke","year":"1984","journal-title":"Clin. Chim. Acta"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1365-2788.2011.01384.x","article-title":"Fifteen-Year Follow-up of Thyroid Status in Adults with Down Syndrome","volume":"55","author":"Prasher","year":"2011","journal-title":"J. Intellect. Disabil. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4274\/Jcrpe.884","article-title":"Profile of Hypothyroidism in Down\u2019s Syndrome","volume":"5","author":"Cebeci","year":"2013","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00383-013-3361-1","article-title":"Hirschsprung\u2019s Disease Associated with Down Syndrome: A Meta-Analysis of Incidence, Functional Outcomes and Mortality","volume":"29","author":"Friedmacher","year":"2013","journal-title":"Pediatr. Surg. Int."},{"key":"ref_14","first-page":"6","article-title":"Gastrointestinal Disorders in Down Syndrome","volume":"7","author":"Holmes","year":"2014","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.5009\/gnl.2011.5.1.105","article-title":"A Case of Congenital Duodenal Web Causing Duodenal Stenosis in a Down Syndrome Child: Endoscopic Resection with an Insulated-Tip Knife","volume":"5","author":"Lee","year":"2011","journal-title":"Gut Liver"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2249.2011.04335.x","article-title":"Infections and Immunodeficiency in Down Syndrome","volume":"164","author":"Ram","year":"2011","journal-title":"Clin. Exp. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2249.2009.03890.x","article-title":"De Intrinsic Defect of the Immune System in Children with Down Syndrome: A Review","volume":"156","author":"Kusters","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"ref_18","first-page":"77","article-title":"Are Down\u2019s Syndrome Patients a Risk Group for Celiac Disease?","volume":"8","year":"2013","journal-title":"Gastroenterol. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1542\/peds.2006-1194","article-title":"Screening for Celiac Disease in Asymptomatic Children with Down Syndrome: Cost-Effectiveness of Preventing Lymphoma","volume":"118","author":"Kawatu","year":"2006","journal-title":"Pediatrics"},{"key":"ref_20","first-page":"862","article-title":"Ocena Cz\u0119sto\u015bci Wyst\u0119powania Celiakii W\u015br\u00f3d Pacjent\u00f3w Poradni Gastroenterologicznej Instytutu Matki i Dziecka","volume":"93","author":"Rowicka","year":"2012","journal-title":"Probl. Hig. Epidemiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3104\/reports.86","article-title":"IGG Antibodies to Beta-Lactoglobulin and Cow\u2019s Milk Protein Intolerance in Down Syndrome","volume":"5","author":"Failla","year":"2007","journal-title":"Down Syndr. Res. Pract."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1038\/bjc.2013.237","article-title":"Allergy and acute leukaemia in children with Down syndrome: A population study. Report from the Mexican inter-institutional group for the identification of the causes of childhood leukaemia","volume":"108","year":"2013","journal-title":"Br. J. Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ijporl.2010.03.050","article-title":"Body mass index as an indicator of obstructive sleep apnea in pediatric Down","volume":"74","author":"Shires","year":"2010","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/bmj.2.6081.226","article-title":"Down\u2019s syndrome: An atheroma-free model?","volume":"2","author":"Rodger","year":"1977","journal-title":"Br. Med. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4067\/S0370-41062017000500004","article-title":"High Frequency of Dyslipidemia in Children and Adolescents with Down Syndrome Alta Frecuencia de Dislipidemias En Ni\u00f1os y Adolescentes Con S\u00edndrome de Down","volume":"88","author":"Alberti","year":"2017","journal-title":"Rev. Chil. Pediatr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.braindev.2004.07.008","article-title":"Down syndrome, Alzheimer\u2019s disease and seizures","volume":"27","year":"2005","journal-title":"Brain Dev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1365-2788.2006.00842.x","article-title":"Dementia and mortality in persons with Down\u2019s syndrome","volume":"50","author":"Coppus","year":"2006","journal-title":"J. Intellect. Disabil. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/gps.502","article-title":"Dementia in people with Down\u2019s syndrome","volume":"16","author":"Tyrrell","year":"2001","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1474-4422(10)70112-5","article-title":"Cognitive deficits and associated neurological complications in individuals with Down\u2019s syndrome","volume":"9","author":"Lott","year":"2010","journal-title":"Lancet Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1352\/0895-8017(2004)109<186:NSARFF>2.0.CO;2","article-title":"Nutritional Status and Risk Factors for Chronic Disease in Urban-Dwelling Adults With Down Syndrome","volume":"109","author":"Braunschweig","year":"2004","journal-title":"Am. J. Ment. Retard."