{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:06:47Z","timestamp":1778897207999,"version":"3.51.4"},"reference-count":31,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Baxter Healthcare (46394 Ribarroja del Turia. Valencia. Spain)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background and Objective: To evaluate the effectiveness and safety of intradialytic parenteral nutrition (IDPN) on different nutritional outcomes. Methods: This was a retrospective analysis for a \u201croutinely collected data bank\u201d in a multicenter cohort, conducted on consecutive malnourished or at-risk of malnutrition patients with chronic kidney disease on hemodialysis who underwent IDPN with a three-in-one parenteral nutrition formula for a period \u2265 2 weeks. The primary endpoint was the mean change in the malnutrition inflammation score (MIS) score between baseline and the last follow-up visit on IDPN. Results: Fifty-six patients were included. The mean age was 72.4 \u00b1 12.0 years, and 24 (42.9%) were women. In the overall study sample, MIS significantly decreased from 16.4 (95%CI: 15.3\u201317.65) at baseline to 14.3 (95%CI: 12.8\u201315.8) at the last follow-up visit on IDPN (p = 0.0019). Fifteen (26.8%) patients achieved a MIS reduction \u2265 5 points after IDPN. As compared to baseline, IDPN significantly reduced the proportion of patients with protein-energy wasting (PEW) (89.3% versus 66.1%, respectively, p = 0.0023). Regarding analytical parameters, serum albumin (p = 0.0003) and total proteins (p = 0.0024) significantly increased after IDPN administration. Throughout the study\u2019s follow-up period, 45 (80.4%) patients reported experiencing some type of adverse event. Conclusions: IDPN was associated with a significant improvement in the nutritional profile. Notably, our research found that the administration of IDPN over a duration &gt; 3 months significantly improved the nutritional status of patients evaluated by the MIS test.<\/jats:p>","DOI":"10.3390\/nu16234018","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T08:38:24Z","timestamp":1732523904000},"page":"4018","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Intradialytic Parenteral Nutrition in Patients on Hemodialysis: A Multicenter Retrospective Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8023-2589","authenticated-orcid":false,"given":"Marta","family":"Arias-Guill\u00e9n","sequence":"first","affiliation":[{"name":"Renal Transplantation and Nephrology Department, Hospital Clinic Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital de Mollet, 08100 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-2976","authenticated-orcid":false,"given":"Loreley","family":"Betancourt","sequence":"additional","affiliation":[{"name":"Nephrology Department, Corporaci\u00f3 Sanitaria Parc Taul\u00ed, 08208 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Coll","sequence":"additional","affiliation":[{"name":"Nephrology Department, Fundaci\u00f3 Puigvert, 08025 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1812-1367","authenticated-orcid":false,"given":"Silvia","family":"Collado","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital del Mar-Parc de Salut Mar, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0746-142X","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Romano-Andrioni","sequence":"additional","affiliation":[{"name":"Nutrition and Dietetic Unit, Hospital Clinic Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-7089","authenticated-orcid":false,"given":"Ascensi\u00f3n","family":"Lupia\u00f1ez-Barbero","sequence":"additional","affiliation":[{"name":"Diaverum Renal Services, Nutrition, Catalonia, 08024 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Garro","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitari Joan XXIII, 43005 Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Duarte","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital de Terrassa, 08227 Terrassa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Soler-Majoral","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Germans Trias I Pujol, 08916 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6806-9539","authenticated-orcid":false,"given":"Jordi","family":"Calabia","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitari Dr. J Trueta, 17007 Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.clnu.2016.06.007","article-title":"Protein-energy wasting and nutritional supplementation in patients with end-stage renal disease on hemodialysis","volume":"36","author":"Sabatino","year":"2017","journal-title":"Clin. 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