{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:48:56Z","timestamp":1779914936351,"version":"3.53.1"},"reference-count":58,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Royal Golden Jubilee (RGJ) Ph.D. Programme","award":["PHD\/0134\/2559"],"award-info":[{"award-number":["PHD\/0134\/2559"]}]},{"name":"Research Institute for Human High Performance and Health Promotion, Khon Kaen University, Khon Kaen, Thailand","award":["PHD\/0134\/2559"],"award-info":[{"award-number":["PHD\/0134\/2559"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Backgrounds\/Objectives: Despite the increasing importance of the condition of post-stroke cognitive impairment (PSCI), the current therapy efficacy is limited. Since oxidative stress and inflammation are targeted in anti-stroke therapy, we aimed to assess the protective effect against PSI of an orodispersible film loaded with silkworm pupae hydrolysate and a combined extract of holy basil and ginger (JP1), which show antioxidant, and anti-inflammation effects. Methods: Male Wistar rats (200\u2013250 g) were administered JP1 at doses of 1, 10, and 100 mg\/kg BW 45 min before a 6 h immobilization stress exposure for 14 days. Then, the right middle cerebral artery was permanently occluded (MCAO) and JP1 was continually administered for 21 days after MCAO. Spatial and non-spatial memory and the possible underlying mechanisms were also explored. Results: JP1 improved oxidative stress, inflammation, apoptosis, Erk signaling pathway, cholinergic function, and the growth of Lactobacillus and Bifidobacterium spp. in feces. These results suggest that JP1 improves PSCI, possibly involving the above mechanisms. Furthermore, serum corticosterone also decreased. Conclusions: Our results suggest that JP1 is a potential candidate for combating PSCI following exposure to stroke plus stress. However, a clear understanding of the precise active ingredient and the detailed mechanisms require further investigation.<\/jats:p>","DOI":"10.3390\/nu16234144","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T03:50:57Z","timestamp":1733111457000},"page":"4144","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Novel Supplement Consisting of Rice, Silkworm Pupae and a Mixture of Ginger and Holy Basil Improves Post-Stroke Cognitive Impairment"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-1946","authenticated-orcid":false,"given":"Putthiwat","family":"Thongwong","sequence":"first","affiliation":[{"name":"Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7383-2348","authenticated-orcid":false,"given":"Jintanaporn","family":"Wattanathorn","sequence":"additional","affiliation":[{"name":"Research Institute for High Human Performance and Health Promotion, Khon Kaen University, Khon Kaen 40000, Thailand"},{"name":"Center of Excellence for Functional Food and Health Innovation Faculty of Medicine, Khon Kaen University, Khon Kaen 40000, Thailand"},{"name":"Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wipawee","family":"Thukham-mee","sequence":"additional","affiliation":[{"name":"Research Institute for High Human Performance and Health Promotion, Khon Kaen University, Khon Kaen 40000, Thailand"},{"name":"Center of Excellence for Functional Food and Health Innovation Faculty of Medicine, Khon Kaen University, Khon Kaen 40000, Thailand"},{"name":"Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"ref_1","first-page":"e272","article-title":"Cognitive Impairment After Ischemic and Hemorrhagic Stroke: A Scientific Statement from the American Heart Association\/American Stroke Association","volume":"54","author":"Katzan","year":"2023","journal-title":"Stroke"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Guo, X., Phan, C., Batarseh, S., Wei, M., and Dye, J. 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