{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T08:05:23Z","timestamp":1782201923495,"version":"3.54.5"},"reference-count":54,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Introduction: Parkinson\u2019s disease (PD) is a highly prevalent disease characterized by motor and non-motor symptoms; the latter include constipation, which is considered a prodromal symptom. On the other hand, sarcopenia, polypharmacy, and malnutrition due to deficits are common in PD and lead to poorer health and quality of life. Objective: to associate constipation and use of levodopa with nutritional status, sarcopenia, duration and stage of the disease, and polypharmacy in individuals with PD. Materials and methods: analytical cross-sectional observational study where an online survey was applied to 161 people suffering from PD. Results: a significant association is observed between constipation and BMI (p = 0.022), as well as between the use of levodopa with BMI (p = 0.049) and polypharmacy (p = 0.046). On the other hand, there is a relationship between the average time of PD diagnosis and constipation (p = 0.0047). Finally, there is a relationship between SARC-F score applied to those over 60 years of age (p = 0.0446) and the use of levodopa. Having sarcopenia, being overweight, and having had the disease for less than five years is associated with a higher probability of experiencing constipation, according to the logistic regression analysis (p &gt; 0.005). Conclusion: nutritional assessment and subsequent follow-up is of vital importance to avoid complications that could be associated with levodopa use, constipation, and sarcopenia.<\/jats:p>","DOI":"10.3390\/nu16183092","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T10:02:54Z","timestamp":1726221774000},"page":"3092","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations between Constipation and Use of Levodopa with Nutritional Status, Polypharmacy, and Stage of Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6583-7491","authenticated-orcid":false,"given":"Paula","family":"Garc\u00eda-Milla","sequence":"first","affiliation":[{"name":"Department of Food Technology, Nutrition and Food Science, Veterinary Faculty, University of Murcia, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Campus de Espinardo, Espinardo, 30100 Murcia, Spain"},{"name":"Carrera Nutrici\u00f3n y Diet\u00e9tica, Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Providencia 7500975, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-3676","authenticated-orcid":false,"given":"Samuel","family":"Duran-Ag\u00fcero","sequence":"additional","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Ciencias para el Cuidado de la Salud, Universidad San Sebasti\u00e1n, Los Leones, Providencia 7510157, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-2899","authenticated-orcid":false,"given":"Gema","family":"Nieto","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Nutrition and Food Science, Veterinary Faculty, University of Murcia, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Campus de Espinardo, Espinardo, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"ref_1","unstructured":"Federaci\u00f3n Espa\u00f1ola de Parkinson (2023, November 26). \u00bfQU\u00c9 ES EL P\u00c1RKINSON?. 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