{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:27:33Z","timestamp":1787563653081,"version":"build-2736575974"},"reference-count":53,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>(1) Background: Frailty in older adults is a condition that involves an interaction of psychological, biological, and social factors. This study aimed to assess the frailty status of older adults (65 years old and above) who receive home care services. Additionally, this work aimed to explore the key factors that have a statistically significant impact on the frailty of this vulnerable population. (2) Methods: This study represents the first phase of an intervention trial involving individuals aged 65 and over who received primary healthcare services and resided in the municipality of Archanes-Asterousia in Crete, Greece. Frailty was assessed using the SHARE-Frailty Instrument, while nutritional status was evaluated with the Mini Nutritional Assessment. Diet-related factors were analyzed, including health factors (oral hygiene, depression, cognitive decline, impaired functioning, quality of life), social factors (educational attainment, marital status, type of work before the age of 60), and lifestyle factors (smoking, alcohol consumption, diet). (3) Results: A total of 730 older adults were evaluated (31.5% male), with an average age (\u00b1SD) of 76.83 (\u00b16.68) years. The frailty status analysis revealed 108 (14.8%) to be frail, 249 (34.1%) to be pre-frail, and 373 (51.1%) to be non-frail. Statistically significant associations were found between the MNA and Barthel scores (rs = 0.822, p &lt; 0.001). Higher nutritional evaluations (MNA) were revealed in non-frail adults (mean (\u00b1SD); 26.97 \u00b1 1.96) compared to pre-fail (mean (\u00b1SD); 19.37 \u00b1 3.36) and frail adults (mean (\u00b1SD); 13.08 \u00b1 3.16), as well as in pre-fail compared to frail adults (F = 1338.08, p &lt; 0.001). Functional independence (Barthel) significantly differed with the frailty status of older adults (H = 521.98, p &lt; 0.001; median for non-frail: 20.00, pre-fail: 19.00, frail adults: 15.00). (4) Conclusions: This study demonstrated that good nutritional status, good oral health, functional independence, and good quality of life are strongly correlated with lower frailty. Additionally, having chronic conditions is positively associated with one\u2019s frailty status. Educational programs for both healthcare personnel and older adults are recommended.<\/jats:p>","DOI":"10.3390\/nu16233982","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T06:11:54Z","timestamp":1732169514000},"page":"3982","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An Investigation of the Risk Factors Related to Frailty in Older Adults Receiving Home Care Services"],"prefix":"10.3390","volume":"16","author":[{"given":"Eirini","family":"Stratidaki","sequence":"first","affiliation":[{"name":"Department of Nursing, School of Health Sciences, Hellenic Mediterranean University, 71004 Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4072-296X","authenticated-orcid":false,"given":"Enkeleint A.","family":"Mechili","sequence":"additional","affiliation":[{"name":"Department of Healthcare, Faculty of Health, University of Vlora, 9401 Vlora, Albania"},{"name":"School of Medicine, University of Crete, 71500 Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Ouzouni","sequence":"additional","affiliation":[{"name":"Occupational Therapy Department, University of West Attica, 12243 Egaleo, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0300-0650","authenticated-orcid":false,"given":"Athina E.","family":"Patelarou","sequence":"additional","affiliation":[{"name":"Department of Nursing, School of Health Sciences, Hellenic Mediterranean University, 71004 Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8533-6323","authenticated-orcid":false,"given":"Ioannis","family":"Savvakis","sequence":"additional","affiliation":[{"name":"Department of Nursing, School of Health Sciences, Hellenic Mediterranean University, 71004 Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-7746","authenticated-orcid":false,"given":"Konstantinos","family":"Giakoumidakis","sequence":"additional","affiliation":[{"name":"Department of Nursing, School of Health Sciences, Hellenic Mediterranean University, 71004 Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-2053","authenticated-orcid":false,"given":"Aggelos","family":"Laliotis","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Venizeleio General Hospital, 71409 Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0892-3200","authenticated-orcid":false,"given":"Evridiki","family":"Patelarou","sequence":"additional","affiliation":[{"name":"Department of Nursing, School of Health Sciences, Hellenic