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Objective: HEMEO was formulated for applications in intestinal motility disorders. Methods: HEMEO was evaluated for spontaneous and induced motility effects in isolated guinea pig ileum, colon, and stomach. Ex vivo experiments were conducted using LabChart software v7.0, and the product\u2019s antibacterial action against Helicobacter pylori and its antioxidant effects were assessed through disc diffusion and FRAP assays. The presence of the volatile compounds in the formulation was confirmed by GC-MS analysis; the TPC of HEMEO, determined using the Folin\u2013Ciocalteu method, was 9.925 \u00b1 0.42 mg GAE\/g. Conclusions: HEMEO showed a phenolic content correlated with its antioxidant potential and in addition inhibited H. pylori growth and demonstrated notable antioxidant properties, suggesting its role as a supportive agent in digestive processes and in managing motility disorders.<\/jats:p>","DOI":"10.3390\/nu16244357","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T03:40:56Z","timestamp":1734493256000},"page":"4357","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Herbal Extracts Mixed with Essential Oils: A Network Approach for Gastric and Intestinal Motility Disorders"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-9740","authenticated-orcid":false,"given":"Roberta","family":"Budriesi","sequence":"first","affiliation":[{"name":"Food Chemistry and Nutraceutical Laboratory, Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2078-1978","authenticated-orcid":false,"given":"Ivan","family":"Corazza","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Roncioni","sequence":"additional","affiliation":[{"name":"Valsambro S.r.l., 40121 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Scanferlato","sequence":"additional","affiliation":[{"name":"Valsambro S.r.l., 40121 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalila","family":"De Luca","sequence":"additional","affiliation":[{"name":"Valsambro S.r.l., 40121 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Marzetti","sequence":"additional","affiliation":[{"name":"Valsambro S.r.l., 40121 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-2248","authenticated-orcid":false,"given":"Roberto","family":"Gotti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9294-7116","authenticated-orcid":false,"given":"Nicola","family":"Rizzardi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Irnerio 48, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4387-5117","authenticated-orcid":false,"given":"Christian","family":"Bergamini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Irnerio 48, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-1531","authenticated-orcid":false,"given":"Matteo","family":"Micucci","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, University of Urbino \u201cCarlo Bo\u201d, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6923-6087","authenticated-orcid":false,"given":"Davide","family":"Roncarati","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Selmi 3, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Beatrice","family":"Mattioli","sequence":"additional","affiliation":[{"name":"Food Chemistry and Nutraceutical Laboratory, Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/wsbm.19","article-title":"Gastrointestinal System","volume":"2","author":"Cheng","year":"2010","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e14560","DOI":"10.1111\/nmo.14560","article-title":"Functional and Anatomical Gastric Regions and Their Relations to Motility Control","volume":"35","author":"Athavale","year":"2023","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejps.2016.08.060","article-title":"The Dynamic Gastric Environment and Its Impact on Drug and Formulation Behaviour","volume":"96","author":"Rubbens","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_4","first-page":"895","article-title":"Gastrointestinal Motility Disorders","volume":"53","author":"Abell","year":"1996","journal-title":"Am. Fam. Physician"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000505810","article-title":"The Brain-Gut Team","volume":"38","author":"Malagelada","year":"2020","journal-title":"Dig. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1097\/MOG.0b013e32833ece1e","article-title":"Gastroduodenal Motility","volume":"26","author":"Tack","year":"2010","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.mayocp.2018.04.032","article-title":"Management Options for Irritable Bowel Syndrome","volume":"93","author":"Camilleri","year":"2018","journal-title":"Mayo Clin. Proc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1136\/gutjnl-2014-307595","article-title":"The Stomach in Health and Disease","volume":"64","author":"Hunt","year":"2015","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/jgh.15032","article-title":"Marshall and Warren Lecture 2019: A Paradigm Shift in Pathophysiological Basis of Irritable Bowel Syndrome and Its Implication on Treatment","volume":"35","author":"Ghoshal","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e12403","DOI":"10.1111\/hel.12403","article-title":"Epidemiology of Helicobacter Pylori Infection","volume":"22","author":"Burucoa","year":"2017","journal-title":"Helicobacter"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.3748\/wjg.v24.i29.3204","article-title":"Helicobacter Pylori and Extragastric Diseases: A Review","volume":"24","author":"Gravina","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.metabol.2018.06.008","article-title":"Potential Impact of Helicobacter Pylori-Related Metabolic Syndrome on Upper and Lower Gastrointestinal Tract Oncogenesis","volume":"87","author":"Kountouras","year":"2018","journal-title":"Metabolism"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.3748\/wjg.v29.i30.4604","article-title":"Immune Response Modulation in Inflammatory Bowel Diseases by Helicobacter Pylori Infection","volume":"29","author":"Teixeira","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10812-021-01156-w","article-title":"Synergistic Interactions of Phytochemicals in Polyherbal Formulation Enhance the Chemical Transformations of Active Constituents","volume":"88","author":"Sulaiman","year":"2021","journal-title":"J. Appl. Spectrosc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/ptr.8163","article-title":"Long COVID-19 Gastrointestinal Related Disorders and Traditional Chinese Medicine: A Network Target-Based Approach","volume":"38","author":"Mattioli","year":"2024","journal-title":"Phytother. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"115319","DOI":"10.1016\/j.jep.2022.115319","article-title":"Jawarish Shahi: A Special Dosage Form of Herbal Formulations for Functional Gastrointestinal Disorders in Unani Medicine\u2014A Comprehensive Review","volume":"293","author":"Mobeen","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_17","first-page":"e20230003","article-title":"Exploring Novel Herbal Compounds and Formulations for Inflammatory Bowel Disease (IBD) Management","volume":"39","author":"Dubey","year":"2023","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.2174\/0113892010261502231102040149","article-title":"Systematic Review on Herbal Preparations for Controlling Visceral Hypersensitivity in Functional Gastrointestinal Disorders","volume":"25","author":"Lashgari","year":"2024","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Singh, R., Zogg, H., Ghoshal, U.C., and Ro, S. (2022). Current Treatment Options and Therapeutic Insights for Gastrointestinal Dysmotility and Functional Gastrointestinal Disorders. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.808195"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Zhang, R., Zhu, X., Bai, H., and Ning, K. (2019). Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00123"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3920\/BM2010.0033","article-title":"Antibacterial Activity of Selected Medicinal Plants against Multiple Antibiotic Resistant Uropathogens: A Study from Kolli Hills, Tamil Nadu, India","volume":"2","author":"Narayanan","year":"2011","journal-title":"Benef. Microbes"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2007.01.001","article-title":"Asparagus Racemosus--Ethnopharmacological Evaluation and Conservation Needs","volume":"110","author":"Bopana","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/(SICI)1099-1573(200003)14:2<118::AID-PTR493>3.0.CO;2-P","article-title":"Evaluation of Antibacterial Activity of Asparagus Racemosus Willd. Root","volume":"14","author":"Mandal","year":"2000","journal-title":"Phytother. Res."