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Spain)","award":["FI2100040"],"award-info":[{"award-number":["FI2100040"]}]},{"name":"Consejer\u00eda de Salud","award":["PI23\/00347"],"award-info":[{"award-number":["PI23\/00347"]}]},{"name":"Consejer\u00eda de Salud","award":["PI20\/01322"],"award-info":[{"award-number":["PI20\/01322"]}]},{"name":"Consejer\u00eda de Salud","award":["PI18\/01165"],"award-info":[{"award-number":["PI18\/01165"]}]},{"name":"Consejer\u00eda de Salud","award":["PI17\/02136"],"award-info":[{"award-number":["PI17\/02136"]}]},{"name":"Consejer\u00eda de Salud","award":["PI14\/00710"],"award-info":[{"award-number":["PI14\/00710"]}]},{"name":"Consejer\u00eda de Salud","award":["PI14\/01104"],"award-info":[{"award-number":["PI14\/01104"]}]},{"name":"Consejer\u00eda de Salud","award":["PI14\/00970"],"award-info":[{"award-number":["PI14\/00970"]}]},{"name":"Consejer\u00eda de Salud","award":["PI14\/00874"],"award-info":[{"award-number":["PI14\/00874"]}]},{"name":"Consejer\u00eda de Salud","award":["PIE14\/00031"],"award-info":[{"award-number":["PIE14\/00031"]}]},{"name":"Consejer\u00eda de Salud","award":["C-0060-2012"],"award-info":[{"award-number":["C-0060-2012"]}]},{"name":"Consejer\u00eda de Salud","award":["FI2100040"],"award-info":[{"award-number":["FI2100040"]}]},{"name":"Instituto de Salud Carlos III","award":["PI23\/00347"],"award-info":[{"award-number":["PI23\/00347"]}]},{"name":"Instituto de Salud Carlos III","award":["PI20\/01322"],"award-info":[{"award-number":["PI20\/01322"]}]},{"name":"Instituto de Salud Carlos III","award":["PI18\/01165"],"award-info":[{"award-number":["PI18\/01165"]}]},{"name":"Instituto de Salud Carlos III","award":["PI17\/02136"],"award-info":[{"award-number":["PI17\/02136"]}]},{"name":"Instituto de Salud Carlos III","award":["PI14\/00710"],"award-info":[{"award-number":["PI14\/00710"]}]},{"name":"Instituto de Salud Carlos III","award":["PI14\/01104"],"award-info":[{"award-number":["PI14\/01104"]}]},{"name":"Instituto de Salud Carlos III","award":["PI14\/00970"],"award-info":[{"award-number":["PI14\/00970"]}]},{"name":"Instituto de Salud Carlos III","award":["PI14\/00874"],"award-info":[{"award-number":["PI14\/00874"]}]},{"name":"Instituto de Salud Carlos III","award":["PIE14\/00031"],"award-info":[{"award-number":["PIE14\/00031"]}]},{"name":"Instituto de Salud Carlos III","award":["C-0060-2012"],"award-info":[{"award-number":["C-0060-2012"]}]},{"name":"Instituto de Salud Carlos III","award":["FI2100040"],"award-info":[{"award-number":["FI2100040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) increases the risk of Type-2 Diabetes (T2DM). The Mediterranean diet (MD) has shown advantages in the management of MAFLD and preventing co-morbidities; however, its relationship with T2DM development in MAFLD has been less investigated. We aimed to evaluate the association of MD adherence with the risk of incident T2DM in the Spanish adult population with MAFLD and according to their weight gain at 7.5 years follow-up. Methods: A cohort of 714 participants (without weight increment: 377; with weight increment: 337) from the Di@bet.es cohort study with MAFLD and without T2DM at baseline were investigated. Anthropometric, sociodemographic, clinical data, and a survey on habits were recorded. OGTT and fasting blood biochemistry determinations were made. Baseline adherence to MD was estimated by the adapted 14-point MEDAS questionnaire and categorized as high and low adherence. Results: In total, 98 people developed T2DM at follow-up. The high adherence to MD was inversely associated with the development of T2DM in both the overall population (0.52 [0.31\u20130.87]) and subjects without weight gain at follow-up (0.35 [0.16\u20130.78]). Conclusions: Our results suggest the protective effect of high adherence to MD regarding the risk of T2DM in subjects with MAFLD, with this health benefit being more evident in men with the absence of weight gain. These results support the recommendations for MD use in these patients.