{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T10:03:57Z","timestamp":1774001037353,"version":"3.50.1"},"reference-count":61,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Development Agency","award":["P2050054"],"award-info":[{"award-number":["P2050054"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Currently, the adjuvant therapy to optimize the restorative process after stroke is required due to the unsatisfied therapeutic efficacy. A combined extract of black sticky rice and dill showed potential in the preclinical state, so we hypothesized that it could provide clinical benefits. A three-arm, randomized, placebo-controlled study was set up to elucidate this issue. Both males and females (18\u201380 years old) who had experienced transient ischemic attacks or ischemic strokes within the last 5\u201310 days with an NIHSS score \u2264 7 and received standard treatment were randomly assigned to receive either a placebo or capsule containing a combined extract of black sticky rice and dill at a dose of 600 or 1200 mg per day. The safety parameters, movement control, and degree of disability were assessed 1, 2, and 6 weeks after the intervention, and serum stroke biomarkers were assessed at the mentioned time points, except at 2 weeks. After week 1, the high-dose (1200 mg\/day) treatment group had improved NIHSSS, VCAM1, and MMP-9. Both S100\u03b2 and VCAM1 also improved at week 6, while the low-dose treatment group (600 mg\/day) only exhibited improved VCAM1. Therefore, a high dose of the developed adjuvant supplement improves stroke recovery by improving motor impairment by reducing endothelial dysfunction and inflammation.<\/jats:p>","DOI":"10.3390\/nu16223946","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T06:06:54Z","timestamp":1731996414000},"page":"3946","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Combined Extract Derived from Black Sticky Rice and Dill Improves Clinical Symptoms and Ischemic Stroke Biomarkers in Transient Ischemic Attack and Ischemic Stroke Patients"],"prefix":"10.3390","volume":"16","author":[{"given":"Kannikar","family":"Kongbunkiat","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"North-Eastern Stroke Research Group, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wipawee","family":"Thukham-mee","sequence":"additional","affiliation":[{"name":"Research Institute for High Human Performance and Health Promotion, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somsak","family":"Tiamkao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narongrit","family":"Kasemsap","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"North-Eastern Stroke Research Group, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0751-8967","authenticated-orcid":false,"given":"Nisa","family":"Vorasoot","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"North-Eastern Stroke Research Group, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7383-2348","authenticated-orcid":false,"given":"Jintanaporn","family":"Wattanathorn","sequence":"additional","affiliation":[{"name":"Research Institute for High Human Performance and Health Promotion, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.2174\/09298673113209990153","article-title":"Interaction of anthocyanins with drug-metabolizing and antioxidant enzymes","volume":"20","year":"2013","journal-title":"Curr. 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