{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:39:29Z","timestamp":1783953569848,"version":"3.55.0"},"reference-count":60,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Fondo Sectorial de Investigaci\u00f3n en Salud y Seguridad Social, Consejo Nacional de Ciencia y Tecnolog\u00eda","award":["SALUD-2018-01-A3-S-41347"],"award-info":[{"award-number":["SALUD-2018-01-A3-S-41347"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Gut microbiota disturbances may influence cognitive function, increasing uremic toxins and inflammation in dialysis patients; therefore, we aimed to evaluate the association of the gut microbiota profile with cognitive impairment (CI) in patients on automated peritoneal dialysis (APD). In a cross-sectional study, cognitive function was evaluated using the Montreal Cognitive Assessment in 39 APD patients and classified as normal cognitive function and CI. The gut microbiota was analyzed using the 16S rRNA gene sequencing approach. All patients had clinical, biochemical and urea clearance evaluations. Eighty-two percent of patients were men, with a mean age of 47 \u00b1 24 years and 11 (7\u201348) months on PD therapy; 64% had mild CI. Patients with CI were older (53 \u00b1 16 vs. 38 \u00b1 14, p = 0.006) and had a higher frequency of diabetes mellitus (56% vs. 21%, p = 0.04) and constipation (7% vs. 48%, p = 0.04) and lower creatinine concentrations (11.3 \u00b1 3.7 vs. 14.9 \u00b1 5.4, p = 0.02) compared to normal cognitive function patients. Patients with CI showed a preponderance of S24_7, Rikenellaceae, Odoribacteraceae, Odoribacter and Anaerotruncus, while patients without CI had a greater abundance of Dorea, Ruminococcus, Sutterella and Fusobacteria (LDA score (Log10) &gt; 2.5; p &lt; 0.05). After glucose and age adjustment, Odoribacter was still associated with CI. In conclusion, patients with CI had a different gut microbiota characterized by the higher abundance of indole-producing and mucin-fermenting bacteria compared to normal cognitive function patients.<\/jats:p>","DOI":"10.3390\/nu16162659","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T08:54:08Z","timestamp":1723452848000},"page":"2659","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gut Microbiome Is Related to Cognitive Impairment in Peritoneal Dialysis Patients"],"prefix":"10.3390","volume":"16","author":[{"given":"Fabiola","family":"Mart\u00edn-del-Campo","sequence":"first","affiliation":[{"name":"Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Belisario Dominguez #1000, Guadalajara 44320, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natali","family":"Vega-Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, Department of Microbiology and Pathology, Health Sciences University Center, University of Guadalajara, Sierra Mojada #950, Guadalajara 44350, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9","family":"Salazar-F\u00e9lix","sequence":"additional","affiliation":[{"name":"Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Belisario Dominguez #1000, Guadalajara 44320, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Cueto-Manzano","sequence":"additional","affiliation":[{"name":"Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Belisario Dominguez #1000, Guadalajara 44320, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Pe\u00f1a-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Research Institute on Chronic and Degenerative Diseases, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Sierra Mojada #950, Guadalajara 44350, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-3896","authenticated-orcid":false,"given":"Laura","family":"Cort\u00e9s-Sanabria","sequence":"additional","affiliation":[{"name":"Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Belisario Dominguez #1000, Guadalajara 44320, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Romo-Flores","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Regional General Hospital 46, Mexican Institute of Social Security, L\u00e1zaro C\u00e1rdenas Av. 1060, Guadalajara 44910, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Rojas-Campos","sequence":"additional","affiliation":[{"name":"Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Belisario Dominguez #1000, Guadalajara 44320, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Berger, I., Wu, S., Masson, P., Kelly, P.J., Duthie, F.A., Whiteley, W., Parker, D., Gillespie, D., and Webster, A.C. (2016). Cognition in chronic kidney disease: A systematic review and meta-analysis. BMC Med., 14.","DOI":"10.1186\/s12916-016-0745-9"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1111\/jan.15746","article-title":"Risk factors and prevalence of cognitive impairment in maintenance haemodialysis patients: A systematic review and meta-analysis of observational studies","volume":"79","author":"Cao","year":"2023","journal-title":"J. Adv. Nurs."