{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:10:19Z","timestamp":1792516219094,"version":"4.5.0"},"reference-count":130,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Obesity is currently an increasing public health burden due to its related metabolic and cardiovascular complications. In Western countries, a significant number of people are overweight or obese, and this trend is, unfortunately, becoming increasingly common even among the pediatric population. In this narrative review, we analyzed the role of nutrition during growth and its impact on the risk of developing metabolic syndrome and cardiovascular complications later in life. An impactful role in determining the phenotypic characteristics of the offspring is the parental diet carried out before conception. During intrauterine growth, the main risk factors are represented by an unbalanced maternal diet, excessive gestational weight gain, and impaired glycemic status. Breastfeeding, on the other hand, has many beneficial effects, but at the same time the quality of breast milk may be modified if maternal overweight or obesity subsists. Complementary feeding is likewise pivotal because an early introduction before 4 months of age and a high protein intake contribute to weight gain later. Knowledge of these mechanisms may allow early modification of risk factors by implementing targeted preventive strategies.<\/jats:p>","DOI":"10.3390\/nu16223801","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T04:03:24Z","timestamp":1730865804000},"page":"3801","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Influence of Nutrition on Growth and Development of Metabolic Syndrome in Children"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-4867","authenticated-orcid":false,"given":"Alessia","family":"Quarta","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Chieti\u2014Pescara, G. D\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Quarta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chieti\u2014Pescara, G. D\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Mastromauro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chieti\u2014Pescara, G. D\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Chiarelli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chieti\u2014Pescara, G. D\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2904-2744","authenticated-orcid":false,"given":"Cosimo","family":"Giannini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chieti\u2014Pescara, G. D\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100957","DOI":"10.1016\/j.arr.2019.100957","article-title":"Developmental origins of type 2 diabetes: Focus on epigenetics","volume":"55","author":"Vaiserman","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"485082","DOI":"10.1155\/2013\/485082","article-title":"Early Life Factors and Type 2 Diabetes Mellitus","volume":"2013","author":"Jiang","year":"2013","journal-title":"J. Diabetes Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/ajcn\/nqaa216","article-title":"Maternal adiposity alters the human milk metabolome: Associations between nonglucose monosaccharides and infant adiposity","volume":"112","author":"Saben","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kim, O.Y., Kim, E.M., and Chung, S. (2020). Impacts of Dietary Macronutrient Pattern on Adolescent Body Composition and Metabolic Risk: Current and Future Health Status\u2014A Narrative Review. Nutrients, 12.","DOI":"10.3390\/nu12123722"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e20171603","DOI":"10.1542\/peds.2017-1603","article-title":"The Metabolic Syndrome in Children and Adolescents: Shifting the Focus to Cardiometabolic Risk Factor Clustering","volume":"140","author":"Magge","year":"2017","journal-title":"Pediatrics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e2434699","DOI":"10.1001\/jamanetworkopen.2024.34699","article-title":"Early-Life Risk Factors for Carotid Intima-Media Thickness and Carotid Stiffness in Adolescence","volume":"7","author":"Roodenburg","year":"2024","journal-title":"JAMA Netw. Open."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.2337\/dc17-2141","article-title":"Childhood BMI and Adult Type 2 Diabetes, Coronary Artery Diseases, Chronic Kidney Disease, and Cardiometabolic Traits: A Mendelian Randomization Analysis","volume":"41","author":"Geng","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Herti\u0161 Petek, T., Petek, T., Mo\u010dnik, M., and Mar\u010dun Varda, N. (2022). Systemic Inflammation, Oxidative Stress and Cardiovascular Health in Children and Adolescents: A Systematic Review. Antioxidants, 11.","DOI":"10.3390\/antiox11050894"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1097\/HJH.0b013e328346d787","article-title":"Association between plasma leptin and blood pressure in two population-based samples of children and adolescents","volume":"29","author":"Kynde","year":"2011","journal-title":"J. Hypertens."