{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:59:07Z","timestamp":1791572347302,"version":"4.3.4"},"reference-count":155,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Innovation and Technology of Hungary","award":["TKP2021-EGA-32"],"award-info":[{"award-number":["TKP2021-EGA-32"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The olive tree (Olea europaea) and olive oil hold significant cultural and historical importance in Europe. The health benefits associated with olive oil consumption have been well documented. This paper explores the mechanisms of the anti-cancer effects of olive oil and olive leaf, focusing on their key bioactive compounds, namely oleocanthal, oleacein, and oleuropein. The chemopreventive potential of oleocanthal, oleacein, and oleuropein is comprehensively examined through this systematic review. We conducted a systematic literature search to identify eligible articles from Scopus, PubMed, and Web of Science databases published up to 10 October 2023. Among 4037 identified articles, there were 88 eligible articles describing mechanisms of chemopreventive effects of oleocanthal, oleacein, and oleuropein. These compounds have the ability to inhibit cell proliferation, induce cell death (apoptosis, autophagy, and necrosis), inhibit angiogenesis, suppress tumor metastasis, and modulate cancer-associated signalling pathways. Additionally, oleocanthal and oleuropein were also reported to disrupt redox hemostasis. This review provides insights into the chemopreventive mechanisms of O. europaea-derived secoiridoids, shedding light on their role in chemoprevention. The bioactivities summarized in the paper support the epidemiological evidence demonstrating a negative correlation between olive oil consumption and cancer risk. Furthermore, the mapped and summarized secondary signalling pathways may provide information to elucidate new synergies with other chemopreventive agents to complement chemotherapies and develop novel nutrition-based anti-cancer approaches.<\/jats:p>","DOI":"10.3390\/nu16162755","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T05:19:36Z","timestamp":1724044776000},"page":"2755","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Anticancer Effects of Secoiridoids\u2014A Scoping Review of the Molecular Mechanisms behind the Chemopreventive Effects of the Olive Tree Components Oleocanthal, Oleacein, and Oleuropein"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1248-042X","authenticated-orcid":false,"given":"Ikhwan Yuda","family":"Kusuma","sequence":"first","affiliation":[{"name":"Institute of Clinical Pharmacy, University of Szeged, 6725 Szeged, Hungary"},{"name":"Pharmacy Study Program, Universitas Harapan Bangsa, Purwokerto 53182, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habibie","family":"Habibie","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6582-5615","authenticated-orcid":false,"given":"Muh. Akbar","family":"Bahar","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacy, University of Szeged, 6725 Szeged, Hungary"},{"name":"Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1562-9496","authenticated-orcid":false,"given":"Ferenc","family":"Bud\u00e1n","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4088-3333","authenticated-orcid":false,"given":"Dezs\u0151","family":"Csupor","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacy, University of Szeged, 6725 Szeged, Hungary"},{"name":"Institute for Translational Medicine, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,18]]},"reference":[{"key":"ref_1","unstructured":"WHO (2024). Global Cancer Burden Growing, Amidst Mounting Need for Services, WHO. Available online: https:\/\/www.who.int\/news\/item\/01-02-2024-global-cancer-burden-growing--amidst-mounting-need-for-services."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1001\/jamaoncol.2022.7826","article-title":"Estimates and Projections of the Global Economic Cost of 29 Cancers in 204 Countries and Territories from 2020 to 2050","volume":"9","author":"Chen","year":"2023","journal-title":"JAMA Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1001\/jamaoncol.2021.6987","article-title":"Cancer Incidence, Mortality, Years of Life Lost, Years Lived with Disability, and Disability-Adjusted Life Years for 29 Cancer Groups from 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019","volume":"8","author":"Kocarnik","year":"2022","journal-title":"JAMA Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1039\/C6FO00958A","article-title":"Anti-Cancer Properties of Olive Oil Secoiridoid Phenols: A Systematic Review of in Vivo Studies","volume":"7","author":"Fabiani","year":"2016","journal-title":"Food Funct."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Emma, M.R., Augello, G., Stefano, V., Azzolina, A., Giannitrapani, L., Montalto, G., Cervello, M., and Cusimano, A. (2021). Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer: A Narrative Review of Preclinical Studies. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031234"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Quiles, J.L., Ram\u00edrez-Tortosa, M.C., and Yaqoob, P. (2006). Olive Oil and Health, CABI Publishing.","DOI":"10.1079\/9781845930684.0000"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Albini, A., Albini, F., Corradino, P., Dugo, L., Calabrone, L., and Noonan, D.M. (2023). From Antiquity to Contemporary Times: How Olive Oil by-Products and Waste Water Can Contribute to Health. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1254947"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/oxfordjournals.aje.a114480","article-title":"The Diet and 15-Year Death Rate in the Seven Countries Study","volume":"124","author":"Keys","year":"1986","journal-title":"Am. J. Epidemiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Jimenez-Lopez, C., Carpena, M., Louren\u00e7o-Lopes, C., Gallardo-Gomez, M., Lorenzo, J.M., Barba, F.J., Prieto, M.A., and Simal-Gandara, J. (2020). Bioactive Compounds and Quality of Extra Virgin Olive Oil. Foods, 9.","DOI":"10.3390\/foods9081014"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1207\/S15327914NC4601_04","article-title":"The Protective Effect of the Mediterranean Diet on Lung Cancer","volume":"46","author":"Fortes","year":"2003","journal-title":"Nutr. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2174\/138161211795428920","article-title":"Olive Oil and Cancer Risk: An Update of Epidemiological Findings through 2010","volume":"17","author":"Pelucchi","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/ijc.10485","article-title":"Food Groups and Laryngeal Cancer Risk: A Case-control Study from Italy and Switzerland","volume":"100","author":"Bosetti","year":"2002","journal-title":"Int. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Markellos, C., Ourailidou, M.-E., Gavriatopoulou, M., Halvatsiotis, P., Sergentanis, T.N., and Psaltopoulou, T. (2022). Olive Oil Intake and Cancer Risk: A Systematic Review and Meta-Analysis. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0261649"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ejca.2010.09.027","article-title":"Consumption of Animal Products, Olive Oil and Dietary Fat and Results from the Belgian Case\u2013Control Study on Bladder Cancer Risk","volume":"47","author":"Brinkman","year":"2011","journal-title":"Eur. J. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Tian, M., Bai, Y., Tian, H., and Zhao, X. (2023). The Chemical Composition and Health-Promoting Benefits of Vegetable Oils\u2014A Review. Molecules, 28.","DOI":"10.3390\/molecules28176393"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0049-3848(00)00321-2","article-title":"Antithrombotic Potential of Olive Oil Administration in Rabbits with Elevated Cholesterol","volume":"100","author":"Villalobos","year":"2000","journal-title":"Thromb. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1093\/ajcn\/70.6.976","article-title":"Are Olive Oil Diets Antithrombotic? Diets Enriched with Olive, Rapeseed, or Sunflower Oil Affect Postprandial Factor VII Differently","volume":"70","author":"Larsen","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gorzynik-Debicka, M., Przychodzen, P., Cappello, F., Kuban-Jankowska, A., Marino Gammazza, A., Knap, N., Wozniak, M., and Gorska-Ponikowska, M. (2018). Potential Health Benefits of Olive Oil and Plant Polyphenols. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030686"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1021\/jf00035a076","article-title":"Simple and Hydrolyzable Compounds in Virgin Olive Oil. 3. Spectroscopic Characterizations of the Secoiridoid Derivatives","volume":"41","author":"Montedoro","year":"1993","journal-title":"J. Agric. Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/437045a","article-title":"Phytochemistry: Ibuprofen-like Activity in Extra-Virgin Olive Oil","volume":"437","author":"Beauchamp","year":"2005","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0944-7113(96)80076-6","article-title":"Isolation of an Angiotensin Converting Enzyme (ACE) Inhibitor from Olea Europaea and Olea Lancea","volume":"2","author":"Hansen","year":"1996","journal-title":"Phytomedicine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.clnu.2023.06.027","article-title":"Rich Oleocanthal and Oleacein Extra Virgin Olive Oil and Inflammatory and Antioxidant Status in People with Obesity and Prediabetes. The APRIL Study: A Randomised, Controlled Crossover Study","volume":"42","author":"Lara","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_23","unstructured":"HMPC (2016). Assessment Report on Olea Europaea L., Folium, European Medicines Agency."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1080\/10408398.2019.1650715","article-title":"Health-Promoting Properties of Oleocanthal and Oleacein: Two Secoiridoids from Extra-Virgin Olive Oil","volume":"60","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Szabo, L., Molnar, R., Tomesz, A., Deutsch, A., Darago, R., Varjas, T., Ritter, Z., Szentpeteri, J.L., Andreidesz, K., and Mathe, D. (2022). Olive Oil Improves While Trans Fatty Acids Further Aggravate the Hypomethylation of LINE-1 Retrotransposon DNA in an Environmental Carcinogen Model. Nutrients, 14.","DOI":"10.3390\/nu14040908"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Goren, L., Zhang, G., Kaushik, S., Breslin, P.A.S., Du, Y.-C.N., and Foster, D.A. (2019). (\u2212)-Oleocanthal and (\u2212)-Oleocanthal-Rich Olive Oils Induce Lysosomal Membrane Permeabilization in Cancer Cells. PLoS ONE, 14.","DOI":"10.1101\/610097"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Siddique, A.B., Ebrahim, H.Y., Tajmim, A., King, J.A., Abdelwahed, K.S., Abd Elmageed, Z.Y., and El Sayed, K.A. (2022). Oleocanthal Attenuates Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence by Targeting SMYD2. Cancers, 14.","DOI":"10.3390\/cancers14143542"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1080\/01635581.2016.1180407","article-title":"Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells","volume":"68","author":"Fogli","year":"2016","journal-title":"Nutr. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"11334","DOI":"10.1039\/D2FO01222G","article-title":"(\u2212)-Oleocanthal Induces Death Preferentially in Tumor Hematopoietic Cells through Caspase Dependent and Independent Mechanisms","volume":"13","author":"Pastorio","year":"2022","journal-title":"Food Funct."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejphar.2017.06.019","article-title":"The Olive Oil Phenolic (\u2212)-Oleocanthal Modulates Estrogen Receptor Expression in Luminal Breast Cancer in Vitro and in Vivo and Synergizes with Tamoxifen Treatment","volume":"810","author":"Ayoub","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.bbamcr.2018.10.010","article-title":"(\u2212)-Oleocanthal Inhibits Proliferation and Migration by Modulating Ca2+ Entry through TRPC6 in Breast Cancer Cells","volume":"1866","author":"Jardin","year":"2019","journal-title":"Biochim. Biophys. Acta BBA Mol. Cell Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3892\/ijo.2017.4049","article-title":"Oleocanthal Exerts Antitumor Effects on Human Liver and Colon Cancer Cells through ROS Generation","volume":"51","author":"Cusimano","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"43475","DOI":"10.18632\/oncotarget.9782","article-title":"(\u2212)-Oleocanthal Inhibits Growth and Metastasis by Blocking Activation of STAT3 in Human Hepatocellular Carcinoma","volume":"7","author":"Pei","year":"2016","journal-title":"Oncotarget"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Siddique, A.B., Ayoub, N.M., Tajmim, A., Meyer, S.A., Hill, R.A., and El Sayed, K.A. (2019). (\u2212)-Oleocanthal Prevents Breast Cancer Locoregional Recurrence After Primary Tumor Surgical Excision and Neoadjuvant Targeted Therapy in Orthotopic Nude Mouse Models. Cancers, 11.","DOI":"10.3390\/cancers11050637"},{"key":"ref_35","first-page":"43","article-title":"Pre-Initiation Effect of Oleuropein towards Apoptotic and Oxidative Stress Levels on the Early Development of Two-Stage Skin Carcinogenesis","volume":"8","author":"John","year":"2019","journal-title":"J. Krishna Inst. Med. Sci. Univ."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e1006077","DOI":"10.1080\/23723556.2015.1006077","article-title":"(\u2212)-Oleocanthal Rapidly and Selectively Induces Cancer Cell Death via Lysosomal Membrane Permeabilization","volume":"2","author":"LeGendre","year":"2015","journal-title":"Mol. Cell. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/ptr.5434","article-title":"Olive Oil-Derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies","volume":"29","author":"Khanfar","year":"2015","journal-title":"Phytother. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Siddique, A.B., Kilgore, P., Tajmim, A., Singh, S.S., Meyer, S.A., Jois, S.D., Cvek, U., Trutschl, M., and El Sayed, K.A. (2020). (\u2212)-Oleocanthal as a Dual c-MET-COX2 Inhibitor for the Control of Lung Cancer. Nutrients, 12.","DOI":"10.3390\/nu12061749"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Akl, M.R., Ayoub, N.M., Mohyeldin, M.M., Busnena, B.A., Foudah, A.I., Liu, Y.Y., and Sayed, K.A.E. (2014). Olive Phenolics as C-Met Inhibitors: (\u2212)-Oleocanthal Attenuates Cell Proliferation, Invasiveness, and Tumor Growth in Breast Cancer Models. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097622"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1055\/s-0030-1270724","article-title":"(\u2212)-Oleocanthal as a c-Met Inhibitor for the Control of Metastatic Breast and Prostate Cancers","volume":"77","author":"Elnagar","year":"2011","journal-title":"Planta Med."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Qusa, M.H., Abdelwahed, K.S., Siddique, A.B., and El Sayed, K.A. (2021). Comparative Gene Signature of (\u2212)-Oleocanthal Formulation Treatments in Heterogeneous Triple Negative Breast Tumor Models: Oncological Therapeutic Target Insights. Nutrients, 13.","DOI":"10.3390\/nu13051706"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Tajmim, A., Siddique, A.B., and El Sayed, K. (2019). Optimization of Taste-Masked (\u2212)-Oleocanthal Effervescent Formulation with Potent Breast Cancer Progression and Recurrence Suppressive Activities. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11100515"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/10520295.2019.1674919","article-title":"Inhibiting Effect of Oleocanthal on Neuroblastoma Cancer Cell Proliferation in Culture","volume":"95","author":"Mete","year":"2020","journal-title":"Biotech. Histochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3892\/or.2016.5270","article-title":"(\u2212)-Oleocanthal Exerts Anti-Melanoma Activities and Inhibits STAT3 Signalling Pathway","volume":"37","author":"Gu","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10142-023-01230-w","article-title":"Next-Generation Sequencing Reveals Altered Gene Expression and Enriched Pathways in Triple-Negative Breast Cancer Cells Treated with Oleuropein and Oleocanthal","volume":"23","author":"Karousi","year":"2023","journal-title":"Funct. Integr. Genom."