{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:15:01Z","timestamp":1793931301025,"version":"4.8.0"},"reference-count":71,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Sarcopenia and sarcopenic obesity, perceived as a reflection of cancer-induced cachexia, are often diagnosed in patients with periampullary malignancies. The pathophysiology of those conditions is multifactorial regarding the tumor microenvironment, immunological response, and the relationship to surrounding tissues. Methods: The PubMed and SCOPUS databases were systematically searched between November 2023 and December 2023. A total of 254 studies were primarily identified. Regarding the inclusion and exclusion criteria, 26 studies were finally included in the review. Results: Evaluated papers disclosed that sarcopenia was significantly associated with a higher incidence of postoperative complications, including pancreatic fistula (POPF) type B and C, with the odds ratio (OR) ranging from 2.65 (95%CI 1.43\u20134.93, p = 0.002) to 4.30 (95%CI 1.15\u201316.01, p &lt; 0.03). Sarcopenic patients also suffered more often from delayed gastric emptying (DGE) with an OR of 6.04 (95%CI 1.13\u201332.32, p = 0.036). Infectious complications, postoperative hemorrhage, and intra-abdominal abscesses occurred more often in sarcopenic patients. Surgical complications were also noted more frequently when sarcopenic obesity was present. Preoperative nutritional prehabilitation seems to reduce the risk of postoperative complications. However, more prospective studies are needed. Conclusions: Sarcopenia and sarcopenic obesity were associated with a higher incidence of multiple postoperative complications, including POPF (type B and C), DGE, hemorrhage, and infectious complications.<\/jats:p>","DOI":"10.3390\/nu16203569","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T09:58:24Z","timestamp":1729504704000},"page":"3569","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Association Between Preoperative Sarcopenia and Sarcopenic Obesity and the Occurrence of Postoperative Complications in Patients Undergoing Pancreaticoduodenectomy for Periampullary Malignancies\u2014A Literature Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-9982","authenticated-orcid":false,"given":"Jakub","family":"Ciesielka","sequence":"first","affiliation":[{"name":"Student\u2019s Scientific Association, Department of Digestive Tract Surgery, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9563-4855","authenticated-orcid":false,"given":"Krzysztof","family":"Jakim\u00f3w","sequence":"additional","affiliation":[{"name":"Student\u2019s Scientific Association, Department of Digestive Tract Surgery, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4001-199X","authenticated-orcid":false,"given":"Karolina","family":"Majewska","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract Surgery, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomir","family":"Mrowiec","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract Surgery, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5495-2969","authenticated-orcid":false,"given":"Beata","family":"Jab\u0142o\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract Surgery, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/jpen.2415","article-title":"Prevalence of Sarcopenia in Patients with Solid Tumors: A Meta-Analysis Based on 81,814 Patients","volume":"46","author":"Surov","year":"2022","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.4251\/wjgo.v14.i12.2302","article-title":"Sarcopenia in Pancreatic Cancer: Effect on Patient Outcomes","volume":"14","author":"Choi","year":"2022","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"104534","DOI":"10.1016\/j.archger.2021.104534","article-title":"Impact of Preoperative Sarcopenia on Postoperative Complications and Prognosis of Gastric Cancer Resection: A Meta-Analysis of Cohort Studies","volume":"98","author":"Chen","year":"2022","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"doy115","DOI":"10.1093\/dote\/doy115","article-title":"Preoperative Sarcopenia Is a Predictor of Poor Prognosis of Esophageal Cancer after Esophagectomy: A Comprehensive Systematic Review and Meta-Analysis","volume":"32","author":"Deng","year":"2019","journal-title":"Dis. Esophagus"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1016\/j.asjsur.2021.12.075","article-title":"Impact of Sarcopenia on Surgical and Oncologic Outcomes of Laparoscopic Surgery for Colorectal Cancer","volume":"45","author":"Takenami","year":"2022","journal-title":"Asian J. