{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T11:37:35Z","timestamp":1785670655588,"version":"3.56.0"},"reference-count":29,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Minister of Science"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Sleeve gastrectomy (SG) has become the predominant bariatric surgery, leading to significant weight loss and reductions in obesity-related complications. However, postoperative gastrointestinal symptoms such as constipation and bloating are common. This study aims to evaluate the impact of probiotic supplementation on postoperative gastrointestinal symptoms in patients undergoing SG. The secondary aim is to analyze laboratory and stool test results. Materials and methods: This prospective, placebo-controlled study included patients undergoing SG at a single center. Participants were adults without specific gastrointestinal diseases. They were randomly assigned to either the Probiotics or Controls group. Gastrointestinal symptoms and laboratory and stool tests were assessed before surgery and one month after. Results: Thirty-one patients participated, with 15 in the Probiotics group and 16 in the Controls group. Probiotic supplementation significantly increased the number of stools per week (p = 0.027) and reduced constipation incidence (p = 0.002). Patients in the Probiotics group reported easier defecation and greater bowel movement completeness (p = 0.015, p = 0.004). No significant differences in weight loss or laboratory tests were observed between the groups. Stool microbiota analysis showed a return to normal levels of Enterococcus faecalis, Enterococcus faecium, and Clostridium perfringens in the Probiotics group and an increase in the Controls group. Conclusions: Probiotic supplementation after SG significantly reduces constipation without adverse effects. These findings suggest that incorporating probiotics into postoperative care protocols can enhance patient comfort and recovery.<\/jats:p>","DOI":"10.3390\/nu16203498","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T03:49:34Z","timestamp":1729136974000},"page":"3498","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Initial Study on the Impact of Probiotics on Postoperative Gastrointestinal Symptoms and Gut Microbiota after Sleeve Gastrectomy: A Placebo-Controlled Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2204-5088","authenticated-orcid":false,"given":"Natalia","family":"Dowgia\u0142\u0142o-Gornowicz","sequence":"first","affiliation":[{"name":"Department of General, Minimally Invasive and Elderly Surgery, Collegium Medicum, University of Warmia and Mazury, 10-045 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8331-6785","authenticated-orcid":false,"given":"Dominika","family":"Mysiorska","sequence":"additional","affiliation":[{"name":"Department of General, Minimally Invasive and Elderly Surgery, Collegium Medicum, University of Warmia and Mazury, 10-045 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Sosnowska-Turek","sequence":"additional","affiliation":[{"name":"Probios Ltd., 10-683 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Botuli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Infectious Disease, Collegium Medicum, University of Warmia and Mazury, Warszawska 30 St., 10-082 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Lech","sequence":"additional","affiliation":[{"name":"Department of General, Minimally Invasive and Elderly Surgery, Collegium Medicum, University of Warmia and Mazury, 10-045 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"ref_1","unstructured":"WHO (2024, July 01). Obesity and Overweight. 2021 June, Fact Sheet. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s11695-024-07118-3","article-title":"Collaborative Study Group for the IFSO Worldwide Survey. IFSO Worldwide Survey 2020\u20132021: Current Trends for Bariatric and Metabolic Procedures","volume":"34","author":"Angrisani","year":"2024","journal-title":"Obes. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e2223927","DOI":"10.1001\/jamanetworkopen.2022.23927","article-title":"Comparison of Sleeve Gastrectomy vs Intensive Lifestyle Modification in Patients With a BMI of 30 to Less Than 35","volume":"5","author":"Stenberg","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1056\/NEJMoa1600869","article-title":"Bariatric Surgery versus Intensive Medical Therapy for Diabetes\u20145-Year Outcomes","volume":"376","author":"Schauer","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.surg.2022.04.040","article-title":"Gastroesophageal reflux after sleeve gastrectomy. Fact or fiction?","volume":"172","author":"Tomasicchio","year":"2022","journal-title":"Surgery"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40608-018-0206-4","article-title":"Changes in gastrointestinal symptoms and food tolerance 6 months following weight loss surgery: Associations with dietary changes, weight loss and the surgical procedure","volume":"5","author":"Kvehaugen","year":"2018","journal-title":"BMC Obes."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1007\/s00464-022-09389-2","article-title":"BODY-Q eating-related symptoms following sleeve gastrectomy","volume":"37","author":"Hu","year":"2023","journal-title":"Surg. Endosc."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Liao, W.C., Wang, T.J., Liu, C.Y., Liu, T.P., Liang, S.Y., and Chang, K.S. (2023). Risk of Malnutrition in Adults Who Have Undergone Sleeve Gastrectomy: A Retrospective Study. Nutrients, 15.","DOI":"10.3390\/nu15173858"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ciob\u00e2rc\u0103, D., C\u0103toi, A.F., Cop\u0103escu, C., Miere, D., and Cri\u0219an, G. (2020). Bariatric Surgery in Obesity: Effects on Gut Microbiota and Micronutrient Status. Nutrients, 12.","DOI":"10.3390\/nu12010235"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Han, Y., Zhou, Y., Xu, X., Chen, S., Zhang, S., Jiang, N., Liu, Z., Zhang, J., Luo, Z., and Zhang, X. (2024). Improvement of Post-Surgery Constipation in Patients with Fractures by Lactobacillus rhamnosus JYLR-127: A Single-Blind Randomized Controlled Trial. Nutrients, 16.","DOI":"10.3390\/nu16101505"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7861297","DOI":"10.1155\/2019\/7861297","article-title":"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?","volume":"2019","author":"Vigna","year":"2019","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1089\/jmf.2018.4288","article-title":"Hericium erinaceus Mycelium and Its Isolated Compound, Erinacine A, Ameliorate High-Fat High-Sucrose Diet-Induced Metabolic Dysfunction and Spatial Learning Deficits in Aging Mice","volume":"22","author":"Tsai","year":"2019","journal-title":"J. Med. Food."