{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:16:14Z","timestamp":1791288974645,"version":"4.3.0"},"reference-count":33,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nutricia Metabolics, Danone Deutschland GmbH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Maternal phenylketonuria (PKU) syndrome, leading to severe psychomotor retardation, microcephaly, cardiac defects and undergrowth, affects the unborn children of mothers with PKU with insufficient metabolic control during pregnancy. To improve long-term outcomes, a specific prevention program was developed. Methods: We designed a group training program for young women with PKU (&gt;14 years) and their partners. Knowledge regarding PKU therapy and pregnancy was evaluated by a specifically developed multiple-choice questionnaire. In addition, scores of anxiety and depression were evaluated. Results: Patients (n = 20) and their partners (n = 13) significantly improved their knowledge after participation (correct answers: patients\u201486% vs. 90%, p = 0.003; partners\u201478% vs. 89%, p = 0.012). Females significantly improved their knowledge about diet (90% vs. 100%, p = 0.035) and metabolism (91% vs. 100%, p = 0.016), but not concerning gynecological topics. Patients\u2019 median depression scores were within the normative range, with a slight decrease over time (6 points vs. 4 points, p = 0.836). Patients\u2019 anxiety score remained stable over time (5.5 vs. 5, p = 0.247). Of trained mothers with PKU, four pregnancies with ideal metabolic control and healthy offspring could be observed. Conclusion: We suggest the inclusion of specific training programs in the standard care of female young adults with PKU, including for their partners.<\/jats:p>","DOI":"10.3390\/nu16234111","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T07:28:01Z","timestamp":1732778881000},"page":"4111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Prevention of Maternal Phenylketonuria (PKU) Syndrome: The Development and Evaluation of a Specific Training Program"],"prefix":"10.3390","volume":"16","author":[{"given":"Carmen","family":"Rohde","sequence":"first","affiliation":[{"name":"Department of Women and Child Health, Hospital for Children and Adolescents, University Hospitals, University of Leipzig, Liebigstra\u00dfe 20 a, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena Gerlinde","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Women and Child Health, Hospital for Children and Adolescents, University Hospitals, University of Leipzig, Liebigstra\u00dfe 20 a, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6038-8808","authenticated-orcid":false,"given":"Anne","family":"Tomm","sequence":"additional","affiliation":[{"name":"Department of Women and Child Health, Hospital for Children and Adolescents, University Hospitals, University of Leipzig, Liebigstra\u00dfe 20 a, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinah","family":"Lier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Klinikum am Steinenberg, Steinenbergstr. 31, 72764 Reutlingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Eschrich","sequence":"additional","affiliation":[{"name":"Outpatient Clinic for Obstetrics and Gynecology, Eilenburger Stra\u00dfe 59, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Baerwald","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Hospital for Internal Medicine, University Hospital, University of Leipzig, Liebigstra\u00dfe 20, 04103 Leipzig, Germany"},{"name":"Center for Rare Diseases, University Hospital, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skadi","family":"Beblo","sequence":"additional","affiliation":[{"name":"Department of Women and Child Health, Hospital for Children and Adolescents, University Hospitals, University of Leipzig, Liebigstra\u00dfe 20 a, 04103 Leipzig, Germany"},{"name":"Center for Rare Diseases, University Hospital, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"ref_1","unstructured":"(2024, November 10). 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