{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:13:14Z","timestamp":1792177994411,"version":"4.4.0"},"reference-count":69,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kasetsart University, Kamphaeng Saen Campus","award":["KPS-RDI 2021-010"],"award-info":[{"award-number":["KPS-RDI 2021-010"]}]},{"name":"Kasetsart University, Kamphaeng Saen Campus","award":["JRCMU2566R_086"],"award-info":[{"award-number":["JRCMU2566R_086"]}]},{"name":"CMU Junior Research Fellowship Program","award":["KPS-RDI 2021-010"],"award-info":[{"award-number":["KPS-RDI 2021-010"]}]},{"name":"CMU Junior Research Fellowship Program","award":["JRCMU2566R_086"],"award-info":[{"award-number":["JRCMU2566R_086"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Mulberries exhibit antioxidant properties that may attenuate metabolic abnormalities. Kamphaeng Saen mulberry (KPS-MB-42-1) contains anthocyanins, polyphenols, and nutrients, but few studies have explored its benefits for human health. This study investigated the effects of a concentrated mulberry drink (CMD) from the KPS-MB-42-1 cultivar on metabolic and cardiovascular risk factors in obese individuals. Methods: A single-blind, randomized crossover clinical pilot trial was performed on individuals with obesity. Participants consumed 100 g of CMD daily, alternating with placebo for 6 weeks. Body composition, blood pressure, and blood samples were assessed at baseline and post-intervention. Results: This study was completed with 12 participants (7 men, 5 women, aged 30\u201355 years, BMI 32.1 \u00b1 5.98 kg\/m2) consuming CMD with 1041.90 mg total phenolic compounds and 35.34 mg total anthocyanins. No significant changes in body composition were observed. CMD consumption significantly reduced systolic and diastolic blood pressure, and mean arterial pressure, compared to baseline and placebo periods (p &lt; 0.05). While total cholesterol, LDL-C, and HDL-C remained unchanged, triglycerides were significantly lower during CMD consumption compared to placebo periods (p &lt; 0.05). Fasting plasma glucose (FPG) levels were stable during CMD consumption but increased significantly with the placebo period (p &lt; 0.05). C-reactive protein levels were also significantly lower during CMD consumption compared to placebo periods (p &lt; 0.05). No changes in blood coagulation indicators (prothrombin time, activated partial thromboplastin time, and the international normalized ratio) were found. Conclusions: CMD improved metabolic markers, particularly regarding its antihypertensive effects. These findings highlight CMD\u2019s potential as a health drink for managing metabolic syndrome and preventing chronic diseases.<\/jats:p>","DOI":"10.3390\/nu16244336","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T10:08:53Z","timestamp":1734343733000},"page":"4336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Nutraceutical Properties of Thai Mulberry (Morus alba L.) and Their Effects on Metabolic and Cardiovascular Risk Factors in Individuals with Obesity: A Randomized, Single-Blind Crossover Trial"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9418-3642","authenticated-orcid":false,"given":"Wason","family":"Parklak","sequence":"first","affiliation":[{"name":"Research Center for Non-Infectious Diseases and Environmental Health, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-3061","authenticated-orcid":false,"given":"Monchai","family":"Chottidao","sequence":"additional","affiliation":[{"name":"College of Sports Science and Technology, Mahidol University, Nakhon Pathom 73170, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0097-6746","authenticated-orcid":false,"given":"Narongsuk","family":"Munkong","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, University of Phayao, Phayao 56000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surat","family":"Komindr","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Biochemical Medicine, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudjai","family":"Monkhai","sequence":"additional","affiliation":[{"name":"Wangnumkeaw Sub-District Health Promotion Hospital, Nakhon Pathom 73140, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bandhita","family":"Wanikorn","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Agro-Industry, Kasetsart University, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9989-710X","authenticated-orcid":false,"given":"Niromlee","family":"Makaje","sequence":"additional","affiliation":[{"name":"Department of Sports Science, Faculty of Sports and Health Science, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanokwan","family":"Kulprachakarn","sequence":"additional","affiliation":[{"name":"Research Center for Non-Infectious Diseases and Environmental Health, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hataichanok","family":"Chuljerm","sequence":"additional","affiliation":[{"name":"Research Center for Non-Infectious Diseases and Environmental Health, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1638-9212","authenticated-orcid":false,"given":"Surasawadee","family":"Somnuk","sequence":"additional","affiliation":[{"name":"Department of Sports Science, Faculty of Sports and Health Science, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Meli\u00e1n-Fleitas, L., Franco-P\u00e9rez, \u00c1., Sanz-Valero, J., and Wanden-Berghe, C. 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