{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:26:01Z","timestamp":1792506361521,"version":"4.5.0"},"reference-count":94,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Chronic pouchitis occurs in about 50% of patients undergoing a restorative proctocolectomy for ulcerative colitis. This affection represents a significant therapeutic challenge, particularly for symptomatic patients who do not respond to antibiotic treatments and biologic therapies. Several dietary approaches, including low FODMAP diets and the Mediterranean diet, have shown promising results in improving symptoms and disease burden. The rationale for dietary intervention lies in the reduction in inflammation and modulation of gut microbiota. However, conflicting results and methodological heterogeneity jeopardize the transition of these approaches from the field of research to clinical practice. Together with a nutritional approach, innovative methods of microbiota modulation, including probiotics and fecal microbiota transplantation, are emerging as safe and effective strategies in managing chronic pouchitis. This narrative review analyzes recent advancements in nutritional therapies and microbiota modulation as innovative and complementary approaches for managing chronic pouchitis. After examining microbiota modulation strategies, specifically the effectiveness of probiotics, prebiotics, and fecal microbiota transplantation in restoring microbial diversity and their potential role in alleviating symptoms, the review assesses the available clinical evidence concerning dietary interventions and their impact on gut microbiota. A comprehensive understanding of interventions aimed at modulating the microbiota is crucial for enhancing the effectiveness of conventional therapies. Such strategies may lead to significant improvements in patients\u2019 quality of life and their perception of the disease. However, the variability in microbiota composition, the use of restrictive diets, and the lack of standardized methods for evaluating these interventions remain significant challenges. Future research is essential to improve our understanding of the underlying mechanisms and optimize clinical application.<\/jats:p>","DOI":"10.3390\/nu16244337","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T10:08:53Z","timestamp":1734343733000},"page":"4337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diet and Microbiota Modulation for Chronic Pouchitis: Evidence, Challenges, and Opportunities"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0935-8853","authenticated-orcid":false,"given":"Pierluigi","family":"Puca","sequence":"first","affiliation":[{"name":"IBD Unit, UOC CEMAD Centro Malattie dell\u2019Apparato Digerente, Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Del Gaudio","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2815-914X","authenticated-orcid":false,"given":"Guia","family":"Becherucci","sequence":"additional","affiliation":[{"name":"IBD Unit, UOC CEMAD Centro Malattie dell\u2019Apparato Digerente, Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Sacchetti","sequence":"additional","affiliation":[{"name":"Abdominal Surgery Unit, Department of Gastroenterological, Endocrine-Metabolic and Nephro-Urological Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, L. go A. Gemelli 8, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Sofo","sequence":"additional","affiliation":[{"name":"Abdominal Surgery Unit, Department of Gastroenterological, Endocrine-Metabolic and Nephro-Urological Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, L. go A. Gemelli 8, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-2055","authenticated-orcid":false,"given":"Loris Riccardo","family":"Lopetuso","sequence":"additional","affiliation":[{"name":"IBD Unit, UOC CEMAD Centro Malattie dell\u2019Apparato Digerente, Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-7298","authenticated-orcid":false,"given":"Alfredo","family":"Papa","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"},{"name":"Abdominal Surgery Unit, Department of Gastroenterological, Endocrine-Metabolic and Nephro-Urological Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, L. go A. Gemelli 8, 00168 Rome, Italy"},{"name":"Department of Medical and Surgical Sciences, UOC Gastroenterologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cammarota","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"},{"name":"Abdominal Surgery Unit, Department of Gastroenterological, Endocrine-Metabolic and Nephro-Urological Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, L. go A. Gemelli 8, 00168 Rome, Italy"},{"name":"Department of Medical and Surgical Sciences, UOC Gastroenterologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8334-7541","authenticated-orcid":false,"given":"Franco","family":"Scaldaferri","sequence":"additional","affiliation":[{"name":"IBD Unit, UOC CEMAD Centro Malattie dell\u2019Apparato Digerente, Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/codi.15995","article-title":"Prevalence of pouchitis in both ulcerative colitis and familial adenomatous polyposis: A systematic review and meta-analysis","volume":"24","author":"Sriranganathan","year":"2022","journal-title":"Color. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1053\/j.scrs.2017.05.002","article-title":"Incidence, prevalence, and risk factors for pouchitis","volume":"28","author":"Szeto","year":"2017","journal-title":"Semin. Colon Rectal Surg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Syal, G., Barnes, E., Raffals, L., Al Kazzi, E., Haydek, J., Agarwal, M., and Singh, S. (Am. J. Gastroenterol., 2024). Medical Therapies for Prevention and Treatment of Inflammatory Pouch Disorders\u2014A Systematic Review and Meta-analysis, Am. J. Gastroenterol., Online ahead of print.","DOI":"10.14309\/ajg.0000000000003136"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1159\/000441427","article-title":"Frequency, Clinical Features and Factors Associated with Pouchitis after Proctocolectomy with Ileo-Pouch-Anal Anastomosis in Patients with Ulcerative Colitis: A Latin-American Country Retrospective-Cohort Study","volume":"32","author":"Aguilar","year":"2015","journal-title":"Dig. Surg."},{"key":"ref_5","first-page":"352","article-title":"Dysbiosis in pouchitis: Evidence of unique microfloral patterns in pouch inflammation","volume":"5","author":"Komanduri","year":"2007","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"21460","DOI":"10.1002\/ibd.21460","article-title":"Distinct microbiome in pouchitis compared to healthy pouches in ulcerative colitis and familial adenomatous polyposis","volume":"17","author":"Zella","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"309398","DOI":"10.1136\/gutjnl-2015-309398","article-title":"Specific members of the predominant gut microbiota predict pouchitis following colectomy and IPAA in UC","volume":"66","author":"Machiels","year":"2017","journal-title":"Gut"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1053\/j.gastro.2020.12.030","article-title":"Single-Cell Transcriptional Survey of Ileal-Anal Pouch Immune Cells From Ulcerative Colitis Patients","volume":"160","author":"Devlin","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Puca, P., Capobianco, I., Coppola, G., Di Vincenzo, F., Trapani, V., Petito, V., Laterza, L., Pugliese, D., Lopetuso, L.R., and Scaldaferri, F. (2024). Cellular and Molecular Determinants of Biologic Drugs Resistance and Therapeutic Failure in Inflammatory Bowel Disease. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25052789"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10151-008-0395-9","article-title":"Differential expression of pro-inflammatory cytokines and a pro-apoptotic protein in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis","volume":"12","author":"Leal","year":"2008","journal-title":"Tech. Coloproctology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1097\/MIB.0000000000001129","article-title":"Intestinal Barrier Disruption in Ileal Pouchitis After Ileal Pouch-Anal Anastomosis in a Rat Model","volume":"23","author":"Li","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1159\/000503283","article-title":"A Polymorphism in Interleukin-1\u03b2 Gene Is Associated with the Development of Pouchitis in Japanese Patients with Ulcerative Colitis","volume":"102","author":"Okada","year":"2021","journal-title":"Digestion"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kasti, A.N., Katsas, K., Petsis, K., Lambrinou, S., Synodinou, K.D., Kapetani, A., Smart, L.K., Nikolaki, M.D., and Halvatsiotis, P. (2024). Is the Mediterranean Low Fodmap Diet Effective in Managing Irritable Bowel Syndrome Symptoms and Gut Microbiota? An Innovative Research Protocol. Nutrients, 16.","DOI":"10.3390\/nu16111592"},{"key":"ref_14","first-page":"e13066","article-title":"Evolution, adaptation, and new applications of the FODMAP diet","volume":"8","author":"Kasti","year":"2024","journal-title":"JGH Open Open Access J. Gastroenterol. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-3-031-58572-2_8","article-title":"Probiotics in the Treatment of Inflammatory Bowel Diseases","volume":"1449","author":"Guandalini","year":"2024","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Almeida, C., Oliveira, R., Baylina, P., Fernandes, R., Teixeira, F.G., and Barata, P. (2022). Current Trends and Challenges of Fecal Microbiota Transplantation\u2014An Easy Method That Works for All?. Biomedicines, 10.","DOI":"10.3390\/biomedicines10112742"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Duo, H., Yang, Y., Zhang, G., Chen, Y., Cao, Y., Luo, L., Pan, H., and Ye, Q. (2024). Comparative effectiveness of treatments for recurrent Clostridioides difficile infection: A network meta-analysis of randomized controlled trials. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1430724"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1136\/gutjnl-2023-329948","article-title":"The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease","volume":"72","author":"Lopetuso","year":"2023","journal-title":"Gut"},{"key":"ref_19","first-page":"342","article-title":"Update of the PANCCO clinical practice guidelines for the treatment of ulcerative colitis in the adult population","volume":"87","author":"Alfaro","year":"2022","journal-title":"Rev. Gastroenterol. Mex. Engl."