{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:14:47Z","timestamp":1775909687958,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of NSW, Sydney"},{"name":"St Vincent\u2019s Clinic Foundation Grant"},{"name":"St Vincent\u2019s Curran Foundation Endowment Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Diet has been linked to gut dysbiosis and the onset, course, and response to treatment of patients with IBD and metabolic disease. Methods: This single-centre prospective case-control study investigated the relationship between dietary intake, metabolic profile, and stool microbial composition in 57 individuals with IBD in clinical remission and 24 healthy individuals (HC). Participants\u2019 baseline anthropometric measurements, serum metabolic parameters, lipid profiles, and oral and stool samples for microbiota testing were collected. Their dietary intake and physical activity were documented. A partially corrected correlation was performed to examine the associations between variables and p-values adjusted for multiple comparisons using the Benjamini\u2013Hochberg equation (adj-p). Results: In participants with IBD, the intake of saturated fat correlated positively, and the intake of dietary fibre correlated negatively with anthropometric indices (saturated fat and BMI: r = 0.37, adj-p = 0.04, fibre and BMI: r = \u22120.45, adj-p = 0.01). Higher anthropometric indices were associated with poorer glucose control and a less favourable serum lipid profile (BMI and insulin: r = 0.48, p &lt; 0.01, WHR and triglycerides: r = 0.57, p &lt; 0.01). The stool microbiota of participants in the IBD group was less diverse and more similar to their oral microbiota than was observed in the HC group (Mann\u2013Whitney U test p = 0.03). Within the IBD group, a higher intake of added sugar and processed meat and a higher serum insulin level was associated with lower stool microbial alpha diversity (processed meat intake and Shannon\u2019s diversity: r = \u22120.43, adj-p = 0.02; added sugar and Shannon\u2019s diversity: r = \u22120.39, adj-p = 0.03; insulin and Shannon\u2019s diversity: r = \u22120.45, adj-p = 0.02). Neither the dietary intake nor stool microbial composition correlated with the risk of disease flaring. Conclusions: Our findings suggest that dietary intake is associated with the metabolic health and gut microbial composition of IBD patients.<\/jats:p>","DOI":"10.3390\/nu16193233","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T10:41:47Z","timestamp":1727174507000},"page":"3233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dietary Determinants of Metabolic and Gut Microbial Health in Patients with Inflammatory Bowel Disease"],"prefix":"10.3390","volume":"16","author":[{"given":"Gabrielle","family":"Wark","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, St Vincent\u2019s Healthcare Campus, Faculty of Medicine & Health, University of New South Wales, Sydney 2010, Australia"},{"name":"Department of Gastroenterology and Hepatology, St Vincent\u2019s Hospital, Sydney 2010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadeem O.","family":"Kaakoush","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney 2052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9422-7852","authenticated-orcid":false,"given":"Dorit","family":"Samocha-Bonet","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, St Vincent\u2019s Healthcare Campus, Faculty of Medicine & Health, University of New South Wales, Sydney 2010, Australia"},{"name":"Garvan Institute of Medical Research, Sydney 2010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Ghaly","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, St Vincent\u2019s Healthcare Campus, Faculty of Medicine & Health, University of New South Wales, Sydney 2010, Australia"},{"name":"Department of Gastroenterology and Hepatology, St Vincent\u2019s Hospital, Sydney 2010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-6811","authenticated-orcid":false,"given":"Mark","family":"Danta","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, St Vincent\u2019s Healthcare Campus, Faculty of Medicine & Health, University of New South Wales, Sydney 2010, Australia"},{"name":"Department of Gastroenterology and Hepatology, St Vincent\u2019s Hospital, Sydney 2010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S614","DOI":"10.1016\/S0016-5085(18)32218-2","article-title":"Trends in the prevelence of overweight and obesity at the time of inflammatory bowel disease diagnosis: A population-based study","volume":"154","author":"Lynn","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12328-019-01037-y","article-title":"Relationship(s) between obesity and inflammatory bowel diseases: Possible intertwined pathogenic mechanisms","volume":"13","author":"Szilagyi","year":"2020","journal-title":"Clin. 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