},{"key":"ref_24","first-page":"1173","article-title":"Antiulcerogenic Activity of Satavari Mandur--an Ayurvedic Herbo-Mineral Preparation","volume":"40","author":"Datta","year":"2002","journal-title":"Indian. J. Exp. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/J157v06n01_02","article-title":"Antisecretory and Antiulcer Activity of Asparagus Racemosus Willd. against Indomethacin plus Phyloric Ligation-Induced Gastric Ulcer in Rats","volume":"6","author":"Bhatnagar","year":"2006","journal-title":"J. Herb. Pharmacother."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1196\/annals.1352.027","article-title":"Antiulcer and Antioxidant Activity of Asparagus Racemosus Willd and Withania Somnifera Dunal in Rats","volume":"1056","author":"Bhatnagar","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_27","first-page":"39","article-title":"Anti-Diarrhoeal Potential of Asparagus Racemosus Wild Root Extracts in Laboratory Animals","volume":"8","author":"Venkatesan","year":"2005","journal-title":"J. Pharm. Pharm. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jep.2008.05.013","article-title":"Antiulcerogenic Activity of Bark Extract of Tabebuia Avellanedae, Lorentz Ex Griseb","volume":"118","author":"Twardowschy","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.2042-7158.1987.tb06962.x","article-title":"Effect of Lapachol, a Naphthaquinone Isolated from Tectona Grandis, on Experimental Peptic Ulcer and Gastric Secretion","volume":"39","author":"Goel","year":"1987","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_30","first-page":"119","article-title":"Liquorice and Hypertension","volume":"63","year":"2005","journal-title":"Neth. J. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/ptr.2660","article-title":"Isoliquiritigenin, a Flavonoid from Licorice, Plays a Dual Role in Regulating Gastrointestinal Motility in Vitro and in Vivo","volume":"23","author":"Chen","year":"2009","journal-title":"Phytother. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/1541-4337.12549","article-title":"Antivirulence Properties and Related Mechanisms of Spice Essential Oils: A Comprehensive Review","volume":"19","author":"Zhang","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1099\/mic.0.061127-0","article-title":"Sensitivity of Pathogenic and Commensal Bacteria from the Human Colon to Essential Oils","volume":"158","author":"Thapa","year":"2012","journal-title":"Microbiology"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Badgujar, S.B., Patel, V.V., and Bandivdekar, A.H. (2014). Foeniculum Vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology. Biomed. Res. Int., 2014.","DOI":"10.1155\/2014\/842674"},{"key":"ref_35","first-page":"65","article-title":"Antibacterial Activity of Some Plants from Family Apiaceae in Relation to Selected Phytopathogenic Bacteria","volume":"28","year":"2006","journal-title":"Kragujev. J. Sci."},{"key":"ref_36","first-page":"4364","article-title":"Composition and Antimicrobial Properties of Essential Oil of Foeniculum Vulgare","volume":"7","author":"Gulfraz","year":"2008","journal-title":"Afr. J. Biotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0367-326X(03)00028-5","article-title":"Hepatoprotective Effect of Foeniculum Vulgare Essential Oil","volume":"74","author":"Ozbek","year":"2003","journal-title":"Fitoterapia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbrc.2016.02.078","article-title":"Anethole Restores Delayed Gastric Emptying and Impaired Gastric Accommodation in Rodents","volume":"472","author":"Asano","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.lfs.2018.12.010","article-title":"Water-Soluble Ru(II)-Anethole Compounds with Promising Cytotoxicity toward the Human Gastric Cancer Cell Line AGS","volume":"217","author":"Carrillo","year":"2019","journal-title":"Life Sci."