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Current therapeutic strategies primarily target immune dysregulation, but limitations in efficacy and tolerability highlight the need for alternative treatments. Plant-derived compounds, including alkaloids, phenylpropanoids, and terpenoids, have demonstrated anti-inflammatory effects in both preclinical and clinical studies. By modulating immune responses and promoting neuroregeneration, these compounds offer potential as novel adjunctive therapies for MS. This review provides insights into the molecular and cellular basis of MS pathogenesis, emphasizing the role of inflammation in disease progression. It critically evaluates emerging evidence supporting the use of plant-derived compounds to attenuate inflammation and MS symptomology. In addition, we provide a comprehensive source of information detailing the known mechanisms of action and assessing the clinical potential of plant-derived compounds in the context of MS pathogenesis, with a focus on their anti-inflammatory and neuroprotective properties.<\/jats:p>","DOI":"10.3390\/nu16172996","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T04:15:11Z","timestamp":1725509711000},"page":"2996","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Potential Application of Plant-Derived Compounds in Multiple Sclerosis Management"],"prefix":"10.3390","volume":"16","author":[{"given":"Seth","family":"Woodfin","sequence":"first","affiliation":[{"name":"Department of Biology and Chemistry, School of Health Sciences, Liberty University, Lynchburg, VA 24515, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sierra","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Biology and Chemistry, School of Health Sciences, Liberty University, Lynchburg, VA 24515, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Ramerth","sequence":"additional","affiliation":[{"name":"Department of Biology and Chemistry, School of Health Sciences, Liberty University, Lynchburg, VA 24515, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Chapple","sequence":"additional","affiliation":[{"name":"Department of Biology and Chemistry, School of Health Sciences, Liberty University, Lynchburg, VA 24515, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3770-3506","authenticated-orcid":false,"given":"Dane","family":"Fausnacht","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Sciences and Agriculture, Ferrum College, Ferrum, VA 24088, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-3660","authenticated-orcid":false,"given":"William","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Biology and Chemistry, School of Health Sciences, Liberty University, Lynchburg, VA 24515, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-6349","authenticated-orcid":false,"given":"Hana","family":"Alkhalidy","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA 24061, USA"},{"name":"Department of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-8198","authenticated-orcid":false,"given":"Dongmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA 24061, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"ref_1","unstructured":"Tafti, D., Ehsan, M., and Xixis, K.L. (2024, May 06). 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