{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:27:32Z","timestamp":1792448852406,"version":"4.5.0"},"reference-count":103,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Natural Science Foundation in China","award":["7224356"],"award-info":[{"award-number":["7224356"]}]},{"name":"Beijing Natural Science Foundation in China","award":["242102111100"],"award-info":[{"award-number":["242102111100"]}]},{"name":"Henan Province Science and Technology Research Project","award":["7224356"],"award-info":[{"award-number":["7224356"]}]},{"name":"Henan Province Science and Technology Research Project","award":["242102111100"],"award-info":[{"award-number":["242102111100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Flax (Linum usitatissimum L.) is the richest plant source of lignin secondary metabolites. Lignans from flax have been applied in the fields of food, medicine, and health due to their significant physiological activities. The most abundant lignan is secoisolariciresinol, which exists in a glycosylated form in plants. Results: After ingestion, it is converted by human intestinal flora into enterodiol and enterolactone, which both have physiological roles. Here, the basic structures, contents, synthesis, regulatory, and metabolic pathways, as well as extraction and isolation methods, of flax lignans were reviewed. Additionally, the physiological activity-related mechanisms and their impacts on human health, from the biosynthesis of lignans in plants to the physiological activity effects observed in animal metabolites, were examined. Conclusions: The review elucidates that lignans, as phenolic compounds, not only function as active substances in plants but also offer significant nutritional values and health benefits when flax is consumed.<\/jats:p>","DOI":"10.3390\/nu16203520","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T08:56:32Z","timestamp":1729155392000},"page":"3520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Unveiling the Power of Flax Lignans: From Plant Biosynthesis to Human Health Benefits"],"prefix":"10.3390","volume":"16","author":[{"given":"Zhan","family":"Gao","sequence":"first","affiliation":[{"name":"School of Physical Education and Training, Capital University of Physical Education and Sports, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Physical Education, University of Science and Technology Beijing, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyuan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Physical Education, University of Science and Technology Beijing, Beijing 100083, China"},{"name":"School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Muir, A.D., and Westcott, N.D. 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