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Bossio, S., Perri, A., Malivindi, R., Giordano, F., Rago, V., Mirabelli, M., Salatino, A., Brunetti, A., Greco, E.A., and Aversa, A. (2022). Oleuropein Counteracts Both the Proliferation and Migration of Intra- and Extragonadal Seminoma Cells. Nutrients, 14.","DOI":"10.3390\/nu14112323"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0024-3205(97)01150-8","article-title":"Oleuropein, the Bitter Principle of Olives, Enhances Nitric Oxide Production by Mouse Macrophages","volume":"62","author":"Visioli","year":"1998","journal-title":"Life Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.fct.2012.12.009","article-title":"Olive Oil Oleuropein Has Anti-Breast Cancer Properties with Higher Efficiency on ER-Negative Cells","volume":"53","author":"Elamin","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.21873\/anticanres.13234","article-title":"Anticancer Potential of Oleuropein, the Polyphenol of Olive Oil, With 2-Methoxyestradiol, Separately or in Combination, in Human Osteosarcoma Cells","volume":"39","author":"Przychodzen","year":"2019","journal-title":"Anticancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Ruzzolini, J., Peppicelli, S., Andreucci, E., Bianchini, F., Scardigli, A., Romani, A., La Marca, G., Nediani, C., and Calorini, L. (2018). Oleuropein, the Main Polyphenol of Olea Europaea Leaf Extract, Has an Anti-Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies. Nutrients, 10.","DOI":"10.20944\/preprints201811.0277.v1"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10616-009-9191-2","article-title":"Anti-Proliferative and Apoptotic Effects of Oleuropein and Hydroxytyrosol on Human Breast Cancer MCF-7 Cells","volume":"59","author":"Han","year":"2009","journal-title":"Cytotechnology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.bbrc.2005.06.161","article-title":"Oleuropein, a Non-Toxic Olive Iridoid, Is an Anti-Tumor Agent and Cytoskeleton Disruptor","volume":"334","author":"Hamdi","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Gioti, K., Papachristodoulou, A., Benaki, D., Aligiannis, N., Skaltsounis, A.L., Mikros, E., and Tenta, R. (2021). Assessment of the Nutraceutical Effects of Oleuropein and the Cytotoxic Effects of Adriamycin, When Administered Alone and in Combination, in MG-63 Human Osteosarcoma Cells. Nutrients, 13.","DOI":"10.3390\/nu13020354"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/mnfr.200900111","article-title":"Oleuropein and Hydroxytyrosol Inhibit MCF-7 Breast Cancer Cell Proliferation Interfering with ERK1\/2 Activation","volume":"54","author":"Sirianni","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.yexcr.2013.11.022","article-title":"Olive Oil Compounds Inhibit Vascular Endothelial Growth Factor Receptor-2 Phosphorylation","volume":"322","author":"Lamy","year":"2014","journal-title":"Exp. Cell Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.3945\/jn.109.104992","article-title":"Olive Leaf Extract and Its Main Component Oleuropein Prevent Chronic Ultraviolet B Radiation-Induced Skin Damage and Carcinogenesis in Hairless Mice","volume":"139","author":"Kimura","year":"2009","journal-title":"J. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1002\/jcb.27738","article-title":"Oleuropein Induces Apoptosis via Abrogating NF-\u03baB Activation Cascade in Estrogen Receptor-Negative Breast Cancer Cells","volume":"120","author":"Liu","year":"2019","journal-title":"J. Cell Biochem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.3892\/mmr.2015.3266","article-title":"Oleuropein Induces Apoptosis via Activation of Caspases and Suppression of Phosphatidylinositol 3-Kinase\/Protein Kinase B Pathway in HepG2 Human Hepatoma Cell Line","volume":"11","author":"Yan","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10549-020-06054-x","article-title":"Oleuropein Is a Natural Inhibitor of PAI-1-Mediated Proliferation in Human ER-\/PR- Breast Cancer Cells","volume":"186","author":"Tzekaki","year":"2021","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Messeha, S.S., Zarmouh, N.O., Asiri, A., and Soliman, K.F.A. (2020). Gene Expression Alterations Associated with Oleuropein-Induced Antiproliferative Effects and S-Phase Cell Cycle Arrest in Triple-Negative Breast Cancer Cells. Nutrients, 12.","DOI":"10.3390\/nu12123755"},{"key":"ref_61","first-page":"31","article-title":"Antiproliferative Effect of Oleuropein in Prostate Cell Lines","volume":"41","author":"Vanella","year":"2012","journal-title":"Int. J. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"35344","DOI":"10.18632\/oncotarget.6119","article-title":"Oleuropein Aglycone Induces Autophagy via the AMPK\/mTOR Signalling Pathway: A Mechanistic Insight","volume":"6","author":"Rigacci","year":"2015","journal-title":"Oncotarget"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.7314\/APJCP.2013.14.11.6739","article-title":"Oleuropein Induces Apoptosis via the P53 Pathway in Breast Cancer Cells","volume":"14","author":"Hassan","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.7314\/APJCP.2012.13.9.4555","article-title":"Oleuropein Induces Anti-Metastatic Effects in Breast Cancer","volume":"13","author":"Hassan","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/mnfr.201500605","article-title":"Chemopreventive Effect of Oleuropein in Colitis-Associated Colorectal Cancer in C57bl\/6 Mice","volume":"60","author":"Giner","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"110023","DOI":"10.1016\/j.foodres.2020.110023","article-title":"Gender Differences in the Antioxidant Response of Oral Administration of Hydroxytyrosol and Oleuropein against N-Ethyl-N-Nitrosourea (ENU)-Induced Glioma","volume":"140","author":"Mayas","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Goldsmith, C.D., Bond, D.R., Jankowski, H., Weidenhofer, J., Stathopoulos, C.E., Roach, P.D., and Scarlett, C.J. (2018). The Olive Biophenols Oleuropein and Hydroxytyrosol Selectively Reduce Proliferation, Influence the Cell Cycle, and Induce Apoptosis in Pancreatic Cancer Cells. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19071937"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.2174\/1871520619666190722101207","article-title":"Hydroxytyrosol and Oleuropein Inhibit Migration and Invasion of MDA-MB-231 Triple-Negative Breast Cancer Cell via Induction of Autophagy","volume":"19","author":"Lu","year":"2019","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.21873\/anticanres.16628","article-title":"Oleuropein Induces Cytotoxicity and Peroxiredoxin Over-Expression in MCF-7 Human Breast Cancer Cells","volume":"43","author":"Junkins","year":"2023","journal-title":"Anticancer Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1080\/01635581.2020.1807575","article-title":"Oleuropein: A Potential Inhibitor for Prostate Cancer Cell Motility by Blocking Voltage-Gated Sodium Channels","volume":"73","author":"Aktas","year":"2021","journal-title":"Nutr. Cancer"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"173509","DOI":"10.1016\/j.ejphar.2020.173509","article-title":"The Effect of Oleuropein on Apoptotic Pathway Regulators in Breast Cancer Cells","volume":"886","author":"Asgharzade","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1177\/0960327119855123","article-title":"Oleuropein Modulates Glioblastoma miRNA Pattern Different from Olea Europaea Leaf Extract","volume":"38","author":"Tezcan","year":"2019","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/01635581.2013.741758","article-title":"Oleuropein, a Secoiridoid Derived from Olive Tree, Inhibits the Proliferation of Human Colorectal Cancer Cell through Downregulation of HIF-1\u03b1","volume":"65","author":"Rosillo","year":"2013","journal-title":"Nutr. Cancer"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1007\/s11033-023-08773-y","article-title":"Oleuropein Exhibits Anticarcinogen Effects against Gastric Cancer Cell Lines","volume":"50","author":"Demir","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"119353","DOI":"10.1016\/j.lfs.2021.119353","article-title":"Oleuropin Controls miR-194\/XIST\/PD-L1 Loop in Triple Negative Breast Cancer: New Role of Nutri-Epigenetics in Immune-Oncology","volume":"277","author":"Hamed","year":"2021","journal-title":"Life Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.gene.2016.03.038","article-title":"Investigation of Anticancer Mechanism of Oleuropein via Cell Cycle and Apoptotic Pathways in SH-SY5Y Neuroblastoma Cells","volume":"585","author":"Dodurga","year":"2016","journal-title":"Gene"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1089\/jmf.2016.0026","article-title":"Oleuropein Prevents Azoxymethane-Induced Colon Crypt Dysplasia and Leukocytes DNA Damage in A\/J Mice","volume":"19","author":"Sepporta","year":"2016","journal-title":"J. Med. Food"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1530\/JME-12-0241","article-title":"Antioxidant and Antigrowth Action of Peracetylated Oleuropein in Thyroid Cancer Cells","volume":"51","author":"Bulotta","year":"2013","journal-title":"J. Mol. Endocrinol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1002\/jcb.26754","article-title":"Simultaneous Downregulation of miR-21 and miR-155 through Oleuropein for Breast Cancer Prevention and Therapy","volume":"119","author":"Abtin","year":"2018","journal-title":"J. Cell Biochem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1002\/jcb.27827","article-title":"Mitochondria-Mediated Apoptosis Was Induced by Oleuropein in H1299 Cells Involving Activation of P38 MAP Kinase","volume":"120","author":"Wang","year":"2019","journal-title":"J. Cell Biochem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"104624","DOI":"10.1016\/j.tiv.2019.104624","article-title":"PTP1B Phosphatase as a Novel Target of Oleuropein Activity in MCF-7 Breast Cancer Model","volume":"61","author":"Przychodzen","year":"2019","journal-title":"Toxicol. Vitr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"17042","DOI":"10.1002\/jcb.28965","article-title":"The Hopeful Anticancer Role of Oleuropein in Breast Cancer through Histone Deacetylase Modulation","volume":"120","author":"Mansouri","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.lfs.2018.02.027","article-title":"Oleuropein Potentiates Anti-Tumor Activity of Cisplatin against HepG2 through Affecting proNGF\/NGF Balance","volume":"198","author":"Sherif","year":"2018","journal-title":"Life Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"119525","DOI":"10.1016\/j.lfs.2021.119525","article-title":"Oleuropein Reduces Cisplatin Resistance in Ovarian Cancer by Targeting Apoptotic Pathway Regulators","volume":"278","author":"Rahmati","year":"2021","journal-title":"Life Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.biopha.2017.09.072","article-title":"P38 MAP Kinase Is Involved in Oleuropein-Induced Apoptosis in A549 Cells by a Mitochondrial Apoptotic Cascade","volume":"95","author":"Cao","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"154770","DOI":"10.1016\/j.phymed.2023.154770","article-title":"Glycolysis, a New Mechanism of Oleuropein against Liver Tumor","volume":"114","author":"Hong","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.lfs.2019.01.053","article-title":"Surface Functionalized Folate Targeted Oleuropein Nano-Liposomes for Prostate Tumor Targeting: Invitro and Invivo Activity","volume":"220","author":"Nassir","year":"2019","journal-title":"Life Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.3892\/or.2016.4978","article-title":"Oleuropein Inhibits the Proliferation and Invasion of Glioma Cells via Suppression of the AKT Signalling Pathway","volume":"36","author":"Liu","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"8576961","DOI":"10.1155\/2019\/8576961","article-title":"Oleuropein-Induced Apoptosis Is Mediated by Mitochondrial Glyoxalase 2 in NSCLC A549 Cells: A Mechanistic Inside and a Possible Novel Nonenzymatic Role for an Ancient Enzyme","volume":"2019","author":"Antognelli","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Scicchitano, S., Vecchio, E., Battaglia, A.M., Oliverio, M., Nardi, M., Procopio, A., Costanzo, F., Biamonte, F., and Faniello, M.C. (2023). The Double-Edged Sword of Oleuropein in Ovarian Cancer Cells: From Antioxidant Functions to Cytotoxic Effects. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010842"},{"key":"ref_91","first-page":"61","article-title":"The Impact of Oleuropein on miRNAs Regulating Cell Death Signalling Pathway in Human Cervical Cancer Cells","volume":"71","author":"Shaygan","year":"2023","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1002\/jcp.27586","article-title":"Oleuropein Inhibits Migration Ability through Suppression of Epithelial-Mesenchymal Transition and Synergistically Enhances Doxorubicin-Mediated Apoptosis in MCF-7 Cells","volume":"234","author":"Choupani","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Barzegar, F., Zaefizadeh, M., Yari, R., and Salehzadeh, A. (2019). Synthesis of Nano-Paramagnetic Oleuropein to Induce KRAS Over-Expression: A New Mechanism to Inhibit AGS Cancer Cells. Medicina, 55.","DOI":"10.3390\/medicina55070388"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1254\/jphs.14012FP","article-title":"Oleuropein Induced Apoptosis in HeLa Cells via a Mitochondrial Apoptotic Cascade Associated with Activation of the C-Jun NH2-Terminal Kinase","volume":"125","author":"Yao","year":"2014","journal-title":"J. Pharmacol. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1080\/01635581.2020.1750661","article-title":"Hydroxytyrosol and Oleuropein Inhibit Migration and Invasion via Induction of Autophagy in ER-Positive Breast Cancer Cell Lines (MCF7 and T47D","volume":"73","author":"Lu","year":"2021","journal-title":"Nutr. Cancer"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Xu, T., and Liu, X. (2022). Oleuropein Inhibits Invasion of Squamous Cell Carcinoma of the Head and Neck through TGF-\u03921 Signalling Pathway. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-09979-2"},{"key":"ref_97","first-page":"3073","article-title":"Exploring the Therapeutic Potential of Fe3O4@Glu-Oleuropein Nanoparticles in Targeting KRAS Pathway-Regulating lncRNAs in Colorectal Cancer Cells","volume":"202","author":"Salehzadeh","year":"2023","journal-title":"Biol. Trace Element Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s13273-022-00260-y","article-title":"Oleuropein Induces Apoptosis in Colorectal Tumor Spheres via Mitochondrial Fission","volume":"19","author":"Kim","year":"2023","journal-title":"Mol. Cell. Toxicol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2174\/1871523018666190201145824","article-title":"Antioxidant Effects of Oleuropein on Hydrogen Peroxide-Induced Neuronal Stress-An In Vitro Study","volume":"19","author":"Kucukgul","year":"2020","journal-title":"Antiinflamm. Antiallergy Agents Med. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"347","DOI":"10.17576\/jsm-2019-4802-11","article-title":"The Effects of Oleuropein on Apoptotic Rate and Oxidative Stress Profiles during Tumour Promotion Stage in the Mouse Skin Carcinogenesis Model","volume":"48","author":"Masre","year":"2019","journal-title":"Sains Malays."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jff.2018.12.026","article-title":"Oleuropein Aglycone Attenuates the Pro-Angiogenic Phenotype of Senescent Fibroblasts: A Functional Study in Endothelial Cells","volume":"53","author":"Margheri","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"47","DOI":"10.6000\/2292-2598.2019.07.02.3","article-title":"Study of a Nano-Oleuropein\u2019s Effect on the TCA Cycles Protein Expression in the Breast Cancer Cell Line Using Proteomics","volume":"7","author":"Kamrani","year":"2019","journal-title":"J. Intellect. Disabil. Diagn. Treat."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"32027","DOI":"10.18632\/oncotarget.16757","article-title":"Dietary Oleuropein Inhibits Tumor Angiogenesis and Lymphangiogenesis in the B16F10 Melanoma Allograft Model: A Mechanism for the Suppression of High-Fat Diet-Induced Solid Tumor Growth and Lymph Node Metastasis","volume":"8","author":"Song","year":"2017","journal-title":"Oncotarget"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1179\/1351000215Y.0000000039","article-title":"The Olive Leaf Extract Oleuropein Exerts Protective Effects against Oxidant-Induced Cell Death, Concurrently Displaying pro-Oxidant Activity in Human Hepatocarcinoma Cells","volume":"21","author":"Katsoulieris","year":"2016","journal-title":"Redox Rep."},{"key":"ref_105","first-page":"765","article-title":"Ameliorative Role of Oleuropein Extracted from Olive Leaf on Tamoxifen-Induced Hepatic 8-Hydroxydeoxyguanosine in DNA of Balb\/C Mice","volume":"30","author":"Jamshed","year":"2014","journal-title":"World Appl. Sci. J."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jff.2014.09.006","article-title":"Phenolic Compounds Oleuropein and Hydroxytyrosol Exert Differential Effects on Glioma Development via Antioxidant Defense Systems","volume":"11","author":"Mayas","year":"2014","journal-title":"J. Funct. Foods"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.foodchem.2011.02.025","article-title":"Antiproliferative and Antioxidant Effects on Breast Cancer Cells of Oleuropein and Its Semisynthetic Peracetylated Derivatives","volume":"127","author":"Bulotta","year":"2011","journal-title":"Food Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.fct.2016.03.015","article-title":"The Effect of Oleuropein from Olive Leaf (Olea Europaea) Extract on Ca2+ Homeostasis, Cytotoxicity, Cell Cycle Distribution and ROS Signalling in HepG2 Human Hepatoma Cells","volume":"91","author":"Cheng","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Marrero, A.D., Ortega-Vidal, J., Salido, S., Castilla, L., Vidal, I., Quesada, A.R., Altarejos, J., Mart\u00ednez-Poveda, B., and Medina, M. (2023). Anti-Angiogenic Effects of Oleacein and Oleocanthal: New Bioactivities of Compounds from Extra Virgin Olive Oil. Biomed. Pharmacother., 165.","DOI":"10.1016\/j.biopha.2023.115234"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Carpi, S., Polini, B., Manera, C., Digiacomo, M., Salsano, J.E., Macchia, M., Scoditti, E., and Nieri, P. (2020). miRNA Modulation and Antitumor Activity by the Extra-Virgin Olive Oil Polyphenol Oleacein in Human Melanoma Cells. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.574317"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1039\/D0FO00089B","article-title":"Oleacein Inhibits STAT3, Activates the Apoptotic Machinery, and Exerts Anti-Metastatic Effects in the SH-SY5Y Human Neuroblastoma Cells","volume":"11","author":"Cirmi","year":"2020","journal-title":"Food Funct."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Juli, G., Oliverio, M., Bellizzi, D., Gallo Cantafio, M.E., Grillone, K., Passarino, G., Colica, C., Nardi, M., Rossi, M., and Procopio, A. (2019). Anti-Tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma. Cancers, 11.","DOI":"10.3390\/cancers11070990"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1245\/s10434-015-4715-9","article-title":"Chemoprevention for Breast Cancer","volume":"22","author":"Pruthi","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mrfmmm.2005.02.029","article-title":"Overview of Mechanisms of Cancer Chemopreventive Agents","volume":"591","author":"Flora","year":"2005","journal-title":"Mutat. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"703","DOI":"10.4161\/rna.20481","article-title":"The Hallmarks of Cancer: A Long Non-Coding RNA Point of View","volume":"9","author":"Gutschner","year":"2012","journal-title":"RNA Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.ccell.2021.03.010","article-title":"Targeting Cell-Cycle Machinery in Cancer","volume":"39","author":"Suski","year":"2021","journal-title":"Cancer Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.2741\/2834","article-title":"Cell Cycle Control as a Basis for Cancer Chemoprevention through Dietary Agents","volume":"13","author":"Meeran","year":"2008","journal-title":"Front. Biosci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1158\/0008-5472.CAN-09-0309","article-title":"Cell Cycle Regulation by MicroRNAs in Embryonic Stem Cells","volume":"69","author":"Wang","year":"2009","journal-title":"Cancer Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1158\/0008-5472.CAN-05-2203","article-title":"Cyclin D1 Is Transcriptionally Regulated by and Required for Transformation by Activated Signal Transducer and Activator of Transcription 3","volume":"66","author":"Leslie","year":"2006","journal-title":"Cancer Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/bies.950170605","article-title":"Calcium Signalling and Cell Proliferation","volume":"17","author":"Berridge","year":"1995","journal-title":"Bioessays"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jecm.2013.04.001","article-title":"Role of Apoptosis in the Chemoprevention of Cancer","volume":"5","author":"Tanaka","year":"2013","journal-title":"J. Exp. Clin. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e985913","DOI":"10.4161\/23723556.2014.985913","article-title":"Autophagy, Cell Death, and Cancer","volume":"2","author":"Lin","year":"2015","journal-title":"Mol. Cell Oncol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell Death: Critical Control Points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physrev.00013.2006","article-title":"Mitochondrial Membrane Permeabilization in Cell Death","volume":"87","author":"Kroemer","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1158\/0008-5472.CAN-04-1427","article-title":"Sensitization to the Lysosomal Cell Death Pathway upon Immortalization and Transformation","volume":"64","author":"Fehrenbacher","year":"2004","journal-title":"Cancer Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/tra.12613","article-title":"Lysosomal Membrane Permeabilization and Cell Death","volume":"19","author":"Wang","year":"2018","journal-title":"Traffic"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Antognelli, C., and Talesa, V.N. (2018). Glyoxalases in Urological Malignancies. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020415"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S1470-2045(01)00586-1","article-title":"Angiogenesis as a Biomarker and Target in Cancer Chemoprevention","volume":"2","author":"Sharma","year":"2001","journal-title":"Lancet Oncol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR Signalling Transduction Pathway and Targeted Therapies in Cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol. Cancer"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/gerona\/gly175","article-title":"Chronic Resveratrol Treatment Reduces the Pro-Angiogenic Effect of Human Fibroblast \u201cSenescent-Associated Secretory Phenotype\u201d on Endothelial Colony-Forming Cells: The Role of IL8","volume":"74","author":"Menicacci","year":"2019","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1615\/CritRevOncog.v18.i1-2.40","article-title":"On the origin of cancer metastasis","volume":"18","author":"Seyfried","year":"2013","journal-title":"Crit. Rev. Oncog."