Mediterranean University, 71004 Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.maturitas.2020.05.018","article-title":"The World Health Organization (WHO): Approach to healthy ageing","volume":"139","author":"Rudnicka","year":"2020","journal-title":"Maturitas"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: Evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jamda.2013.12.002","article-title":"Transitions in frailty states among community-living older adults and their associated factors","volume":"15","author":"Lee","year":"2014","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10654-014-9924-1","article-title":"Adverse outcomes of frailty in the elderly: The Rotterdam Study","volume":"29","author":"Lahousse","year":"2014","journal-title":"Eur. J. Epidemiol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Hsieh, T., Chang, H., Wu, I., Chen, C., Tsai, H., Chiu, F., Chuang, S.C., Hsiung, C.A., and Hsu, C.C. (2018). Independent association between subjective cognitive decline and frailty in the elderly. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0201351"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ahmad, N.S., Hairi, N.N., Said, M.A., Kamaruzzaman, S.B., Choo, W.Y., Hairi, F., Othman, S., Ismail, N., Peramalah, D., and Kandiben, S. (2018). Prevalence, transitions, and factors predicting transition between frailty states among rural community-dwelling older adults in Malaysia. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0206445"},{"key":"ref_7","first-page":"675","article-title":"Prevalence of frailty in middle-aged and older community-dwelling Europeans living in 10 countries","volume":"64","author":"Spagnoli","year":"2009","journal-title":"J. Gerontol. Biol. Sci. Med. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e018195","DOI":"10.1136\/bmjopen-2017-018195","article-title":"Prevalence of frailty and prefrailty among community-dwelling older adults in low-income and middle-income countries: A systematic review and meta-analysis","volume":"8","author":"Siriwardhana","year":"2018","journal-title":"BMJ Open"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s12603-014-0568-3","article-title":"Frailty and nutrition: Searching for evidence","volume":"19","author":"Bonnefoy","year":"2015","journal-title":"J. Nutr. Health Aging"},{"key":"ref_10","unstructured":"(2024, July 29). Food Intake. ScienceDirect. Available online: https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/food-intake."},{"key":"ref_11","unstructured":"(2024, July 29). Risk Factors. ScienceDirect. Available online: https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/risk-factor."},{"key":"ref_12","unstructured":"(2024, August 02). Skeletal Muscle. ScienceDirect. Available online: https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/skeletal-muscle."},{"key":"ref_13","first-page":"220","article-title":"Prognostic value of gasometric parameters of carbon dioxide in resuscitation of septic patients: A bibliography review","volume":"63","year":"2016","journal-title":"Rev. Esp. Anestesiol. Reanim."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/gerona\/61.6.589","article-title":"Low nutrient intake is an essential component of frailty in older persons","volume":"61","author":"Bartali","year":"2006","journal-title":"J. Gerontol. Biol. Sci. Med. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/gerona\/61.6.600","article-title":"Vitamin and carotenoid status in older women: Associations with the frailty syndrome","volume":"61","author":"Michelon","year":"2006","journal-title":"J. Gerontol. Biol. Sci. Med. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Niesten, D., van Mourik, K., and van der Sanden, W. (2012). The impact of having natural teeth on the quality of life of frail dentulous older people: A qualitative study. BMC Public Health, 12.","DOI":"10.1186\/1471-2458-12-839"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1469-0691.2007.01802.x","article-title":"Oral infections and systemic disease\u2014An emerging problem in medicine","volume":"13","author":"Rautemaa","year":"2007","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3399\/bjgp18X700241","article-title":"Delaying and reversing frailty: A systematic review of primary care interventions","volume":"69","author":"Travers","year":"2019","journal-title":"Br. J. Gen. Pract."