{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:19Z","timestamp":1787029219534,"version":"build-2736575974"},"reference-count":49,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:00:00Z","timestamp":1724457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Industrial Metal Powders (IMP; Maharashtra, India)","award":["CON110654V2"],"award-info":[{"award-number":["CON110654V2"]}]},{"name":"Industrial Metal Powders (IMP; Maharashtra, India)","award":["HSAF-G-RB13G"],"award-info":[{"award-number":["HSAF-G-RB13G"]}]},{"DOI":"10.13039\/100008136","name":"Case Western Reserve University, Cleveland, OH, USA","doi-asserted-by":"publisher","award":["CON110654V2"],"award-info":[{"award-number":["CON110654V2"]}],"id":[{"id":"10.13039\/100008136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008136","name":"Case Western Reserve University, Cleveland, OH, USA","doi-asserted-by":"publisher","award":["HSAF-G-RB13G"],"award-info":[{"award-number":["HSAF-G-RB13G"]}],"id":[{"id":"10.13039\/100008136","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Elemental iron powders are used as food fortificants to reduce the incidence of iron deficiency anemia. However, many commercially available iron powders are relatively untested in vivo. The purpose of this study was to determine the hemoglobin regeneration efficiency (HRE) and relative iron bioavailability (RBV) of an electrolytic elemental iron powder (EIP), by treating anemic rats with 14 d iron repletion diets fortified with four different concentrations (12, 24, 36, or 48 mg iron\/kg diet) of EIP and bakery-grade ferrous sulfate monohydrate (FS; FeSO4\u2022H2O), or no added iron (control); n = 9\u201312\/group. The HRE of FS was significantly higher (p \u2264 0.05) than EIP at each concentration of dietary iron tested. For EIP, the HREs (ratios) of diets containing 12, 24, 36, and 48 mg iron\/kg were 0.356, 0.205, 0.197, and 0.163, respectively. For both EIP and FS, HRE was inversely associated with increasing dietary iron. The RBVs (%) of iron from EIP in diets at 12, 24, 36, and 48 mg iron\/kg as compared to FS were 64.5, 59.1, 50.6, and 54.3%, respectively. Overall, findings show that at the concentrations of iron tested, EIP has RBVs greater than 50% and is an effective fortification agent to replenish hemoglobin and correct iron deficiency anemia.<\/jats:p>","DOI":"10.3390\/nu16172833","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T03:14:31Z","timestamp":1724642071000},"page":"2833","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An Electrolytic Elemental Iron Powder Effectively Regenerates Hemoglobin in Anemic Rats and Is Relatively Well Absorbed When Compared to Ferrous Sulfate Monohydrate"],"prefix":"10.3390","volume":"16","author":[{"given":"James H.","family":"Swain","sequence":"first","affiliation":[{"name":"Department of Nutrition, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0978-7930","authenticated-orcid":false,"given":"Logan D.","family":"Glosser","sequence":"additional","affiliation":[{"name":"School of Medicine, Emory University, 100 Woodruff Circle, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"Jang","sequence":"additional","affiliation":[{"name":"Scientific Enrichment Opportunity Program, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C.","family":"Nemeth","sequence":"additional","affiliation":[{"name":"Scientific Enrichment Opportunity Program, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshul R.","family":"Bethi","sequence":"additional","affiliation":[{"name":"Scientific Enrichment Opportunity Program, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva L.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Scientific Enrichment Opportunity Program, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn R.","family":"Boron","sequence":"additional","affiliation":[{"name":"Scientific Enrichment Opportunity Program, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah M.","family":"Fox","sequence":"additional","affiliation":[{"name":"Baylor University Medical Center, 3500 Gaston Ave, Dallas, TX 75246, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2174\/1573396320666230727102042","article-title":"Iron Deficiency Anemia: An Updated Review","volume":"20","author":"Leung","year":"2024","journal-title":"Curr. 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