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.14206\/canad.j.clin.nutr.2013.01.05","article-title":"Dietary Practice and Physical Activity in Children with Down Syndrome and Their Siblings in Saudi Arabia","volume":"1","author":"Mohamed","year":"2013","journal-title":"Can. J. Clin. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"25487","DOI":"10.3402\/fnr.v59.25487","article-title":"Dietary Aspects Related to Health and Obesity in Williams Syndrome, Down Syndrome, and Prader-Willi Syndrome","volume":"59","author":"Paus","year":"2015","journal-title":"Food Nutr. Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Roccatello, G., Cocchi, G., Dimastromatteo, R.T., Cavallo, A., Biserni, G.B., Selicati, M., and Forchielli, M.L. (2021). Eating and Lifestyle Habits in Youth With Down Syndrome Attending a Care Program: An Exploratory Lesson for Future Improvements. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.641112"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wernio, E., K\u0142osowska, A., Kuchta, A., Cwikl\u00ed\u0144ska, A., Sa\u0142aga-Zaleska, K., Jankowski, M., K\u0142osowski, P., Wi\u015bniewski, P.W., Wierzba, J., and Ma\u0142gorzewicz, S. (2022). Analysis of Dietary Habits and Nutritional Status of Children with Down Syndrome in the Context of Lipid and Oxidative Stress Parameters. Nutrients, 14.","DOI":"10.3390\/nu14122390"},{"key":"ref_35","first-page":"96","article-title":"Imbalanced Dietary Patterns, Anthropometric, and Body Composition Profiles amongst Adults with Down Syndrome","volume":"27","author":"Moya","year":"2014","journal-title":"Nutr. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Peiris, H., Duffield, M.D., Fadista, J., Jessup, C.F., Kashmir, V., Genders, A.J., McGee, S.L., Martin, A.M., Saiedi, M., and Morton, N. (2016). A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to \u03b2-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genet., 12.","DOI":"10.1371\/journal.pgen.1006033"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3109\/00365521.2015.1079645","article-title":"The Celiac Iceberg: From the Clinical Spectrum to Serology and Histopathology in Children and Adolescents with Type 1 Diabetes Mellitus and Down Syndrome","volume":"51","author":"Gomes","year":"2016","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archneur.1989.00520440031017","article-title":"A Prospective Study of Alzheimer Disease in Down Syndrome","volume":"46","author":"Lai","year":"1989","journal-title":"Arch. Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1007\/s11033-014-3424-y","article-title":"Meta-Analysis of Methylenetetrahydrofolate Reductase Maternal Gene in Down Syndrome: Increased Susceptibility in Women Carriers of the MTHFR 677T Allele","volume":"41","author":"Victorino","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s43042-019-0010-9","article-title":"MTHFR Gene Polymorphism and Associated Nutritional Deficiency in the Etiology and Pathogenesis of Down Syndrome","volume":"20","author":"Kedar","year":"2019","journal-title":"Egypt. J. Med. Hum. Genet."},{"key":"ref_41","unstructured":"Pavarino, E.C., Zampieri, L.B., Biselli, M.J., and Goloni Bertollo, E.M. (2011). Abnormal Folate Metabolism and Maternal Risk for Down Syndrome. Genetics and Etiology of Down Syndrome, InTech."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Vione, B., Ramacieri, G., Zavaroni, G., Piano, A., La Rocca, G., Caracausi, M., Vitale, L., Piovesan, A., Gori, C., and Pirazzoli, G.L. (2022). One-Carbon Pathway Metabolites Are Altered in the Plasma of Subjects with Down Syndrome: Relation to Chromosomal Dosage. Front. Med., 9.","DOI":"10.3389\/fmed.2022.1006891"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/jn\/138.3.439","article-title":"Metabolic Effects of Dietary Fiber Consumption and Prevention of Diabetes 1","volume":"138","author":"Weickert","year":"2008","journal-title":"J. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/10408398.2013.792772","article-title":"Impact of Diet Composition on Blood Glucose Regulation","volume":"56","author":"Russell","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/sj.ejcn.1602747","article-title":"Muesli with 4 g Oat Beta-Glucans Lowers Glucose and Insulin Responses after a Bread Meal in Healthy Subjects","volume":"62","author":"Granfeldt","year":"2008","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"266S","DOI":"10.1093\/ajcn\/76\/1.266S","article-title":"Glycemic Index: Overview of Implications in Health and Disease","volume":"76","author":"Jenkins","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/jn\/nxx008","article-title":"Impact of Dietary Fiber Consumption on Insulin Resistance and the Prevention of Type 2 Diabetes","volume":"148","author":"Weickert","year":"2018","journal-title":"J. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s11883-008-0074-3","article-title":"Effects of Soluble Dietary Fiber on Low-Density Lipoprotein Cholesterol and Coronary Heart Disease Risk","volume":"10","author":"Bazzano","year":"2008","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1136\/gutjnl-2017-314050","article-title":"Butyrate Reduces Appetite and Activates Brown Adipose Tissue via the Gut-Brain Neural Circuit","volume":"67","author":"Li","year":"2018","journal-title":"Gut"},{"key":"ref_50","first-page":"223","article-title":"Rola Kr\u00f3tko\u0142a\u0144cuchowych Kwas\u00f3w T\u0142uszczowych w Nieswoistych Chorobach Zapalnych Jelit i Raku Jelita Grubego","volume":"67","author":"Fichna","year":"2021","journal-title":"Adv. Biochem."},{"key":"ref_51","first-page":"1059","article-title":"Nutritional status of intellectual disabled persons with Down syndrome","volume":"26","year":"2011","journal-title":"Nutr. Hosp."},{"key":"ref_52","first-page":"181","article-title":"Glycemic Index and Glycemic Load of diets in children and young people with Down\u2019s Syndrome","volume":"12","author":"Kunowski","year":"2013","journal-title":"Acta Sci. Pol. Technol. Aliment."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/S0002-8223(96)00330-6","article-title":"Nutrient Intake and Obesity in Prapubescent Children with Down Syndrome","volume":"96","author":"Luke","year":"1996","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.4236\/health.2018.109095","article-title":"Osteoporosis and People with Down Syndrome: A Preliminary Descriptive Examination of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing Wave 1 Results","volume":"10","author":"Burke","year":"2018","journal-title":"Health"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1212\/01.wnl.0000210503.89488.88","article-title":"Use of Antiepileptic Drugs and Risk of Fractures: Case-Control Study among Patients with Epilepsy","volume":"66","author":"Souverein","year":"2006","journal-title":"Neurology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.31729\/jnma.7950","article-title":"Intracranial Calcification and Seizure with Down Syndrome: A Case Report","volume":"60","author":"Rai","year":"2022","journal-title":"J. Nepal Med. Assoc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.38192\/1.7.2.8","article-title":"Abnormal Calcium, Calcinosis, and Creatinine in Down\u2019s Syndrome","volume":"7","author":"Hosdurga","year":"2021","journal-title":"Physician"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF00862098","article-title":"A Toddler with Down Syndrome, Hypercalcaemia, Hypercalciuria, Medullary Nephrocalcinosis and Renal Failure","volume":"10","author":"Manz","year":"1996","journal-title":"Pediatr. Nephrol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/1744629516686571","article-title":"Dietary Practices of Children and Adolescents with Down Syndrome","volume":"22","author":"Magenis","year":"2018","journal-title":"J. Intellect. Disabil."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1161\/01.ATV.0000151283.33976.e6","article-title":"Betaine and Folate Status as Cooperative Determinants of Plasma Homocysteine in Humans","volume":"25","author":"Holm","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_61","first-page":"897","article-title":"Hyperhomocysteinemia as a New Risk Factor for Different Diseases","volume":"15","author":"Kazimierska","year":"2006","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_62","first-page":"696","article-title":"Predicting Preeclampsia in the Second Pregnancy from Low Birth Weight in the First Pregnancy","volume":"96","author":"Rasmussen","year":"2000","journal-title":"Obstet. Gynecol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1079\/PHN2005727","article-title":"Invited Paper Public Health Implications of Meat Production and Consumption","volume":"8","author":"Walker","year":"2005","journal-title":"Public Health Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"eaam5324","DOI":"10.1126\/science.aam5324","article-title":"Meat Consumption, Health, and the Environment","volume":"361","author":"Godfray","year":"2018","journal-title":"Science"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1210\/en.2011-0243","article-title":"Minireview: Vitamin D: Is There a Role in Extraskeletal Health?","volume":"152","author":"Christakos","year":"2011","journal-title":"Endocrinology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1136\/ard.2007.069831","article-title":"Vitamin D and Autoimmunity: New Aetiological and Therapeutic Considerations","volume":"66","author":"Arnson","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1210\/jc.2008-0784","article-title":"Association of Vitamin D Deficiency with Heart Failure and Sudden Cardiac Death in a Large Cross-Sectional Study of Patients Referred for Coronary Angiography","volume":"93","author":"Pilz","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12020-008-9115-5","article-title":"Vitamin D and Diabetes Mellitus","volume":"35","author":"Danescu","year":"2009","journal-title":"Endocrine"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1600-0625.2007.00570.x","article-title":"Vitamin D and the skin: An ancient friend, revisited-cutaneous vitamin D endocrine system-inflammatory skin diseases-skin-vitamin D-vitamin D deficiency","volume":"16","author":"Reichrath","year":"2007","journal-title":"Exp. Dermatol."