},{"key":"ref_19","first-page":"383","article-title":"Interventions to prevent or reduce the level of frailty in community-dwelling older adults: A scoping review of the literature and international policies","volume":"46","author":"Puts","year":"2017","journal-title":"Age Ageing"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnesp.2019.11.003","article-title":"The role of nutrition and physical activity in frailty: A review","volume":"35","author":"Coppinger","year":"2020","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/gerona\/63.10.1089","article-title":"Frailty among community-dwelling elderly people in France: The Three-City Study","volume":"63","author":"Helmer","year":"2008","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s12603-020-1310-y","article-title":"Factors associated with frailty syndrome in older adults","volume":"24","year":"2020","journal-title":"J. Nutr. Health Aging"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1111\/j.1532-5415.2008.02041.x","article-title":"Preliminary evidence for subdimensions of geriatric frailty: The MacArthur Study of Successful Aging","volume":"56","author":"Sarkisian","year":"2008","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Stratidaki, E., Mechili, E.A., Ouzouni, C., Patelarou, A.E., Giakoumidakis, K., Laliotis, A., and Patelarou, E. (2024). A Study of Factors Contributing to the Nutritional Status of Elderly People Receiving Home Care. Nutrients, 17.","DOI":"10.3390\/nu16183135"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1007\/s12603-009-0214-7","article-title":"MNA-International Group. Validation of the Mini Nutritional Assessment short-form (MNA-SF): A practical tool for identification of nutritional status","volume":"13","author":"Kaiser","year":"2009","journal-title":"J. Nutr. Health Aging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1834-7819.2005.tb00360.x","article-title":"The oral health assessment tool\u2014validity and reliability","volume":"50","author":"Chalmers","year":"2005","journal-title":"Aust. Dent. J."},{"key":"ref_27","first-page":"56","article-title":"Functional Evaluation: The Barthel Index","volume":"14","author":"Mahoney","year":"1965","journal-title":"Md. State Med. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1177\/153331750001500604","article-title":"Mini Mental State Examination (MMSE): A validation study in Greece","volume":"15","author":"Fountoulakis","year":"2000","journal-title":"Am. J. Alzheimer\u2019s Dis. Other Dement."},{"key":"ref_29","first-page":"367","article-title":"The validation of the short form of the Geriatric Depression Scale (GDS) in Greece","volume":"11","author":"Fountoulakis","year":"1999","journal-title":"Aging"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis."},{"key":"ref_31","first-page":"1180","article-title":"The Epidemiology of the Homebound in the United States","volume":"175","author":"Ornstein","year":"2015","journal-title":"J. Am. Med. Assoc. Intern. Med."},{"key":"ref_32","first-page":"130","article-title":"Psychometric properties of WHOQOL-BREF in clinical and health Greek populations: Incorporating new culture-relevant items","volume":"23","author":"Ginieri","year":"2012","journal-title":"Psychiatriki"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1447-0594.2012.00948.x","article-title":"The SHARE Frailty Instrument for primary care predicts mortality similarly to a frailty index based on comprehensive geriatric assessment","volume":"13","year":"2013","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_34","first-page":"18","article-title":"Prevalence of physical frailty: Results from the DO-HEALTH study","volume":"11","author":"Gagesch","year":"2022","journal-title":"J. Frailty Aging"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/ageing\/afw165","article-title":"Physical inactivity among older adults across Europe based on the SHARE database","volume":"46","author":"Gomes","year":"2017","journal-title":"Age Ageing"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Psarrou, A., Adamakidou, T., Apostolara, P., Koreli, A., Drakopoulou, M., Plakas, S., Mastrogiannis, D., Mantoudi, A., Parissopoulos, S., and Zartaloudi, A. (2023). Associations between physical activity and health-related quality of life among community-dwelling older adults: A cross-sectional study in urban Greece. Geriatrics, 8.","DOI":"10.3390\/geriatrics8030061"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/ggi.13689","article-title":"Prevalence of frailty status among the European elderly population: Findings from the Survey of Health, Aging and Retirement in Europe","volume":"19","author":"Manfredi","year":"2019","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Klesiora, M., Tsaras, K., Papathanasiou, I.V., Malliarou, M., Bakalis, N., Kourkouta, L., Melas, C., and Kleisiaris, C. (2024). Frailty assessment and its impact on loneliness among older adults receiving home-based healthcare during the COVID-19 pandemic. Healthcare, 12.","DOI":"10.3390\/healthcare12161666"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Pierrakos, G., Goula, A., and Latsou, D. (2023). Predictors of unmet healthcare needs during economic and health crisis