{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T18:57:10Z","timestamp":1793473030270,"version":"4.5.0"},"reference-count":40,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Technological Development Program","award":["S3323696"],"award-info":[{"award-number":["S3323696"]}]},{"name":"Ministry of SMEs and Startups (MSS, Korea)","award":["S3323696"],"award-info":[{"award-number":["S3323696"]}],"id":[{"id":"https:\/\/ror.org\/022c4zk48","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Sarcopenia, a condition marked by muscle wasting due to aging or inactivity, severely affects older populations. We previously showed that pasteurized Akkermansia muciniphila HB05 (HB05P), sourced from the breast milk of healthy Korean women, could mitigate muscle wasting in a dexamethasone-induced rat model. Here, we explored whether the oral administration of HB05P can enhance muscle strength and functionality in elderly individuals. Our objective was to determine if HB05P supplementation could benefit muscle performance in aging adults. Methods: We conducted a 12-week, double-blind, placebo-controlled clinical trial involving 100 individuals aged 60 and above, randomly assigned to receive either HB05P (1.0 \u00d7 1010 cells\/day) or a placebo. Results: The HB05P group showed significant improvements in peak torque and peak torque per body weight of the left leg extensor muscles compared to the placebo group (p = 0.0103 and p = 0.0052). Furthermore, HB05P notably elevated follistatin levels, which counteract myostatin, relative to the placebo group (p = 0.0063). No notable safety concerns arose between the groups. Conclusions: HB05P is a promising postbiotic derived from Akkermansia muciniphila that may enhance muscle strength and be used as a safe postbiotic ingredient of Akkermansia muciniphila to improve muscle health.<\/jats:p>","DOI":"10.3390\/nu16234037","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T04:02:18Z","timestamp":1732593738000},"page":"4037","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Pasteurized Akkermansia muciniphila HB05 (HB05P) Improves Muscle Strength and Function: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Clinical Trial"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-8550","authenticated-orcid":false,"given":"Chang-Ho","family":"Kang","sequence":"first","affiliation":[{"name":"HealthBiome, Co., Ltd., 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9166-9265","authenticated-orcid":false,"given":"Eun-Soo","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea"},{"name":"Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1103-7477","authenticated-orcid":false,"given":"Su-Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea"},{"name":"Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon-Hee","family":"Han","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea"},{"name":"Department of Nuclear Medicine, Jeonbuk National University Medical School, Jeonju 54907, Republic of Korea"},{"name":"Department of Nuclear Medicine, Jeonbuk National University Hospital, Jeonju 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Wan","family":"Chae","sequence":"additional","affiliation":[{"name":"Clinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea"},{"name":"Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Yeun","family":"Jeong","sequence":"additional","affiliation":[{"name":"HealthBiome, Co., Ltd., 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung-Chan","family":"Kim","sequence":"additional","affiliation":[{"name":"HealthBiome, Co., Ltd., 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Ok","family":"Lee","sequence":"additional","affiliation":[{"name":"Clinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea"},{"name":"Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea"},{"name":"Department of Gastroenterology and Hepatology, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3487-6863","authenticated-orcid":false,"given":"Sun-Jung","family":"Yoon","sequence":"additional","affiliation":[{"name":"Clinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea"},{"name":"Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea"},{"name":"Department of Orthopedic Surgery, Jeonbuk National University Medical School, 567 Baekje-daero, Jeonju 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1249\/00005768-199404000-00006","article-title":"Skeletal muscle weakness in old age: Underlying mechanisms","volume":"26","author":"Brooks","year":"1994","journal-title":"Med. 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