{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:12:40Z","timestamp":1792789960433,"version":"4.5.0"},"reference-count":90,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T00:00:00Z","timestamp":1729382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas (CONAHCYT)","award":["789385"],"award-info":[{"award-number":["789385"]}]},{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas (CONAHCYT)","award":["780270"],"award-info":[{"award-number":["780270"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objective: Obesity, clinically defined as a body mass index (BMI) of 30 kg\/m2 or higher, is a medical condition characterized by the excessive accumulation of body fat, which can lead to adverse health consequences. As a global public health issue with an escalating prevalence, controlling appetite and satiety is essential for regulating energy balance and managing body weight. Dietary proteins and peptides have gained interest in their potential to prevent and treat obesity by modulating satiety signals. This narrative review analyzes scientific evidence highlighting the role of dietary proteins and peptides in regulating satiety signals and investigates their therapeutic potential in preventing and treating obesity. Methods: A comprehensive literature search was conducted in multiple electronic databases, including PubMed, Scopus, and Web of Science. The search focused on articles examining the impact of dietary proteins and peptides on satiety and obesity, encompassing both preclinical and clinical trials. Results: Several studies have demonstrated a correlation between the intake of specific proteins or peptides from plant and animal sources and satiety regulation. These investigations identified mechanisms where amino acids and peptides interact with enteroendocrine cell receptors, activating intracellular signaling cascades that promote the release of anorexigenic gut hormones such as cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), and peptide YY (PYY). Both in vitro and in vivo assays have shown that these interactions contribute to appetite regulation and the sensation of satiety. Conclusions: Using proteins and peptides in the diet may be an effective strategy for regulating appetite and controlling body weight. However, more research\u2014including clinical trials\u2014is needed to understand the underlying mechanisms better and optimize the application of these bioactive compounds in preventing and treating obesity.<\/jats:p>","DOI":"10.3390\/nu16203560","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T08:53:11Z","timestamp":1729500791000},"page":"3560","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Proteins and Peptides from Food Sources with Effect on Satiety and Their Role as Anti-Obesity Agents: A Narrative Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1595-550X","authenticated-orcid":false,"given":"Ana\u00eds","family":"Ignot-Guti\u00e9rrez","sequence":"first","affiliation":[{"name":"Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s\/n, Industrial \u00c1nimas, Xalapa 91193, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloricel","family":"Serena-Romero","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s\/n, Industrial \u00c1nimas, Xalapa 91193, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5540-0357","authenticated-orcid":false,"given":"Daniel","family":"Guajardo-Flores","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico de Monterrey, Escuela de Ingenier\u00eda y Ciencias, Centro de Biotecnolog\u00eda FEMSA, Eugenio Garza Sada 2501 Sur, Monterrey 64849, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2568-7788","authenticated-orcid":false,"given":"Mayvi","family":"Alvarado-Olivarez","sequence":"additional","affiliation":[{"name":"Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s\/n, Industrial \u00c1nimas, Xalapa 91193, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1248-2516","authenticated-orcid":false,"given":"Armando J.","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s\/n, Industrial \u00c1nimas, Xalapa 91193, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5861-8802","authenticated-orcid":false,"given":"Elvia","family":"Cruz-Huerta","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Desarrollo en Alimentos, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s\/n, Industrial \u00c1nimas, Xalapa-Enr\u00edquez 91193, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,20]]},"reference":[{"key":"ref_1","first-page":"s176","article-title":"Obesity: Definition, Comorbidities, Causes, and Burden","volume":"22","author":"Apovian","year":"2016","journal-title":"Am. J. Manag. CARE"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.pcl.2011.09.006","article-title":"Etiologies of Obesity in Children: Nature and Nurture","volume":"58","author":"Skelton","year":"2011","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kumar, U., and Singh, S. (2020). Role of Somatostatin in the Regulation of Central and Peripheral Factors of Satiety and Obesity. Int. J. Mol. 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