{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:35:28Z","timestamp":1792794928749,"version":"4.5.0"},"reference-count":46,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["07586\/2023-5"],"award-info":[{"award-number":["07586\/2023-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/objectives: The oral administration of hydrolyzed collagen peptides is a scientifically validated intervention for enhancing skeletal muscle health and performance. This integrative review consolidates the evidence supporting the use of low molecular weight collagen peptides (2000\u20133500 daltons) for their superior bioavailability and absorption. Our objective was to review the effects of collagen peptide or hydrolyzed collagen supplementation on muscle damage, recovery, and construction related to physical exercise. Methods: A bibliographic search was conducted in major English-language databases, including PubMed\/Medline, using terms like \u201cPeptides Collagen and Damage\u201d and \u201ccollagen peptides AND Soreness Muscle\u201d. This review followed PRISMA guidelines, with bias risk assessed via the PEDro scale. The inclusion criteria were (a) randomized clinical trials, (b) randomized studies in humans with a control or placebo group, (c) studies assessing muscle damage or delayed onset muscle soreness via physiological markers or strength performance tests, and (d) studies using hydrolyzed collagen or collagen peptides. Results: Initially, 752 articles were identified. After applying the inclusion and exclusion criteria, including duplicate removal, eight articles with 286 participants were included. Of these, 130 participants received collagen peptide supplementation, while 171 received a placebo or control. Conclusion: This integrative review supports the potential of collagen peptide supplementation to mitigate muscle stress from acute strenuous resistance training. However, due to the methodological heterogeneity among the studies, further clinical trials are needed to clarify the mechanisms underlying muscle improvement with collagen supplementation.<\/jats:p>","DOI":"10.3390\/nu16193403","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T04:29:26Z","timestamp":1728361766000},"page":"3403","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Effects of Collagen Peptides as a Dietary Supplement on Muscle Damage Recovery and Fatigue Responses: An Integrative Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9354-1460","authenticated-orcid":false,"given":"Pedro Augusto Querido","family":"Inacio","sequence":"first","affiliation":[{"name":"Laboratory of Applied Neurosciences, Evangelical University of Goi\u00e1s, UniEvang\u00e9lica, Av. Universit\u00e1ria S\/N, An\u00e1polis P.O. Box 75083-515, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin Salgado Mussel","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Biophotonics and Experimental Therapeutics, LABITEX, Evangelical University of Goi\u00e1s, UniEvang\u00e9lica, Av. Universit\u00e1ria S\/N, An\u00e1polis P.O. Box 75083-515, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Julia Nunes","family":"de Aguiar","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Neurosciences, Evangelical University of Goi\u00e1s, UniEvang\u00e9lica, Av. Universit\u00e1ria S\/N, An\u00e1polis P.O. Box 75083-515, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8548-3150","authenticated-orcid":false,"given":"Pedro Sardinha Leonardo","family":"Lopes-Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Biophotonics and Experimental Therapeutics, LABITEX, Evangelical University of Goi\u00e1s, UniEvang\u00e9lica, Av. Universit\u00e1ria S\/N, An\u00e1polis P.O. Box 75083-515, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4290-541X","authenticated-orcid":false,"given":"Fl\u00e1vio","family":"Aimbire","sequence":"additional","affiliation":[{"name":"Translational Medicine, Federal University of S\u00e3o Paulo-UNIFESP, S\u00e3o Jos\u00e9 dos Campos P.O. Box 12247-014, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Sardinha","family":"Leonardo","sequence":"additional","affiliation":[{"name":"Laboratory of Health Technologies, LATES, Evangelical University of Goi\u00e1s, UniEvang\u00e9lica, Av. Universit\u00e1ria S\/N, An\u00e1polis P.O. Box 75083-515, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Souza","family":"S\u00e1 Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Neurosciences, Evangelical University of Goi\u00e1s, UniEvang\u00e9lica, Av. Universit\u00e1ria S\/N, An\u00e1polis P.O. Box 75083-515, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4533-1335","authenticated-orcid":false,"given":"Rodrigo Alvaro B.","family":"Lopes-Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Biophotonics and Experimental Therapeutics, LABITEX, Evangelical University of Goi\u00e1s, UniEvang\u00e9lica, Av. Universit\u00e1ria S\/N, An\u00e1polis P.O. Box 75083-515, GO, Brazil"},{"name":"Post-Graduate Program in Bioengineering, University Brasil, Av. Carolina Fonseca 236, Itaquera, S\u00e3o Paulo P.O. Box 08230-030, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American College of Sports Medicine (2009). American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med. Sci. 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