in Greece. Int. J. Environ. Res. Public Health, 20.","DOI":"10.20944\/preprints202308.1610.v1"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/psyg.13160","article-title":"Assessment of the relation between depression, frailty, nutrition and quality of life among older adults: Findings from a cross-sectional study in Greece","volume":"24","author":"Argyriou","year":"2024","journal-title":"Psychogeriatrics"},{"key":"ref_41","first-page":"e13049","article-title":"Frailty and quality of life among community-dwelling older adults","volume":"13","author":"Papathanasiou","year":"2021","journal-title":"Cureus"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2147\/CIA.S90077","article-title":"The relationship between frailty, anxiety and depression, and health-related quality of life in elderly patients with heart failure","volume":"10","author":"Uchmanowicz","year":"2015","journal-title":"Clin. Interv. Aging"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Murillo-Llorente, M.T., Lafuente-Sarabia, B., Samper de la Paz, J., Flores-P\u00faa, M., Tejeda-Adell, M., Legidos-Garc\u00eda, M.E., and Perez-Bermejo, M. (2023). Assessing nutritional status and frailty among poor elderly individuals in Requena del Tapiche, Peru. Nutrients, 15.","DOI":"10.3390\/nu15173840"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Liang, H., Li, X., Lin, X., Ju, Y., and Leng, J. (2021). The correlation between nutrition and frailty and the receiver operating characteristic curve of different nutritional indexes for frailty. BMC Geriatr., 21.","DOI":"10.1186\/s12877-021-02580-5"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Lorenzo-L\u00f3pez, L., Maseda, A., de Labra, C., Regueiro-Folgueira, L., Rodr\u00edguez-Villamil, J.L., and Mill\u00e1n-Calenti, J.C. (2017). Nutritional determinants of frailty in older adults: A systematic review. BMC Geriatr., 17.","DOI":"10.1186\/s12877-017-0496-2"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"105628","DOI":"10.1016\/j.archger.2024.105628","article-title":"Effectiveness of non-pharmacological therapies for preventing frailty in older people: An umbrella review","volume":"128","author":"Ueshima","year":"2024","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/ger.12406","article-title":"Association between oral health and frailty: A systematic review of longitudinal studies","volume":"36","author":"Hakeem","year":"2019","journal-title":"Gerodontology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"eAO0103","DOI":"10.31744\/einstein_journal\/2023AO0103","article-title":"Impact of oral health on frailty syndrome in frail older adults","volume":"21","author":"Vendola","year":"2023","journal-title":"Einstein"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e507","DOI":"10.1016\/S2666-7568(21)00143-4","article-title":"Oral frailty and its determinants in older age: A systematic review","volume":"2","author":"Dibello","year":"2021","journal-title":"Lancet Healthy Longev."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Boyer, S., Trimouillas, J., Cardinaud, N., Gayot, C., Laubarie-Mouret, C., Dumoitier, N., Rudelle, K., Druet-Cabanac, M., Laroche, M.L., and Tchalla, A. (2022). Frailty and functional dependence in older population: Lessons from the FREEDOM Limousin\u2014Nouvelle Aquitaine Cohort Study. BMC Geriatr., 22.","DOI":"10.1186\/s12877-022-02834-w"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Tornero-Qui\u00f1ones, I., S\u00e1ez-Padilla, J., Espina D\u00edaz, A., Abad Robles, M.T., and Sierra Robles, \u00c1. (2020). Functional Ability, Frailty and Risk of Falls in the Elderly: Relations with Autonomy in Daily Living. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17031006"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jocn.2024.07.002","article-title":"Construction and application of a home exercise rehabilitation management program for elderly stroke patients based on the Functional Independence Measure score","volume":"126","author":"Wu","year":"2024","journal-title":"J. Clin. Neurosci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s10741-011-9258-y","article-title":"Frailty and multiple comorbidities in the elderly patient with heart failure: Implications for management","volume":"17","author":"Murad","year":"2012","journal-title":"Heart Fail. Rev."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/23\/3982\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:36:37Z","timestamp":1760114197000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/23\/3982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,21]]},"references-count":53,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["nu16233982"],"URL":"https:\/\/doi.org\/10.3390\/nu16233982","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,21]]}}}