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Drozdz, D., Alvarez-Pitti, J., W\u00f3jcik, M., Borghi, C., Gabbianelli, R., Mazur, A., Herceg-\u010cavrak, V., Gonzalez Lopez-Valcarcel, B., Brzez\u0144ski, M., and Lurbe, E. (2021). Obesity and Cardiometabolic Risk Factors: From Childhood to Adulthood. Nutrients, 13.","DOI":"10.3390\/nu13114176"},{"key":"ref_11","first-page":"e984","article-title":"Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association","volume":"143","author":"Poirier","year":"2021","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Inzaghi, E., Pampanini, V., Deodati, A., and Cianfarani, S. (2022). The Effects of Nutrition on Linear Growth. Nutrients, 14.","DOI":"10.3390\/nu14091752"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/CM9.0000000000001920","article-title":"Early life 1000 days: Opportunities for preventing adult diseases","volume":"135","author":"Juan","year":"2022","journal-title":"Chin. Med. J. Engl."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000471876","article-title":"The Physiology of Childhood Growth: Hormonal Regulation","volume":"88","author":"Benyi","year":"2017","journal-title":"Horm. Res. Paediatr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"111052","DOI":"10.1016\/j.mce.2020.111052","article-title":"Effects of GH\/IGF axis on bone and cartilage","volume":"519","author":"Dixit","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000342573","article-title":"New Aspects of the Physiology of the GH-IGF-1 Axis","volume":"24","author":"Vottero","year":"2013","journal-title":"Endocr. Dev."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Street, M.E., Moghetti, P., and Chiarelli, F. (2022). The Multiple Functions of Insulin Put into Perspective: From Growth to Metabolism, and from Well-Being to Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010200"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1001\/jamapediatrics.2016.0486","article-title":"Thyroid Disorders in Children and Adolescents","volume":"170","author":"Hanley","year":"2016","journal-title":"JAMA Pediatr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000342545","article-title":"Obesity and Growth during Childhood and Puberty","volume":"106","author":"Marcovecchio","year":"2013","journal-title":"World Rev. Nutr. Diet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1007\/s00125-019-4951-9","article-title":"Intrauterine programming of obesity and type 2 diabetes","volume":"62","author":"Hjort","year":"2019","journal-title":"Diabetologia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1055\/a-1830-5519","article-title":"Individuelle somatische Klassifikation von Neugeborenen auf der Grundlage von K\u00f6rperh\u00f6he und K\u00f6rpergewicht der Mutter (Ergebnisse einer Validierungsstudie)","volume":"226","author":"Voigt","year":"2022","journal-title":"Z. Geburtshilfe Neonatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"101260","DOI":"10.1016\/j.beem.2019.01.001","article-title":"IUGR: Genetic influences, metabolic problems, environmental associations\/triggers, current and future management","volume":"33","author":"Darendeliler","year":"2019","journal-title":"Best Prac. Res. Clin. Endocrinol. Metab."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1055\/s-0038-1675779","article-title":"Developmental Origins of Health and Disease: The History of the Barker Hypothesis and Assisted Reproductive Technology","volume":"36","author":"Carpinello","year":"2018","journal-title":"Semin. Reprod. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"462","DOI":"10.23736\/S0026-4946.20.05981-2","article-title":"Nutrition and growth in children","volume":"72","author":"Matonti","year":"2021","journal-title":"Minerva Pediatr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1093\/ajcn\/nqab405","article-title":"A high-protein low\u2013glycemic index diet attenuates gestational weight gain in pregnant women with obesity: The \u201cAn optimized programming of healthy children\u201d (APPROACH) randomized controlled trial","volume":"115","author":"Geiker","year":"2022","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e3792","DOI":"10.1097\/MD.0000000000003792","article-title":"Effects of Low Glycemic Index Diets on Gestational Diabetes