},{"key":"ref_70","first-page":"23","article-title":"Nowe spojrzenie na suplementacj\u0119 witamin\u0105 D (Pol.)\/A New Perspective on Vitamin D Supplementation (Ang.)","volume":"1","author":"Karczmarewicz","year":"2009","journal-title":"Stand. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1515\/ptse-2015-0016","article-title":"Development of Walking and Self-Sufficiency Ability Related to Nutrition among People with Down Syndrome","volume":"10","year":"2015","journal-title":"Pract. Theory Syst. Educ."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Espinosa, R.M., Vila, M.D.M., and Garc\u00eda-Galbis, M.R. (2020). Evidences from Clinical Trials in Down Syndrome: Diet, Exercise and Body Composition. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17124294"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jand.2012.06.365","article-title":"Academy of Nutrition and Dietetics: Standards of Practice and Standards of Professional Performance for Registered Dietitians (Competent, Proficient, and Expert) in Intellectual and Developmental Disabilities","volume":"112","author":"Spear","year":"2012","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_74","unstructured":"Jarosz, M. (2012). (red) Normy \u017bywienia Dla Populacji Polskiej Nowelizacja (Pol)\/Nutrition Standards for the Polish Population\u2014Amendment (Ang), Institute of Food and Nutrition."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Revilla, N.R., and Mart\u00ednez-Cu\u00e9, C. (2020). Antioxidants in Down Syndrome: From Preclinical Studies to Clinical Trials. Antioxidants, 9.","DOI":"10.3390\/antiox9080692"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"742","DOI":"10.30574\/wjarr.2022.16.1.1097","article-title":"Folic Acid and Its Implications in Genetic Pathology","volume":"16","author":"Albu","year":"2022","journal-title":"World J. Adv. Res. Rev. World"},{"key":"ref_77","first-page":"e41571","article-title":"Early Detection of Subclinical Atherosclerosis: Hyperhomocysteinemia as a Promising Marker in Adolescents With Vitamin B Deficiency","volume":"15","author":"Shirode","year":"2023","journal-title":"Cureus"},{"key":"ref_78","first-page":"12","article-title":"Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase Gene and Congenital Heart Defects in Down Syndrome","volume":"4","year":"2020","journal-title":"Genet. Appl."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Lyon, P., Strippoli, V., Fang, B., and Cimmino, L. (2020). B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease. Nutrients, 12.","DOI":"10.3390\/nu12092867"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/NT.0000000000000512","article-title":"Dietary Guidelines for Americans, 2020\u20132025: Understanding the Scientific Process, Guidelines, and Key Recommendations","volume":"56","author":"Snetselaar","year":"2021","journal-title":"Nutr. Today"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Cobiac, L.J., Scarborough, P., Kaur, A., and Rayner, M. (2016). The Eatwell Guide: Modelling the Health Implications of Incorporating New Sugar and Fibre Guidelines. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0167859"},{"key":"ref_82","first-page":"0005E","article-title":"Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on Sustainable Dietary and Physical Activity Recommendations for the Spanish Population","volume":"1","year":"2023","journal-title":"Food Risk Assess Europe"},{"key":"ref_83","unstructured":"(2024, May 12). DGE-Ern\u00e4hrungskreis (Germ)\/DGE German Society for Nutrition (Eng). Available online: https:\/\/www.dge.de\/gesunde-ernaehrung\/gut-essen-und-trinken\/dge-ernaehrungskreis\/."},{"key":"ref_84","unstructured":"Wolnicka, K. (2024, February 11). Talerz Zdrowego \u017bywienia (Pol)\/Healtly Eating Plate (Ang), Available online: https:\/\/ncez.pzh.gov.pl\/abc-zywienia\/talerz-zdrowego-zywienia\/."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2656\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:34:53Z","timestamp":1760110493000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,11]]},"references-count":84,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["nu16162656"],"URL":"https:\/\/doi.org\/10.3390\/nu16162656","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,11]]}}}