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1215329","DOI":"10.3389\/fimmu.2023.1215329","article-title":"Hericium erinaceus, in combination with natural flavonoid\/alkaloid and B3\/B8 vitamins, can improve inflammatory burden in Inflammatory bowel diseases tissue: An ex vivo study","volume":"14","author":"Gravina","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.soard.2015.02.003","article-title":"Standardized outcomes reporting in metabolic and bariatric surgery","volume":"11","author":"Brethauer","year":"2015","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s11695-019-04032-x","article-title":"Standardization of Bariatric Metabolic Procedures: World Consensus Meeting Statement","volume":"29","author":"Bhandari","year":"2019","journal-title":"Obes. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.soard.2020.08.038","article-title":"Efficacy of probiotics in patients with morbid obesity undergoing bariatric surgery: A systematic review and meta-analysis","volume":"16","author":"Swierz","year":"2020","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_17","first-page":"138","article-title":"Effect of Bacillius Coagulans and Galactomannans on Obese Patients Undergoing Sleeve Gastrectomy, A Randomized-Controlled Clinical Trial","volume":"27","author":"Kazzi","year":"2021","journal-title":"Altern. Ther. Health Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1007\/s11695-024-07225-1","article-title":"Impact of Probiotics on Gastrointestinal Function and Metabolic Status After Roux-en-Y Gastric Bypass: A Double-Blind, Randomized Trial","volume":"34","author":"Melali","year":"2024","journal-title":"Obes. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/s41366-023-01375-5","article-title":"Effects of probiotics in patients with morbid obesity undergoing bariatric surgery: A systematic review and meta-analysis","volume":"47","author":"Wang","year":"2023","journal-title":"Int. J. Obes."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e12552","DOI":"10.1111\/cob.12552","article-title":"Bacteria with potential: Improving outcomes through probiotic use following Roux-en-Y gastric bypass","volume":"13","author":"Nowicki","year":"2023","journal-title":"Clin. Obes."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/ijo.2017.210","article-title":"Probiotics administration following sleeve gastrectomy surgery: A randomized double-blind trial","volume":"42","author":"Webb","year":"2018","journal-title":"Int. J. Obes."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1038\/s41366-022-01213-0","article-title":"Effect of probiotic supplementation on plasma metabolite profile after Roux-Y gastric bypass: A prospective, randomized, double-blind, placebo-controlled clinical trial","volume":"46","author":"Ramos","year":"2022","journal-title":"Int. J. Obes."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4103\/sjmms.sjmms_146_23","article-title":"Effect of Bariatric Surgery on Gut Microbiota: A Scientometric Analysis","volume":"12","author":"Guerrero","year":"2024","journal-title":"Saudi J. Med. Med. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1018212","DOI":"10.3389\/fnut.2022.1018212","article-title":"Gut microbiota and obesity: New insights","volume":"9","author":"Quintero","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Komorniak, N., Kaczmarczyk, M., \u0141oniewski, I., Martynova-Van Kley, A., Nalian, A., Wro\u0144ski, M., Kaseja, K., Kowalewski, B., Folwarski, M., and Stachowska, E. (2023). Analysis of the Efficacy of Diet and Short-Term Probiotic Intervention on Depressive Symptoms in Patients after Bariatric Surgery: A Randomized Double-Blind Placebo Controlled Pilot Study. Nutrients, 15.","DOI":"10.20944\/preprints202309.2157.v1"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1007\/s11605-009-0891-x","article-title":"Probiotics improve outcomes after Roux-en-Y gastric bypass surgery: A prospective randomized trial","volume":"13","author":"Woodard","year":"2009","journal-title":"J. Gastrointest. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1007\/s11695-018-03667-6","article-title":"The Effects of Probiotic Supplements on Blood Markers of Endotoxin and Lipid Peroxidation in Patients Undergoing Gastric Bypass Surgery; a Randomized, Double-Blind, Placebo-Controlled, Clinical Trial with 13 Months Follow-Up","volume":"29","author":"Mokhtari","year":"2019","journal-title":"Obes. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1186\/s40064-016-2821-1","article-title":"Intestinal microbiota and chronic constipation","volume":"5","author":"Zhao","year":"2016","journal-title":"Springerplus"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ohkusa, T., Koido, S., Nishikawa, Y., and Sato, N. (2019). Gut Microbiota and Chronic Constipation: A Review and Update. Front. Med., 6.","DOI":"10.3389\/fmed.2019.00019"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/20\/3498\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:13:58Z","timestamp":1760112838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/20\/3498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,15]]},"references-count":29,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["nu16203498"],"URL":"https:\/\/doi.org\/10.3390\/nu16203498","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,15]]}}}