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1007\/s10157-019-01762-1","article-title":"Prevalence of cognitive impairment among peritoneal dialysis patients: A systematic review and meta-analysis","volume":"23","author":"Shea","year":"2019","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1093\/ndt\/gfab238","article-title":"Prevalence of mild cognitive impairment in automated peritoneal dialysis patients","volume":"36","year":"2021","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3747\/pdi.2018.00048","article-title":"Self-Care Peritoneal Dialysis Patients with Cognitive Impairment Have a Higher Risk of Peritonitis in the Second Year","volume":"39","author":"Shea","year":"2019","journal-title":"Perit. Dial. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1159\/000514172","article-title":"Risk Factors and Clinical Outcomes of Cognitive Impairment in Diabetic Patients Undergoing Peritoneal Dialysis","volume":"46","author":"Huang","year":"2021","journal-title":"Kidney Blood Press. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000524475","article-title":"Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis","volume":"8","author":"Xie","year":"2022","journal-title":"Kidney Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2174\/1570159X15666170915141036","article-title":"The Microbiota-Gut-Brain Axis in Neuropsychiatric Disorders: Pathophysiological Mechanisms and Novel Treatments","volume":"16","author":"Kim","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lun, H., Yang, W., Zhao, S., Jiang, M., Xu, M., Liu, F., and Wang, Y. (2019). Altered gut microbiota and microbial biomarkers associated with chronic kidney disease. Microbiologyopen, 8.","DOI":"10.1002\/mbo3.678"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1136\/gutjnl-2019-319766","article-title":"Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents","volume":"69","author":"Wang","year":"2020","journal-title":"Gut"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41581-019-0172-1","article-title":"Intestinal microbiome and fitness in kidney disease","volume":"15","author":"Meijers","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"9816","DOI":"10.1080\/10408398.2022.2076064","article-title":"Dietary polyphenols: Regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases","volume":"63","author":"Li","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Luo, D., Zhao, W., Lin, Z., Wu, J., Lin, H., Li, Y., Song, J., Zhang, J., and Peng, H. (2021). The Effects of Hemodialysis and Peritoneal Dialysis on the Gut Microbiota of End-Stage Renal Disease Patients, and the Relationship Between Gut Microbiota and Patient Prognoses. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.579386"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1007\/s00213-020-05569-x","article-title":"Abnormalities in gut microbiota and serum metabolites in hemodialysis patients with mild cognitive decline: A single-center observational study","volume":"237","author":"Zhu","year":"2020","journal-title":"Psychopharmacology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.7150\/thno.35387","article-title":"The gut microbiota-inflammation-brain axis in end-stage renal disease: Perspectives from default mode network","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1093\/ndt\/gfr045","article-title":"Is cystatin C a better marker than creatinine for evaluating residual renal function in patients on continuous ambulatory peritoneal dialysis?","volume":"26","author":"Yang","year":"2011","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"National Kidney Foundation, Inc. (1997). NKF-DOQI Clinical Practice Guidelines for Peritoneal Dialysis Adequacy. Am. J. Kidney Dis., 30, S67\u2013S136.","DOI":"10.1016\/S0272-6386(97)70028-3"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1177\/0896860820976983","article-title":"Clinical characteristics associated with the properties of gut microbiota in peritoneal dialysis patients","volume":"41","author":"Jiang","year":"2021","journal-title":"Perit. Dial. Int."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Merino-Ribas, A., Araujo, R., Pereira, L., Campos, J., Barreiros, L., Segundo, M.A., Silva, N., Costa, C.F., Quelhas-Santos, J., and Trindade, F. (2022). Vascular Calcification and the Gut and Blood Microbiome in Chronic Kidney Disease Patients on Peritoneal Dialysis: A Pilot Study. Biomolecules, 12.","DOI":"10.3390\/biom12070867"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s40520-023-02645-y","article-title":"Analysis of intestinal flora and cognitive function in maintenance hemodialysis patients using combined 16S ribosome DNA and shotgun metagenome sequencing","volume":"36","author":"Gao","year":"2024","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Wang, J., Wu, S., Zhang, J., Li, Y., Wu, Y., and Qi, X. (2023). Correlation between gut microbiome and cognitive impairment in patients undergoing peritoneal dialysis. BMC Nephrol., 24.","DOI":"10.1186\/s12882-023-03410-z"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Li, J., Xing, H., Lin, W., Yu, H., Yang, B., Jiang, C., Zhang, J., Wu, R., Ding, F., and Pei, M. (2024). Specific gut microbiome and metabolome changes in patients with continuous ambulatory peritoneal dialysis and comparison between patients with different dialysis vintages. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1302352"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Han, W., Wang, N., Han, M., Ban, M., Sun, T., and Xu, J. (2022). Reviewing the role of gut microbiota in the pathogenesis of depression and exploring new therapeutic options. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.1029495"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"477","DOI":"10.18632\/aging.203826","article-title":"Gut microbiota in patients with Alzheimer\u2019s disease spectrum: A systematic review and meta-analysis","volume":"14","author":"Hung","year":"2022","journal-title":"Aging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4161\/gmic.19897","article-title":"Microbial degradation of complex carbohydrates in the gut","volume":"3","author":"Flint","year":"2012","journal-title":"Gut Microbes"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1080\/10408398.2020.1755949","article-title":"Polysaccharides: Bowel health and gut microbiota","volume":"61","author":"Seo","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"100508","DOI":"10.1016\/j.nmni.2019.01.004","article-title":"Anaerotruncus massiliensis sp. nov., a succinate-producing bacterium isolated from human stool from an obese patient after bariatric surgery","volume":"29","author":"Togo","year":"2019","journal-title":"New Microbes New Infect."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ren, T., Gao, Y., Qiu, Y., Jiang, S., Zhang, Q., Zhang, J., Wang, L., Zhang, Y., Wang, L., and Nie, K. (2020). Gut Microbiota Altered in Mild Cognitive Impairment Compared With Normal Cognition in Sporadic Parkinson\u2019s Disease. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.00137"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/cns.13990","article-title":"Gut bacterial profiles in Parkinson\u2019s disease: A systematic review","volume":"29","author":"Li","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbi.2018.02.016","article-title":"Alteration of the fecal microbiota in Chinese patients with Parkinson\u2019s disease","volume":"70","author":"Qian","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/mds.27105","article-title":"The nasal and gut microbiome in Parkinson\u2019s disease and idiopathic rapid eye movement sleep behavior disorder","volume":"33","author":"Pandey","year":"2018","journal-title":"Mov. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ijbiomac.2020.05.180","article-title":"Yeast \u03b2-glucan alleviates cognitive deficit by regulating gut microbiota and metabolites in A\u03b21-42-induced AD-like mice","volume":"161","author":"Xu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Liu, P., Gao, M., Liu, Z., Zhang, Y., Tu, H., Lei, L., Wu, P., Zhang, A., Yang, C., and Li, G. (2022). Gut Microbiome Composition Linked to Inflammatory Factors and Cognitive Functions in First-Episode, Drug-Naive Major Depressive Disorder Patients. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.800764"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bbi.2017.02.004","article-title":"Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse","volume":"65","author":"Scott","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3233\/JAD-160884","article-title":"Alzheimer\u2019s Disease Histological and Behavioral Manifestations in Transgenic Mice Correlate with Specific Gut Microbiome State","volume":"56","author":"Shen","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.3233\/JAD-215495","article-title":"Transfer of Tumor-Bearing Mice Intestinal Flora Can Ameliorate Cognition in Alzheimer\u2019s Disease Mice","volume":"86","author":"Hang","year":"2022","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40035-022-00323-z","article-title":"Gut microbiome, cognitive function and brain structure: A multi-omics integration analysis","volume":"11","author":"Liang","year":"2022","journal-title":"Transl. Neurodegener."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1161\/CIRCRESAHA.118.313234","article-title":"A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis","volume":"124","author":"Brandsma","year":"2019","journal-title":"Circ. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1099\/ijs.0.014571-0","article-title":"Alistipes indistinctus sp. nov. and Odoribacter laneus sp. nov., common members of the human intestinal microbiota isolated from faeces","volume":"60","author":"Nagai","year":"2010","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuro.2019.02.019","article-title":"Indole-3 acid increased risk of impaired cognitive function in patients receiving hemodialysis","volume":"73","author":"Lin","year":"2019","journal-title":"Neurotoxicology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuro.2016.01.006","article-title":"Indoxyl sulfate, not p-cresyl sulfate, is associated with cognitive impairment in early-stage chronic kidney disease","volume":"53","author":"Yeh","year":"2016","journal-title":"Neurotoxicology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrmicro1817","article-title":"Polysaccharide utilization by gut bacteria: Potential for new insights from genomic analysis","volume":"6","author":"Flint","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13568-018-0629-9","article-title":"The influence of in vitro pectin fermentation on the human fecal microbiome","volume":"8","author":"Bang","year":"2018","journal-title":"AMB Express"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wu, H., Qiu, W., Zhu, X., Li, X., Xie, Z., Carreras, I., Dedeoglu, A., Van Dyke, T., Han, Y.W., and Karimbux, N. (2022). The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer\u2019s Pathogenesis via Specific Pathways. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.912709"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1080\/0886022X.2020.1864404","article-title":"Specific alterations in gut microbiota in patients with chronic kidney disease: An updated systematic review","volume":"43","author":"Zhao","year":"2021","journal-title":"Ren. Fail."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2017","journal-title":"Environ. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/ndt\/gfv095","article-title":"Altered intestinal microbial flora and impaired epithelial barrier structure and function in CKD: The nature, mechanisms, consequences and potential treatment","volume":"31","author":"Vaziri","year":"2016","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1038\/s41380-023-02146-4","article-title":"A systematic review exploring the association between the human gut microbiota and brain connectivity in health and disease","volume":"28","author":"Mulder","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Cooke, M.B., Catchlove, S., and Tooley, K.L. (2022). Examining the Influence of the Human Gut Microbiota on Cognition and Stress: A Systematic Review of the Literature. Nutrients, 14.","DOI":"10.3390\/nu14214623"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2006586","DOI":"10.1080\/19490976.2021.2006586","article-title":"Multivariate associative patterns between the gut microbiota and large-scale brain network connectivity","volume":"13","author":"Kohn","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Eicher, T.P., and Mohajeri, M.H. (2022). Overlapping Mechanisms of Action of Brain-Active Bacteria and Bacterial Metabolites in the Pathogenesis of Common Brain Diseases. Nutrients, 14.","DOI":"10.3390\/nu14132661"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Atzeni, A., Bastiaanssen, T.F., Cryan, J.F., Tinahones, F.J., Vioque, J., Corella, D., Fit\u00f3, M., Vidal, J., Moreno-Indias, I., and G\u00f3mez-P\u00e9rez, A.M. (2022). Taxonomic and Functional Fecal Microbiota Signatures Associated with Insulin Resistance in Non-Diabetic Subjects with Overweight\/Obesity within the Frame of the PREDIMED-Plus Study. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.804455"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.2337\/dc20-0631","article-title":"Erythrocyte n-6 Polyunsaturated Fatty Acids, Gut Microbiota, and Incident Type 2 Diabetes: A Prospective Cohort Study","volume":"43","author":"Miao","year":"2020","journal-title":"Diabetes Care"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2298026","DOI":"10.1080\/19490976.2023.2298026","article-title":"Pasteurized akkermansia muciniphila improves irritable bowel syndrome-like symptoms and related behavioral disorders in mice","volume":"16","author":"Meynier","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Liang, H., Wang, Y., Cheng, R., Pu, F., Yang, Y., Li, J., Wu, S., Shen, X., and He, F. (2022). Heat-inactivated Lacticaseibacillus paracasei N1115 alleviates the damage due to brain function caused by long-term antibiotic cocktail exposure in mice. BMC Neurosci., 23.","DOI":"10.1186\/s12868-022-00724-w"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.7150\/ijms.6251","article-title":"Citrobacter peritoneal dialysis peritonitis: Rare occurrence with poor outcomes","volume":"10","author":"Chao","year":"2013","journal-title":"Int. J. Med. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Labarthe, S., Plancade, S., Raguideau, S., Plaza O\u00f1ate, F., Le Chatelier, E., Leclerc, M., and Laroche, B. (2023). Four functional profiles for fibre and mucin metabolism in the human gut microbiome. Microbiome, 11.","DOI":"10.1186\/s40168-023-01667-y"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3748\/wjg.v30.i3.225","article-title":"Relationship among Parkinson\u2019s disease, constipation, microbes, and microbiological therapy","volume":"30","author":"Yuan","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Campbell, A., Gdanetz, K., Schmidt, A.W., and Schmidt, T.M. (2023). H2 generated by fermentation in the human gut microbiome influences metabolism and competitive fitness of gut butyrate producers. Microbiome, 11.","DOI":"10.1186\/s40168-023-01565-3"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2659\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:35:01Z","timestamp":1760110501000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":60,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["nu16162659"],"URL":"https:\/\/doi.org\/10.3390\/nu16162659","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,12]]}}}