{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:29:53Z","timestamp":1760146193265,"version":"build-2065373602"},"reference-count":78,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Despite advances in ulcer treatment research, the search for new, safe, and effective strategies for preventing and treating ulcer diseases persists. Methods: In this study, the protective effects of dietary supplementation with krill oil (KO), fish oil (FO), and astaxanthin (ASX) on an ethanol-induced gastric ulcer model were compared during biochemical and histological observations. Sprague\u2013Dawley (n = 64) rats randomly divided into four groups\u2014normal control (vehicle), KO, FO, and ASX groups\u2014received the supplements via the orogastric route at a rate of 2.5% (v\/w) of their daily feed consumption for 4 weeks. Then, ulcer induction was performed with ethanol. Results: The ulcer group showed increased levels of malondialdehyde (MDA), chemiluminescence (CL), and myeloperoxidase (MPO) activity and decreased levels of glutathione in the gastric tissues. While KO, FO, and ASX supplementation decreased chemiluminescence levels in the ulcer group, only ASX supplementation decreased MDA levels and MPO activity. Conclusions: In conclusion, supplementation with KO or FO has a similar protective effect against ethanol-induced ulcer damage, as it inhibits ROS formation and reduces lipid peroxidation. However, ASX supplementation has a higher protective effect than KO or FO supplementations against experimental ethanol-induced gastric lesions in rats, as it inhibits ROS formation and reduces neutrophil infiltration and lipid peroxidation.<\/jats:p>","DOI":"10.3390\/nu16203426","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T07:54:09Z","timestamp":1728546849000},"page":"3426","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Dietary Supplementation with Krill Oil, Fish Oil, and Astaxanthin on an Experimental Ethanol-Induced Gastric Ulcer Model: A Biochemical and Histological Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-9185","authenticated-orcid":false,"given":"Esra Tansu","family":"Sar\u0131yer","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkey"},{"name":"Department of Nutrition and Dietetics, Faculty of Health Science, University of Health Sciences, 34668 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-301X","authenticated-orcid":false,"given":"Murat","family":"Ba\u015f","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"\u00c7olak","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, \u00dcsk\u00fcdar University, 34662 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naziye","family":"\u00d6zkan Yenal","sequence":"additional","affiliation":[{"name":"Department of Pathology Laboratory Techniques, Vocational School of Health-Related Services, Marmara University, 34865 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem","family":"Unay Demirel","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Bah\u00e7e\u015fehir University G\u00f6ztepe Medical Park Hospital Central Laboratory, Faculty of Medicine, Bah\u00e7e\u015fehir University, 34353 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4760-3306","authenticated-orcid":false,"given":"Meral","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Techniques, Vocational School of Health-Related Services, Marmara University, 34865 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhang, W., Lian, Y., Li, Q., Sun, L., Chen, R., Lai, X., Lai, Z., Yuan, E., and Sun, S. 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