{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:23Z","timestamp":1787029223089,"version":"build-2736575974"},"reference-count":46,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lifedoc Research team"},{"name":"Novo Nordisk Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>As adiposity increases in youth, so does the prevalence of cardiometabolic risk factors (CMRFs). The etiology of adiposity-based chronic disease and CMRFs includes ethnoracial disparities that are rarely considered in current treatment approaches. Precision interventions require further characterization of these disparities among high-risk youth. The objective of this study was to characterize differences in CMRF among African American (AA) and Hispanic (H) adolescents with varying levels of adiposity. A cross-sectional analysis of 2284 adolescents aged 12\u201317 was conducted using 3-year clinical data from Lifedoc Health. CMRF prevalence were compared using \u03c72, with logistic regression models (LRM) applied to explore the relationships between exposures (age, sex, ethnoracial group, adiposity) and CMRF outcomes. Prevalence of CMRF rose with increasing adiposity, which was the strongest determinant of risk overall. However, individual risk profiles differed between the two groups, with H having higher prevalence of metabolic syndrome (MetS), higher triglycerides and liver enzymes, and low high-density lipoprotein cholesterol (HDL-c). Meanwhile, AA had higher prevalence of elevated blood pressure (BP) in the overweight category, prediabetes in overweight to severe obesity, and type 2 diabetes in obesity. LRM showed 3.0-fold greater chance of impaired glucose metabolism in AA than H, who were 1.7, 5.9, and 8.3 times more likely to have low HDL-c, high liver enzymes, and high triglycerides, respectively. Overweight\/obesity prevalence was very high among AA and H adolescents. Excess adiposity was associated with an increased prevalence of CMRF, with individual risk factors differing between groups as adiposity increased. Research within routine clinical settings is required to better characterize these discrepancies and ameliorate their adverse impact on health in the transition to adulthood.<\/jats:p>","DOI":"10.3390\/nu16183143","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T09:43:13Z","timestamp":1726652593000},"page":"3143","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Disparities in the Cardiometabolic Impact of Adiposity among African American and Hispanic Adolescents"],"prefix":"10.3390","volume":"16","author":[{"given":"Pedro A.","family":"Vel\u00e1squez-Mieyer","sequence":"first","affiliation":[{"name":"Lifedoc Health, Memphis, TN 38115, USA"},{"name":"Lifedoc Research, 6625 Lenox Park Drive, Suite 205, Memphis, TN 38115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-7534","authenticated-orcid":false,"given":"Ramfis","family":"Nieto-Martinez","sequence":"additional","affiliation":[{"name":"Lifedoc Health, Memphis, TN 38115, USA"},{"name":"Departments of Global Health and Population and Epidemiology, Harvard TH Chan School of Public Health, Harvard University, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1062-1065","authenticated-orcid":false,"given":"Andres E.","family":"Velasquez","sequence":"additional","affiliation":[{"name":"Lifedoc Research, 6625 Lenox Park Drive, Suite 205, Memphis, TN 38115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1326-7877","authenticated-orcid":false,"given":"Xichen","family":"Mou","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Memphis, Memphis, TN 38152, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Young-Moss","sequence":"additional","affiliation":[{"name":"Independent Researcher, Indianapolis, IN 47906, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0657-588X","authenticated-orcid":false,"given":"Jeffrey I.","family":"Mechanick","sequence":"additional","affiliation":[{"name":"The Marie-Jos\u00e9e and Henry R. Kravis Center for Cardiovascular Health at Mount Sinai Heart, Division of Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9741-4610","authenticated-orcid":false,"given":"Cori Cohen","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Tennessee Population Health Consortium, The University of Tennessee Health Science Center, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia P.","family":"Neira","sequence":"additional","affiliation":[{"name":"Lifedoc Health, Memphis, TN 38115, USA"},{"name":"Lifedoc Research, 6625 Lenox Park Drive, Suite 205, Memphis, TN 38115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"ref_1","unstructured":"Robert Wood Johnson Foundation (2023, April 25). 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