{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:51:30Z","timestamp":1790635890247,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNCE Innovaci\u00f3n S.L.","award":["B98333586"],"award-info":[{"award-number":["B98333586"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This study aimed to assess the impact of a combination of probiotic strains of Lactiplantibacillus on the treatment of androgenic alopecia (AGA). To this end, 136 individuals with AGA (62 men and 74 women) aged 18\u201365 years were enrolled in a double-blind, parallel-group clinical trial. A total of 115 individuals (57 in the probiotic group and 58 in the placebo group) completed this study within a 16-week intervention period. Capillary density, thickness, and length of hair were analyzed before and after the intervention using FotoFinder Trichoscale Pro. In addition, the gut microbiota was assessed by paired-end sequencing on the Illumina MiSeq platform (2 \u00d7 300 bp). At the conclusion of the treatment period, a notable decline (p &lt; 0.05) in the number of telogen hairs was evident in the probiotic group while hair thickness decreased in the placebo group (p &lt; 0.05). However, the remaining variables did not exhibit any statistically significant changes. In the probiotic-treated group, individuals aged less than 37.5 years exhibited a reduction in the number and density of telogen hair (p = 0.0693 and p = 0.0669, respectively) and an increase in hair length (p = 0.0871). Furthermore, a notable decline in the number and density of vellus hair (p &lt; 0.05) was observed, and this was accompanied by no change in the hair thickness. The probiotic-treated group exhibited a significantly higher abundance of Lactobacillus (p-adjusted &lt; 0.05, DEseq2 test) and demonstrated a notable reduction in the number and density of telogen hair, and this was accompanied by an increase in the percentage of anagen hair. The probiotic mixture was well tolerated by the participants, with a treatment adherence rate of 90%. In light of this study\u2019s limitations, it can be concluded that a mixture of three strains of Lactiplantibacillus promotes the presence of terminal follicles, preventing their gradual miniaturization, which is a characteristic of AGA.<\/jats:p>","DOI":"10.3390\/nu16172900","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T06:46:29Z","timestamp":1725000389000},"page":"2900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Randomized Clinical Trial to Evaluate the Effect of Probiotic Intake on Androgenic Alopecia"],"prefix":"10.3390","volume":"16","author":[{"given":"Alejandro","family":"Garc\u00eda-Navarro","sequence":"first","affiliation":[{"name":"Centro Dermatol\u00f3gico Est\u00e9tico, 03014 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Vasallo-Morillas","sequence":"additional","affiliation":[{"name":"San Antonio Technologies S.L., 30107 Murcia, Spain"},{"name":"Faculty of Medicine, Faculty of Pharmacy and Nutrition, UCAM, Universidad Cat\u00f3lica de Murcia, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roge","family":"Navarro-Belmonte","sequence":"additional","affiliation":[{"name":"Centro Dermatol\u00f3gico Est\u00e9tico, 03014 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Vilanova","sequence":"additional","affiliation":[{"name":"Darwing Bioprospecting Excellence S.L., 46980 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Torrent","sequence":"additional","affiliation":[{"name":"Darwing Bioprospecting Excellence S.L., 46980 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8544-635X","authenticated-orcid":false,"given":"Alina","family":"Kilasoniya","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Faculty of Pharmacy and Nutrition, UCAM, Universidad Cat\u00f3lica de Murcia, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Moles-Ugeda","sequence":"additional","affiliation":[{"name":"Centro Dermatol\u00f3gico Est\u00e9tico, 03014 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Gallego-Herrera","sequence":"additional","affiliation":[{"name":"Centro Dermatol\u00f3gico Est\u00e9tico, 03014 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1853-7790","authenticated-orcid":false,"given":"Ana","family":"Ram\u00edrez-Bosc\u00e1","sequence":"additional","affiliation":[{"name":"Centro Dermatol\u00f3gico Est\u00e9tico, 03014 Alicante, Spain"},{"name":"Faculty of Medicine, Faculty of Pharmacy and Nutrition, UCAM, Universidad Cat\u00f3lica de Murcia, 30107 Murcia, Spain"},{"name":"Department of Dermatology, Hospital Universitario del Vinalop\u00f3, 03293 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4103\/ijdvl.IJDVL_262_17","article-title":"Genetic and molecular aspects of androgenetic alopecia","volume":"84","year":"2018","journal-title":"Indian J. 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