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zhao, H., Ren, S., Yang, H., Tang, S., Guo, C., Liu, M., Tao, Q., Ming, T., and Xu, H. (2022). Peppermint Essential Oil: Its Phytochemistry, Biological Activity, Pharmacological Effect and Application. Biomed. Pharmacother., 154.","DOI":"10.1016\/j.biopha.2022.113559"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s11894-017-0601-x","article-title":"Medicinal Foods for Functional GI Disorders","volume":"19","author":"Acker","year":"2017","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Dumitrescu, E., Muselin, F., T\u00eerziu, E., Folescu, M., Dumitrescu, C.S., Orboi, D.M., and Cristina, R.T. (2023). Pimpinella Anisum L. Essential Oil a Valuable Antibacterial and Antifungal Alternative. Plants, 12.","DOI":"10.3390\/plants12132428"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Wang, Y., and Minden, A. (2022). Current Molecular Combination Therapies Used for the Treatment of Breast Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911046"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Mattioli, L.B., Corazza, I., Budriesi, R., Hrelia, S., Malaguti, M., Caliceti, C., Amoroso, R., Maccallini, C., Crupi, P., and Clodoveo, M.L. (2024). From Waste to Health: Olive Mill Wastewater for Cardiovascular Disease Prevention. Nutrients, 16.","DOI":"10.3390\/nu16172986"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Cavalluzzi, M.M., Lamonaca, A., Rotondo, N.P., Miniero, D.V., Muraglia, M., Gabriele, P., Corbo, F., De Palma, A., Budriesi, R., and De Angelis, E. (2022). Microwave-Assisted Extraction of Bioactive Compounds from Lentil Wastes: Antioxidant Activity Evaluation and Metabolomic Characterization. Molecules, 27.","DOI":"10.3390\/molecules27217471"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1089\/jmf.2015.0072","article-title":"Hibiscus Sabdariffa L. Flowers and Olea Europea L. Leaves Extract-Based Formulation for Hypertension Care: In Vitro Efficacy and Toxicological Profile","volume":"19","author":"Micucci","year":"2016","journal-title":"J. Med. Food"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ejmech.2016.05.046","article-title":"Synthesis, Antiarrhythmic Activity, and Toxicological Evaluation of Mexiletine Analogues","volume":"121","author":"Roselli","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e2300116","DOI":"10.1002\/ardp.202300116","article-title":"hERG Stereoselective Modulation by Mexiletine-Derived Ureas: Molecular Docking Study, Synthesis, and Biological Evaluation","volume":"356","author":"Milani","year":"2023","journal-title":"Arch. Pharm."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Mattioli, L.B., Frosini, M., Amoroso, R., Maccallini, C., Chiano, E., Aldini, R., Urso, F., Corazza, I., Micucci, M., and Budriesi, R. (2022). Olea Europea L. Leaves and Hibiscus Sabdariffa L. Petals Extracts: Herbal Mix from Cardiovascular Network Target to Gut Motility Dysfunction Application. Nutrients, 14.","DOI":"10.3390\/nu14030463"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.drudis.2021.08.008","article-title":"Histamine 2 Receptors in Cardiovascular Biology: A Friend for the Heart","volume":"27","author":"Saheera","year":"2022","journal-title":"Drug Discov. Today"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Tallarida, R.J., and Murray, R.B. (1987). Mean, Standard Deviation, and Confidence Limits. Manual of Pharmacologic Calculations: With Computer Programs, Springer.","DOI":"10.1007\/978-1-4612-4974-0_3"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Motulsky, H., and Christopoulos, A. (2004). Fitting Models to Biological Data Using Linear and Nonlinear Regression: A Practical Guide to Curve Fitting, Oxford University Press.","DOI":"10.1093\/oso\/9780195171792.001.0001"},{"key":"ref_53","unstructured":"Motulsky, H.J. (2007). Prism 5 Statistics Guide, GraphPad Software Inc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jpha.2015.11.005","article-title":"Methods for in Vitro Evaluating Antimicrobial Activity: A Review","volume":"6","author":"Balouiri","year":"2016","journal-title":"J. Pharm. Anal."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The Ferric Reducing Ability of Plasma (FRAP) as a Measure of \u201cAntioxidant Power\u201d: The FRAP Assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal. Biochem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/14786410701424667","article-title":"Essential Oil Composition of Pimpinella Anisum L. Fruits from Various European Countries","volume":"22","author":"Orav","year":"2008","journal-title":"Nat. Prod. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1080\/14786419.2010.535154","article-title":"Essential Oil Composition of Foeniculum Vulgare Mill. Fruits from Pharmacies in Different Countries","volume":"26","author":"Raal","year":"2012","journal-title":"Nat. Prod. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1080\/00032719.2013.834444","article-title":"Determination of Estragole in Fennel Herbal Teas by HS-SPME and GC\u2013MS","volume":"47","author":"Basaglia","year":"2014","journal-title":"Anal. Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1365\/s10337-010-1735-2","article-title":"HS\u2013SPME\u2013GC\u2013MS for the Quantitation and Chiral Characterization of Camphor and Menthol in Creams","volume":"72","author":"Fiori","year":"2010","journal-title":"Chromatographia"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Curci, F., Corbo, F., Clodoveo, M.L., Salvagno, L., Rosato, A., Corazza, I., Budriesi, R., Micucci, M., and Mattioli, L.B. (2022). Polyphenols from Olive-Mill Wastewater and Biological Activity: Focus on Irritable Bowel Syndrome. Nutrients, 14.","DOI":"10.3390\/nu14061264"},{"key":"ref_61","first-page":"1001","article-title":"Molecular Properties of the Histamine H2-Receptor. Covalent Inhibition by Tetraamine Disulfides","volume":"45","author":"Chiarini","year":"1990","journal-title":"Farmaco"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1080\/14786419.2010.501763","article-title":"In Vitro Antibacterial Activity of Some Iranian Medicinal Plant Extracts against Helicobacter Pylori","volume":"25","author":"Hajimahmoodi","year":"2011","journal-title":"Nat. Prod. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0378-8741(99)00054-9","article-title":"Cinnamon Extracts\u2019 Inhibitory Effect on Helicobacter Pylori","volume":"67","author":"Tabak","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3109\/13880209.2013.853811","article-title":"Anti-Helicobactor Pylori Activity of Some Jordanian Medicinal Plants","volume":"52","author":"Masadeh","year":"2014","journal-title":"Pharm. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ngnameko, C.R., Marchetti, L., Zambelli, B., Quotadamo, A., Roncarati, D., Bertelli, D., Njayou, F.N., Smith, S.I., Moundipa, P.F., and Costi, M.P. (2020). New Insights into Bioactive Compounds from the Medicinal Plant Spathodea Campanulata P. Beauv. and Their Activity against Helicobacter Pylori. Antibiotics, 9.","DOI":"10.3390\/antibiotics9050258"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0024-3205(02)01864-7","article-title":"Anti-Helicobacter Pylori Flavonoids from Licorice Extract","volume":"71","author":"Fukai","year":"2002","journal-title":"Life Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.2174\/13816128113199990572","article-title":"Gastrointestinal Motility and Functional Gastrointestinal Diseases","volume":"20","author":"Kusano","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrgastro.2012.168","article-title":"Regulation of Gastrointestinal Motility\u2014Insights from Smooth Muscle Biology","volume":"9","author":"Sanders","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Hildebrand, F., Ebersbach, T., Nielsen, H.B., Li, X., Sonne, S.B., Bertalan, M., Dimitrov, P., Madsen, L., Qin, J., and Wang, J. (2012). A Comparative Analysis of the Intestinal Metagenomes Present in Guinea Pigs (Cavia porcellus) and Humans (Homo sapiens). BMC Genom., 13.","DOI":"10.1186\/1471-2164-13-514"},{"key":"ref_70","first-page":"G349","article-title":"Effect of Trimebutine on Intestinal Motility and Plasma Motilin in the Dog","volume":"251","author":"Poitras","year":"1986","journal-title":"Am. J. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/cmdc.202000692","article-title":"Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities","volume":"16","author":"Carocci","year":"2021","journal-title":"ChemMedChem"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.2174\/092986711797535173","article-title":"1,4-Dihydropyridine Scaffold in Medicinal Chemistry, the Story so Far and Perspectives (Part 1): Action in Ion Channels and GPCRs","volume":"18","author":"Ioan","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/030006059902700501","article-title":"Otilonium Bromide: A Selective Spasmolytic for the Gastrointestinal Tract","volume":"27","author":"Evangelista","year":"1999","journal-title":"J. Int. Med. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2982.2004.00517.x","article-title":"Otilonium Bromide Inhibits Calcium Entry through L-Type Calcium Channels in Human Intestinal Smooth Muscle","volume":"16","author":"Strege","year":"2004","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00384-012-1598-0","article-title":"IBS and the Role of Otilonium Bromide","volume":"28","author":"Boeckxstaens","year":"2013","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Korecka, A., and Arulampalam, V. (2012). The Gut Microbiome: Scourge, Sentinel or Spectator?. J. Oral. Microbiol., 4.","DOI":"10.3402\/jom.v4i0.9367"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1742-7843.2005.pto960202.x","article-title":"Gastric Juice: A Barrier against Infectious Diseases","volume":"96","author":"Martinsen","year":"2005","journal-title":"Basic. Clin. Pharmacol. Toxicol."},{"key":"ref_78","first-page":"13B","article-title":"Role of Bacterial Overgrowth in the Stomach as an Additional Risk Factor for Gastritis","volume":"17","author":"Naylor","year":"2003","journal-title":"Can. J. Gastroenterol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Reyes, V.E. (2023). Helicobacter Pylori and Its Role in Gastric Cancer. Microorganisms, 11.","DOI":"10.3390\/microorganisms11051312"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0140-6736(02)07273-2","article-title":"Role of Helicobacter Pylori Infection and Non-Steroidal Anti-Inflammatory Drugs in Peptic-Ulcer Disease: A Meta-Analysis","volume":"359","author":"Huang","year":"2002","journal-title":"Lancet"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"25","DOI":"10.15430\/JCP.2015.20.1.25","article-title":"Review of Atrophic Gastritis and Intestinal Metaplasia as a Premalignant Lesion of Gastric Cancer","volume":"20","author":"Park","year":"2015","journal-title":"J. Cancer Prev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.3748\/wjg.v20.i18.5283","article-title":"Treatment of Helicobacter Pylori Infection: Current Status and Future Concepts","volume":"20","author":"Yang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/ptr.1640","article-title":"Antibacterial Effect of Plant Extracts against Helicobacter Pylori","volume":"19","author":"Nostro","year":"2005","journal-title":"Phytother. Res."},{"key":"ref_84","first-page":"31","article-title":"Inhibition by the Essential Oils of Peppermint and Spearmint of the Growth of Pathogenic Bacteria","volume":"106","author":"Imai","year":"2001","journal-title":"Microbios"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4103\/japtr.JAPTR_11_17","article-title":"African Peppermint (Mentha Piperita) from Morocco: Chemical Composition and Antimicrobial Properties of Essential Oil","volume":"8","author":"Marwa","year":"2017","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Alomar, H.A., Fathallah, N., Abdel-Aziz, M.M., Ibrahim, T.A., and Elkady, W.M. (2022). GC-MS Profiling, Anti-Helicobacter Pylori, and Anti-Inflammatory Activities of Three Apiaceous Fruits\u2019 Essential Oils. Plants, 11.","DOI":"10.3390\/plants11192617"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"105594","DOI":"10.1016\/j.micpath.2022.105594","article-title":"A New Approach against Helicobacter Pylori Using Plants and Its Constituents: A Review Study","volume":"168","author":"Sathianarayanan","year":"2022","journal-title":"Microb. Pathog."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/ptr.5893","article-title":"Toxicological Effects of Glycyrrhiza Glabra (Licorice): A Review","volume":"31","author":"Nazari","year":"2017","journal-title":"Phytother. Res."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Wahab, S., Annadurai, S., Abullais, S.S., Das, G., Ahmad, W., Ahmad, M.F., Kandasamy, G., Vasudevan, R., Ali, M.S., and Amir, M. (2021). Glycyrrhiza Glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology. Plants, 10.","DOI":"10.3390\/plants10122751"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/futurepharmacol2010001","article-title":"Exploring the Pharmacological Potential of Glycyrrhizic Acid: From Therapeutic Applications to Trends in Nanomedicine","volume":"2","year":"2022","journal-title":"Future Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1002\/ijc.33379","article-title":"Calcium Channel Blockers Are Associated with Lower Gastric Cancer Risk: A Territory-Wide Study