{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:46:18Z","timestamp":1791837978548,"version":"4.3.4"},"reference-count":77,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss National Science Foundation (SNF)","award":["33IC30_166844"],"award-info":[{"award-number":["33IC30_166844"]}]},{"name":"Swiss National Science Foundation (SNF)","award":["NCT04000139"],"award-info":[{"award-number":["NCT04000139"]}]},{"name":"Litwin Foundation","award":["33IC30_166844"],"award-info":[{"award-number":["33IC30_166844"]}]},{"name":"Litwin Foundation","award":["NCT04000139"],"award-info":[{"award-number":["NCT04000139"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Bilberries are effective in inducing clinical, endoscopic, and biochemical improvement in ulcerative colitis (UC) patients. The aim of this study was to investigate the efficacy of anthocyanin-rich extract (ACRE), the bioactive ingredient of bilberries, in a controlled clinical trial in moderate-to-severe UC. Methods: A multi-center, randomized, placebo-controlled, double-blind study with a parallel group was conducted. Initially, the study was planned for 100 patients; nevertheless, it prematurely ended due to COVID-19. Patients had moderate-to-severe active UC at screening (a Mayo score of 6\u201312, an endoscopic sub-score \u2265 2) and were randomized at baseline. The primary endpoint was a clinical response (week 8, a total Mayo score reduction \u2265 3 points). Fecal calprotectin (FC) and a centrally read endoscopic response were among the secondary endpoints. Results: Out of 48 patients (6 Swiss centers), 34 were randomized. Eighteen ACRE and eight placebo patients could be analyzed (per protocol set). Half (9\/18) of ACRE patients and 3\/8 of placebo patients responded clinically (p = 0.278). An improvement in the Mayo score was observed in the ACRE arm (77.8% vs. 62.5% placebo). FC dropped from 1049 \u00b1 1139 to 557 \u00b1 756 \u03bcg\/g for ACRE but not for the placebo group (947 \u00b1 1039 to 1040 \u00b1 1179; p = 0.035). Serious adverse events were rare. Conclusions: ACRE treatment did not yield significant superiority to the placebo. Furthermore, the placebo response was unusually high. Moreover, there was a significant calprotectin decrease at the end of treatment, indicative of ACRE efficacy in UC.<\/jats:p>","DOI":"10.3390\/nu16234197","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T06:38:25Z","timestamp":1733294305000},"page":"4197","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and Safety of Anthocyanin-Rich Extract in Patients with Ulcerative Colitis: A Randomized Controlled Trial"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0824-4125","authenticated-orcid":false,"given":"Luc","family":"Biedermann","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0396-5081","authenticated-orcid":false,"given":"Michael","family":"Doulberis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland"},{"name":"Gastroklinik, Private Gastroenterological Practice, 8810 Horgen, Switzerland"},{"name":"Division of Gastroenterology and Hepatology, Medical University Department, Kantonsspital Aarau, 5001 Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Schreiner","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4612-8635","authenticated-orcid":false,"given":"Ole Haagen","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans Olivier","family":"The","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Brand","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Burk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Hruz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Clarunis-University Center for Gastrointestinal and Liver Diseases, 4052 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Juillerat","sequence":"additional","affiliation":[{"name":"Intesto Crohn and Colitis Center, 3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7949-0385","authenticated-orcid":false,"given":"Claudia","family":"Krieger-Gr\u00fcbel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Leu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4463-166X","authenticated-orcid":false,"given":"Gabriel E.","family":"Leventhal","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Misselwitz","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital Bern University Hospital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4000-7200","authenticated-orcid":false,"given":"Sylvie","family":"Scharl","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Schoepfer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Seibold","sequence":"additional","affiliation":[{"name":"Intesto Crohn and Colitis Center, 3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-823X","authenticated-orcid":false,"given":"Hans","family":"Herfarth","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1733-9188","authenticated-orcid":false,"given":"Gerhard","family":"Rogler","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/17562848231179335","article-title":"Because I\u2019m happy\u2014Positive affect and its predictive value for future disease activity in patients with inflammatory bowel diseases: A retrospective cohort study","volume":"16","author":"Lang","year":"2023","journal-title":"Therap Adv. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1055449","DOI":"10.3389\/fpsyg.2023.1055449","article-title":"Identification of the informational and supportive needs of patients diagnosed with inflammatory bowel disease: A scoping review","volume":"14","author":"Norouzkhani","year":"2023","journal-title":"Front. Psychol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Awadhi, S.A., Alboraie, M., Albaba, E.A., Almutairdi, A., Alsaad, M., Azzam, N., Barakat, H., D\u2019Amico, F., Danese, S., and El Kady, M. (2023). Treatment of Patients with Mild to Moderate Ulcerative Colitis: A Middle East Expert Consensus. J. Clin. Med., 12.","DOI":"10.3390\/jcm12216929"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/ecco-jcc\/jjx009","article-title":"Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management","volume":"11","author":"Harbord","year":"2017","journal-title":"J. Crohns Colitis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.dld.2022.08.039","article-title":"Colectomy rates in ulcerative colitis: A systematic review and meta-analysis","volume":"55","author":"Dai","year":"2023","journal-title":"Dig. Liver Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e25357","DOI":"10.1016\/j.heliyon.2024.e25357","article-title":"Adverse events of biologic or small molecule therapies in clinical trials for inflammatory bowel disease: A systematic review and meta-analysis","volume":"10","author":"Wang","year":"2024","journal-title":"Heliyon"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bpg.2010.01.002","article-title":"Adverse effects of biologics used for treating IBD","volume":"24","author":"Stallmach","year":"2010","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"key":"ref_9","first-page":"289","article-title":"Real-life burden of adverse reactions to biological therapy in inflammatory bowel disease: A single-centre prospective case series","volume":"94","author":"Larussa","year":"2021","journal-title":"Med. Pharm. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1186\/s12913-021-06816-3","article-title":"The cost burden of Crohn\u2019s disease and ulcerative colitis depending on biologic treatment status\u2014A Danish register-based study","volume":"21","author":"Alulis","year":"2021","journal-title":"BMC Health Serv. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/apt.16445","article-title":"Systematic review: Societal cost of illness of inflammatory bowel disease is increasing due to biologics and varies between continents","volume":"54","author":"Visser","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S2468-1253(21)00377-0","article-title":"Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis: A systematic review and network meta-analysis","volume":"7","author":"Lasa","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"otac005","DOI":"10.1093\/crocol\/otac005","article-title":"Breaking the Therapeutic Ceiling: Dual Biologic or Small Molecule Therapy for Refractory Inflammatory Bowel Disease","volume":"4","author":"Ahmed","year":"2022","journal-title":"Crohns Colitis 360"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Pituch-Zdanowska, A., Dembinski, L., and Banaszkiewicz, A. (2022). Old but Fancy: Curcumin in Ulcerative Colitis-Current Overview. Nutrients, 14.","DOI":"10.3390\/nu14245249"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Iyengar, P., Godoy-Brewer, G., Maniyar, I., White, J., Maas, L., Parian, A.M., and Limketkai, B. (2024). Herbal Medicines for the Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis. Nutrients, 16.","DOI":"10.3390\/nu16070934"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10787-022-00931-1","article-title":"Natural compounds as safe therapeutic options for ulcerative colitis","volume":"30","author":"Gupta","year":"2022","journal-title":"Inflammopharmacology"},{"key":"ref_17","first-page":"210","article-title":"Herbal and plant therapy in patients with inflammatory bowel disease","volume":"28","author":"Triantafyllidi","year":"2015","journal-title":"Ann. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jfutfo.2023.07.002","article-title":"Classification and antioxidant assays of polyphenols: A review","volume":"4","author":"Lang","year":"2024","journal-title":"J. Future Foods"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.tjnut.2024.01.002","article-title":"Consumption of Berries and Flavonoids in Relation to Mortality in NHANES, 1999\u20132014","volume":"154","author":"Zhang","year":"2024","journal-title":"J. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1021\/acs.jafc.8b06737","article-title":"Anthocyanins: From Sources and Bioavailability to Cardiovascular-Health Benefits and Molecular Mechanisms of Action","volume":"67","author":"Krga","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1002\/mnfr.201100380","article-title":"Bilberries and their anthocyanins ameliorate experimental colitis","volume":"55","author":"Piberger","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Tena, N., Martin, J., and Asuero, A.G. (2020). State of the Art of Anthocyanins: Antioxidant Activity, Sources, Bioavailability, and Therapeutic Effect in Human Health. Antioxidants, 9.","DOI":"10.3390\/antiox9050451"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/0016-5085(90)90329-Y","article-title":"Clinical evidence supporting the radical scavenger mechanism of 5-aminosalicylic acid","volume":"98","author":"Nielsen","year":"1990","journal-title":"Gastroenterology"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Verediano, T.A., Stampini Duarte Martino, H., Dias Paes, M.C., and Tako, E. (2021). Effects of Anthocyanin on Intestinal Health: A Systematic Review. Nutrients, 13.","DOI":"10.3390\/nu13041331"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/BF01296156","article-title":"Inhibition of 5-lipoxygenase pathway of arachidonic acid metabolism in human neutrophils by sulfasalazine and 5-aminosalicylic acid","volume":"32","author":"Nielsen","year":"1987","journal-title":"Dig. Dis. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0162-3109(88)90041-0","article-title":"A comparison of effects of sulfasalazine and its metabolites on the metabolism of endogenous vs. exogenous arachidonic acid","volume":"15","author":"Allgayer","year":"1988","journal-title":"Immunopharmacology"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Al-Khayri, J.M., Sahana, G.R., Nagella, P., Joseph, B.V., Alessa, F.M., and Al-Mssallem, M.Q. (2022). Flavonoids as Potential Anti-Inflammatory Molecules: A Review. Molecules, 27.","DOI":"10.3390\/molecules27092901"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1217165","DOI":"10.3389\/fendo.2023.1217165","article-title":"Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease","volume":"14","author":"Sahoo","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.3390\/cimb44100313","article-title":"Anti-Inflammatory Activity of Bilberry (Vaccinium myrtillus L.)","volume":"44","author":"Sharma","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Kumkum, R., Aston-Mourney, K., McNeill, B.A., Hernandez, D., and Rivera, L.R. (2024). Bioavailability of Anthocyanins: Whole Foods versus Extracts. Nutrients, 16.","DOI":"10.3390\/nu16101403"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kowalczyk, T., Muskala, M., Merecz-Sadowska, A., Sikora, J., Picot, L., and Sitarek, P. (2024). Anti-Inflammatory and Anticancer Effects of Anthocyanins in In Vitro and In Vivo Studies. Antioxidants, 13.","DOI":"10.3390\/antiox13091143"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/biof.1008","article-title":"Effects of anthocyanin-rich tea \u201cSunrouge\u201d on dextran sodium sulfate-induced colitis in mice","volume":"38","author":"Akiyama","year":"2012","journal-title":"Biofactors"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.1038\/srep06234","article-title":"Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis","volume":"4","author":"Li","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1039\/C7FO01490B","article-title":"Black rice anthocyanin-rich extract and rosmarinic acid, alone and in combination, protect against DSS-induced colitis in mice","volume":"9","author":"Zhao","year":"2018","journal-title":"Food Funct."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.freeradbiomed.2019.04.005","article-title":"Gut microbiota modulation and anti-inflammatory properties of anthocyanins from the fruits of Lycium ruthenicum Murray in dextran sodium sulfate-induced colitis in mice","volume":"136","author":"Peng","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"108616","DOI":"10.1016\/j.jnutbio.2021.108616","article-title":"Anthocyanin-containing purple potatoes ameliorate DSS-induced colitis in mice","volume":"93","author":"Li","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11503","DOI":"10.1039\/D1FO02454J","article-title":"Anti-inflammatory effects of purple sweet potato anthocyanin extract in DSS-induced colitis: Modulation of commensal bacteria and attenuated bacterial intestinal infection","volume":"12","author":"Mu","year":"2021","journal-title":"Food Funct."