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Masi, L., Ciuffini, C., Petito, V., Pisani, F.L., Lopetuso, L.R., Graziani, C., Pugliese, D., Laterza, L., Puca, P., and Di Vincenzo, F. (2022). Innovative, complementary and alternative therapy in inflammatory bowel diseases: A broad 2020s update. Front. Gastroenterol., 1.","DOI":"10.3389\/fgstr.2022.1022530"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12664-024-01537-x","article-title":"Antibiotics for inflammatory bowel disease: Current status","volume":"43","author":"Jha","year":"2024","journal-title":"Indian J. Gastroenterol. Off. J. Indian Soc. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/ibd\/izab209","article-title":"Long-term Antibiotic Treatment in Pouchitis-Patterns of Use and Safety","volume":"28","author":"Bar","year":"2022","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/MIB.0000000000001057","article-title":"Frequency and Risk Factors of Clostridium difficile Infection in Hospitalized Patients With Pouchitis: A Population-based Study","volume":"23","author":"Kistangari","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/ibd\/izac165","article-title":"Prevalence of Clostridioides difficile Infection After Ileal Pouch-anal Anastomosis in Patients with Chronic Antibiotic-dependent Pouchitis and Crohn\u2019s-like Disease of the Pouch","volume":"29","author":"Shore","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Panda, S., Panda, S., El khader, I., Casellas, F., L\u00f3pez Vivancos, J., Garc\u00eda Cors, M., Santiago, A., Cuenca, S., Guarner, F., and Manichanh, C. (2014). Short-term effect of antibiotics on human gut microbiota. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0095476"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1053\/j.gastro.2019.10.001","article-title":"Predominantly Antibiotic-resistant Intestinal Microbiome Persists in Patients With Pouchitis Who Respond to Antibiotic Therapy","volume":"158","author":"Dubinsky","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.1159\/000504750","article-title":"ncreased Quinolone-Resistant Mutations of gyrA and parC Genes after Pouchitis Treatment with Ciprofloxacin","volume":"37","author":"Fukushima","year":"2020","journal-title":"Dig. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1365-2036.2010.04401.x","article-title":"Extended spectrum beta-lactamase-producing bacteria and Clostridium difficile in patients with pouchitis","volume":"32","author":"McLaughlin","year":"2010","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/s41586-024-08095-4","article-title":"Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin","volume":"635","author":"Turner","year":"2024","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1080\/10408398.2021.2022595","article-title":"Effects of prebiotics, probiotics, and synbiotics on the infant gut microbiota and other health outcomes: A systematic review","volume":"63","author":"Ferro","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.3748\/wjg.v29.i14.2078","article-title":"Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives","volume":"29","author":"Roy","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/ueg2.12636","article-title":"Efficacy and safety of probiotics in IBD: An overview of systematic reviews and updated meta-analysis of randomized controlled trials","volume":"12","author":"Estevinho","year":"2024","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_33","first-page":"401","article-title":"The efficacy of probiotics on the prevention of pouchitis for patients after ileal pouch-anal anastomosis: A meta-analysis","volume":"31","author":"Xiao","year":"2023","journal-title":"Technol. Health Care Off. J. Eur. Soc. Eng. Med."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Tomasz, B., Zoran, S., Jaros\u0142aw, W., Ryszard, M., Marcin, G., Robert, B., Piotr, K., Lukasz, K., Jacek, P., and Piotr, G. (2014). Long-term use of probiotics Lactobacillus and Bifidobacterium has a prophylactic effect on the occurrence and severity of pouchitis: A randomized prospective study. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/208064"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3109\/00365521.2016.1161067","article-title":"Effect of probiotics (Lactobacillus plantarum 299 plus Bifidobacterium Cure 21) in patients with poor ileal pouch function: A randomised controlled trial","volume":"51","author":"Bengtsson","year":"2016","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2423037","DOI":"10.1080\/19490976.2024.2423037","article-title":"Oral administration of Lactobacillus casei DG\u00ae after ileostomy closure in restorative proctocolectomy: A randomized placebo-controlled trial (microbiota and immune microenvironment in pouchitis -MEP1)","volume":"16","author":"Angriman","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/S0016-5085(03)00171-9","article-title":"Prophylaxis of pouchitis onset with probiotic therapy: A double-blind, placebo-controlled trial","volume":"124","author":"Gionchetti","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/MEG.0000000000002362","article-title":"Network meta-analysis: Efficacy of treatment for acute, chronic, and prevention of pouchitis in ulcerative colitis","volume":"34","author":"Poo","year":"2022","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00595-015-1261-9","article-title":"The effect of Clostridium butyricum MIYAIRI on the prevention of pouchitis and alteration of the microbiota profile in patients with ulcerative colitis","volume":"46","author":"Yasueda","year":"2016","journal-title":"Surg. Today"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s10350-004-6257-2","article-title":"Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis","volume":"45","author":"Welters","year":"2002","journal-title":"Dis. Colon Rectum"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"125","DOI":"10.5603\/FHC.2012.0018","article-title":"Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis","volume":"50","author":"Banasiewicz","year":"2012","journal-title":"Folia Histochem. Cytobiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Xu, Y., Yu, Z., Li, S., Zhang, T., Zhu, F., and Gong, J. (2023). Pouchitis Is Associated with Paneth Cell Dysfunction and Ameliorated by Exogenous Lysosome in a Rat Model Undergoing Ileal Pouch Anal Anastomosis. Microorganisms, 11.","DOI":"10.3390\/microorganisms11122832"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Lopetuso, L.R., Laterza, L., Petito, V., Pecere, S., Quaranta, G., Del Chierico, F., Puca, P., Schiavoni, E., Napolitano, D., and Poscia, A. (2023). Serial Fecal Microbiota Infusions via Colonoscopy for Active Ulcerative Colitis: A Feasibility, Safety, and Translational Monocentric Italian Study. Microorganisms, 11.","DOI":"10.3390\/microorganisms11102536"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Karimi, M., Shirsalimi, N., Hashempour, Z., Salehi Omran, H., Sedighi, E., Beigi, F., and Mortezazadeh, M. (2024). Safety and efficacy of fecal microbiota transplantation (FMT) as a modern adjuvant therapy in various diseases and disorders: A comprehensive literature review. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1439176"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1701703","DOI":"10.1080\/07853890.2019.1701703","article-title":"Treatment of Clostridioides (Clostridium) difficile infection","volume":"52","author":"Jarmo","year":"2020","journal-title":"Ann. Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Feng, J., Chen, Y., Liu, Y., Lin, L., Lin, X., Gong, W., Xia, R., He, J., Sheng, J., and Cai, H. (2023). Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: A systematic review and meta-analysis. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-41182-6"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000497042","article-title":"Combined Endoscopic and Oral Fecal Microbiota Transplantation in Patients with Antibiotic-Dependent Pouchitis: Low Clinical Efficacy due to Low Donor Microbial Engraftment","volume":"4","author":"Herfarth","year":"2019","journal-title":"Inflamm. Intest. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1093\/ibd\/izab001","article-title":"Fecal Microbiota Transplantation in Chronic Pouchitis: A Randomized, Parallel, Double-Blinded Clinical Trial","volume":"27","author":"Karjalainen","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s10620-019-05715-2","article-title":"Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study","volume":"65","author":"Selvig","year":"2020","journal-title":"Dig. Dis. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/ecco-jcc\/jjad120","article-title":"Faecal Microbiota Transplantation [FMT] in the Treatment of Chronic Refractory Pouchitis: A Systematic Review and Meta-analysis","volume":"18","author":"Zaman","year":"2024","journal-title":"J. Crohns Colitis"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Deng, Z.L., Pieper, D.H., Stallmach, A., Steube, A., Vital, M., Reck, M., and Wagner-D\u00f6bler, I. (2023). Engraftment of essential functions through multiple fecal microbiota transplants in chronic antibiotic-resistant pouchitis-a case study using metatranscriptomics. Microbiome, 11.","DOI":"10.1186\/s40168-023-01713-9"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/00365521.2020.1748221","article-title":"Clinical results and microbiota changes after faecal microbiota transplantation for chronic pouchitis: A pilot study","volume":"55","author":"Kousgaard","year":"2020","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2295445","DOI":"10.1080\/19490976.2023.2295445","article-title":"Microbiota and mucosal gene expression of fecal microbiota transplantation or placebo treated patients with chronic pouchitis","volume":"16","author":"Hartikainen","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_54","first-page":"250","article-title":"Nutrition considerations surrounding restorative proctocolectomy","volume":"25","author":"Buckman","year":"2010","journal-title":"Nutr. Clin. Pract. Off. Publ. Am. Soc. Parenter. Enter. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Yan, J., Wang, L., Gu, Y., Hou, H., Liu, T., Ding, Y., and Cao, H. (2022). Dietary Patterns and Gut Microbiota Changes in Inflammatory Bowel Disease: Current Insights and Future Challenges. Nutrients, 14.","DOI":"10.3390\/nu14194003"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"9665","DOI":"10.3748\/wjg.v20.i29.9665","article-title":"Relationship between pouch microbiota and pouchitis following restorative proctocolectomy for ulcerative colitis","volume":"20","author":"Angriman","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Loy, L., Petronio, L., Marcozzi, G., Bezzio, C., and Armuzzi, A. (2024). Dietary Fiber in Inflammatory Bowel Disease: Are We Ready to Change the Paradigm?. Nutrients, 16.","DOI":"10.3390\/nu16081108"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.3748\/wjg.v19.i38.6458","article-title":"Diet of patients after pouch surgery may affect pouch inflammation","volume":"19","author":"Ianco","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/advances\/nmz061","article-title":"Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review","volume":"11","author":"Rohr","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"otad039","DOI":"10.1093\/crocol\/otad039","article-title":"Dietary Patterns Are Not Associated With Disease Activity Among Patients With Inflammatory Conditions of the Pouch in a Prospective Cohort","volume":"5","author":"Barnes","year":"2023","journal-title":"Crohns Colitis 360"},{"key":"ref_61","first-page":"2095","article-title":"Perceived dietary intolerances, habitual intake and diet quality of patients with an ileoanal pouch: Associations with pouch phenotype (and behaviour)","volume":"42","author":"Ardalan","year":"2023","journal-title":"Clin. Nutr. Edinb. Scotl."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/ecco-jcc\/jjz053","article-title":"Fruit Consumption is Associated with Alterations in Microbial Composition and Lower Rates of Pouchitis","volume":"13","author":"Godny","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/advances\/nmaa145","article-title":"Association of Dietary Fiber, Fruit, and Vegetable Consumption with Risk of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis","volume":"12","author":"Milajerdi","year":"2021","journal-title":"Adv. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/imj.13094","article-title":"Influence of food and lifestyle on the risk of developing inflammatory bowel disease","volume":"46","author":"Niewiadomski","year":"2016","journal-title":"Intern. Med. J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.3748\/wjg.v16.i34.4297","article-title":"Pre-illness changes in dietary habits and diet as a risk factor for inflammatory bowel disease: A case-control study","volume":"16","author":"Maconi","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1111\/j.1572-0241.2007.01411.x","article-title":"Imbalances in dietary consumption of fatty acids, vegetables, and fruits are associated with risk for Crohn\u2019s disease in children","volume":"102","author":"Amre","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1007\/s00384-020-03648-1","article-title":"Consumption of yoghurt favours remission after faecal microbiota transplantation for chronic pouchitis","volume":"35","author":"Kousgaard","year":"2020","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1002\/eji.201444876","article-title":"Human intestinal epithelial cells respond to \u03b2-glucans via Dectin-1 and Syk","volume":"44","author":"Baram","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/10408398.2010.499806","article-title":"Beta glucan: A valuable functional ingredient in foods","volume":"52","author":"Ahmad","year":"2012","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.carbpol.2017.02.030","article-title":"Potential of glucans as vaccine adjuvants: A review of the \u03b1-glucans case","volume":"165","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/ibd\/izy370","article-title":"Starch Consumption May Modify Antiglycan Antibodies and Fecal Fungal Composition in Patients With Ileo-Anal Pouch","volume":"25","author":"Goren","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0016-5085(91)90463-U","article-title":"The effect of elemental diet on intestinal permeability and inflammation in Crohn\u2019s disease","volume":"101","author":"Teahon","year":"1991","journal-title":"Gastroenterology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1365-2036.2000.00707.x","article-title":"Mucosal healing and a fall in mucosal pro-inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn\u2019s disease","volume":"14","author":"Jm","year":"2000","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.crohns.2012.07.009","article-title":"Exclusive elemental diet impacts on the gastrointestinal microbiota and improves symptoms in patients with chronic pouchitis","volume":"7","author":"McLaughlin","year":"2013","journal-title":"J. Crohns Colitis"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1053\/j.gastro.2023.11.303","article-title":"AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients With Inflammatory Bowel Disease: Expert Review","volume":"166","author":"Hashash","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_76","first-page":"1654","article-title":"The Effect of the Crohn\u2019s Disease Exclusion Diet on Patients With Pouch Inflammation: An Interventional Pilot Study","volume":"21","author":"Kornblum","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Andreo-L\u00f3pez, M.C., Contreras-Bol\u00edvar, V., Mu\u00f1oz-Torres, M., Garc\u00eda-Fontana, B., and Garc\u00eda-Fontana, C. (2023). Influence of the Mediterranean Diet on Healthy Aging. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054491"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1136\/gutjnl-2015-309957","article-title":"High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome","volume":"65","author":"Pellegrini","year":"2016","journal-title":"Gut"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/jcag\/gwad041","article-title":"Is the Mediterranean Diet in Inflammatory Bowel Diseases Ready for Prime Time?","volume":"7","author":"Godny","year":"2024","journal-title":"J. Can. Assoc. Gastroenterol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/MCO.0000000000000872","article-title":"The anti-inflammatory effects of a Mediterranean diet: A review","volume":"25","author":"Itsiopoulos","year":"2022","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Arp\u00f3n, A., Milagro, F.I., Razquin, C., Corella, D., Estruch, R., Fit\u00f3, M., Marti, A., Mart\u00ednez-Gonz\u00e1lez, M.A., Ros, E., and Salas-Salvad\u00f3, J. (2017). Impact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids. Nutrients, 10.","DOI":"10.3390\/nu10010015"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Jab\u0142o\u0144ska, B., and Mrowiec, S. (2023). Nutritional Status and Its Detection in Patients with Inflammatory Bowel Diseases. Nutrients, 15.","DOI":"10.3390\/nu15081991"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1007\/s00394-019-02158-3","article-title":"Adherence to the Mediterranean diet is associated with decreased fecal calprotectin in patients with ulcerative colitis after pouch surgery","volume":"59","author":"Godny","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1002\/ibd.20249","article-title":"Pilot study on the effect of reducing dietary FODMAP intake on bowel function in patients without a colon","volume":"13","author":"Croagh","year":"2007","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Comeche, J.M., Gutierrez-Herv\u00e1s, A., Tuells, J., Altavilla, C., and Caballero, P. (2020). Predefined Diets in Patients with Inflammatory Bowel Disease: Systematic Review and Meta-Analysis. Nutrients, 13.","DOI":"10.3390\/nu13010052"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1038\/ctg.2016.22","article-title":"Consistent Prebiotic Effect on Gut Microbiota With Altered FODMAP Intake in Patients with Crohn\u2019s Disease: A Randomised, Controlled Cross-Over Trial of Well-Defined Diets","volume":"7","author":"Halmos","year":"2016","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/jhn.12706","article-title":"The long-term effect and adherence of a low fermentable oligosaccharides disaccharides monosaccharides and polyols (FODMAP) diet in patients with irritable bowel syndrome","volume":"33","author":"Weynants","year":"2020","journal-title":"J. Hum. Nutr. Diet. Off. J. Br. Diet. Assoc."},{"key":"ref_88","first-page":"942","article-title":"A novel Monash Pouch diet in patients with an ileoanal pouch is tolerable and has favorable metabolic luminal effects","volume":"7","author":"Zs","year":"2023","journal-title":"JGH Open Open Access J. Gastroenterol. Hepatol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking long-term dietary patterns with gut microbial enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1136\/gutjnl-2022-327811","article-title":"Faecal microbiota transplantation with anti-inflammatory diet (FMT-AID) followed by anti-inflammatory diet alone is effective in inducing and maintaining remission over 1 year in mild to moderate ulcerative colitis: A randomised controlled trial","volume":"71","author":"Kedia","year":"2022","journal-title":"Gut"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.clnesp.2022.04.006","article-title":"Exclusive enteral nutrition practices in the management of Crohn\u2019s disease: A cross sectional survey of specialist paediatric dietitians","volume":"49","author":"Jackman","year":"2022","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.ajcnut.2023.12.027","article-title":"Gut Metabolome and Microbiota Signatures Predict Response to Treatment with Exclusive Enteral Nutrition in a Prospective Study in Children with Active Crohn\u2019s Disease","volume":"119","author":"Nichols","year":"2024","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"otad077","DOI":"10.1093\/crocol\/otad077","article-title":"Diet and Nutrition in Inflammatory Bowel Disease: A Review of the Literature","volume":"6","author":"Manski","year":"2024","journal-title":"Crohns Colitis"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/24\/4337\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:53:14Z","timestamp":1760115194000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/24\/4337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":94,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["nu16244337"],"URL":"https:\/\/doi.org\/10.3390\/nu16244337","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,16]]}}}