{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:47:38Z","timestamp":1790711258125,"version":"4.1.0"},"reference-count":174,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation (NRF) of Korea","award":["NRF- 2021R1G1A1093362"],"award-info":[{"award-number":["NRF- 2021R1G1A1093362"]}]},{"name":"National Research Foundation (NRF) of Korea","award":["NRF-RS-2024-00353119"],"award-info":[{"award-number":["NRF-RS-2024-00353119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Numerous studies have established associations between vitamin D and diabetes. The vitamin D receptor is widely distributed throughout the human body, including in pancreatic beta cells (\u03b2-cells), hepatocytes, and immune cells. Therefore, vitamin D\u2019s effect on the risk, progression, or complications of diabetes may be mediated through various mechanisms. These include the regulation of insulin secretion or sensitivity and modulation of \u03b2-cell function and its immunomodulatory and anti-inflammatory effects. This review extensively explores the relationship between vitamin D status and diabetes, as well as the preventive or therapeutic effects of vitamin D supplementation on diabetes from human studies. Additionally, it examines in detail the impact of vitamin D on immune and inflammatory responses in the diabetic milieux and \u03b2-cell function to better understand the underlying mechanisms through which vitamin D influences diabetes.<\/jats:p>","DOI":"10.3390\/nu16183185","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T07:38:57Z","timestamp":1726817937000},"page":"3185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Multifaceted Roles of Vitamin D for Diabetes: From Immunomodulatory Functions to Metabolic Regulations"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-7210","authenticated-orcid":false,"given":"Chan Yoon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Food & Nutrition, College of Life Care Science Technology, The University of Suwon, Hwaseong-si 18323, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5916-5390","authenticated-orcid":false,"given":"Sunhye","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, College of Science and Convergence Technology, Seoul Women\u2019s University, Seoul 01797, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0647-2992","authenticated-orcid":false,"given":"Sung Nim","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Republic of Korea"},{"name":"Research Institute of Human Ecology, Seoul National University, Seoul 08826, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.3390\/nu5093605","article-title":"Vitamin D: Deficiency, sufficiency and toxicity","volume":"5","author":"Alshahrani","year":"2013","journal-title":"Nutrients"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Carlberg, C. 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