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However, the causality of these associations remains uncertain. This study postulates a causal relationship between specific plasma fatty acids and pre-eclampsia or other maternal hypertensive disorders (PE-HTPs). To test this hypothesis, two-sample bidirectional Mendelian randomization (MR) analyses were employed to determine the causality effects. Methods: Single-nucleotide polymorphisms associated with PE-HTPs and fatty acids were obtained from a genome-wide association study (GWAS) of European ancestry. Bidirectional MR analyses were conducted using methods such as inverse variance weighted, MR-Egger, weighted median, simple mode, and weighted mode. Sensitivity analyses, including tests for heterogeneity, horizontal pleiotropy, and co-localization, were conducted to assess the robustness of MR results. Results: The analyses revealed causal relationships between PE-HTPs and several fatty acids, including monounsaturated fatty acid (MUFA), omega-6 fatty acid (n-6 FA), linoleic acid (LA), docosahexaenoic acid (DHA), and the PUFA\/MUFA ratio. Genetically predicted higher risk of PE-HTPs was significantly associated with lower plasma n-6 FA (OR = 0.96, 95% CI: 0.93\u20130.99), particularly LA (OR = 0.95, 95% CI: 0.92\u20130.98). Conversely, increased DHA (OR = 0.86, 95% CI: 0.78\u20130.96) and a higher PUFA\/MUFA ratio (OR = 0.86, 95% CI: 0.76\u20130.98) were associated with a reduced risk of PE-HTPs. Elevated MUFA levels (OR = 1.12, 95% CI: 1.00\u20131.25) were related to an increased risk. Conclusions: This study provides robust genetic evidence supporting bidirectional causal relationships between PE-HTPs and specific plasma fatty acids, underscoring the critical role of fatty acid metabolism in maternal hypertensive disorders.<\/jats:p>","DOI":"10.3390\/nu16213748","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T12:31:32Z","timestamp":1730377892000},"page":"3748","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bidirectional Mendelian Randomization Analysis of Genetic Proxies of Plasma Fatty Acids and Pre-Eclampsia Risk"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9961-199X","authenticated-orcid":false,"given":"Jingqi","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1097-2175","authenticated-orcid":false,"given":"Shuo","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dangyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, The Affiliated Huaian No. 1 People\u2019s Hospital of Nanjing Medical University, Huai\u2019an 223300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Fox, R., Kitt, J., Leeson, P., Aye, C.Y.L., and Lewandowski, A.J. (2019). Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring. J. Clin. Med., 8.","DOI":"10.3390\/jcm8101625"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1136\/heartjnl-2021-320684","article-title":"Pregnancy-related cardiovascular conditions and outcomes in a United States Medicaid population","volume":"108","author":"Marschner","year":"2022","journal-title":"Heart"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"f6564","DOI":"10.1136\/bmj.f6564","article-title":"Pre-eclampsia rates in the United States, 1980\u20132010: Age-period-cohort analysis","volume":"347","author":"Ananth","year":"2013","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Chang, K.J., Seow, K.M., and Chen, K.H. (2023). Preeclampsia: Recent Advances in Predicting, Preventing, and Managing the Maternal and Fetal Life-Threatening Condition. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20042994"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Roberts, L., Henry, A., Harvey, S.B., Homer, C.S.E., and Davis, G.K. (2022). Depression, anxiety and posttraumatic stress disorder six months following preeclampsia and normotensive pregnancy: A P4 study. BMC Pregnancy Childbirth, 22.","DOI":"10.1186\/s12884-022-04439-y"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1161\/HYPERTENSIONAHA.122.19408","article-title":"Brain Vascular Dysfunction in Mothers and Their Children Exposed to Preeclampsia","volume":"80","author":"Escudero","year":"2023","journal-title":"Hypertension"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preghy.2017.07.144","article-title":"Neurological function in children born to preeclamptic and hypertensive mothers\u2014A systematic review","volume":"10","author":"Mak","year":"2017","journal-title":"Pregnancy Hypertens."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2019.07.004","article-title":"The two-stage placental model of preeclampsia: An update","volume":"134\u2013135","author":"Staff","year":"2019","journal-title":"J. Reprod. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Elhakeem, A., Ronkainen, J., Mansell, T., Lange, K., Mikkola, T.M., Mishra, B.H., Wahab, R.J., Cadman, T., Yang, T., and Burgner, D. (2023). Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: A multi-cohort study. BMC Med., 21.","DOI":"10.1186\/s12916-022-02711-8"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Duttaroy, A.K., and Basak, S. (2021). Maternal Fatty Acid Metabolism in Pregnancy and Its Consequences in the Feto-Placental Development. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.787848"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102080","DOI":"10.1016\/j.plefa.2020.102080","article-title":"Maternal dietary fatty acids and their roles in human placental development","volume":"155","author":"Duttaroy","year":"2020","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Basak, S., Mallick, R., and Duttaroy, A.K. (2020). Maternal Docosahexaenoic Acid Status during Pregnancy and Its Impact on Infant Neurodevelopment. Nutrients, 12.","DOI":"10.20944\/preprints202010.0406.v1"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Basak, S., Mallick, R., Banerjee, A., Pathak, S., and Duttaroy, A.K. (2021). Maternal Supply of Both Arachidonic and Docosahexaenoic Acids Is Required for Optimal Neurodevelopment. Nutrients, 13.","DOI":"10.20944\/preprints202104.0665.v3"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"102155","DOI":"10.1016\/j.plefa.2020.102155","article-title":"Metabolic syndrome in postmenopausal women is associated with lower erythrocyte PUFA\/MUFA and n-3\/n-6 ratio: A case-control study","volume":"159","author":"Muzsik","year":"2020","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12944-018-0693-9","article-title":"Omega-6\/omega-3 fatty acid intake of children and older adults in the U.S.: Dietary intake in comparison to current dietary recommendations and the Healthy Eating Index","volume":"17","author":"Sheppard","year":"2018","journal-title":"Lipids Health Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.tjnut.2024.03.004","article-title":"Maternal and Offspring Fatty Acid Desaturase Variants, Prenatal DHA Supplementation, and Dietary n-6:n-3 Fatty Acid Ratio in Relation to Cardiometabolic Health in Mexican Children","volume":"154","author":"Wimalasena","year":"2024","journal-title":"J. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jacc.2020.05.077","article-title":"Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review","volume":"76","author":"Astrup","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhong, N., Han, P., Wang, Y., and Zheng, C. (2023). Associations of polyunsaturated fatty acids with cardiovascular disease and mortality: A study of NHANES database in 2003\u20132018. BMC Endocr. Disord., 23.","DOI":"10.1186\/s12902-023-01412-4"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Yang, Y., Wang, Y., Lv, Y., and Ding, H. (2022). Dissecting the Roles of Lipids in Preeclampsia. Metabolites, 12.","DOI":"10.3390\/metabo12070590"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jacl.2022.02.005","article-title":"Hyperlipidemia and risk for preclampsia","volume":"16","author":"Poornima","year":"2022","journal-title":"J. Clin. Lipidol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/HJH.0000000000002596","article-title":"Placental lipid metabolism in preeclampsia","volume":"39","author":"Khaire","year":"2021","journal-title":"J. Hypertens."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Gray, N.L., Stoodley, I., Wood, L.G., Collins, C.E., Brown, L.J., Rae, K.M., Pringle, K.G., Schumacher, T.L., and The Gomeroi Gaaynggal Advisory, C. (2023). Omega-3 Fatty Acids during Pregnancy in Indigenous Australian Women of the Gomeroi Gaaynggal Cohort. Nutrients, 15.","DOI":"10.3390\/nu15081943"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbacli.2015.06.004","article-title":"Differential regional fatty acid distribution in normotensive and preeclampsia placenta","volume":"4","author":"Rani","year":"2015","journal-title":"BBA Clin."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Irwinda, R., Hiksas, R., Siregar, A.A., Saroyo, Y.B., and Wibowo, N. (2021). Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: A cross sectional study. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-93846-w"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.plefa.2014.05.006","article-title":"Altered maternal proportions of long chain polyunsaturated fatty acids and their transport leads to disturbed fetal stores in preeclampsia","volume":"91","author":"Wadhwani","year":"2014","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000252971","article-title":"Long-Chain Polyunsaturated Fatty Acid Composition of Breast Milk in Pre-Eclamptic Mothers","volume":"97","author":"Dangat","year":"2009","journal-title":"Neonatology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1093\/eurheartj\/ehad736","article-title":"Mendelian randomization for cardiovascular diseases: Principles and applications","volume":"44","author":"Larsson","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/jamacardio.2023.1312","article-title":"Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy","volume":"8","author":"Tyrmi","year":"2023","journal-title":"JAMA Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Richardson, T.G., Leyden, G.M., Wang, Q., Bell, J.A., Elsworth, B., Davey Smith, G., and Holmes, M.V. (2022). Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation. PLoS Biol., 20.","DOI":"10.1371\/journal.pbio.3001547"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"D977","DOI":"10.1093\/nar\/gkac1010","article-title":"The NHGRI-EBI GWAS Catalog: Knowledgebase and deposition resource","volume":"51","author":"Sollis","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e63033","DOI":"10.7554\/eLife.63033","article-title":"Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population","volume":"10","author":"Julkunen","year":"2021","journal-title":"eLife"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e34408","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"eLife"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.ajhg.2022.04.001","article-title":"Combining evidence from Mendelian randomization and colocalization: Review and comparison of approaches","volume":"109","author":"Zuber","year":"2022","journal-title":"Am. J. Hum. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1158\/0008-5472.CAN-20-0985","article-title":"LDtrait: An Online Tool for Identifying Published Phenotype Associations in Linkage Disequilibrium","volume":"80","author":"Lin","year":"2020","journal-title":"Cancer Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/10641950500281118","article-title":"Placental tissue levels of nonesterified polyunsaturated fatty acids in normal and preeclamptic pregnancies","volume":"24","author":"Wang","year":"2005","journal-title":"Hypertens. Pregnancy"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/hr.2010.31","article-title":"Circulating angiogenic factors and their association with birth outcomes in preeclampsia","volume":"33","author":"Kulkarni","year":"2010","journal-title":"Hypertens. Res."},{"key":"ref_37","first-page":"Cd003402","article-title":"Marine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by pre-eclampsia or intrauterine growth restriction","volume":"3","author":"Makrides","year":"2006","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.plefa.2017.08.002","article-title":"Maternal long chain polyunsaturated fatty acid status and pregnancy complications","volume":"136","author":"Wadhwani","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Gil-S\u00e1nchez, A., Demmelmair, H., Parrilla, J.J., Koletzko, B., and Larqu\u00e9, E. (2011). Mechanisms involved in the selective transfer of long chain polyunsaturated Fatty acids to the fetus. Front. Genet., 2.","DOI":"10.3389\/fgene.2011.00057"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Burchakov, D.I., Kuznetsova, I.V., and Uspenskaya, Y.B. (2017). Omega-3 Long-Chain Polyunsaturated Fatty Acids and Preeclampsia: Trials Say \u201cNo,\u201d but Is It the Final Word?. Nutrients, 9.","DOI":"10.3390\/nu9121364"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Coscia, A., Riboldi, L., Spada, E., Bertino, E., Sottemano, S., Barbagallo, I., Livolti, G., Galvano, F., Gazzolo, D., and Peila, C. (2023). Preeclampsia and Its Impact on Human Milk Activin A Concentration. Nutrients, 15.","DOI":"10.20944\/preprints202309.0284.v1"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ijdevneu.2013.12.007","article-title":"Preeclampsia alters milk neurotrophins and long chain polyunsaturated fatty acids","volume":"33","author":"Dangat","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/1389201015666140330192345","article-title":"Lipid metabolism during pregnancy and its implications for fetal growth","volume":"15","author":"Herrera","year":"2014","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1203\/PDR.0b013e31818702a2","article-title":"Maternal and fetal fatty acid profile in normal and intrauterine growth restriction pregnancies with and without preeclampsia","volume":"64","author":"Alvino","year":"2008","journal-title":"Pediatr. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.plefa.2009.05.002","article-title":"Free fatty acid profiles in preeclampsia","volume":"81","author":"Villa","year":"2009","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12944-023-01889-x","article-title":"Fatty acids and pregnancy-induced hypertension: A Mendelian randomization study","volume":"22","author":"Ma","year":"2023","journal-title":"Lipids Health Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.clnu.2016.01.014","article-title":"Placental MFSD2a transporter is related to decreased DHA in cord blood of women with treated gestational diabetes","volume":"36","author":"Pagan","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s12967-023-04239-8","article-title":"DHA supplementation and pregnancy complications","volume":"21","author":"Jiang","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1080\/10408398.2021.1973364","article-title":"Association of omega-6 polyunsaturated fatty acids with blood pressure: A systematic review and meta-analysis of observational studies","volume":"63","author":"Hajihashemi","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41440-021-00849-1","article-title":"Association between dietary intake of polyunsaturated fatty acid and prevalence of hypertension in U.S. adults: A cross-sectional study using data from NHANES 2009\u20132016","volume":"45","author":"Ni","year":"2022","journal-title":"Hypertens. Res."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/21\/3748\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:25:54Z","timestamp":1760113554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/21\/3748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":50,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["nu16213748"],"URL":"https:\/\/doi.org\/10.3390\/nu16213748","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]}}}