{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:22:59Z","timestamp":1775665379425,"version":"3.50.1"},"reference-count":161,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Practice Plan and the Farouk Jabre Interfaculty Grant at the American University of Beirut","award":["U54MD007602"],"award-info":[{"award-number":["U54MD007602"]}]},{"name":"National Council for Scientific Research of Lebanon (CNRS-L)","award":["U54MD007602"],"award-info":[{"award-number":["U54MD007602"]}]},{"name":"Research Centers in Minority Institutions (RCMI)","award":["U54MD007602"],"award-info":[{"award-number":["U54MD007602"]}]},{"name":"National Institute of Minority Health and Health Disparities (NIMHD)","award":["U54MD007602"],"award-info":[{"award-number":["U54MD007602"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D deficiency is a global problem. Vitamin D, the vitamin D receptor, and its enzymes are found throughout neuronal, ependymal, and glial cells in the brain and are implicated in certain processes and mechanisms in the brain. To investigate the processes affected by vitamin D deficiency in adults, we studied vitamin D deficient, control, and supplemented diets over 6 weeks in male and female C57Bl\/6 mice. The effect of the vitamin D diets on proliferation in the neurogenic niches, changes in glial cells, as well as on memory, locomotion, and anxiety-like behavior, was investigated. Six weeks on a deficient diet was adequate time to reach deficiency. However, vitamin D deficiency and supplementation did not affect proliferation, neurogenesis, or astrocyte changes, and this was reflected on behavioral measures. Supplementation only affected microglia in the dentate gyrus of female mice. Indicating that vitamin D deficiency and supplementation do not affect these processes over a 6-week period.<\/jats:p>","DOI":"10.3390\/nu16172938","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T07:59:40Z","timestamp":1725263980000},"page":"2938","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Vitamin D Deficiency Does Not Affect Cognition and Neurogenesis in Adult C57Bl\/6 Mice"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9378-311X","authenticated-orcid":false,"given":"Mark","family":"Doumit","sequence":"first","affiliation":[{"name":"Department of Anatomy, Cell Biology, and Physiology, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2693-6603","authenticated-orcid":false,"given":"Carla","family":"El-Mallah","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, Faculty of Agriculture and Food Sciences, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"El-Makkawi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Cell Biology, and Physiology, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-1296","authenticated-orcid":false,"given":"Omar","family":"Obeid","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, Faculty of Agriculture and Food Sciences, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5008-6944","authenticated-orcid":false,"given":"Firas","family":"Kobeissy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5744-6466","authenticated-orcid":false,"given":"Hala","family":"Darwish","sequence":"additional","affiliation":[{"name":"Hariri School of Nursing, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9719-9324","authenticated-orcid":false,"given":"Wassim","family":"Abou-Kheir","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Cell Biology, and Physiology, Faculty of Medicine, American University of Beirut, Beirut P.O. 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