Mellitus","volume":"95","author":"Wei","year":"2016","journal-title":"Medicine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.2337\/dc14-1530","article-title":"Dietary Intervention in Patients With Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis of Randomized Clinical Trials on Maternal and Newborn Outcomes","volume":"37","author":"Viana","year":"2014","journal-title":"Diabetes Care"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00394-016-1306-x","article-title":"Effects of low-glycemic-index diets in pregnancy on maternal and newborn outcomes in pregnant women: A meta-analysis of randomized controlled trials","volume":"57","author":"Zhang","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/00016340600572228","article-title":"Association of maternal protein intake before conception and throughout pregnancy with birth weight","volume":"85","author":"Arija","year":"2006","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_30","first-page":"CD000032","article-title":"Antenatal dietary education and supplementation to increase energy and protein intake","volume":"2","author":"Ota","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1017\/S000711451800291X","article-title":"Optimal protein intake during pregnancy for reducing the risk of fetal growth restriction: The Japan Environment and Children\u2019s Study","volume":"120","author":"Morisaki","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1017\/S2040174420000318","article-title":"Repercussions of maternal exposure to high-fat diet on offspring feeding behavior and body composition: A systematic review","volume":"12","author":"Chaves","year":"2021","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/obr.12524","article-title":"Animal models of maternal high fat diet exposure and effects on metabolism in offspring: A meta-regression analysis","volume":"18","author":"Ribaroff","year":"2017","journal-title":"Obes. Rev."},{"key":"ref_34","first-page":"CD003402","article-title":"Omega-3 fatty acid addition during pregnancy","volume":"11","author":"Middleton","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11892-019-1121-x","article-title":"Breastfeeding and Type 2 Diabetes: Systematic Review and Meta-Analysis","volume":"19","author":"Horta","year":"2019","journal-title":"Curr. Diab. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Sun, J., Han, J., Jiang, X., Ying, Y., and Li, S. (2024). Association between breastfeeding duration and BMI, 2009\u20132018: A population-based study. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1463089"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e181161","DOI":"10.1001\/jamapediatrics.2018.1161","article-title":"Association of Exposure to Formula in the Hospital and Subsequent Infant Feeding Practices with Gut Microbiota and Risk of Overweight in the First Year of Life","volume":"172","author":"Forbes","year":"2018","journal-title":"JAMA Pediatr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.nutres.2016.03.003","article-title":"Introduction of complementary feeding before 4months of age increases the risk of childhood overweight or obesity: A meta-analysis of prospective cohort studies","volume":"36","author":"Wang","year":"2016","journal-title":"Nutr. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/ijo.2013.8","article-title":"The types of food introduced during complementary feeding and risk of childhood obesity: A systematic review","volume":"37","author":"Pearce","year":"2013","journal-title":"Int. J. Obes."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1093\/advances\/nmac032","article-title":"Unhealthy Food and Beverage Consumption in Children and Risk of Overweight and Obesity: A Systematic Review and Meta-Analysis","volume":"13","author":"Rousham","year":"2022","journal-title":"Adv. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wang, K., Niu, Y., Lu, Z., Duo, B., Effah, C.Y., and Guan, L. (2023). The effect of breakfast on childhood obesity: A systematic review and meta-analysis. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1222536"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Safaei, M., Sundararajan, E.A., Driss, M., Boulila, W., and Shapi\u2019I, A. (2021). A systematic literature review on obesity: Understanding the causes & consequences of obesity and reviewing various machine learning approaches used to predict obesity. Comput. Biol. Med., 136.","DOI":"10.1016\/j.compbiomed.2021.104754"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000520811","article-title":"Early Nutrition and Later Excess Adiposity during Childhood: A Narrative Review","volume":"95","author":"Mesa","year":"2022","journal-title":"Horm. Res. Paediatr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00002.2020","article-title":"Developmental