{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:47:30Z","timestamp":1792806450029,"version":"4.5.0"},"reference-count":48,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nestl\u00e9 Health Science","id":[{"id":"https:\/\/ror.org\/03y8jvk69","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: User-friendly tools for assessing nutrition status and interventions in malnourished patients are crucial. This study evaluated the effectiveness of a personalised nutrition intervention using a novel oral nutritional supplement and AI-supported morphofunctional assessment to monitor clinical outcomes in patients with disease-related malnutrition (DRM). Methods: This prospective observational study involved patients receiving concentrated high-protein, high-calorie ONS (cHPHC-ONS), per usual clinical practice. Comprehensive assessments were performed at baseline (B0) and three months (M3) post-intervention. Results: 65 patients participated in the study. Significant decreases were observed in the percentage weight loss from B0 (\u22126.75 \u00b1 7.5%) to M3 (0.5 \u00b1 3.48%) (p &lt; 0.01), in the prevalence of malnutrition (B0: 93.4%; M3: 78.9%; p &lt; 0.01), severe malnutrition (B0: 60.7%; M3: 40.3%; p &lt; 0.01), and sarcopenia (B0: 19.4%; M3: 15.5%; p &lt; 0.04). Muscle area increased (p = 0.03), and there were changes in the echogenicity of the rectus femoris muscle (p = 0.03) from B0 to M3. In patients aged \u226560, an increase in muscle thickness (p = 0.04), pennation angle (p = 0.02), and handgrip strength (p = 0.04) was observed. There was a significant reduction in the prevalence of malnutrition (B0: 93.4%; M3: 78.9%; p &lt; 0.01) and severe malnutrition (B0: 60.7%; M3: 40.3%; p &lt; 0.01). Conclusions: In patients with DRM, a personalised intervention with cHPHC-ONS significantly reduces the prevalence of malnutrition, severe malnutrition, and sarcopenia and improves muscle mass and function.<\/jats:p>","DOI":"10.3390\/nu16183136","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:51:43Z","timestamp":1726620703000},"page":"3136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effectiveness of High-Protein Energy-Dense Oral Supplements on Patients with Malnutrition Using Morphofunctional Assessment with AI-Assisted Muscle Ultrasonography: A Real-World One-Arm Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3144-343X","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"L\u00f3pez-G\u00f3mez","sequence":"first","affiliation":[{"name":"Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain"},{"name":"Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Primo-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain"},{"name":"Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5878-2832","authenticated-orcid":false,"given":"Angela","family":"Cebria","sequence":"additional","affiliation":[{"name":"DAWAKO Medtech S.L., Parc Cientific de la Universitat de Valencia, Calle del Catedratic Agust\u00edn Escardino Benlloch, 9, 46980 Paterna, Spain"},{"name":"Escola T\u00e8cnica Superior d\u2019Enginyeria, Department d\u2019Inform\u00e0tica, Universitat de Val\u00e8ncia, Avenida de La Universidad, s\/n, 46100 Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olatz","family":"Izaola-Jauregui","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain"},{"name":"Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5625-2846","authenticated-orcid":false,"given":"Eduardo Jorge","family":"Godoy","sequence":"additional","affiliation":[{"name":"DAWAKO Medtech S.L., Parc Cientific de la Universitat de Valencia, Calle del Catedratic Agust\u00edn Escardino Benlloch, 9, 46980 Paterna, Spain"},{"name":"Escola T\u00e8cnica Superior d\u2019Enginyeria, Department d\u2019Inform\u00e0tica, Universitat de Val\u00e8ncia, Avenida de La Universidad, s\/n, 46100 Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7473-5216","authenticated-orcid":false,"given":"Paloma","family":"P\u00e9rez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain"},{"name":"Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Jim\u00e9nez Sahag\u00fan","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain"},{"name":"Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Ramos Bachiller","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain"},{"name":"Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Gonz\u00e1lez Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain"},{"name":"Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1745-9315","authenticated-orcid":false,"given":"Daniel A.","family":"De Luis Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain"},{"name":"Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"111943","DOI":"10.1016\/j.nut.2022.111943","article-title":"Prevalence and Economic Cost of Malnutrition in Italy: A Systematic Review and Metanalysis from the Italian Society of Artificial Nutrition and Metabolism (SINPE)","volume":"108","author":"Pradelli","year":"2023","journal-title":"Nutrition"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ejim.2006.02.030","article-title":"Nutritional Status of Adult Patients Admitted to Internal Medicine Departments in Public 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