{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:09:24Z","timestamp":1792616964746,"version":"4.5.0"},"reference-count":24,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"daptable and Seamless Technology transfer Program (A-STEP)"},{"name":"Try-out program by the Japan Science and Technology Agency (JST)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>ATP-binding cassette transporter subfamily G member 2 (ABCG2) is responsible for the excretion of foreign substances, such as uric acid (UA) and indoxyl sulfate (IS), from the body. Given the importance of increased ABCG2 expression in UA excretion, we investigated the enhancement of intestinal ABCG2 expression using Lactiplantibacillus plantarum 06CC2 (LP06CC2). Mice were reared on a potassium oxonate-induced high-purine model at doses of 0.02% or 0.1% LP06CC2 for three weeks. Results showed that LP06CC2 feeding resulted in increased ABCG2 expression in the small intestine. The expression level of large intestinal ABCG2 also showed a tendency to increase, suggesting upregulation of the intestinal excretion transporter ABCG2 by LP06CC2. Overall, LP06CC2 treatment increased fecal UA excretion and showed a trend towards increased fecal excretion of IS, suggesting that LP06CC2 treatment enhanced the expression of intestinal ABCG2, thereby promoting the excretion of UA and other substances from the intestinal tract.<\/jats:p>","DOI":"10.3390\/nu16173042","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T05:59:08Z","timestamp":1725861548000},"page":"3042","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lactiplantibacillus plantarum 06CC2 Enhanced the Expression of Intestinal Uric Acid Excretion Transporter in Mice"],"prefix":"10.3390","volume":"16","author":[{"given":"Shunsuke","family":"Nei","sequence":"first","affiliation":[{"name":"Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Matsusaki","sequence":"additional","affiliation":[{"name":"Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan"},{"name":"Research and Development Division, Minami Nihon Rakuno Kyodo Co., Ltd., 5282 Takagi, Miyakonojo 885-0003, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hibiki","family":"Kawakubo","sequence":"additional","affiliation":[{"name":"Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjirou","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuluunbat","family":"Tsend-Ayush","sequence":"additional","affiliation":[{"name":"School of Industrial Technology, Mongolian University of Science and Technology, P.O. Box 46\/520, Baga Toiruu, Sukhbaatar District, Ulaanbaatar 46, Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-8548","authenticated-orcid":false,"given":"Tomoki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Research and Development Division, Minami Nihon Rakuno Kyodo Co., Ltd., 5282 Takagi, Miyakonojo 885-0003, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0739-8571","authenticated-orcid":false,"given":"Masahiko","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Research and Development Division, Minami Nihon Rakuno Kyodo Co., Ltd., 5282 Takagi, Miyakonojo 885-0003, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuo","family":"Shinyama","sequence":"additional","affiliation":[{"name":"Research and Development Division, Minami Nihon Rakuno Kyodo Co., Ltd., 5282 Takagi, Miyakonojo 885-0003, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7758-9405","authenticated-orcid":false,"given":"Masao","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Li, S., Yang, H., Guo, Y., Wei, F., Yang, X., Li, D., Li, M., Xu, W., Li, W., and Sun, L. 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