{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:36:37Z","timestamp":1768275397345,"version":"3.49.0"},"reference-count":31,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea National Institute of Health (KNIH)","award":["2019-ER-7304-00"],"award-info":[{"award-number":["2019-ER-7304-00"]}]},{"name":"Korea National Institute of Health (KNIH)","award":["2019-ER-7304-01"],"award-info":[{"award-number":["2019-ER-7304-01"]}]},{"name":"Korea National Institute of Health (KNIH)","award":["2019-ER-7304-02"],"award-info":[{"award-number":["2019-ER-7304-02"]}]},{"name":"Korea National Institute of Health (KNIH)","award":["2024-0089"],"award-info":[{"award-number":["2024-0089"]}]},{"name":"Seoul Women\u2019s University","award":["2019-ER-7304-00"],"award-info":[{"award-number":["2019-ER-7304-00"]}]},{"name":"Seoul Women\u2019s University","award":["2019-ER-7304-01"],"award-info":[{"award-number":["2019-ER-7304-01"]}]},{"name":"Seoul Women\u2019s University","award":["2019-ER-7304-02"],"award-info":[{"award-number":["2019-ER-7304-02"]}]},{"name":"Seoul Women\u2019s University","award":["2024-0089"],"award-info":[{"award-number":["2024-0089"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Autosomal dominant polycystic kidney disease (ADPKD) is a genetic kidney disorder with multiple cyst formation that progresses to chronic kidney disease (CKD) and end-stage kidney disease. Plant-based diets have attracted considerable attention because they may prevent CKD development. This study investigated whether adherence to a plant-based diet is associated with kidney function in patients with ADPKD. The overall plant-based diet index (PDI), healthful PDI (hPDI), and unhealthful PDI (uPDI) were calculated using dietary intake data. Among 106 ADPKD patients, 37 (34.91%) were classified as having advanced CKD (eGFR &lt; 60 mL\/min\/1.73 m2). The overall PDI and hPDI were lower, but the uPDI was higher in patients with advanced CKD than in those with early CKD. The hPDI was negatively correlated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Moreover, the hPDI was inversely associated with advanced CKD [odds ratio (OR): 0.117 (95% confidence interval (CI): 0.039\u20130.351), p &lt; 0.001], and the uPDI was positively associated with advanced CKD [OR: 8.450 (95% CI: 2.810\u201325.409), p &lt; 0.001]. The findings of the current study demonstrate that greater adherence to a healthful plant-based diet is associated with improved kidney function in ADPKD patients.<\/jats:p>","DOI":"10.3390\/nu16162749","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T05:19:36Z","timestamp":1724044776000},"page":"2749","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Compliance with a Healthful Plant-Based Diet Is Associated with Kidney Function in Patients with Autosomal Dominant Polycystic Kidney Disease"],"prefix":"10.3390","volume":"16","author":[{"given":"Sumin","family":"Heo","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, Seoul Women\u2019s University, Seoul 01797, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyeun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Medical Center, Seoul 04564, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunjin","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-2784","authenticated-orcid":false,"given":"Eunjeong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-198X","authenticated-orcid":false,"given":"Minsang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curie","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Medical Center, Seoul 04564, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7892-7648","authenticated-orcid":false,"given":"Soo Jin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Seoul Women\u2019s University, Seoul 01797, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kook-Hwan","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.xkme.2019.11.009","article-title":"Advances in Autosomal Dominant Polycystic Kidney Disease: A Clinical Review","volume":"2","author":"Nobakht","year":"2020","journal-title":"Kidney Med."},{"key":"ref_2","first-page":"1356","article-title":"Prevalence of autosomal dominant polycystic kidney disease in the European Union","volume":"32","author":"Willey","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1681\/ASN.2018050493","article-title":"Prevalence Estimates of Polycystic Kidney and Liver Disease by Population Sequencing","volume":"29","author":"Lanktree","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1053\/j.ajkd.2015.07.037","article-title":"Autosomal Dominant Polycystic Kidney Disease: Core Curriculum 2016","volume":"67","author":"Chebib","year":"2016","journal-title":"Am. J. Kidney Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100639","DOI":"10.1016\/j.xkme.2023.100639","article-title":"Tolvaptan and Kidney Function Decline in Older Individuals with Autosomal Dominant Polycystic Kidney Disease: A Pooled Analysis of Randomized Clinical Trials and Observational Studies","volume":"5","author":"Chebib","year":"2023","journal-title":"Kidney Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ki.2015.59","article-title":"Autosomal-dominant polycystic kidney disease (ADPKD): Executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"88","author":"Chapman","year":"2015","journal-title":"Kidney Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/j.ajkd.2020.05.006","article-title":"KDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update","volume":"76","author":"Ikizler","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/advances\/nmab131","article-title":"Dietary Interventions in Autosomal Dominant Polycystic Kidney Disease","volume":"13","author":"Pickel","year":"2022","journal-title":"Adv. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Capelli, I., Lerario, S., Aiello, V., Provenzano, M., Di Costanzo, R., Squadrani, A., Vella, A., Vicennati, V., Poli, C., and La Manna, G. (2023). Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature. Nutrients, 15.","DOI":"10.3390\/nu15112621"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S275","DOI":"10.1093\/advances\/nmy117","article-title":"Plant-Based Diets for Personal, Population, and Planetary Health","volume":"10","author":"Hemler","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.tcm.2018.02.004","article-title":"Plant-based diets and cardiovascular health","volume":"28","author":"Satija","year":"2018","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"101499","DOI":"10.1016\/j.diabet.2023.101499","article-title":"A healthful plant-based diet is associated with lower type 2 diabetes risk via improved metabolic state and organ function: A prospective cohort study","volume":"50","author":"Thompson","year":"2023","journal-title":"Diabetes Metab."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Samtiya, M., Aluko, R.E., Dhewa, T., and Moreno-Rojas, J.M. (2021). Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview. Foods, 10.","DOI":"10.3390\/foods10040839"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"682","DOI":"10.2215\/CJN.12391018","article-title":"Plant-Based Diets and Incident CKD and Kidney Function","volume":"14","author":"Kim","year":"2019","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41581-020-0297-2","article-title":"Plant-based diets to manage the risks and complications of chronic kidney disease","volume":"16","author":"Carrero","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Satija, A., Bhupathiraju, S.N., Rimm, E.B., Spiegelman, D., Chiuve, S.E., Borgi, L., Willett, W.C., Manson, J.E., Sun, Q., and Hu, F.B. (2016). Plant-Based Dietary Patterns and Incidence of Type 2 Diabetes in US Men and Women: Results from Three Prospective Cohort Studies. PLoS Med., 13.","DOI":"10.1371\/journal.pmed.1002039"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1053\/j.jrn.2023.09.002","article-title":"Association Between Plant-based Diet and Kidney Function in Adults","volume":"34","author":"Moloudpour","year":"2024","journal-title":"J. Ren. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1053\/j.ajkd.2023.05.007","article-title":"Association of Plant Protein Intake with Risk of Incident CKD: A UK Biobank Study","volume":"82","author":"Heo","year":"2023","journal-title":"Am. J. Kidney Dis."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Li, P., Xia, C., Liu, P., Peng, Z., Huang, H., Wu, J., and He, Z. (2020). Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in evaluation of inflammation in non-dialysis patients with end-stage renal disease (ESRD). BMC Nephrol., 21.","DOI":"10.1186\/s12882-020-02174-0"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.5414\/CN108584","article-title":"Neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio in evaluation of inflammation in end-stage renal disease","volume":"85","author":"Ahbap","year":"2016","journal-title":"Clin. Nephrol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2515690X221079688","article-title":"Promoting Plant-Based Therapies for Chronic Kidney Disease","volume":"27","author":"Khan","year":"2022","journal-title":"J. Evid.-Based Integr. Med."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ranganathan, N., and Anteyi, E. (2022). The Role of Dietary Fiber and Gut Microbiome Modulation in Progression of Chronic Kidney Disease. Toxins, 14.","DOI":"10.3390\/toxins14030183"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.2215\/CJN.00490114","article-title":"Effect of increasing dietary fiber on plasma levels of colon-derived solutes in hemodialysis patients","volume":"9","author":"Sirich","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_25","first-page":"1363","article-title":"Effects of fermentable dietary fiber supplementation on oxidative and inflammatory status in hemodialysis patients","volume":"8","author":"Xie","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/ki.2011.355","article-title":"High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease","volume":"81","author":"Krishnamurthy","year":"2012","journal-title":"Kidney Int."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Sakaguchi, Y., Kaimori, J.Y., and Isaka, Y. (2023). Plant-Dominant Low Protein Diet: A Potential Alternative Dietary Practice for Patients with Chronic Kidney Disease. Nutrients, 15.","DOI":"10.3390\/nu15041002"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.kint.2020.04.053","article-title":"Salt, but not protein intake, is associated with accelerated disease progression in autosomal dominant polycystic kidney disease","volume":"98","author":"Kramers","year":"2020","journal-title":"Kidney Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"664","DOI":"10.2215\/CJN.0000000000000326","article-title":"Polycystic Kidney Disease Diet: What is Known and What is Safe","volume":"19","author":"Chebib","year":"2024","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev-animal-022516-022943","article-title":"Animal Proteins as Important Contributors to a Healthy Human Diet","volume":"5","author":"Elmadfa","year":"2017","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Alvirdizadeh, S., Yuzbashian, E., Mirmiran, P., Eghtesadi, S., and Azizi, F. (2020). A prospective study on total protein, plant protein and animal protein in relation to the risk of incident chronic kidney disease. BMC Nephrol., 21.","DOI":"10.1186\/s12882-020-02079-y"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2749\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:38:20Z","timestamp":1760110700000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,17]]},"references-count":31,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["nu16162749"],"URL":"https:\/\/doi.org\/10.3390\/nu16162749","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,17]]}}}