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1093\/annonc\/mdx810","article-title":"Sarcopenic Obesity: Hidden Muscle Wasting and Its Impact for Survival and Complications of Cancer Therapy","volume":"29","author":"Baracos","year":"2018","journal-title":"Ann. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"\u015eahin, M.E.H., Akba\u015f, F., Yardimci, A.H., and \u015eahin, E. (2023). The Effect of Sarcopenia and Sarcopenic Obesity on Survival in Gastric Cancer. BMC Cancer, 23.","DOI":"10.1186\/s12885-023-11423-y"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Tschann, P., Weigl, M.P., Clemens, P., Szeverinski, P., Attenberger, C., Kowatsch, M., J\u00e4ger, T., Emmanuel, K., Brock, T., and K\u00f6nigsrainer, I. (2023). Sarcopenic Obesity Is a Risk Factor for Worse Oncological Long-Term Outcome in Locally Advanced Rectal Cancer Patients: A Retrospective Single-Center Cohort Study. Nutrients, 15.","DOI":"10.3390\/nu15112632"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Wang, P., Wang, S., Ma, Y., Li, H., Liu, Z., Lin, G., Li, X., Yang, F., and Qiu, M. (2022). Sarcopenic Obesity and Therapeutic Outcomes in Gastrointestinal Surgical Oncology: A Meta-Analysis. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.921817"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/oxfordjournals.aje.a009520","article-title":"Epidemiology of Sarcopenia among the Elderly in New Mexico","volume":"147","author":"Baumgartner","year":"1998","journal-title":"Am. J. Epidemiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European Consensus on Definition and Diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00223-013-9758-y","article-title":"Quality of Life in Sarcopenia and Frailty","volume":"93","author":"Rizzoli","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.clnu.2009.12.004","article-title":"Consensus Definition of Sarcopenia, Cachexia and Pre-Cachexia: Joint Document Elaborated by Special Interest Groups (SIG) \u201cCachexia-Anorexia in Chronic Wasting Diseases\u201d and \u201cNutrition in Geriatrics\u201d","volume":"29","author":"Muscaritoli","year":"2010","journal-title":"Clin. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Poulia, K.A., Sarantis, P., Antoniadou, D., Koustas, E., Papadimitropoulou, A., Papavassiliou, A.G., and Karamouzis, M.V. (2020). Pancreatic Cancer and Cachexia-Metabolic Mechanisms and Novel Insights. Nutrients, 12.","DOI":"10.3390\/nu12061543"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Principe, D.R., Timbers, K.E., Atia, L.G., Koch, R.M., and Rana, A. (2021). TGF\u03b2 Signaling in the Pancreatic Tumor Microenvironment. Cancers, 13.","DOI":"10.3390\/cancers13205086"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/MCO.0000000000000401","article-title":"The Role of Hypothalamic Inflammation, the Hypothalamic-Pituitary-Adrenal Axis and Serotonin in the Cancer Anorexia-Cachexia Syndrome","volume":"20","author":"Dwarkasing","year":"2017","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Felsenstein, M., Lindhammer, F., Feist, M., Hillebrandt, K.H., Timmermann, L., Benzing, C., Globke, B., Zocholl, D., Hu, M., and Fehrenbach, U. (2022). Perineural Invasion in Pancreatic Ductal Adenocarcinoma (PDAC): A Saboteur of Curative Intended Therapies?. J. Clin. Med., 11.","DOI":"10.3390\/jcm11092367"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1002\/ijc.27594","article-title":"Neural Invasion Induces Cachexia via Astrocytic Activation of Neural Route in Pancreatic Cancer","volume":"131","author":"Imoto","year":"2012","journal-title":"Int. J. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1210\/jcem.86.1.7104","article-title":"Weight Loss Is Not Associated with Hyperleptinemia in Humans with Pancreatic Cancer","volume":"86","author":"Brown","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.1074\/jbc.M610378200","article-title":"Skeletal Muscle Atrophy, a Link between Depression of Protein Synthesis and Increase in Degradation","volume":"282","author":"Eley","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_21","first-page":"2353","article-title":"Purification and Characterization of a Tumor Lipid-Mobilizing Factor","volume":"58","author":"Todorov","year":"1998","journal-title":"Cancer Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2147\/CMAR.S29297","article-title":"Malignant Bowel Obstruction in Advanced Cancer Patients: Epidemiology, Management, and Factors Influencing Spontaneous Resolution","volume":"4","author":"Tuca","year":"2012","journal-title":"Cancer Manag. Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Shinoda, S., Nakamura, N., Roach, B., Bernlohr, D.A., Ikramuddin, S., and Yamamoto, M. (2022). Obesity and Pancreatic Cancer: Recent Progress in Epidemiology, Mechanisms and Bariatric Surgery. Biomedicines, 10.","DOI":"10.3390\/biomedicines10061284"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"155639","DOI":"10.1016\/j.metabol.2023.155639","article-title":"Sarcopenic Obesity: Emerging Mechanisms and Therapeutic Potential","volume":"146","author":"Axelrod","year":"2023","journal-title":"Metabolism"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Hong, S.-H., and Choi, K.M. (2020). Sarcopenic Obesity, Insulin Resistance, and Their Implications in Cardiovascular and Metabolic Consequences. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21020494"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Giovannini, S., Brau, F., Forino, R., Berti, A., D\u2019Ignazio, F., Loreti, C., Bellieni, A., D\u2019Angelo, E., Di Caro, F., and Biscotti, L. (2021). Sarcopenia: Diagnosis and Management, State of the Art and Contribution of Ultrasound. J. Clin. Med., 10.","DOI":"10.3390\/jcm10235552"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1007\/s00261-021-03294-3","article-title":"Sarcopenia: Imaging Assessment and Clinical Application","volume":"47","author":"Chianca","year":"2022","journal-title":"Abdom. Radiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1007\/s00330-018-5790-7","article-title":"Predictive Value of Sarcopenia and Visceral Obesity for Postoperative Pancreatic Fistula after Pancreaticoduodenectomy Analyzed on Clinically Acquired CT and MRI","volume":"29","author":"Jang","year":"2019","journal-title":"Eur. Radiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/bjs.10063","article-title":"Effect of Sarcopenia and Visceral Obesity on Mortality and Pancreatic Fistula Following Pancreatic Cancer Surgery","volume":"103","author":"Pecorelli","year":"2016","journal-title":"Br. J. Surg."},{"key":"ref_30","first-page":"3670","article-title":"The Role of Sarcopenia in the Pancreatic Adenocarcinoma","volume":"25","author":"Pessia","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Derstine, B.A., Holcombe, S.A., Ross, B.E., Wang, N.C., Su, G.L., and Wang, S.C. (2021). Optimal Body Size Adjustment of L3 CT Skeletal Muscle Area for Sarcopenia Assessment. Sci. Rep., 11.","DOI":"10.1038\/s41598-020-79471-z"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s10151-023-02812-3","article-title":"The Impact of Preoperative Sarcopenia on Postoperative Ileus Following Colorectal Cancer Surgery","volume":"27","author":"Traeger","year":"2023","journal-title":"Tech. Coloproctol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and Classification of Cancer Cachexia: An International Consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1093\/gerona\/glz034","article-title":"Approaches to Assessment of Muscle Mass and Myosteatosis on Computed Tomography: A Systematic Review","volume":"74","author":"Amini","year":"2019","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1634\/theoncologist.2019-0600","article-title":"Bioelectrical Impedance Analysis for the Assessment of Sarcopenia in Patients with Cancer: A Systematic Review","volume":"25","author":"Aleixo","year":"2020","journal-title":"Oncologist"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1741904","DOI":"10.1080\/19932820.2020.1741904","article-title":"Evaluating of Altered Hydration Status on Effectiveness of Body Composition Analysis Using Bioelectric Impedance Analysis","volume":"15","author":"Ugras","year":"2020","journal-title":"Libyan J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s11547-022-01450-3","article-title":"Sarcopenia: How to Measure, When and Why","volume":"127","author":"Tagliafico","year":"2022","journal-title":"Radiol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bone.2017.06.010","article-title":"Body Composition by DXA","volume":"104","author":"Shepherd","year":"2017","journal-title":"Bone"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1139\/H08-075","article-title":"A Practical and Precise Approach to Quantification of Body Composition in Cancer Patients Using Computed Tomography Images Acquired during Routine Care","volume":"33","author":"Mourtzakis","year":"2008","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.pan.2023.05.006","article-title":"Comparative Analysis of the Sarcopenia and HALP Score on Postoperative Outcomes in Pancreatic Cancer Patients after Pancreatoduodenectomy","volume":"23","author":"Tazeoglu","year":"2023","journal-title":"Pancreatology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1245\/s10434-017-6216-5","article-title":"Impact of Sarcopenic Obesity on Failure to Rescue from Major Complications Following Pancreaticoduodenectomy for Cancer: Results from a Multicenter Study","volume":"25","author":"Pecorelli","year":"2018","journal-title":"Ann. Surg. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"936","DOI":"10.21037\/jgo.2017.08.09","article-title":"A Semi-Automated Assessment of Sarcopenia Using Psoas Area and Density Predicts Outcomes after Pancreaticoduodenectomy for Pancreatic Malignancy","volume":"8","author":"Namm","year":"2017","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Stretch, C., Aubin, J.-M., Mickiewicz, B., Leugner, D., Al-Manasra, T., Tobola, E., Salazar, S., Sutherland, F.R., Ball, C.G., and Dixon, E. (2018). Sarcopenia and Myosteatosis Are Accompanied by Distinct Biological Profiles in Patients with Pancreatic and Periampullary Adenocarcinomas. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0196235"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.clnesp.2018.05.011","article-title":"Sarcopenia Is Associated with a Greater Incidence of Delayed Gastric Emptying Following Pancreaticoduodenectomy","volume":"27","author":"Tankel","year":"2018","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Linder, N., Schaudinn, A., Langenhan, K., Krenzien, F., Hau, H.-M., Benzing, C., Atanasov, G., Schmelzle, M., Kahn, T., and Busse, H. (2019). Power of Computed-Tomography-Defined Sarcopenia for Prediction of Morbidity after Pancreaticoduodenectomy. BMC Med. Imaging, 19.","DOI":"10.1186\/s12880-019-0332-6"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"E433","DOI":"10.1111\/ans.15379","article-title":"Sarcopenia Is an Independent Predictor of Delayed Gastric Emptying Following Pancreaticoduodenectomy: A Retrospective Study","volume":"89","author":"Shintakuya","year":"2019","journal-title":"ANZ J. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/ans.15431","article-title":"Sarcopenic Obesity and Post-Operative Morbidity after Pancreatic Surgery: A Cohort Study","volume":"89","author":"Ratnayake","year":"2019","journal-title":"ANZ J. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.hpb.2020.04.004","article-title":"The Effects of Sarcopenia and Sarcopenic Obesity after Pancreaticoduodenectomy in Patients with Pancreatic Head Cancer","volume":"22","author":"Ryu","year":"2020","journal-title":"HPB"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"111660","DOI":"10.1016\/j.nut.2022.111660","article-title":"Influence of Sarcopenia as Defined by EWGSOP2 on Complications after Pancreaticoduodenectomy and on the Prognosis of Pancreatic Head Cancer: A Prospective Cohort Study","volume":"99\u2013100","author":"Aoki","year":"2022","journal-title":"Nutrition"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1159\/000504703","article-title":"The Impact of Sarcopenia on Postoperative Course Following Pancreatoduodenectomy: Single-Center Experience of 110 Consecutive Cases","volume":"37","author":"Centonze","year":"2020","journal-title":"Dig. Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1245\/s10434-015-4763-1","article-title":"Radiographic Sarcopenia and Self-Reported Exhaustion Independently Predict NSQIP Serious Complications After Pancreaticoduodenectomy in Older Adults","volume":"22","author":"Sur","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Takagi, K., Yoshida, R., Yagi, T., Umeda, Y., Nobuoka, D., Kuise, T., and Fujiwara, T. (2017). Radiographic Sarcopenia Predicts Postoperative Infectious Complications in Patients Undergoing Pancreaticoduodenectomy. BMC Surg., 17.","DOI":"10.1186\/s12893-017-0261-7"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00595-017-1622-7","article-title":"Correlation between the Skeletal Muscle Index and Surgical Outcomes of Pancreaticoduodenectomy","volume":"48","author":"Sui","year":"2018","journal-title":"Surg. Today"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1007\/s00423-022-02558-w","article-title":"Preoperative Sarcopenia Is a Negative Predictor for Enhanced Postoperative Recovery after Pancreaticoduodenectomy","volume":"407","author":"Nauheim","year":"2022","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1007\/s11605-016-3146-7","article-title":"Preoperative Sarcopenia Strongly Influences the Risk of Postoperative Pancreatic