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zhang, G., Gu, Y., and Dai, X. (2022). Protective Effect of Bilberry Anthocyanin Extracts on Dextran Sulfate Sodium-Induced Intestinal Damage in Drosophila melanogaster. Nutrients, 14.","DOI":"10.3390\/nu14142875"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000366055","article-title":"Bilberry-derived anthocyanins prevent IFN-gamma-induced pro-inflammatory signalling and cytokine secretion in human THP-1 monocytic cells","volume":"90","author":"Roth","year":"2014","journal-title":"Digestion"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e0154817","DOI":"10.1371\/journal.pone.0154817","article-title":"Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis","volume":"11","author":"Roth","year":"2016","journal-title":"PLoS ONE"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000475524","article-title":"Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model","volume":"95","author":"Lippert","year":"2017","journal-title":"Digestion"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1358\/mf.2009.31.1.1346608","article-title":"Anthocyanins and anthocyanidins are poor inhibitors of CYP2D6","volume":"31","author":"Dreiseitel","year":"2009","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbrc.2008.04.140","article-title":"Inhibition of proteasome activity by anthocyanins and anthocyanidins","volume":"372","author":"Dreiseitel","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000475584","article-title":"Anthocyane, Heidelbeeren und Curcuma: Wirksame Therapeutika bei Darmentz\u00fcndungen?","volume":"29","author":"Scharl","year":"2017","journal-title":"Swiss J. Integr. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.crohns.2012.07.010","article-title":"Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis\u2014An open pilot study","volume":"7","author":"Biedermann","year":"2013","journal-title":"J. Crohns Colitis"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Li, S., Wu, B., Fu, W., and Reddivari, L. (2019). The Anti-inflammatory Effects of Dietary Anthocyanins against Ulcerative Colitis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20102588"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13099-015-0076-y","article-title":"Animal models to study acute and chronic intestinal inflammation in mammals","volume":"7","author":"Jiminez","year":"2015","journal-title":"Gut Pathog."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e813","DOI":"10.1136\/bmj.e813","article-title":"Impact of single centre status on estimates of intervention effects in trials with continuous outcomes: Meta-epidemiological study","volume":"344","author":"Bafeta","year":"2012","journal-title":"BMJ"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12919-023-00285-8","article-title":"Rethinking the pros and cons of randomized controlled trials and observational studies in the era of big data and advanced methods: A panel discussion","volume":"18","author":"Fernainy","year":"2024","journal-title":"BMC Proc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"384","DOI":"10.14309\/ajg.0000000000000152","article-title":"ACG Clinical Guideline: Ulcerative Colitis in Adults","volume":"114","author":"Rubin","year":"2019","journal-title":"Am. J. Gastroenterol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1136\/bmj.2.4947.1041","article-title":"Cortisone in ulcerative colitis; final report on a therapeutic trial","volume":"2","author":"Truelove","year":"1955","journal-title":"Br. Med. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects","volume":"310","year":"2013","journal-title":"JAMA"},{"key":"ref_53","unstructured":"(2024, March 15). European Medicines Agency. ICH E6 (R3) Guideline on Good Clinical Practice (GCP) Step 2b. Available online: https:\/\/www.ema.europa.eu\/en\/ich-e6-r2-good-clinical-practice-scientific-guideline."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1001\/jama.2022.21022","article-title":"Guidelines for Reporting Outcomes in Trial Reports: The CONSORT-Outcomes 2022 Extension","volume":"328","author":"Butcher","year":"2022","journal-title":"JAMA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.ajcnut.2023.03.017","article-title":"Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: A double-blind randomized controlled trial","volume":"117","author":"Wood","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101474","DOI":"10.1016\/j.redox.2020.101474","article-title":"Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidemia","volume":"32","author":"Zhang","year":"2020","journal-title":"Redox Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJM198712243172603","article-title":"Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study","volume":"317","author":"Schroeder","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/ibd.20520","article-title":"Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis","volume":"14","author":"Lewis","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"17562848221136331","DOI":"10.1177\/17562848221136331","article-title":"Modified Mayo score versus Mayo score for evaluation of treatment efficacy in patients with ulcerative