{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:57:34Z","timestamp":1782316654387,"version":"3.54.5"},"reference-count":39,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2010100"],"award-info":[{"award-number":["2022YFC2010100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: The physical abilities of older adults decline with age, making them more susceptible to micronutrient deficiency, which may affect their sleep quality. Objectives: This study aimed to construct a risk correlative model for sleep disorders in Chinese older adults based on blood micronutrient levels. Methods: In this matched case-control study, we recruited 124 participants with sleep disorders and 124 matched controls from the Tianjin Elderly Nutrition and Cognition cohort in China. Micronutrient levels in whole blood were measured using the dried blood spot technique. We compared the differences in micronutrient levels between the two groups and also constructed a receiver operating characteristic (ROC) model and nomogram for sleep disorders. Results: In comparison to the control group, the sleep disorders group showed lower levels of blood vitamin A, vitamin E (VE), folate, magnesium, copper, iron, and selenium (Se) in the univariate analysis (p &lt; 0.05). The ROC curve analysis indicated that the combination of VE + folate + Se may have an excellent diagnostic effect on sleep disorders, with an area under the curve of 0.964. This VE + folate + Se was integrated into a nomogram model to demonstrate their relationship with sleep disorders. The consistency index of the model was 0.88, suggesting that the model assessed sleep disorders well. Conclusions: The sleep disorders risk correlative model constructed by the levels of VE, folate, and Se in whole blood might show good performance in assessing the risk of sleep disorders in older adults.<\/jats:p>","DOI":"10.3390\/nu16193306","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:45:27Z","timestamp":1727675127000},"page":"3306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Risk Correlative Model for Sleep Disorders in Chinese Older Adults Based on Blood Micronutrient Levels: A Matched Case-Control Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Cheng","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xukun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilian","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiting","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wang","sequence":"additional","affiliation":[{"name":"BYHEALTH Institute of Nutrition & Health, Guangzhou 510663, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxia","family":"Li","sequence":"additional","affiliation":[{"name":"BYHEALTH Institute of Nutrition & Health, Guangzhou 510663, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruikun","family":"He","sequence":"additional","affiliation":[{"name":"BYHEALTH Institute of Nutrition & Health, Guangzhou 510663, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenshu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"},{"name":"Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China"},{"name":"Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China"},{"name":"Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin 300070, China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ma","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China"},{"name":"Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin 300070, China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Du","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China"},{"name":"Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin 300070, China"},{"name":"Department of Social Medicine and Health Management, School of Public Health, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"},{"name":"Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China"},{"name":"Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"},{"name":"Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China"},{"name":"Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin 300070, China"},{"name":"The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev-bioeng-120122-123054","article-title":"Current Trends in Anti-Aging Strategies","volume":"25","author":"Rosen","year":"2023","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cger.2018.01.008","article-title":"Sleep Disorders in the Elderly","volume":"34","author":"Yaremchuk","year":"2018","journal-title":"Clin. Geriatr. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11920-015-0631-8","article-title":"Sleep, Cognition and Dementia","volume":"17","author":"Porter","year":"2015","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.sleep.2020.03.006","article-title":"Association of socioeconomic factors and prevalence of hypertension with sleep disorder among the elderly in rural southwest China","volume":"71","author":"Ma","year":"2020","journal-title":"Sleep Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.slsci.2016.11.003","article-title":"Associations of common chronic non-communicable diseases and medical conditions with sleep-related problems in a population-based health examination study","volume":"9","author":"Basnet","year":"2016","journal-title":"Sleep Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pcad.2023.02.005","article-title":"Sleep physiology, pathophysiology, and sleep hygiene","volume":"77","author":"Baranwal","year":"2023","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Norman, K., Ha\u00df, U., and Pirlich, M. (2021). Malnutrition in Older Adults-Recent Advances and Remaining Challenges. Nutrients, 13.","DOI":"10.3390\/nu13082764"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1183\/09031936.06.00067605","article-title":"Antioxidant status in patients with sleep apnoea and impact of continuous positive airway pressure treatment","volume":"27","author":"Vila","year":"2006","journal-title":"Eur. Respir. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3142874","DOI":"10.1155\/2020\/3142874","article-title":"The Effects of Dietary Nutrition on Sleep and Sleep Disorders","volume":"2020","author":"Zhao","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"An, H., Xue, Q., and Zhang, J. (2023). The association between serum total folic acid concentration and severe difficulty falling asleep in US adults: NHANES 2005\u20132008. Front. Neurol., 14.","DOI":"10.3389\/fneur.2023.1225403"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jad.2022.11.088","article-title":"Associations of serum zinc, copper, and selenium with sleep disorders in the American adults: Data from NHANES 2011\u20132016","volume":"323","author":"Deng","year":"2023","journal-title":"J. Affect. Disord."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"zsab276","DOI":"10.1093\/sleep\/zsab276","article-title":"Association of magnesium intake with sleep duration and sleep quality: Findings from the CARDIA study","volume":"45","author":"Zhang","year":"2022","journal-title":"Sleep"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Cherasse, Y., and Urade, Y. (2017). Dietary Zinc Acts as a Sleep Modulator. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112334"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101274","DOI":"10.1016\/j.smrv.2020.101274","article-title":"Iron deficiency and sleep\u2014A scoping review","volume":"51","author":"Leung","year":"2020","journal-title":"Sleep Med. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zhao, L., Li, S., Zhu, Y., Wang, T., Su, Y., Shi, Z., Zhang, Y., and Zhao, Y. (2023). Association between Selenium Intake and Optimal Sleep Duration: A National Longitudinal Study. Nutrients, 15.","DOI":"10.3390\/nu15020397"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Huang, K., Fang, H., Yu, D., Guo, Q., Xu, X., Ju, L., Cai, S., Yang, Y., Wei, X., and Zhao, L. (2022). Usual Intake of Micronutrients and Prevalence of Inadequate Intake among Chinese Adults: Data from CNHS 2015\u20132017. Nutrients, 14.","DOI":"10.3390\/nu14224714"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jad.2024.05.002","article-title":"Association between magnesium deficiency score and sleep quality in adults: A population-based cross-sectional study","volume":"358","author":"Luo","year":"2024","journal-title":"J. Affect. Disord."},{"key":"ref_18","first-page":"681","article-title":"Sleep-Related Disorders in Neurology and Psychiatry","volume":"116","author":"Spiegelhalder","year":"2019","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1526-4637.2009.00706.x","article-title":"What is the evidence for chronic pain being etiologically associated with the DSM-IV category of sleep disorder due to a general medical condition? A structured evidence-based review","volume":"11","author":"Fishbain","year":"2010","journal-title":"Pain Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hu, J., and Szymczak, S. (2023). A review on longitudinal data analysis with random forest. Brief. Bioinform., 24.","DOI":"10.1093\/bib\/bbad002"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Muscaritoli, M. (2021). The Impact of Nutrients on Mental Health and Well-Being: Insights from the Literature. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.656290"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.6061\/clinics\/2013(04)03","article-title":"Cognition and biomarkers of oxidative stress in obstructive sleep apnea","volume":"68","author":"Sales","year":"2013","journal-title":"Clinics"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Thongchumnum, W., Vallibhakara, S.A., Sophonsritsuk, A., and Vallibhakara, O. (2023). Effect of Vitamin E Supplementation on Chronic Insomnia Disorder in Postmenopausal Women: A Prospective, Double-Blinded Randomized Controlled Trial. Nutrients, 15.","DOI":"10.3390\/nu15051187"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Menezo, Y., Elder, K., Clement, A., and Clement, P. (2022). Folic Acid, Folinic Acid, 5 Methyl TetraHydroFolate Supplementation for Mutations That Affect Epigenesis through the Folate and One-Carbon Cycles. Biomolecules, 12.","DOI":"10.3390\/biom12020197"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1039\/D4FO01303D","article-title":"Association of methyl donor nutrients dietary intake and sleep disorders in the elderly revealed by the intestinal microbiome","volume":"15","author":"Chen","year":"2024","journal-title":"Food Funct."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"53876","DOI":"10.1007\/s11356-023-26164-5","article-title":"Association of vitamins with hearing loss, vision disorder and sleep problem in the US general population","volume":"30","author":"Chen","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.sleep.2020.12.040","article-title":"Maternal sleep quality during early pregnancy, risk factors and its impact on pregnancy outcomes: A prospective cohort study","volume":"79","author":"Du","year":"2021","journal-title":"Sleep Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s12603-013-0023-x","article-title":"Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea","volume":"17","author":"Chen","year":"2013","journal-title":"J. Nutr. Health Aging"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s12011-022-03447-5","article-title":"Evaluation of Serum Selenium Level, Quality of Sleep, and Life in Pregnant Women with Restless Legs Syndrome","volume":"201","author":"Elmas","year":"2023","journal-title":"Biol. Trace. Elem. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1017\/S1368980016002603","article-title":"The relationship between micronutrient status and sleep patterns: A systematic review","volume":"20","author":"Ji","year":"2017","journal-title":"Public Health Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12011-022-03162-1","article-title":"The Role of Magnesium in Sleep Health: A Systematic Review of Available Literature","volume":"201","author":"Arab","year":"2023","journal-title":"Biol. Trace. Elem. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13643-024-02449-9","article-title":"Clinical prediction models for the early diagnosis of obstructive sleep apnea in stroke patients: A systematic review","volume":"13","author":"Yang","year":"2024","journal-title":"Syst. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Xu, R., Miao, L., Ni, J., Ding, Y., Song, Y., Yang, C., Zhu, B., and Jiang, R. (2022). Risk factors and prediction model of sleep disturbance in patients with maintenance hemodialysis: A single center study. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.955352"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e46520","DOI":"10.2196\/46520","article-title":"Predicting the Risk of Sleep Disorders Using a Machine Learning-Based Simple Questionnaire: Development and Validation Study","volume":"25","author":"Ha","year":"2023","journal-title":"J. Med. Internet. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clinbiochem.2020.02.007","article-title":"The application of fully automated dried blood spot analysis for liquid chromatography-tandem mass spectrometry using the CAMAG DBS-MS 500 autosampler","volume":"82","author":"Gaugler","year":"2020","journal-title":"Clin. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/mas.21441","article-title":"The use of mass spectrometry to analyze dried blood spots","volume":"35","author":"Wagner","year":"2016","journal-title":"Mass Spectrom Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.euroneuro.2017.01.009","article-title":"Dried Blood Spot sampling in psychiatry: Perspectives for improving therapeutic drug monitoring","volume":"27","author":"Martial","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Malsagova, K., Kopylov, A., Stepanov, A., Butkova, T., Izotov, A., and Kaysheva, A. (2020). Dried Blood Spot in Laboratory: Directions and Prospects. Diagnostics, 10.","DOI":"10.3390\/diagnostics10040248"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.4155\/bio.13.175","article-title":"State-of-the-art dried blood spot analysis: An overview of recent advances and future trends","volume":"5","author":"Meesters","year":"2013","journal-title":"Bioanalysis"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/19\/3306\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:07:03Z","timestamp":1760112423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/19\/3306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,29]]},"references-count":39,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["nu16193306"],"URL":"https:\/\/doi.org\/10.3390\/nu16193306","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,29]]}}}