{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:30:31Z","timestamp":1764937831989,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2503103"],"award-info":[{"award-number":["2022YFC2503103"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Objectives: We aimed to explore the possible effects of Kashin\u2013Beck disease (KBD) on the risk of sarcopenia and its possible interaction in the association between the risk of sarcopenia and element concentration. Methods: This cross-sectional study was conducted among individuals 18\u201375 years old in Qamdo, a KBD-endemic area. All individuals received physical and radiological examinations before recruitment. Patients with KBD were enrolled in the KBD group based on a diagnosis of national criteria WS\/T 207-2010. Healthy individuals without KBD were enrolled in the non-KBD group. Participants with a history of element supplements, other severe musculoskeletal diseases, or organ dysfunctions were excluded. We adopted WOMAC scores for the assessment of musculoskeletal conditions and SARC-F scores for the risk of sarcopenia. Patients with SARC-F \u2265 4 were at risk of sarcopenia. Serum element concentrations were analyzed by inductively coupled plasma mass spectrometry. Dose\u2013relationship effects of clinical scores and element concentrations on the risk of sarcopenia were determined in correlation analysis. Risk factors were identified using univariate and multivariate regression. Statistical analysis was conducted using R software. Results: A total of 65 patients with KBD and 38 participants without KBD were enrolled in the analysis. After propensity score matching, population characteristics were comparable in the two groups, and the incidence of SARC-F \u2265 4 was determined to be higher in the KBD group (p = 0.002). The WOMAC scores were correlated with SARC-F scores in the KBD group (p &lt; 0.001) and non-KBD (p &lt; 0.001) group, respectively. Further analysis proved that KBD was the independent risk factor for the risk of sarcopenia (p = 0.014). Moreover, high Selenium concentrations were associated with a low risk of sarcopenia in the non-KBD group (p = 0.047), while this association was not observed in the KBD group (p = 0.239). Conclusions: KBD as an independent risk factor increased the risk of sarcopenia for patients. Although high Se concentration was associated with a low risk of sarcopenia in participants without KBD, this association was not observed in those with KBD.<\/jats:p>","DOI":"10.3390\/nu16244343","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T12:09:28Z","timestamp":1734350968000},"page":"4343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Kashin\u2013Beck Disease: A Risk Factor for Sarcopenia and Its Interaction with Selenium"],"prefix":"10.3390","volume":"16","author":[{"given":"Haotian","family":"Wu","sequence":"first","affiliation":[{"name":"Peking University Arthritis Clinic and Research Center, Peking University People\u2019s Hospital, Xicheng, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University Arthritis Clinic and Research Center, Peking University People\u2019s Hospital, Xicheng, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ou","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Element Nutrition of National Health Commission of People\u2019s Republic of China, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Xicheng, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5072-1522","authenticated-orcid":false,"given":"Tong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Element Nutrition of National Health Commission of People\u2019s Republic of China, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Xicheng, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6165-2182","authenticated-orcid":false,"given":"Jian","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Element Nutrition of National Health Commission of People\u2019s Republic of China, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Xicheng, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Food and Drug, Shenzhen Polytechnic University, No. 7098 Liuxian Avenue, Nanshan, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1830-9244","authenticated-orcid":false,"given":"Jianhao","family":"Lin","sequence":"additional","affiliation":[{"name":"Peking University Arthritis Clinic and Research Center, Peking University People\u2019s Hospital, Xicheng, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1007\/s12011-022-03417-x","article-title":"The Prevalence of Kashin-Beck Disease in China: A Systematic Review and Meta-analysis","volume":"201","author":"Xu","year":"2023","journal-title":"Biol. 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