colitis: Data from the tofacitinib OCTAVE program","volume":"15","author":"Sandborn","year":"2022","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1053\/j.gastro.2018.11.035","article-title":"Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate-to-Severe Ulcerative Colitis","volume":"156","author":"Sandborn","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_61","first-page":"1070","article-title":"An optimized patient-reported ulcerative colitis disease activity measure derived from the Mayo score and the simple clinical colitis activity index","volume":"20","author":"Bewtra","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/gut.47.3.404","article-title":"A reproducible grading scale for histological assessment of inflammation in ulcerative colitis","volume":"47","author":"Geboes","year":"2000","journal-title":"Gut"},{"key":"ref_63","first-page":"1571","article-title":"The Short Inflammatory Bowel Disease Questionnaire: A quality of life instrument for community physicians managing inflammatory bowel disease. CCRPT Investigators. Canadian Crohn\u2019s Relapse Prevention Trial","volume":"91","author":"Irvine","year":"1996","journal-title":"Am. J. Gastroenterol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Shi, J.T., Chen, N., Xu, J., Goyal, H., Wu, Z.Q., Zhang, J.X., and Xu, H.G. (2023). Diagnostic Accuracy of Fecal Calprotectin for Predicting Relapse in Inflammatory Bowel Disease: A Meta-Analysis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12031206"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3904\/kjim.2016.324","article-title":"The usefulness of fecal calprotectin in assessing inflammatory bowel disease activity","volume":"34","author":"Lee","year":"2019","journal-title":"Korean J. Intern. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/mnfr.201200504","article-title":"Modulation of Nrf2-dependent gene transcription by bilberry anthocyanins in vivo","volume":"57","author":"Kropat","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1017\/jns.2023.113","article-title":"The INHABIT (synergIstic effect of aNtHocyAnin and proBIoTics in) Inflammatory Bowel Disease trial: A study protocol for a double-blind, randomised, controlled, multi-arm trial","volume":"13","author":"Cosier","year":"2024","journal-title":"J. Nutr. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1089\/jmf.2023.K.0247","article-title":"Anthocyanin Extracted from Purple Sweet Potato Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice by Suppressing Pyroptosis and Altering Intestinal Flora Structure","volume":"27","author":"Chen","year":"2024","journal-title":"J. Med. Food"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Mo, J., Ni, J., Zhang, M., Xu, Y., Li, Y., Karim, N., and Chen, W. (2022). Mulberry Anthocyanins Ameliorate DSS-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Modulating Gut Microbiota. Antioxidants, 11.","DOI":"10.3390\/antiox11091674"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1021\/acs.jafc.3c07741","article-title":"The Role of Anthocyanins in Alleviating Intestinal Diseases: A Mini Review","volume":"72","author":"Liu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1207\/s15327914nc5401_4","article-title":"Berry phenolics: Antimicrobial properties and mechanisms of action against severe human pathogens","volume":"54","author":"Nohynek","year":"2006","journal-title":"Nutr. Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.numecd.2010.04.011","article-title":"Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice","volume":"22","author":"Mauray","year":"2012","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_73","first-page":"CD011572","article-title":"Placebo response and remission rates in randomised trials of induction and maintenance therapy for ulcerative colitis","volume":"9","author":"Jairath","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/ecco-jcc\/jjab135","article-title":"Systematic Review and Meta-Analysis: Clinical, Endoscopic, Histological and Safety Placebo Rates in Induction and Maintenance Trials of Ulcerative Colitis","volume":"16","author":"Sedano","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1177\/0020764015591492","article-title":"Colour, culture and placebo response","volume":"61","author":"Bhugra","year":"2015","journal-title":"Int. J. Soc. Psychiatry"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1136\/bmj.313.7072.1624","article-title":"Effect of colour of drugs: Systematic review of perceived effect of drugs and of their effectiveness","volume":"313","author":"Roos","year":"1996","journal-title":"BMJ"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2466\/pms.1979.49.2.367","article-title":"Classification of placebo drugs: Effect of color","volume":"49","author":"Jacobs","year":"1979","journal-title":"Percept. Mot. 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