{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T19:23:23Z","timestamp":1774293803368,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health, current research IRCCS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Limited data exist on the epidemiology and clinical management of short bowel syndrome (SBS) and chronic intestinal failure (CIF) in Crohn\u2019s disease (CD). This study aimed to evaluate these aspects in Italy. Methods: Members of the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD) were invited to complete a cross-sectional web survey. A subgroup analysis examined the influence of different clinical settings on SBS and CIF management in CD. Results: A total of 47\/128 (36.7%) IG-IBD centers participated. Among them, 31.9% were teduglutide (TED) prescribers, and 48.9% were academic centers. The median estimated prevalence of CIF among small bowel CD patients was 1%, and it was significantly higher in academic centers (2.0% [IQR 1\u20135%] vs. 0.13% [IQR 0\u20131%], p = 0.02). Seventy-eight percent of centers managed fewer than 10 SBS and CD patients. Routine small bowel measurement and nutritional assessment were performed in only 15% and 42.6% of centers, respectively. TED was prescribed by 12 centers to 35 patients, with a treatment success rate exceeding 50% in 81.8% of centers. Conclusions: The estimated prevalence of CIF in CD patients with small bowel involvement in Italy is 1%. The diagnosis and management practices for SBS and CIF are suboptimal, and TED use is limited.<\/jats:p>","DOI":"10.3390\/nu16193311","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:45:27Z","timestamp":1727675127000},"page":"3311","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Epidemiology and Clinical Management of Short Bowel Syndrome and Chronic Intestinal Failure in Crohn\u2019s Disease in Italy: An IG-IBD Survey"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8817-144X","authenticated-orcid":false,"given":"Tommaso","family":"Pessarelli","sequence":"first","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8761-1872","authenticated-orcid":false,"given":"Matilde","family":"Topa","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0285-9949","authenticated-orcid":false,"given":"Andrea","family":"Sorge","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-2593","authenticated-orcid":false,"given":"Nicoletta","family":"Nandi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7930-5402","authenticated-orcid":false,"given":"Daniela","family":"Pugliese","sequence":"additional","affiliation":[{"name":"OU Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5128-3846","authenticated-orcid":false,"given":"Fabio Salvatore","family":"Macaluso","sequence":"additional","affiliation":[{"name":"IBD Unit, \u201cVilla Sofia-Cervello\u201d Hospital, Viale Strasburgo 233, 90146 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambrogio","family":"Orlando","sequence":"additional","affiliation":[{"name":"IBD Unit, \u201cVilla Sofia-Cervello\u201d Hospital, Viale Strasburgo 233, 90146 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-2534","authenticated-orcid":false,"given":"Simone","family":"Saibeni","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Rho Hospital, ASST Rhodense, 20017 Rho, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4345-6051","authenticated-orcid":false,"given":"Andrea","family":"Costantino","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"},{"name":"Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Stalla","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, 10124 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Zadro","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Azienda USL Modena, 41012 Carpi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9460-3296","authenticated-orcid":false,"given":"Lucia","family":"Scaramella","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Vecchi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"},{"name":"Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Caprioli","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"},{"name":"Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-0759","authenticated-orcid":false,"given":"Luca","family":"Elli","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"},{"name":"Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ncp.11015","article-title":"Use of teduglutide in adults with short bowel syndrome-associated intestinal failure","volume":"39","author":"Pironi","year":"2024","journal-title":"Nutr. Clin. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.clnu.2023.07.019","article-title":"ESPEN guideline on chronic intestinal failure in adults\u2013Update 2023","volume":"42","author":"Pironi","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.3748\/wjg.v27.i24.3440","article-title":"Chronic intestinal failure and short bowel syndrome in Crohn\u2019s disease","volume":"27","author":"Aksan","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.clnu.2017.04.013","article-title":"Clinical classification of adult patients with chronic intestinal failure due to benign disease: An international multicenter cross-sectional survey","volume":"37","author":"Pironi","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1007\/s10620-019-05553-2","article-title":"Cumulative Inflammation Could Be a Risk Factor for Intestinal Failure in Crohn\u2019s Disease","volume":"64","author":"Watanabe","year":"2019","journal-title":"Dig. Dis. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00535-013-0797-y","article-title":"Long-term incidence and characteristics of intestinal failure in Crohn\u2019s disease: A multicenter study","volume":"49","author":"Watanabe","year":"2014","journal-title":"J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.clnu.2020.03.005","article-title":"ESPEN guideline on home parenteral nutrition","volume":"39","author":"Pironi","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"32S","DOI":"10.1177\/0148607113517717","article-title":"Clinical, social, and economic impacts of home parenteral nutrition dependence in short bowel syndrome","volume":"38","author":"Winkler","year":"2014","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1053\/j.gastro.2012.09.007","article-title":"Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure","volume":"143","author":"Jeppesen","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ncp.10092","article-title":"Reduction of Parenteral Nutrition and Hydration Support and Safety With Long-Term Teduglutide Treatment in Patients With Short Bowel Syndrome-Associated Intestinal Failure: STEPS-3 Study","volume":"33","author":"Seidner","year":"2018","journal-title":"Nutr. Clin. Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.1038\/ctg.2015.69","article-title":"Long-Term Teduglutide for the Treatment of Patients With Intestinal Failure Associated With Short Bowel Syndrome","volume":"7","author":"Schwartz","year":"2016","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gut.2005.082909","article-title":"The Montreal classification of inflammatory bowel disease: Controversies, consensus, and implications","volume":"55","author":"Satsangi","year":"2006","journal-title":"Gut"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1007\/s11606-021-06737-1","article-title":"A Consensus-Based Checklist for Reporting of Survey Studies (CROSS)","volume":"36","author":"Sharma","year":"2021","journal-title":"J. Gen. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.dld.2019.11.013","article-title":"Understanding short bowel syndrome: Current status and future perspectives","volume":"52","author":"Massironi","year":"2020","journal-title":"Dig. Liver Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1016\/j.clnu.2019.12.019","article-title":"Six-month outcomes of teduglutide treatment in adult patients with short bowel syndrome with chronic intestinal failure: A real-world French observational cohort study","volume":"39","author":"Joly","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E152","DOI":"10.1093\/ibd\/izab171","article-title":"Long-term effects of Teduglutide on intestinal Mucosa in a patient with Crohn\u2019s disease and short bowel syndrome: Clinical, endoscopic and histological data compared","volume":"27","author":"Borghini","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/ajcn\/nqz269","article-title":"Cost-effectiveness of teduglutide in adult patients with short bowel syndrome: Markov modeling using traditional cost-effectiveness criteria","volume":"111","author":"Raghu","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.clnu.2020.06.010","article-title":"The economic costs of home parenteral nutrition: Systematic review of partial and full economic evaluations","volume":"40","author":"Arhip","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1002\/ncp.10955","article-title":"Definition, classification, and causes of short bowel syndrome","volume":"38","author":"Pironi","year":"2023","journal-title":"Nutr. Clin. Pract."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jpen.1011","article-title":"Single-center experience with the use of teduglutide in adult patients with short bowel syndrome","volume":"42","author":"Lam","year":"2018","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.clnu.2018.07.030","article-title":"Experience with teduglutide treatment for short bowel syndrome in clinical practice","volume":"38","author":"Pevny","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/jpen.1838","article-title":"Long-term outcomes with teduglutide from a single center","volume":"45","author":"Puello","year":"2021","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/jpen.1149","article-title":"Long-term therapy with teduglutide in parenteral support-dependent patients with short bowel syndrome: A case series","volume":"42","author":"Ukleja","year":"2018","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/MCG.0000000000000604","article-title":"Safety and efficacy of teduglutide (Gattex) in patients with Crohn\u2019s disease and need for parenteral support due to short bowel syndrome-associated intestinal failure","volume":"51","author":"Kochar","year":"2017","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1177\/0148607115594010","article-title":"Clinical management of patients with parenteral nutrition-dependent short bowel syndrome during teduglutide therapy","volume":"40","author":"Compher","year":"2016","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.clnu.2016.01.028","article-title":"Survival and nutritional dependence on home parenteral nutrition: Three decades of experience from a single referral centre","volume":"36","author":"Dibb","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.ajcnut.2024.02.031","article-title":"Cost-effectiveness of teduglutide in adult patients with short bowel syndrome\u2014A European socioeconomic perspective","volume":"119","author":"Walter","year":"2024","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/2050640617737632","article-title":"Citrulline as a marker of intestinal function and absorption in clinical settings: A systematic review and meta-analysis","volume":"6","author":"Fragkos","year":"2018","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.pharmthera.2013.04.007","article-title":"Glucagon-like peptide 2 in colon carcinogenesis: Possible target for anti-cancer therapy?","volume":"139","author":"Kannen","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.clnesp.2022.08.027","article-title":"Long-term results of teduglutide treatment for chronic intestinal failure\u2014Insights from a national, multi-centric patient home-care service program","volume":"51","author":"Greif","year":"2022","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.dld.2017.07.005","article-title":"The use of oral corticosteroids in inflammatory bowel diseases in Italy: An IG-IBD survey","volume":"49","author":"Meucci","year":"2017","journal-title":"Dig. Liver Dis."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/19\/3311\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:07:13Z","timestamp":1760112433000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/19\/3311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":31,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["nu16193311"],"URL":"https:\/\/doi.org\/10.3390\/nu16193311","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]}}}