{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:44:43Z","timestamp":1788921883586,"version":"build-2803163510"},"reference-count":31,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo State University (UNESP)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background and Aims: Post-exercise recovery strategies include massage, low-intensity active exercise, thermal contrast, hydration, and nutritional and herbal approaches. These strategies aim to accelerate recovery, enhance performance, and optimise the physical training process. L-arginine (L-ARG) is the physiological precursor of nitric oxide (NO), a crucial mediator of vasodilation and the inhibition of platelet aggregation. A previous study reported that L-ARG supplementation could significantly reduce the systolic blood pressure (SBP) and diastolic blood pressure (DBP). This study aimed to investigate the effects of L-ARG on autonomic and cardiovascular recovery immediately following submaximal exercise. Methods and Results: Thirty-two healthy individuals were subjected to two experimental protocols. The first protocol included 60 min of rest, a treadmill warm-up, and load increments until reaching 80% of their maximum HR. Before this protocol, the subjects consumed 3 g of starch (placebo protocol). The second protocol was identical, but the subjects consumed 3 g of L-ARG. Heart rate recovery (HRR), heart rate variability (HRV), and blood pressure (BP) responses were assessed. No significant differences in HRR were found (p = 0.944) regarding the root mean square of successive differences in the RR interval (RMSSD30) of HRV (p = 0.562) or in the BP responses (mean arterial pressure (MAP), p = 0.687; pulse pressure (PP), p = 0.929) between the protocols. Conclusions: L-ARG supplementation did not significantly alter immediate post-exercise autonomic recovery in healthy males.<\/jats:p>","DOI":"10.3390\/nu16234067","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T08:17:42Z","timestamp":1732695462000},"page":"4067","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["L-Arginine Supplementation Did Not Impact the Rapid Recovery of Cardiovascular and Autonomic Function Following Exercise in Physically Active Healthy Males: A Triple-Blind Randomised Placebo-Controlled Crossover Trial"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1097-5285","authenticated-orcid":false,"given":"Andrey Alves","family":"Porto","sequence":"first","affiliation":[{"name":"Postgraduate Program in Movement Sciences, Sao Paulo State University (UNESP), Presidente Prudente 19060-900, SP, Brazil"},{"name":"Systematic Reviews Center for Cardiovascular and Metabolic Health, Sao Paulo State University (UNESP), Marilia 17525-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Almeida","family":"Gonzaga","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Movement Sciences, Sao Paulo State University (UNESP), Presidente Prudente 19060-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Movement Sciences, Sao Paulo State University (UNESP), Presidente Prudente 19060-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Marcondes","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Systematic Reviews Center for Cardiovascular and Metabolic Health, Sao Paulo State University (UNESP), Marilia 17525-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1891-3153","authenticated-orcid":false,"given":"Luiz Carlos","family":"Marques Vanderlei","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Movement Sciences, Sao Paulo State University (UNESP), Presidente Prudente 19060-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7477-3805","authenticated-orcid":false,"given":"Vitor Engr\u00e1cia","family":"Valenti","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Movement Sciences, Sao Paulo State University (UNESP), Presidente Prudente 19060-900, SP, Brazil"},{"name":"Systematic Reviews Center for Cardiovascular and Metabolic Health, Sao Paulo State University (UNESP), Marilia 17525-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1590\/S1517-86922009000200012","article-title":"Post-exercise recovery methods: A systematic review","volume":"15","author":"Pastre","year":"2009","journal-title":"Rev. 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