{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:50:52Z","timestamp":1793206252134,"version":"4.5.0"},"reference-count":88,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian agencies and grants: Matheus dos Santos Fernandez is a research fellow in the Graduate Program in Dentistry and receives","award":["001\/2024"],"award-info":[{"award-number":["001\/2024"]}]},{"name":"Brazilian agencies and grants: Matheus dos Santos Fernandez is a research fellow in the Graduate Program in Dentistry and receives","award":["404804\/2021-7"],"award-info":[{"award-number":["404804\/2021-7"]}]},{"name":"Brazilian agencies and grants: Matheus dos Santos Fernandez is a research fellow in the Graduate Program in Dentistry and receives","award":["88881.710320\/2022-01"],"award-info":[{"award-number":["88881.710320\/2022-01"]}]},{"name":"Brazilian agencies and grants: Matheus dos Santos Fernandez is a research fellow in the Graduate Program in Dentistry and receives","award":["465671\/2014-4"],"award-info":[{"award-number":["465671\/2014-4"]}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["001\/2024"],"award-info":[{"award-number":["001\/2024"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["404804\/2021-7"],"award-info":[{"award-number":["404804\/2021-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["88881.710320\/2022-01"],"award-info":[{"award-number":["88881.710320\/2022-01"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["465671\/2014-4"],"award-info":[{"award-number":["465671\/2014-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007395","name":"INCT\/Excitotoxicity and Neuroprotection","doi-asserted-by":"publisher","award":["001\/2024"],"award-info":[{"award-number":["001\/2024"]}],"id":[{"id":"10.13039\/501100007395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007395","name":"INCT\/Excitotoxicity and Neuroprotection","doi-asserted-by":"publisher","award":["404804\/2021-7"],"award-info":[{"award-number":["404804\/2021-7"]}],"id":[{"id":"10.13039\/501100007395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007395","name":"INCT\/Excitotoxicity and Neuroprotection","doi-asserted-by":"publisher","award":["88881.710320\/2022-01"],"award-info":[{"award-number":["88881.710320\/2022-01"]}],"id":[{"id":"10.13039\/501100007395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007395","name":"INCT\/Excitotoxicity and Neuroprotection","doi-asserted-by":"publisher","award":["465671\/2014-4"],"award-info":[{"award-number":["465671\/2014-4"]}],"id":[{"id":"10.13039\/501100007395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: To collect evidence from studies that explored the associations between serum vitamin D (25[OH]D) concentrations\/status and the presence of depressive\/anxiety symptoms in the ante- and\/or postnatal periods (PROSPERO-CRD42023390895). Methods: Studies that assessed serum 25[OH]D concentrations in adult women during the ante\/postnatal periods and those that used valid instruments to identify the experience\/severity of depressive\/anxiety symptoms were included. Independent researchers performed the identification\/selection of studies, data extraction, risk of bias (RoB) assessment, and bibliometric analysis steps. Results: Of the total of 6769 eligible records, 15 cohort studies [high (n = 3), moderate (n = 7), and low (n = 5) RoB], nine cross-sectional studies [moderate (n = 3) and low (n = 6) RoB], and one case-control study [moderate RoB] were included (n = 25). Depression (n = 24) and anxiety (n = 4) symptoms were assessed. A significant difference in antenatal serum 25[OH]D concentrations between the groups of women with and without depression was identified (mean difference: \u22124.63 ng\/mL; 95% confidence interval [95% CI]: \u22128.88; \u22120.38). Postnatal serum 25[OH]D concentrations were found to be, on average, \u22122.36 ng\/mL (95% CI: \u22124.59; \u22120.14) lower in women with postnatal depression than in those without. Maternal antenatal anxiety was associated with significantly lower concentrations\/deficiency of 25[OH]D in only one included study. Conclusions: Based on very low\/low-quality evidence, it was observed that reduced serum 25[OH]D concentrations in the ante- and postnatal period are associated with the presence of ante- and postnatal depressive symptoms, respectively. Low\/deficient antenatal serum 25[OH]D concentrations may not be related to the presence of anxiety symptoms before childbirth. Well-designed longitudinal studies are needed to explore the estimated pooled effect of these associations.<\/jats:p>","DOI":"10.3390\/nu16213648","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T07:04:04Z","timestamp":1730099044000},"page":"3648","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Is Serum Vitamin D Associated with Depression or Anxiety in Ante- and Postnatal Adult Women? A Systematic Review with Meta-Analysis"],"prefix":"10.3390","volume":"16","author":[{"given":"Luis Ot\u00e1vio Lobo","family":"Centeno","sequence":"first","affiliation":[{"name":"Graduate Program in Health and Behavior, Catholic University of Pelotas (UCPel), Pelotas 96015-560, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7781-3083","authenticated-orcid":false,"given":"Matheus dos Santos","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry, Federal University of Pelotas (UFPel), Pelotas 96015-560, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-1752","authenticated-orcid":false,"given":"Francisco Wilker Mustafa Gomes","family":"Muniz","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry, Federal University of Pelotas (UFPel), Pelotas 96015-560, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Longoni","sequence":"additional","affiliation":[{"name":"Graduate Program in Health and Behavior, Catholic University of Pelotas (UCPel), Pelotas 96015-560, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1953-7831","authenticated-orcid":false,"given":"Adriano Martimbianco","family":"de Assis","sequence":"additional","affiliation":[{"name":"Graduate Program in Health and Behavior, Catholic University of Pelotas (UCPel), Pelotas 96015-560, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.pbiomolbio.2006.02.016","article-title":"Vitamin D physiology","volume":"92","author":"Lips","year":"2006","journal-title":"Prog. 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