<\/jats:p>","DOI":"10.3390\/nu16213788","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T06:30:48Z","timestamp":1730788248000},"page":"3788","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Protective Effect of High Adherence to Mediterranean Diet on the Risk of Incident Type-2 Diabetes in Subjects with MAFLD: The Di@bet.es Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Ana","family":"Lago-Sampedro","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3nn Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"UGC Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Regional Universitario de M\u00e1laga, IBIMA Plataforma BIONAND, 29009 M\u00e1laga, Spain"},{"name":"Departamento de Medicina y Dermatolog\u00eda, Universidad de M\u00e1laga-UMA, 29071 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9760-0883","authenticated-orcid":false,"given":"Wasima","family":"Oualla-Bachiri","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3nn Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"UGC Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Regional Universitario de M\u00e1laga, IBIMA Plataforma BIONAND, 29009 M\u00e1laga, Spain"},{"name":"Departamento de Medicina y Dermatolog\u00eda, Universidad de M\u00e1laga-UMA, 29071 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Garc\u00eda-Serrano","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3nn Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de 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de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"UGC Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Regional Universitario de M\u00e1laga, IBIMA Plataforma BIONAND, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viyey","family":"Doulatram-Gamgaram","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3nn Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"UGC Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Regional Universitario de M\u00e1laga, IBIMA Plataforma BIONAND, 29009 M\u00e1laga, Spain"},{"name":"Departamento de Medicina y Dermatolog\u00eda, Universidad de M\u00e1laga-UMA, 29071 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7646-2899","authenticated-orcid":false,"given":"Gabriel","family":"Olveira","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3nn Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"UGC Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Regional Universitario de M\u00e1laga, IBIMA Plataforma BIONAND, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6114-9712","authenticated-orcid":false,"given":"Elias","family":"Delgado","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3nn Biomedica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Department of Endocrinology and Nutrition, Health Research Institute of the Principality of Asturias (ISPA), Central University Hospital of Asturias, University of Oviedo, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-3689","authenticated-orcid":false,"given":"Felipe","family":"Chaves","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3nn Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Genomic and Genetic Diagnosis Unit, INCLIVA Biomedical Research Institute, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Casta\u00f1o","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3nn Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3nn Biomedica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Biobizkaia Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, CIBERDEM, CIBERER, Endo-ERN, 48903 Barakaldo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3628-9323","authenticated-orcid":false,"given":"Alfonso","family":"Calle-Pascual","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3nn Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Department of Endocrinology and Nutrition, San Carlos University Hospital of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5175-1555","authenticated-orcid":false,"given":"Josep","family":"Franch-Nadal","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3nn Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"EAP Raval Sud, Catalan Institute of Health, GEDAPS Network, Primary Care, Research Support Unit (IDIAP\u2014Jordi Gol Foundation), 08001 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2179-2134","authenticated-orcid":false,"given":"Gemma","family":"Rojo-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3nn Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"UGC Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Regional Universitario de M\u00e1laga, IBIMA Plataforma BIONAND, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-3473","authenticated-orcid":false,"given":"Eva","family":"Garc\u00eda-Escobar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3nn Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"UGC Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Regional Universitario de M\u00e1laga, IBIMA Plataforma BIONAND, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","article-title":"The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis","volume":"71","author":"Younossi","year":"2019","journal-title":"J. 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