origins of metabolic diseases","volume":"101","author":"Hoffman","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1534\/genetics.114.173492","article-title":"What Do You Mean, \u201cEpigenetic\u201d?","volume":"199","author":"Deans","year":"2015","journal-title":"Genetics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrm.2017.94","article-title":"Emerging roles of linker histones in regulating chromatin structure and function","volume":"19","author":"Fyodorov","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7150\/ijbs.11218","article-title":"DNA Methylation, Its Mediators and Genome Integrity","volume":"11","author":"Meng","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Sun, Z., Jia, J., Du, T., Zhang, N., Tang, Y., Fang, Y., and Fang, D. (2021). Overview of Histone Modification. Histone Mutations and Cancer, Springer.","DOI":"10.1007\/978-981-15-8104-5_1"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ryznar, R.J., Phibbs, L., and van Winkle, L.J. (2021). Epigenetic Modifications at the Center of the Barker Hypothesis and Their Transgenerational Implications. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182312728"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ajog.2021.12.035","article-title":"The importance of nutrition in pregnancy and lactation: Lifelong consequences","volume":"226","author":"Marshall","year":"2022","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1107\/S2053230X18010853","article-title":"Carbohydrate structure hits the groove","volume":"74","author":"Agirre","year":"2018","journal-title":"Acta Crystallogr. F. Struct. Biol. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1093\/ajcn\/nqab233","article-title":"International tables of glycemic index and glycemic load values 2021: A systematic review","volume":"114","author":"Atkinson","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Brand-Miller, J., and Buyken, A.E. (2020). The Relationship between Glycemic Index and Health. Nutrients, 12.","DOI":"10.3390\/nu12020536"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Vega-L\u00f3pez, S., Venn, B., and Slavin, J. (2018). Relevance of the Glycemic Index and Glycemic Load for Body Weight, Diabetes, and Cardiovascular Disease. Nutrients, 10.","DOI":"10.3390\/nu10101361"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Filardi, T., Panimolle, F., Crescioli, C., Lenzi, A., and Morano, S. (2019). Gestational Diabetes Mellitus: The Impact of Carbohydrate Quality in Diet. Nutrients, 11.","DOI":"10.3390\/nu11071549"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ecl.2019.05.001","article-title":"Gestational Diabetes Mellitus","volume":"48","author":"Szmuilowicz","year":"2019","journal-title":"Endocrinol Metab. Clin. N. Am."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.tem.2018.09.004","article-title":"Gestational Diabetes Mellitus: Mechanisms, Treatment, and Complications","volume":"29","author":"Johns","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e067946","DOI":"10.1136\/bmj-2021-067946","article-title":"Gestational diabetes mellitus and adverse pregnancy outcomes: Systematic review and meta-analysis","volume":"25","author":"Ye","year":"2022","journal-title":"BMJ"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4093\/dmj.2021.0335","article-title":"Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications","volume":"46","author":"Moon","year":"2022","journal-title":"Diabetes Metab. J."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Savitikadi, P., Pullakhandam, R., Kulkarni, B., Kumar, B.N., Reddy, G.B., and Reddy, V.S. (2021). Chronic Effects of Maternal Low-Protein and Low-Quality Protein Diets on Body Composition, Glucose-Homeostasis and Metabolic Factors, Followed by Reversible Changes upon Rehabilitation in Adult Rat Offspring. Nutrients, 13.","DOI":"10.3390\/nu13114129"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"E1431","DOI":"10.1152\/ajpendo.00619.2011","article-title":"Developmental programming of neonatal pancreatic \u03b2-cells by a maternal low-protein diet in rats involves a switch from proliferation to differentiation","volume":"302","author":"Zambrano","year":"2012","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"619","DOI":"10.4161\/epi.5.7.12882","article-title":"Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation","volume":"5","author":"Gong","year":"2010","journal-title":"Epigenetics"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Peral-Sanchez, I., Hojeij, B., Ojeda, D.A., Steegers-Theunissen, R.P.M., and Willaime-Morawek, S. (2021). Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences. Genes, 13.","DOI":"10.3390\/genes13010031"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.3945\/jn.112.160341","article-title":"Maternal Low-Protein Diet Induces Gender-Dependent Changes in Epigenetic Regulation of the Glucose-6-Phosphatase Gene in Newborn Piglet Liver","volume":"142","author":"Jia","year":"2012","journal-title":"J. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1017\/S0007114514002827","article-title":"DNA methylation: The pivotal interaction between early-life nutrition and glucose metabolism in later life","volume":"112","author":"Zheng","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"R485","DOI":"10.1152\/ajpregu.00284.2019","article-title":"Maternal low-protein diet on the last week of pregnancy contributes to insulin resistance and \u03b2-cell dysfunction in the mouse offspring","volume":"319","author":"Alejandro","year":"2020","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Moreno-Fernandez, J., Ochoa, J.J., Lopez-Frias, M., and Diaz-Castro, J. (2020). Impact of Early Nutrition, Physical Activity and Sleep on the Fetal Programming of Disease in the Pregnancy: A Narrative Review. Nutrients, 12.","DOI":"10.3390\/nu12123900"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1210\/en.2014-2020","article-title":"The Effects of High-Fat Diet Exposure In Utero on the Obesogenic and Diabetogenic Traits Through Epigenetic Changes in Adiponectin and Leptin Gene Expression for Multiple Generations in Female Mice","volume":"156","author":"Masuyama","year":"2015","journal-title":"Endocrinology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.physbeh.2012.07.014","article-title":"Maternal high fat diet consumption during the perinatal period programs offspring behavior","volume":"123","author":"Sullivan","year":"2014","journal-title":"Physiol. Behav."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/liv.14811","article-title":"Maternal high-fat diet disrupted one-carbon metabolism in offspring, contributing to nonalcoholic fatty liver disease","volume":"41","author":"Peng","year":"2021","journal-title":"Liver Int."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Tain, Y.L., and Hsu, C.N. (2022). Maternal High-Fat Diet and Offspring Hypertension. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158179"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1017\/S0007114514004243","article-title":"Effects of prenatal and\/or postnatal supplementation with iron, PUFA or folic acid on neurodevelopment: Update","volume":"122","author":"Chmielewska","year":"2019","journal-title":"Br. J. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Dai, C., Fei, Y., Li, J., Shi, Y., and Yang, X. (2021). A Novel Review of Homocysteine and Pregnancy Complications. Biomed. Res. Int., 2021.","DOI":"10.1155\/2021\/6652231"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1080\/10408398.2016.1220915","article-title":"Vitamin D and its impact on maternal-fetal outcomes in pregnancy: A critical review","volume":"58","author":"Agarwal","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Means, R.T. (2020). Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters. Nutrients, 12.","DOI":"10.3390\/nu12020447"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejogrb.2012.06.020","article-title":"Influence of mineral and vitamin supplements on pregnancy outcome","volume":"164","author":"Hovdenak","year":"2012","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Pascoal, G.d.F.L., Geraldi, M.V., Mar\u00f3stica, M.R., and Ong, T.P. (2022). Effect of Paternal Diet on Spermatogenesis and Offspring Health: Focus on Epigenetics and Interventions with Food Bioactive Compounds. Nutrients, 14.","DOI":"10.3390\/nu14102150"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"E236","DOI":"10.1152\/ajpendo.00095.2016","article-title":"The effects of paternal high-fat diet exposure on offspring metabolism with epigenetic changes in the mouse adiponectin and leptin gene promoters","volume":"311","author":"Masuyama","year":"2016","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Soubry, A., Murphy, S.K., Vansant, G., He, Y., Price, T.M., and Hoyo, C. (2021). Opposing Epigenetic Signatures in Human Sperm by Intake of Fast Food Versus Healthy Food. Front. Endocrinol. Lausanne, 12.","DOI":"10.3389\/fendo.2021.625204"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e1916777","DOI":"10.1001\/jamanetworkopen.2019.16777","article-title":"Association of Periconception Paternal Body Mass Index With Persistent Changes in DNA Methylation of Offspring in Childhood","volume":"2","author":"Noor","year":"2019","journal-title":"JAMA Netw