{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:27:00Z","timestamp":1760146020887,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"a Coordination for the Improvement of Higher Education Personnel (CAPES) grant from the Federal University of Rio Grande do Norte","award":["422667\/2016-1","302298\/2017-7"],"award-info":[{"award-number":["422667\/2016-1","302298\/2017-7"]}]},{"name":"National Council for Scientific and Technological Development (CNPq)","award":["422667\/2016-1","302298\/2017-7"],"award-info":[{"award-number":["422667\/2016-1","302298\/2017-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Zinc plays a crucial role in cell structure and functionality. Neurodegenerative Duchenne muscular dystrophy (DMD) alters muscle membrane structure, leading to a loss of muscle mass and strength. The objective of this study was to evaluate the changes in phase angle (PA) and bioelectrical impedance vector analysis (BIVA) results in patients with DMD after oral zinc supplementation. This clinical trial included 33 boys aged 5.6 to 24.5 years diagnosed with DMD. They were divided into three groups according to age (G1, G2, and G3) and supplemented with oral zinc. The mean serum zinc concentration was 74 \u03bcg\/dL, and 29% of patients had concentrations below the reference value. The baseline values (mean (standard deviation)) of the bioelectrical impedance parameters PA, resistance (R), and reactance (Xc) were 2.59\u00b0 (0.84\u00b0), 924.36 (212.31) \u03a9, and 39.64 (8.41) \u03a9, respectively. An increase in R and a decrease in PA and lean mass proportional to age were observed, along with a negative correlation (r = \u22120.614; p &lt; 0.001) between age and PA. The average cell mass in G1 was greater than that in G3 (p = 0.012). There were no significant differences in serum zinc levels or bioelectrical impedance parameters before and after zinc supplementation. We conclude that this population is at risk of zinc deficiency and the proposed dosage of zinc supplementation was not sufficient to alter serum zinc levels, PA and BIVA results.<\/jats:p>","DOI":"10.3390\/nu16193299","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:45:27Z","timestamp":1727675127000},"page":"3299","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Oral Zinc Supplementation on Phase Angle and Bioelectrical Impedance Vector Analysis in Duchenne Muscular Dystrophy: A Non-Randomized Clinical Trial"],"prefix":"10.3390","volume":"16","author":[{"given":"Karina Marques","family":"Vermeulen-Serpa","sequence":"first","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0011-576X","authenticated-orcid":false,"given":"M\u00e1rcia Marilia Gomes Dantas","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Xavier","family":"Alves","sequence":"additional","affiliation":[{"name":"Nutrition Division, Liga Norte Riograndense Contra o C\u00e2ncer, Natal 59040-000, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evellyn Camara","family":"Grilo","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9932-2338","authenticated-orcid":false,"given":"Thais Alves","family":"Cunha","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7708-4271","authenticated-orcid":false,"given":"Carolinne Thaisa de Oliveira Fernandes","family":"Miranda","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Medicine (Hematology\/Oncology), Federal University of S\u00e3o Paulo, S\u00e3o Paulo 04021-001, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breno Gustavo Porfirio","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Center for Primary Processing and Reuse of Produced Water and Waste, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Leite-Lais","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Brand\u00e3o-Neto","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sancha Helena de Lima","family":"Vale","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil"},{"name":"Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil"},{"name":"Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Costa, M.I., Sarmento-Ribeiro, A.B., and Gon\u00e7alves, A.C. 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