with Propensity Score Analysis","volume":"148","author":"Li","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.2174\/092986712802884204","article-title":"1,4-Dihydropyridine Scaffold in Medicinal Chemistry, The Story So Far And Perspectives (Part 2): Action in Other Targets and Antitargets","volume":"19","author":"Carosati","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10534-020-00271-z","article-title":"The Antibacterial and Antihemolytic Activities Assessment of Zinc Oxide Nanoparticles Synthesized Using Plant Extracts and Gamma Irradiation against the Uro-Pathogenic Multidrug Resistant Proteus Vulgaris","volume":"34","author":"Salem","year":"2021","journal-title":"Biometals"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/ics.12098","article-title":"In vitro anti-Malassezia activity and potential use in anti-dandruff formulation of Asparagus racemosus","volume":"36","author":"Onlom","year":"2014","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.20546\/ijcmas.2017.611.144","article-title":"Pharmacological Profile of Asparagus Racemosus: A Review","volume":"6","author":"Shaha","year":"2017","journal-title":"Int. J. Curr. Microbiol. Appl. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1080\/14786419.2015.1092148","article-title":"Asparagus Racemosus: A Review on Its Phytochemical and Therapeutic Potential","volume":"30","author":"Singh","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"ref_97","first-page":"51","article-title":"Treatment of chronic colitis with an herbal combination of Taraxacum officinale, Hipericum perforatum, Melissa officinaliss, Calendula officinalis and Foeniculum vulgare","volume":"20","author":"Matev","year":"1981","journal-title":"Vutr. Boles."},{"key":"ref_98","first-page":"450","article-title":"In-Vitro Cytoprotection Activity of Foeniculum Vulgare and Helicteres Isora in Cultured Human Blood Lymphocytes and Antitumour Activity against B16F10 Melanoma Cell Line","volume":"1","author":"Pradhan","year":"2008","journal-title":"Res. J. Pharm. Technol."},{"key":"ref_99","unstructured":"(2024, October 30). Tabebuia\u2014An Overview|ScienceDirect Topics. Available online: https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/tabebuia."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Kalpoutzakis, E., Chatzimitakos, T., Athanasiadis, V., Mitakou, S., Aligiannis, N., Bozinou, E., Gortzi, O., Skaltsounis, L.A., and Lalas, S.I. (2023). Determination of the Total Phenolics Content and Antioxidant Activity of Extracts from Parts of Plants from the Greek Island of Crete. Plants, 12.","DOI":"10.3390\/plants12051092"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.disamonth.2009.05.001","article-title":"Herbal Toxicity","volume":"55","author":"Tovar","year":"2009","journal-title":"Dis. Mon."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/bcp.12586","article-title":"Quality and Safety of Herbal Medical Products: Regulation and the Need for Quality Assurance along the Value Chains","volume":"80","author":"Heinrich","year":"2015","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.cnur.2020.06.015","article-title":"Clinical Aromatherapy","volume":"55","author":"Farrar","year":"2020","journal-title":"Nurs. Clin. North. Am."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","article-title":"Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Leri, M., Scuto, M., Ontario, M.L., Calabrese, V., Calabrese, E.J., Bucciantini, M., and Stefani, M. (2020). Healthy Effects of Plant Polyphenols: Molecular Mechanisms. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041250"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yrtph.2016.01.004","article-title":"Assessing Natural Product-Drug Interactions: An End-to-End Safety Framework","volume":"76","author":"Roe","year":"2016","journal-title":"Regul. Toxicol. Pharmacol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/24\/4357\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:54:11Z","timestamp":1760115251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/24\/4357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":106,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["nu16244357"],"URL":"https:\/\/doi.org\/10.3390\/nu16244357","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,17]]}}}