Open"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Gounaris, A.K., Sokou, R., Gounari, E.A., Panagiotounakou, P., and Grivea, I.N. (2023). Extrauterine Growth Restriction and Optimal Growth of Very Preterm Neonates: State of the Art. Nutrients, 15.","DOI":"10.3390\/nu15143231"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"198","DOI":"10.5005\/jp-journals-11002-0072","article-title":"Extrauterine Growth Restriction: Need for an Accurate Definition","volume":"2","author":"Maheshwari","year":"2023","journal-title":"Newborn"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s00431-020-03613-8","article-title":"Comorbidities in childhood associated with extrauterine growth restriction in preterm infants: A scoping review","volume":"179","year":"2020","journal-title":"Eur. J. Pediatr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.nwh.2019.08.002","article-title":"Women\u2019s Choice Regarding Breastfeeding and Its Effect on Well-Being","volume":"23","author":"Flowers","year":"2019","journal-title":"Nurs. Womens Health"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Pinheiro, T.V., and Goldani, M.Z. (2018). Maternal pre-pregnancy overweight\/obesity and gestational diabetes interaction on delayed breastfeeding initiation. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194879"},{"key":"ref_86","first-page":"368","article-title":"Breastfeeding: Common Questions and Answers","volume":"98","author":"Westerfield","year":"2018","journal-title":"Am. Fam. Physician"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4081\/pmc.2017.155","article-title":"Human milk: Composition and health benefits","volume":"39","author":"Mosca","year":"2017","journal-title":"Pediatr. Med. Chir."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pcl.2012.10.002","article-title":"Human Milk Composition","volume":"60","author":"Ballard","year":"2013","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Donovan, S.M. (2019). Human Milk Proteins: Composition and Physiological Significance. Human Milk: Composition, Clinical Benefits and Future Opportunities, Proceedings of the 90th Nestl\u00e9 Nutrition Institute Workshop, Lausanne, Switzerland, 30 October\u20131 November 2017, Karger.","DOI":"10.1159\/isbn.978-3-318-06341-7"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/ajhb.22201","article-title":"Cow milk consumption, insulin-like growth factor-I, and human biology: A life history approach","volume":"24","author":"Wiley","year":"2012","journal-title":"Am. J. Hum. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.nut.2016.05.013","article-title":"Higher concentrations of branched-chain amino acids in breast milk of obese mothers","volume":"32","author":"Hankard","year":"2016","journal-title":"Nutrition"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Moubareck, C.A. (2021). Human Milk Microbiota and Oligosaccharides: A Glimpse into Benefits, Diversity, and Correlations. Nutrients, 13.","DOI":"10.3390\/nu13041123"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000452818","article-title":"Human Milk Oligosaccharides Influence Neonatal Mucosal and Systemic Immunity","volume":"69","author":"Donovan","year":"2016","journal-title":"Ann. Nutr. Metab."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Saben, J.L., Sims, C.R., Abraham, A., Bode, L., and Andres, A. (2021). Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth. Nutrients, 13.","DOI":"10.3390\/nu13020446"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Brink, L.R., and L\u00f6nnerdal, B. (2020). Milk fat globule membrane: The role of its various components in infant health and development. J. Nutr. Biochem., 85.","DOI":"10.1016\/j.jnutbio.2020.108465"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Bzikowska-Jura, A., Czerwonogrodzka-Senczyna, A., Ol\u0119dzka, G., Szostak-W\u0119gierek, D., Weker, H., and Weso\u0142owska, A. (2018). Maternal Nutrition and Body Composition During Breastfeeding: Association with Human Milk Composition. Nutrients, 10.","DOI":"10.3390\/nu10101379"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"313S","DOI":"10.1093\/advances\/nmy017","article-title":"Micronutrients in Human Milk: Analytical Methods","volume":"9","author":"Hampel","year":"2018","journal-title":"Adv. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Melnik, B.C., Stremmel, W., Weiskirchen, R., John, S.M., and Schmitz, G. (2021). Exosome-Derived MicroRNAs of Human Milk and Their Effects on Infant Health and Development. Biomolecules, 11.","DOI":"10.3390\/biom11060851"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Cho, Y.E., Vorn, R., Chimenti, M., Crouch, K., Shaoshuai, C., Narayanaswamy, J., Harken, A., Schmidt, R., Gill, J., and Lee, H. (2022). Extracellular vesicle miRNAs in breast milk of obese mothers. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.976886"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Zaragosi, L.E., Wdziekonski, B., Brigand, K., Villageois, P., Mari, B., Waldmann, R., Dani, C., and Barbry, P. (2011). Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis. Genome Biol., 12.","DOI":"10.1186\/gb-2011-12-7-r64"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.earlhumdev.2015.08.013","article-title":"Human breast milk: A review on its composition and bioactivity","volume":"91","author":"Andreas","year":"2015","journal-title":"Early Hum. Dev."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Specht, I.O., Rohde, J.F., Olsen, N.J., and Heitmann, B.L. (2018). Duration of exclusive breastfeeding may be related to eating behaviour and dietary intake in obesity prone normal weight young children. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0200388"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1017\/S2040174417000964","article-title":"Effects of infant formula composition on long-term metabolic health","volume":"9","author":"Lemaire","year":"2018","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-food-041715-033120","article-title":"Infant Formula Fat Analogs and Human Milk Fat: New Focus on Infant Developmental Needs","volume":"7","author":"Zou","year":"2016","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/MCO.0000000000000528","article-title":"Human milk protein vs. formula protein and their use in preterm infants","volume":"22","author":"Gianni","year":"2019","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Ferr\u00e9, N., Luque, V., Closa-Monasterolo, R., Zaragoza-Jordana, M., Gispert-Llaurad\u00f3, M., Grote, V., Koletzko, B., and Escribano, J. (2021). Association of Protein Intake during the Second Year of Life with Weight Gain-Related Outcomes in Childhood: A Systematic Review. Nutrients, 13.","DOI":"10.3390\/nu13020583"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/MPG.0000000000001454","article-title":"Complementary Feeding: A Position Paper by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Committee on Nutrition","volume":"64","author":"Fewtrell","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Caroli, M., Vania, A., Tomaselli, M.A., Scotese, I., Tezza, G., Verga, M.C., Di Mauro, G., Antignani, A., Miniello, A., and Bergamini, M. (2021). Breastfed and Formula-Fed Infants: Need of a Different Complementary Feeding Model?. Nutrients, 13.","DOI":"10.3390\/nu13113756"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1210\/jc.2014-3157","article-title":"Dietary Protein Intake Affects Amino Acid and Acylcarnitine Metabolism in Infants Aged 6 Months","volume":"100","author":"Kirchberg","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e1529","DOI":"10.1542\/peds.2012-3692","article-title":"Introduction of Complementary Foods and the Relationship to Food Allergy","volume":"132","author":"Grimshaw","year":"2013","journal-title":"Pediatrics"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/pr.2015.116","article-title":"Timing of solid food introduction is associated with urinary F2-isoprostane concentrations in childhood","volume":"78","author":"Frederiksen","year":"2015","journal-title":"Pediatr. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1573396318666220801093225","article-title":"Childhood Obesity: An Updated Review","volume":"20","author":"Leung","year":"2024","journal-title":"Curr. Pediatr. Rev."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e00914-20","DOI":"10.1128\/mBio.00914-20","article-title":"Short-Chain Fatty Acid Production by Gut Microbiota from Children with Obesity Differs According to Prebiotic Choice and Bacterial Community Composition","volume":"11","author":"Holmes","year":"2020","journal-title":"mBio"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Rinninella, E., Cintoni, M., Raoul, P., Lopetuso, L.R., Scaldaferri, F., Pulcini, G., Miggiano, G.A.D., Gasbarrini, A., and Mele, M.C. (2019). Food Components and Dietary Habits: Keys for a Healthy Gut Microbiota Composition. Nutrients, 11.","DOI":"10.3390\/nu11102393"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Rampelli, S., Guenther, K., Turroni, S., Wolters, M., Veidebaum, T., Kourides, Y., Moln\u00e0r, D., Lissner, L., Benitez-Paez, A., and Sanz, Y. (2018). Pre-obese children\u2019s dysbiotic gut microbiome and unhealthy diets may predict the development of obesity. Commun. Biol., 1.","DOI":"10.1038\/s42003-018-0221-5"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.numecd.2017.01.002","article-title":"Adherence to the Mediterranean Diet in children and adolescents: A systematic review","volume":"27","author":"Scalfi","year":"2017","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1017\/S1368980019001058","article-title":"An update of the KIDMED questionnaire, a Mediterranean Diet Quality Index in children and adolescents","volume":"22","author":"Altavilla","year":"2019","journal-title":"Public Health Nutr."