{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:50:11Z","timestamp":1790117411372,"version":"4.0.1"},"reference-count":55,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007509","name":"Sociedad Espa\u00f1ola de Neumolog\u00eda y Cirug\u00eda Tor\u00e1cica","doi-asserted-by":"publisher","award":["SEPAR 72\/2015"],"award-info":[{"award-number":["SEPAR 72\/2015"]}],"id":[{"id":"10.13039\/501100007509","id-type":"DOI","asserted-by":"publisher"}]},{"name":"LINDE","award":["SEPAR 72\/2015"],"award-info":[{"award-number":["SEPAR 72\/2015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Studies focusing on the effects of lifestyle strategies on patients with obstructive sleep apnea (OSA) that go beyond body weight and explore body composition are currently scarce and inconclusive. Objectives\/Methods: The aim of this study was to evaluate the effects of a 12-month intensive life intervention program (ILI), based on a hypocaloric Mediterranean diet, on changes in the body composition parameters as assessed by abdominal computed tomography (CT) and the cardiorespiratory profile of patients with severe OSA and grade I\u2013II obesity, compared to patients receiving standard care. Resultts:Thirty-four patients (30 males and four females) were randomly assigned to an intervention group (IG) (n = 18) or a control group (CG) (n = 16). We observed an improvement in OSA severity following the intervention. Patients in the IG lost 8.2% of their body weight compared to 0.1% of the patients in the CG (p &lt; 0.001), and this loss was primarily due to reductions in total body fat, visceral adipose tissue index (VATI) [IG \u221219.4 (18.1) cm2\/m2 versus CG 2.32 (11.6) cm2\/m2, p &lt; 0.001], and a tendency toward lower intramuscular adipose tissue index (IMATI) [IG \u22120.69 (0.85) cm2\/m2 versus CG 0.04 (1.3) cm2\/m2, p = 0.098]. These changes were associated with an improvement in patients\u2019 metabolic and inflammatory profile. Younger age and a higher degree of obesity at baseline were associated with greater weight loss. Conslusions: In conclusion, the ILI was effective in reducing 8.2% of body weight at 12 months, leading to favorable changes in patients\u2019 body composition profile that resulted in healthier metabolic and inflammatory parameters.<\/jats:p>","DOI":"10.3390\/nu16244255","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T04:15:03Z","timestamp":1733804103000},"page":"4255","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of a One-Year Intensified Weight Loss Program on Body Composition Parameters in Patients with Severe Obesity and Obstructive Sleep Apnea (OSA): A Randomized Controlled Trial"],"prefix":"10.3390","volume":"16","author":[{"given":"Laia","family":"Miralles-Llum\u00e0","sequence":"first","affiliation":[{"name":"Multidisciplinary Sleep Unit, Department of Respiratory Medicine, Hospital Universitari de Bellvitge, L\u2019Hospitalet de Llobregat, Feixa Llarga, s\/n., 08907 Barcelona, Spain"},{"name":"Department of Endocrinology and Nutrition, Hospital Universitari de Bellvitge, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Section of Gastroenterology, Hepatology and Nutrition, Hospital Sant Joan de D\u00e9u, Esplugues de Llobregat, 08907 Barcelona, Spain"},{"name":"Program PhD Nutrition and Food, University of Barcelona, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Vilarrasa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitari de Bellvitge, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Section of Endocrinology, Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Monasterio","sequence":"additional","affiliation":[{"name":"Multidisciplinary Sleep Unit, Department of Respiratory Medicine, Hospital Universitari de Bellvitge, L\u2019Hospitalet de Llobregat, Feixa Llarga, s\/n., 08907 Barcelona, Spain"},{"name":"Section of Respiratory Medicine, Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"L\u00f3pez-Padr\u00f3s","sequence":"additional","affiliation":[{"name":"Multidisciplinary Sleep Unit, Department of Respiratory Medicine, Hospital Universitari de Bellvitge, L\u2019Hospitalet de Llobregat, Feixa Llarga, s\/n., 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Alves","sequence":"additional","affiliation":[{"name":"Multidisciplinary Sleep Unit, Department of Respiratory Medicine, Hospital Universitari de Bellvitge, L\u2019Hospitalet de Llobregat, Feixa Llarga, s\/n., 08907 Barcelona, Spain"},{"name":"Department of Endocrinology and Nutrition, Hospital Universitari de Bellvitge, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Planas","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Hospital Universitari de Bellvitge, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9683-9999","authenticated-orcid":false,"given":"Lorena","family":"Arribas","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Unit, Catalan Institute of Oncology (ICO), L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Section of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, 08907 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