{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:27:21Z","timestamp":1790317641815,"version":"4.1.0"},"reference-count":80,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Helderleigh Nutrition Application Fund"},{"name":"Princess Margaret Cancer Foundation"},{"name":"Butterfield Drew Chair in Cancer Survivorship Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Pelvic radiotherapy (RT) improves survival in gynecologic cancer patients but often results in gastrointestinal (GI) toxicity, affecting quality of life. Standard nutrition guidance lacks specificity for these survivors, complicating dietary choices. To address this gap, the EDIBLE intervention was developed to offer structured dietary self-management skills to alleviate RT-induced GI toxicity. Methods: We conducted a single-arm mixed-methods pilot of the EDIBLE intervention among post-treatment gynecologic cancer survivors to assess its feasibility, acceptability, and preliminary effects on GI symptoms, knowledge, and self-efficacy, with measures at baseline (T1), post-intervention (T2), and after 3 months (T3). Results: Qualitative interviews supported strong perceptions of intervention feasibility; however, the recruitment (32%) and retention (72%) rates were modest, indicating that alternate formats for program delivery may be needed to make it more accessible. The acceptability of the EDIBLE intervention garnered especially high ratings on measures of satisfaction and utility, with program improvements largely rallying around a desire for increased in-class sessions and program expansion. Statistically significant improvements were observed at the three-month mark (T3), such as enhanced confidence in culinary practices, increased knowledge and skills with regard to managing GI side effects, and improvements in bowel and GI symptoms. Conclusions: The results suggest EDIBLE is acceptable, improving GI symptoms and self-efficacy; however, moderate recruitment rates indicate refinement is needed. A randomized control trial and cost-effectiveness analysis is needed to confirm effectiveness and scalability.<\/jats:p>","DOI":"10.3390\/nu16234227","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T10:58:45Z","timestamp":1733482725000},"page":"4227","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Eliminating Digestive Irregularities Caused by Late Effects: A Pilot Study of an Innovative Culinary Nutrition Intervention for Reducing Gastrointestinal Toxicity in Gynecologic Cancer Patients Who Have Undergone Pelvic Radiotherapy"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9627-7562","authenticated-orcid":false,"given":"Cheryl","family":"Pritlove","sequence":"first","affiliation":[{"name":"Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, ON M5C 2T2, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geremy","family":"Capone","sequence":"additional","affiliation":[{"name":"Cancer Rehabilitation and Survivorship Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathankki","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, ON M5C 2T2, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Avery","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Fierini","sequence":"additional","affiliation":[{"name":"Cancer Rehabilitation and Survivorship Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, University Health Network\/Sinai Health Systems, Toronto, ON M5G 1X5, Canada"},{"name":"Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON M5S 1A, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Han","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, Canada"},{"name":"Department of Radiation Oncology, University of Toronto, Toronto, ON M5S 1A, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-8514","authenticated-orcid":false,"given":"Jennifer M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Cancer Rehabilitation and Survivorship Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada"},{"name":"Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13014-021-01899-y","article-title":"The impact of pelvic radiotherapy on the gut microbiome and its role in radiation-induced diarrhoea: A systematic review","volume":"16","author":"Wang","year":"2021","journal-title":"Radiat. 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