{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T09:03:01Z","timestamp":1781600581690,"version":"3.54.5"},"reference-count":46,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Intake of New Zealand blackcurrant (NZBC) extract for 7 days has been shown to improve high-intensity intermittent running (HIIR) performance. Objectives: We examined the repeat response of NZBC extract on HIIR performance. Methods: Sixteen active males (age: 23 \u00b1 3 yrs, height: 179 \u00b1 5 cm, mass: 79 \u00b1 11 kg, V\u02d9O2max: 55.3 \u00b1 5 mL\u2219kg\u22121\u2219min\u22121, velocity at V\u02d9O2max: 17.2 \u00b1 0.8 km\u2219h\u22121, mean \u00b1 SD) participated. Familiarized subjects completed the HIIR test at individualized exercise intensities with stages consisting of six 19 s high-intensity running bouts interspersed by 15 s of low-intensity running and 1 min of inter-stage rest. The test was repeated at increasing speeds until exhaustion, under four conditions; two with a daily dose of 600 mg of NZBC extract (CurraNZ\u2122, providing 210 mg anthocyanins) and two with a placebo, each over 7 days. The study used a double-blind, randomized, cross-over design with a wash-out period of at least 14 days. Results: For the cohort, there were no differences between the placebo and NZBC conditions for mean heart rate (p = 0.071), mean oxygen uptake (p = 0.713), and mean lactate (p = 0.121) at exhaustion for the HIIR. The NZBC extract increased the mean total running distance and mean high-intensity running distance by 7.9% and 8.0% compared to the placebo. With NZBC extract, 8 of the 16 participants (50%) enhanced in both trials beyond the smallest worthwhile change for total running distance (\u2265173 m) and high-intensity running distance (\u2265111 m). For repeated responders, total running distance and high-intensity running distance was increased by 16.7% (95% CI [11.0, 22.4%] and 16.6% (95% CI [11.0, 22.2%]. Three participants had enhanced running performance in one trial beyond the SWC, and five participants were considered non-responders. Conclusions: This is the first study on the repeated response by an anthocyanin-rich supplement on high-intensity running performance. New Zealand blackcurrant extract can substantially enhance intermittent high-intensity running performance in consistent responders. Future work should examine dosing strategies of New Zealand blackcurrant, and whether a repeated response rate exceeding 50% can be attained. These findings suggest that NZBC extract could be beneficial for athletes participating in high-intensity team sports.<\/jats:p>","DOI":"10.3390\/nu16244253","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T04:15:03Z","timestamp":1733804103000},"page":"4253","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Individual Responses to Repeated Dosing with Anthocyanin-Rich New Zealand Blackcurrant Extract During High-Intensity Intermittent Treadmill Running in Active Males"],"prefix":"10.3390","volume":"16","author":[{"given":"Ian C.","family":"Perkins","sequence":"first","affiliation":[{"name":"Institute of Education and Social Sciences, University of Chichester, College Lane, Chichester PO19 6PE, UK"},{"name":"Institute of Applied Sciences, University of Chichester, College Lane, Chichester PO19 6PE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam D.","family":"Blacker","sequence":"additional","affiliation":[{"name":"Institute of Applied Sciences, University of Chichester, College Lane, Chichester PO19 6PE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-8739","authenticated-orcid":false,"given":"Mark E. T.","family":"Willems","sequence":"additional","affiliation":[{"name":"Institute of Applied Sciences, University of Chichester, College Lane, Chichester PO19 6PE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Willems, M.E.T., and Blacker, S.D. (2022). Anthocyanin-Rich Supplementation: Emerging Evidence of Strong Potential for Sport and Exercise Nutrition. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.864323"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1007\/s00421-015-3215-8","article-title":"New Zealand blackcurrant extract improves cycling performance and fat oxidation in cyclists","volume":"115","author":"Cook","year":"2015","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Murphy, C.A., Cook, M.D., and Willems, M.E.T. (2017). 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