Fistula Formation After Pancreaticoduodenectomy","volume":"20","author":"Nishida","year":"2016","journal-title":"J. Gastrointest. Surg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.nut.2016.04.002","article-title":"A High Visceral Adipose Tissue-to-Skeletal Muscle Ratio as a Determinant of Major Complications after Pancreatoduodenectomy for Cancer","volume":"32","author":"Sandini","year":"2016","journal-title":"Nutrition"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"111182","DOI":"10.1016\/j.ejrad.2023.111182","article-title":"Body Composition Analysis Using Convolutional Neural Network in Predicting Postoperative Pancreatic Fistula and Survival after Pancreatoduodenectomy for Pancreatic Cancer","volume":"169","author":"Yoo","year":"2023","journal-title":"Eur. J. Radiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000529429","article-title":"Predictive Value of Body Composition Parameters for Postoperative Complications in Patients Who Received Pancreaticoduodenectomy","volume":"64","author":"Cai","year":"2023","journal-title":"Eur. Surg. Res."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Menozzi, R., Valoriani, F., Ballarin, R., Alemanno, L., Vinciguerra, M., Barbieri, R., Cuoghi Costantini, R., D\u2019Amico, R., Torricelli, P., and Pecchi, A. (2023). Impact of Nutritional Status on Postoperative Outcomes in Cancer Patients Following Elective Pancreatic Surgery. Nutrients, 15.","DOI":"10.3390\/nu15081958"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2147\/RMHP.S257677","article-title":"Total Psoas Area Index Is Valuable to Assess Sarcopenia, Sarcopenic Overweight\/Obesity and Predict Outcomes in Patients Undergoing Open Pancreatoduodenectomy","volume":"13","author":"Xu","year":"2020","journal-title":"Risk Manag. Healthc. Policy"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"106848","DOI":"10.1016\/j.ejso.2023.02.005","article-title":"Prognostic Value of Preoperative CT Scan Derived Body Composition Measures in Resected Pancreatic Cancer","volume":"50","author":"Guarneri","year":"2024","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/jhbp.1283","article-title":"A New Fistula Risk Score Using Sarcopenic Obesity and Subcutaneous Fat Area for Predicting Postoperative Pancreatic Fistula after Pancreaticoduodenectomy","volume":"30","author":"Hayashi","year":"2023","journal-title":"J. Hepatobil. Pancreat. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Lee, N.R., Hwang, H.K., Lee, H., and Kang, C.M. (2024). Oral Protein Supplements Might Improve Nutritional Status and Quality of Life in Elderly Patients after Standard Pancreatic Resection. Nutrients, 16.","DOI":"10.3390\/nu16172988"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"603","DOI":"10.17235\/reed.2019.6182\/2019","article-title":"Prehabilitation in Patients Undergoing Pancreaticoduodenectomy: A Randomized Controlled Trial","volume":"111","author":"Ausania","year":"2019","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1007\/s10147-021-01958-0","article-title":"Impact of Preoperative Nutritional Support and Rehabilitation Therapy in Patients Undergoing Pancreaticoduodenectomy","volume":"26","author":"Tsukagoshi","year":"2021","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Matsumoto, M., Uwagawa, T., Shirai, Y., Tsunematsu, M., Furukawa, K., Haruki, K., Okui, N., Okazaki, K., Ishizaki, S., and Ikegami, T. (2024). Impact of Preoperative Osteosarcopenia and Postoperative Administration of Pancrelipase on the Prognosis of Borderline Resectable and Unresectable Locally Advanced Pancreatic Cancer. Am. Surg., 31348241272420.","DOI":"10.1177\/00031348241272420"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Jab\u0142o\u0144ska, B., and Mrowiec, S. (2020). The Role of Immunonutrition in Patients Undergoing Pancreaticoduodenectomy. Nutrients, 12.","DOI":"10.3390\/nu12092547"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.clnu.2017.02.013","article-title":"ESPEN guideline: Clinical nutrition in surgery","volume":"36","author":"Weimann","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1016\/j.clnu.2021.03.031","article-title":"ESPEN practical guideline: Clinical nutrition in surgery","volume":"40","author":"Weimann","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Jab\u0142o\u0144ska, B., Pawlicki, K., and Mrowiec, S. (2021). Associations between Nutritional and Immune Status and Clinicopathologic Factors in Patients with Pancreatic Cancer: A Comprehensive Analysis. 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