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Seral-Cortes, M., Sabroso-Lasa, S., de Miguel-Etayo, P., Gonzalez-Gross, M., Gesteiro, E., Molina-Hidalgo, C., De Henauw, S., Erhardt, E., Censi, L., and Manios, Y. (2020). Interaction Effect of the Mediterranean Diet and an Obesity Genetic Risk Score on Adiposity and Metabolic Syndrome in Adolescents: The HELENA Study. Nutrients, 12.","DOI":"10.3390\/nu12123841"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1038\/s41366-020-0557-z","article-title":"High adherence to a mediterranean diet at age 4 reduces overweight, obesity and abdominal obesity incidence in children at the age of 8","volume":"44","author":"Guxens","year":"2020","journal-title":"Int. J. Obes."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/dme.13052","article-title":"Effect of interactions of polymorphisms in the Melanocortin-4 receptor gene with dietary factors on the risk of obesity and Type 2 diabetes: A systematic review","volume":"33","author":"Koochakpoor","year":"2016","journal-title":"Diabet. Med."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Santa-Mar\u00eda, C., L\u00f3pez-Enr\u00edquez, S., Montserrat-de la Paz, S., Geniz, I., Reyes-Quiroz, M.E., Moreno, M., Palomares, F., Sobrino, F., and Alba, G. (2023). Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid. Nutrients, 15.","DOI":"10.3390\/nu15010224"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.numecd.2013.04.005","article-title":"Influence of the Mediterranean diet on carotid intima\u2013media thickness in hypercholesterolaemic children: A 12-month intervention study","volume":"24","author":"Giannini","year":"2014","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/MPG.0000000000001733","article-title":"Sugar in Infants, Children and Adolescents: A Position Paper of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition","volume":"65","author":"Braegger","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1111\/obr.12741","article-title":"A systematic review of strategies to reduce sugar-sweetened beverage consumption among 0-year to 5-year olds","volume":"19","author":"Vercammen","year":"2018","journal-title":"Obes. Rev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1017\/S1368980012000973","article-title":"Breakfast consumption and CVD risk factors in European adolescents: The HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study","volume":"16","author":"Labayen","year":"2013","journal-title":"Public Health Nutr."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Jeans, M.R., Vandyousefi, S., Landry, M.J., Leidy, H.J., Gray, M.J., Bray, M.S., Widen, E.M., and Davis, J.N. (2022). Breakfast Consumption May Improve Fasting Insulin, HOMA-IR, and HbA1c Levels in Predominately Low-Income, Hispanic Children 7\u201312 Years of Age. Nutrients, 14.","DOI":"10.3390\/nu14112320"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41430-021-00928-z","article-title":"Non-alcoholic fatty liver disease in obese children and adolescents: A role for nutrition?","volume":"76","author":"Bonsembiante","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Pixner, T., Stummer, N., Schneider, A.M., Lukas, A., Gramlinger, K., Julian, V., Thivel, D., Morwald, K., Maruszczak, K., and Mangge, H. (2022). The Role of Macronutrients in the Pathogenesis, Prevention and Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) in the Paediatric Population\u2014A Review. Life, 12.","DOI":"10.3390\/life12060839"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Nobili, V., Carpino, G., Alisi, A., de Vito, R., Franchitto, A., Alpini, G., Onori, P., and Gaudio, E. (2014). Role of Docosahexaenoic Acid Treatment in Improving Liver Histology in Pediatric Nonalcoholic Fatty Liver Disease. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088005"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"della Corte, C., Carpino, G., de Vito, R., de Stefanis, C., Alisi, A., Cianfarani, S., Overi, D., Mosca, A., Stronati, L., and Cucchiara, S. (2016). Docosahexanoic Acid Plus Vitamin D Treatment Improves Features of NAFLD in Children with Serum Vitamin D Deficiency: Results from a Single Centre Trial. 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