{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:53:52Z","timestamp":1787500432188,"version":"build-2736575974"},"reference-count":53,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"the Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/P008429\/1"],"award-info":[{"award-number":["BB\/P008429\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Institute of Life Course and Medical Sciences, University of Liverpool","award":["BB\/P008429\/1"],"award-info":[{"award-number":["BB\/P008429\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Sarcopenia is characterised by the loss of skeletal muscle mass and function, which leads to a high risk of increased morbidity and mortality. Maternal malnutrition has been linked to impaired development of skeletal muscle of the offspring; however, there are limited studies that report the long-term effect of a maternal low-protein diet during lactation on the ageing of skeletal muscles. This study aimed to examine how a maternal low-protein diet (LPD) during lactation affects skeletal muscle ageing in the offspring. Pups born from control mothers were lactated by mothers fed with an LPD. Post-weaning, mice were either maintained on an LPD or switched to a control, normal-protein diet (NPD). In males, an LPD mainly affected the size of the myofibres without a major effect on fibre number and led to reduced grip strength in ageing mice (24 months). Female mice from mothers on an LPD had a lower body and muscle weight at weaning but caught up with control mice at 3 months. During ageing, the muscle weight, myofibre number and survival rate of female pups were significantly affected. These findings highlight the effect of an LPD during lactation on skeletal muscle ageing, the lifespan of offspring and the importance of sexual dimorphism in response to dietary challenges.<\/jats:p>","DOI":"10.3390\/nu16172926","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T07:59:40Z","timestamp":1725263980000},"page":"2926","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Lactational Low-Protein Diet on Skeletal Muscle during Adulthood and Ageing in Male and Female Mouse Offspring"],"prefix":"10.3390","volume":"16","author":[{"given":"Moussira","family":"Alameddine","sequence":"first","affiliation":[{"name":"Department of Musculoskeletal & Ageing Science, Institute of Life Course & Medical Sciences (ILCaMS), University of Liverpool, Liverpool L7 8TX, UK"},{"name":"Division of Developmental Biology and Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilla Emre","family":"Altinpinar","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal & Ageing Science, Institute of Life Course & Medical Sciences (ILCaMS), University of Liverpool, Liverpool L7 8TX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4014-7985","authenticated-orcid":false,"given":"Ufuk","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal & Ageing Science, Institute of Life Course & Medical Sciences (ILCaMS), University of Liverpool, Liverpool L7 8TX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Kanakis","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal & Ageing Science, Institute of Life Course & Medical Sciences (ILCaMS), University of Liverpool, Liverpool L7 8TX, UK"},{"name":"Chester Medical School, Faculty of Health, Medicine and Society, University of Chester, Chester CH1 4BJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1974-1194","authenticated-orcid":false,"given":"Ioanna","family":"Myrtziou","sequence":"additional","affiliation":[{"name":"Chester Medical School, Faculty of Health, Medicine and Society, University of Chester, Chester CH1 4BJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-5144","authenticated-orcid":false,"given":"Susan E.","family":"Ozanne","sequence":"additional","affiliation":[{"name":"MRC Metabolic Diseases Unit, Welcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Treatment Centre, Addenbrooke\u2019s Hospital, University of Cambridge Metabolic Research Laboratories, Cambridge CB2 0QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Goljanek-Whysall","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal & Ageing Science, Institute of Life Course & Medical Sciences (ILCaMS), University of Liverpool, Liverpool L7 8TX, UK"},{"name":"Department of Physiology, School of Medicine and REMEDI, CMNHS, University of Galway, H91 TK33 Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5652-0895","authenticated-orcid":false,"given":"Aphrodite","family":"Vasilaki","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal & Ageing Science, Institute of Life Course & Medical Sciences (ILCaMS), University of Liverpool, Liverpool L7 8TX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,1]]},"reference":[{"key":"ref_1","first-page":"33","article-title":"Skeletal Muscle Fibre Number in the Rat from Youth to Adulthood","volume":"173","author":"Timson","year":"1990","journal-title":"J. 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