{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:01:26Z","timestamp":1792166486144,"version":"4.4.0"},"reference-count":73,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010739","name":"University of Camerino","doi-asserted-by":"publisher","award":["BVI000082-FAR"],"award-info":[{"award-number":["BVI000082-FAR"]}],"id":[{"id":"10.13039\/501100010739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010739","name":"University of Camerino","doi-asserted-by":"publisher","award":["IT02- KA107-077890"],"award-info":[{"award-number":["IT02- KA107-077890"]}],"id":[{"id":"10.13039\/501100010739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010790","name":"Erasmus plus Project","doi-asserted-by":"publisher","award":["BVI000082-FAR"],"award-info":[{"award-number":["BVI000082-FAR"]}],"id":[{"id":"10.13039\/501100010790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010790","name":"Erasmus plus Project","doi-asserted-by":"publisher","award":["IT02- KA107-077890"],"award-info":[{"award-number":["IT02- KA107-077890"]}],"id":[{"id":"10.13039\/501100010790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Despite efforts within the framework of the Sustainable Development Goal to end malnutrition by 2030, malnutrition and soil-transmitted helminth infections persist in sub-Saharan Africa. A significant barrier to success is the inadequate understanding of effective intervention methods. Most research on the gut microbiota\u2019s role in health has been conducted in developed countries, leaving a critical gap in knowledge regarding low-income populations. This study addresses this gap by expanding research on the gut microbiota of underprivileged populations to help tackle these public health challenges. Methods: We employed 16S rDNA sequencing to assess the bacterial gut microbiota composition of 60 children (mean age: 26.63 \u00b1 6.36 months) and their 58 mothers (mean age: 30.03 \u00b1 6.31 years) in Pemba, with a focus on helminth infection and nutritional status. Results: Our differential abundance analysis identified bacterial taxa that were significantly negatively associated with both helminth infections and malnutrition, highlighting the potential for microbiota-directed interventions to address these health issues simultaneously. Notably, we identified Akkermansia, Blautia, Dorea, and Odoribacter as promising probiotic candidates for such interventions. In stunted children, positive co-occurrences were observed between Lactobacillus, Prevotella, and Bacteroides, while Escherichia\/Shigella displayed negative co-abundance relationships with short-chain fatty acid (SCFA) producers in the gut microbiota. These findings suggest that administering Lactobacillus and SCFA-producing probiotics to children may foster the growth of beneficial bacteria like Prevotella and Bacteroides while reducing the relative abundance of Escherichia\/Shigella, potentially enhancing overall health. Conclusions: This study underscores the importance of microbiota-directed interventions in children and women of reproductive age as promising strategies, alongside established approaches, for combating helminth infections and malnutrition in vulnerable populations.<\/jats:p>","DOI":"10.3390\/nu16234023","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T08:38:24Z","timestamp":1732523904000},"page":"4023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Interplay Between Helminth Infections, Malnutrition, and Gut Microbiota in Children and Mothers from Pemba, Tanzania: Potential of Microbiota-Directed Interventions"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5056-5981","authenticated-orcid":false,"given":"Aristide","family":"Toussaint Ngu\u00e9l\u00e9","sequence":"first","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy"},{"name":"Institut Sup\u00e9rieur des Sciences de la Sant\u00e9, Universit\u00e9 Adventiste Cosendai, Nanga Eboko 04, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9835-8446","authenticated-orcid":false,"given":"Matteo","family":"Mozzicafreddo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Marche Polytechnic University, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Carrara","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2231-8936","authenticated-orcid":false,"given":"Angela","family":"Piersanti","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy"},{"name":"Department of Biology, University of Padova, 35121 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4330-1682","authenticated-orcid":false,"given":"Salum Seif","family":"Salum","sequence":"additional","affiliation":[{"name":"School of Health and Medical Sciences, State University of Zanzibar, Zanzibar City 146, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said M.","family":"Ali","sequence":"additional","affiliation":[{"name":"Public Health Laboratory Ivo de Carneri, Chake Chake 122, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-8471","authenticated-orcid":false,"given":"Cristina","family":"Miceli","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S2213-8587(22)00220-0","article-title":"Food security and nutrition in the world","volume":"10","author":"Burki","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_2","unstructured":"WHO (2018). 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