{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:09:22Z","timestamp":1792084162370,"version":"4.4.0"},"reference-count":65,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Ciencia, e Innovaci\u00f3n y Universidades","award":["PID2020-119084RB-C21"],"award-info":[{"award-number":["PID2020-119084RB-C21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Fortified human milk is the first choice for preterm infants. Although individualized fortification is recommended, the optimal method for this population remains uncertain. We conducted a comparative study assessing the growth effects of adjusted (AF) and targeted fortification (TF) in extremely low birth weight (ELBW) infants. This single-center, randomized, controlled clinical trial was conducted at a tertiary neonatal unit in Spain. Eligible participants were premature infants with a birthweight of &lt;1000 g exclusively fed with human milk. A total of 38 patients were enrolled, 15 of them randomized to AF group and 23 to TF group. AF was based on blood urea nitrogen (BUN) concentration and TF on human milk analysis. The primary outcome was weight gain velocity (g\/kg\/day). No significant differences were found in weight gain velocity at 28 days, at 36 weeks of postmenstrual age, at discharge, nor during the intervention. Protein intake was significantly higher in the AF group (5.02 g\/kg\/day vs. 4.48 g\/kg\/day, p = 0.001). No differences were found in the lipid, carbohydrate, and energy intake; in the weight z score change between the different time points; nor in the length and head circumference growth. Both AF and TF are comparable methods of fortification and provide the appropriate growth rate in ELBW infants.<\/jats:p>","DOI":"10.3390\/nu16172904","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T06:46:29Z","timestamp":1725000389000},"page":"2904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adjusted versus Targeted Fortification in Extremely Low Birth Weight Preterm Infants: Fortin Study\u2014A Randomized Clinical Trial"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-8545","authenticated-orcid":false,"given":"Maria","family":"Sanchez-Holgado","sequence":"first","affiliation":[{"name":"Neonatology Hospital La Paz Institute for Health Research, IdiPaz (Universidad Autonoma de Madrid), 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4793-1561","authenticated-orcid":false,"given":"Miguel","family":"Saenz de Pipaon","sequence":"additional","affiliation":[{"name":"Neonatology Hospital La Paz Institute for Health Research, IdiPaz (Universidad Autonoma de Madrid), 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Concepcion","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Department of Neonatology, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3130-1922","authenticated-orcid":false,"given":"Gema","family":"Crespo Sanchez","sequence":"additional","affiliation":[{"name":"Laboratory of Gastroenterology and Trace Elements, Department of Laboratory Medicine, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6839-1963","authenticated-orcid":false,"given":"Marta","family":"Molero-Luis","sequence":"additional","affiliation":[{"name":"Laboratory of Gastroenterology and Trace Elements, Department of Laboratory Medicine, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-2637","authenticated-orcid":false,"given":"Maria Teresa","family":"Montes","sequence":"additional","affiliation":[{"name":"Department of Neonatology, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Segovia","sequence":"additional","affiliation":[{"name":"Department of Neonatology, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itsaso","family":"Losantos-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital La Paz Institute for Health Research-IdIPAZ, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-731X","authenticated-orcid":false,"given":"Mar\u00eda","family":"Jimenez-Gonzalez","sequence":"additional","affiliation":[{"name":"Clinical trials Unit, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Escribano","sequence":"additional","affiliation":[{"name":"Neonatology Hospital La Paz Institute for Health Research, IdiPaz (Universidad Autonoma de Madrid), 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cabrera-Lafuente","sequence":"additional","affiliation":[{"name":"Neonatology Hospital La Paz Institute for Health Research, IdiPaz (Universidad Autonoma de Madrid), 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Arslanoglu, S., Boquien, C.Y., King, C., Lamireau, D., Tonetto, P., Barnett, D., Bertino, E., Gaya, A., Gebauer, C., and Grovslien, A. 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