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41698-019-0092-3","article-title":"Engineered Models to Parse Apart the Metastatic Cascade","volume":"3","author":"Hapach","year":"2019","journal-title":"NPJ Precis. Oncol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The Basics of Epithelial-Mesenchymal Transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/mc.20665","article-title":"Growth Factor Signalling Pathways as Targets for Prevention of Epithelial Carcinogenesis","volume":"50","author":"Rho","year":"2011","journal-title":"Mol. Carcinog."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.gendis.2017.11.001","article-title":"Effect of Sirtuin 1 Inhibition on Matrix Metalloproteinase 2 and Forkhead Box O3a Expression in Breast Cancer Cells","volume":"4","author":"Abdelmawgoud","year":"2017","journal-title":"Genes Dis."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1038\/onc.2011.612","article-title":"SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis","volume":"31","author":"Byles","year":"2012","journal-title":"Oncogene"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3233\/JAD-160471","article-title":"The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An in Vitro and in Vivo Study","volume":"54","author":"Luccarini","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Deshotels, M.R., Spinu, E., Bailey, E., and Filipeanu, C. (2013). The Role of A-and \u0392-Estrogen Receptors on Neurite Outgrowth In Neuro-2A Cells, Wiley Online Library.","DOI":"10.1096\/fasebj.27.1_supplement.1175.5"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41586-020-1969-6","article-title":"Pan-Cancer Analysis of Whole Genomes","volume":"578","author":"Pritchard","year":"2020","journal-title":"Nature"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/bio.808","article-title":"Scavenging of Reactive Oxygen Species by the Plant Phenols Genistein and Oleuropein","volume":"20","author":"Kruk","year":"2005","journal-title":"Luminescence"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Li, Q., Li, Z., Luo, T., and Shi, H. (2022). Targeting the PI3K\/AKT\/mTOR and RAF\/MEK\/ERK Pathways for Cancer Therapy. Mol. Biomed., 3.","DOI":"10.1186\/s43556-022-00110-2"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41392-021-00828-5","article-title":"Targeting PI3K\/Akt signal transduction for cancer therapy","volume":"6","author":"He","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_143","first-page":"2585","article-title":"Overview of the STAT-3 Signalling Pathway in Cancer and the Development of Specific Inhibitors","volume":"19","author":"Gu","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Tian, T., Li, X., and Zhang, J. (2019). mTOR Signalling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030755"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1038\/onc.2011.62","article-title":"MicroRNA-193a Represses c-Kit Expression and Functions as a Methylation-Silenced Tumor Suppressor in Acute Myeloid Leukemia","volume":"30","author":"Gao","year":"2011","journal-title":"Oncogene"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/onc.2013.574","article-title":"MicroRNA-193a-3p and -5p Suppress the Metastasis of Human Non-Small-Cell Lung Cancer by Downregulating the ERBB4\/PIK3R3\/mTOR\/S6K2 Signalling Pathway","volume":"34","author":"Yu","year":"2015","journal-title":"Oncogene"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"You, C., Liang, H., Sun, W., Li, J., Liu, Y., Fan, Q., Zhang, H., Yue, X., Li, J., and Chen, X. (2016). Deregulation of the miR-16-KRAS Axis Promotes Colorectal Cancer. Sci. Rep., 6.","DOI":"10.1038\/srep37459"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrd2781","article-title":"Is NF-kappaB a Good Target for Cancer Therapy? Hopes and Pitfalls","volume":"8","author":"Baud","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.cr.7290105","article-title":"MAPK Signal Pathways in the Regulation of Cell Proliferation in Mammalian Cells","volume":"12","author":"Zhang","year":"2002","journal-title":"Cell Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tibs.2007.06.007","article-title":"The Pathways to Tumor Suppression via Route P38","volume":"32","author":"Han","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4161\/oxim.3.1.10095","article-title":"Redox Regulation in Cancer: A Double-Edged Sword with Therapeutic Potential","volume":"3","author":"Acharya","year":"2010","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Xing, F., Hu, Q., Qin, Y., Xu, J., Zhang, B., Yu, X., and Wang, W. (2022). The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.862743"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of Apoptosis Signalling Pathways by Reactive Oxygen Species","volume":"1863","year":"2016","journal-title":"Biochim. Biophys. Acta BBA Mol. Cell Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/1947601913484496","article-title":"SIRT1: Regulator of p53 deacetylation","volume":"4","author":"Lee","year":"2013","journal-title":"Genes Cancer"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbrc.2012.06.084","article-title":"Inhibition of SIRT1 by HIV-1 Viral Protein Tat Results in Activation of P53 Pathway","volume":"424","author":"Thakur","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2755\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:38:31Z","timestamp":1760110711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/16\/2755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,18]]},"references-count":155,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["nu16162755"],"URL":"https:\/\/doi.org\/10.3390\/nu16162755","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,18]]}}}