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5854"]}]},{"name":"philanthropic donations to Liggins Institute","award":["STF-13-19"],"award-info":[{"award-number":["STF-13-19"]}]},{"name":"Starship Foundation","award":["14\/174"],"award-info":[{"award-number":["14\/174"]}]},{"name":"Starship Foundation","award":["3550"],"award-info":[{"award-number":["3550"]}]},{"name":"Starship Foundation","award":["3580"],"award-info":[{"award-number":["3580"]}]},{"name":"Starship Foundation","award":["3705291"],"award-info":[{"award-number":["3705291"]}]},{"name":"Starship Foundation","award":["A + 5854"],"award-info":[{"award-number":["A + 5854"]}]},{"name":"Starship Foundation","award":["STF-13-19"],"award-info":[{"award-number":["STF-13-19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Early postnatal growth following extremely preterm birth may have long-term effects on growth, eating behaviours and health. Background\/Objectives: To determine whether growth to age two years is conditional on growth in the NICU, a conditional growth analysis was performed in a cohort of 330 extremely low-birthweight (ELBW; birthweight &lt; 1000 g) participants in the ProVIDe trial who were followed-up at 2 years corrected age (CA); Methods: We used z-score change for weight, length and head circumference from 36 weeks post-menstrual age to 2 years CA as the end-point-adjusted for birth z-score and z-score change from birth to 36 weeks. Growth and body composition were assessed using bioimpedance analysis. Relationships between eating behaviours and body mass index (BMI) at 2 years CA and growth were assessed using a Child Eating Behaviour Questionnaire (CEBQ) completed by parents at 2 years CA; Results: Growth, or change in z-score, from 36 weeks PMA was conditional upon growth in the NICU, with slower neonatal growth associated with faster early childhood growth (weight: R2 = 0.27, \u00df-coefficient \u22120.81 (95% CI: \u22120.96, \u22120.66), p &lt; 0.0001; length: R2 = 0.28, \u00df-coefficient \u22120.64 (95% CI: \u22120.76, \u22120.51), p &lt; 0.0001; head circumference: R2 = 0.18, \u00df-coefficient \u22120.61 (95% CI: \u22120.76, \u22120.46), p &lt; 0.0001). Fat-free mass index, adjusted for confounding factors, was positively correlated with z-score change from NICU discharge to 2 years CA for weight, but not length (weight: R2 = 0.50, \u00df-coefficient = 0.87 (95% CI: 0.56, 1.18), p &lt; 0.0001; length: R2 = 0.32, \u00df-coefficient = 0.01 (95% CI: \u22120.40, 0.42), p = 0.95). At 2 years CA, CEBQ scores for enjoyment were significantly higher and satiety and slowness significantly lower in children with a BMI \u2265 90th percentile than in children with a BMI \u2264 10th percentile or between the 10th\u221290th percentile.; Conclusions: Growth from NICU discharge to 2 years CA is conditional upon growth in the NICU, with slower NICU growth linked to faster early childhood growth, and weight z-score changes positively correlated with fat-free mass index. At age 2, children with a BMI \u2265 90th percentile have significantly different eating behaviour assessments by caregivers compared to children with a BMI \u2264 10th percentile or between the 10th\u201390th percentile; further RCTs are needed to confirm links between nutrition factors and growth outcomes in ELBW infants.<\/jats:p>","DOI":"10.3390\/nu16234095","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T03:21:23Z","timestamp":1732764083000},"page":"4095","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Growth and Eating Behaviours at 2 Years Corrected Age in Extremely Low-Birthweight Babies; Secondary Cohort Analysis from the ProVIDe Trial"],"prefix":"10.3390","volume":"16","author":[{"given":"Morgan J.","family":"Easton","sequence":"first","affiliation":[{"name":"Liggins Institute, University of Auckland, Auckland 1023, New Zealand"},{"name":"Starship Child Health, Auckland City Hospital, Auckland 1023, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-6577","authenticated-orcid":false,"given":"Frank H.","family":"Bloomfield","sequence":"additional","affiliation":[{"name":"Liggins Institute, University of Auckland, Auckland 1023, New Zealand"},{"name":"Starship Child Health, Auckland City Hospital, Auckland 1023, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Liggins Institute, University of Auckland, Auckland 1023, New Zealand"},{"name":"Department of Statistics, University of Auckland, Auckland 1010, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-8287","authenticated-orcid":false,"given":"Barbara E.","family":"Cormack","sequence":"additional","affiliation":[{"name":"Liggins Institute, University of Auckland, Auckland 1023, New Zealand"},{"name":"Starship Child Health, Auckland City Hospital, Auckland 1023, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Casirati, A., Somaschini, A., Perrone, M., Vandoni, G., Sebastiani, F., Montagna, E., Somaschini, M., and Caccialanza, R. 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