{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:06:35Z","timestamp":1782471995084,"version":"3.54.5"},"reference-count":188,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: There is scattered information in the scientific literature regarding the characterization of probiotic bacteria found in fermented milk beverages and the beneficial effects of probiotic bacteria on human health. Our objective was to gather the available information on the use of probiotic bacteria in the prevention of civilization diseases, with a special focus on the prevention of obesity, diabetes, and cancer. Methods: We carried out a literature review including the following keywords, either individually or collectively: lactic acid bacteria; probiotic bacteria; obesity; lactose intolerance; diabetes; cancer protection; civilization diseases; intestinal microbiota; intestinal pathogens. Results: This review summarizes the current state of knowledge on the use of probiotic bacteria in the prevention of civilization diseases. Probiotic bacteria are a set of living microorganisms that, when administered in adequate amounts, exert a beneficial effect on the health of the host and allow for the renewal of the correct quantitative and qualitative composition of the microbiota. Probiotic bacteria favorably modify the composition of the intestinal microbiota, inhibit the development of intestinal pathogens, prevent constipation, strengthen the immune system, and reduce symptoms of lactose intolerance. As fermented milk beverages are an excellent source of probiotic bacteria, their regular consumption can be a strong point in the prevention of various types of civilization diseases. Conclusions: The presence of lactic acid bacteria, including probiotic bacteria in fermented milk beverages, reduces the incidence of obesity and diabetes and serves as a tool in the prevention of cancer diseases.<\/jats:p>","DOI":"10.3390\/nu17010009","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T09:48:58Z","timestamp":1735033738000},"page":"9","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Health-Promoting and Functional Properties of Fermented Milk Beverages with Probiotic Bacteria in the Prevention of Civilization Diseases"],"prefix":"10.3390","volume":"17","author":[{"given":"Milena Alicja","family":"Stachelska","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, University of Lomza, Akademicka 14, 18-400 \u0141om\u017ca, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Karpi\u0144ski","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Lomza, Akademicka 14, 18-400 \u0141om\u017ca, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8762-7460","authenticated-orcid":false,"given":"Bartosz","family":"Kruszewski","sequence":"additional","affiliation":[{"name":"Department of Food Technology and Assessment, Institute of Food Sciences, Warsaw University of Life Sciences\u2014SGGW, Nowoursynowska 159 C, 02-776 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"ref_1","unstructured":"Singh, J., and Vyas, A. (2022). Advancement of yogurt production technology. Advances in Dairy Microbial Products, Woodhead Publishing."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hadjimbei, E., Botsaris, G., and Chrysostomou, S. (2022). Beneficial effects of yoghurts and probiotic fermented milks and their functional food potential. Foods, 11.","DOI":"10.3390\/foods11172691"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Dimidi, E., Cox, S.R., Rossi, M., and Whelan, K. (2019). Fermented foods: Definitions and characteristics, impact on the gut microbiota and effects on gastrointestinal health and disease. Nutrients, 11.","DOI":"10.3390\/nu11081806"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tifs.2014.05.002","article-title":"Fermented beverages with health-promoting potential: Past and future perspectives","volume":"38","author":"Marsh","year":"2014","journal-title":"Trends Food Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3390\/dairy4040044","article-title":"Incorporation of probiotics and other functional ingredients in dairy fat-rich products: Benefits, challenges, and opportunities","volume":"4","author":"Gaba","year":"2023","journal-title":"Dairy"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/elsc.201100119","article-title":"Bacterial diversity and functionalities in food fermentations","volume":"12","author":"Ravyts","year":"2012","journal-title":"Eng. Life Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13099-018-0250-0","article-title":"The role of probiotics, prebiotics and synbiotics in animal nutrition","volume":"10","author":"Markowiak","year":"2018","journal-title":"Gut Pathog."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.numecd.2020.12.023","article-title":"The effect of probiotic fermented milk products on blood lipid concentrations: A systematic review and meta-analysis of randomized controlled trials","volume":"31","author":"Ziaei","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1056\/NEJMoa1014296","article-title":"Changes in diet and lifestyle and long-term weight gain in women and men","volume":"364","author":"Mozaffarian","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_10","first-page":"1","article-title":"Role of probiotics in health and disease\u2014A review","volume":"2","author":"Sen","year":"2019","journal-title":"Int. J. Adv. Life Sci. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Vargas, M.H., Del-Razo-Rodr\u00edguez, R., L\u00f3pez-Garc\u00eda, A., Lezana-Fern\u00e1ndez, J.L., Ch\u00e1vez, J., Furuya, M.E.Y., and Mar\u00edn-Santana, J.C. (2017). Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: A pilot randomized trial. BMC Pulm. Med., 17.","DOI":"10.1186\/s12890-017-0528-x"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1053\/j.gastro.2014.01.058","article-title":"Diet and the intestinal microbiome: Associations, functions, and implications for health and disease","volume":"146","author":"Albenberg","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/pai.12232","article-title":"The first thousand days\u2014Intestinal microbiology of early life: Establishinga symbiosis","volume":"25","author":"Wopereis","year":"2014","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12328-017-0813-5","article-title":"Gut microbiota in the pathogenesis of inflammatory bowel disease","volume":"11","author":"Nishida","year":"2018","journal-title":"Clin. J. Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cmet.2011.02.018","article-title":"The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon","volume":"13","author":"Donohoe","year":"2011","journal-title":"Cell Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn3071","article-title":"Gut feelings: The emerging biology of gut-brain communication","volume":"12","author":"Mayer","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Grenham, S., Clarke, G., Cryan, J.F., and Dinan, T.G. (2011). Brain-gut-microbe communication in health and disease. Front. Physiol., 2.","DOI":"10.3389\/fphys.2011.00094"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Montiel-Castro, A.J., Gonzalez-Cervantes, R.M., Bravo-Ruiseco, G., and Pacheco-L\u00f3pez, G. (2013). The microbiota-gut-brain axis: Neurobehavioral correlates, health and sociality. Front. Integr. Neurosci., 7.","DOI":"10.3389\/fnint.2013.00070"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2015.02.021","article-title":"Collective unconscious: How gut microbes shape human behavior","volume":"63","author":"Dinan","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"ref_20","first-page":"845","article-title":"Role of the intestinal microbiome in health and disease: From correlation to causation","volume":"70","year":"2012","journal-title":"Nutr. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease","volume":"375","author":"Lynch","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_22","first-page":"76","article-title":"Od jelit do depresji-rola zaburze\u0144 ci\u0105g\u0142o\u015bci barieryjelitowej i nast\u0119pcza aktywacja uk\u0142adu immunologicznego w zapalnej hipotezie depresji","volume":"2","author":"Rudzki","year":"2012","journal-title":"Neuropsychiatr. Neuropsychol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/dom.12340","article-title":"Gut microbiota, nutrient sensing and energy balance","volume":"16","author":"Duca","year":"2014","journal-title":"Diabetes Obes. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1053\/j.gastro.2014.02.037","article-title":"Brain-gut microbiome interactions and functional bowel disorders","volume":"146","author":"Mayer","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on thescope and appropriate useof the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_26","first-page":"1","article-title":"Probiotyki aktualny stan wiedzy i zalecenia dla praktyki klinicznej","volume":"7\u20138","author":"Szajewska","year":"2017","journal-title":"Med. Prakt."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/MCG.0b013e31816b903f","article-title":"Recommendations for probiotic use\u20142008","volume":"42","author":"Floch","year":"2008","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/MPG.0000000000000320","article-title":"European Society for Pediatrie Gastroenterology, Hepatology, and Nutrition. Use of probiotics for management of acute gastroenteritis: A position paper by the ESPGHAN Working Group for Probiotics and Prebiotics","volume":"58","author":"Szajewska","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ajg.2016.126","article-title":"ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults","volume":"111","author":"Riddle","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/MPG.0000000000001081","article-title":"ESPGHAN Working Group for Probiotics Prebiotics. Probiotics for the prevention of antibiotic- -associated diarrhea in children","volume":"62","author":"Szajewska","year":"2016","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/apt.13344","article-title":"Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea","volume":"42","author":"Szajewska","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3920\/BM2016.0146","article-title":"Probiotic guidelines and physician practice: A cross-sectional survey and overview of the literature","volume":"8","author":"Draper","year":"2017","journal-title":"Benef. Microbes"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/apt.13404","article-title":"Systematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults","volume":"42","author":"Szajewska","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1053\/j.gastro.2017.02.003","article-title":"Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis","volume":"152","author":"Shen","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_35","first-page":"27","article-title":"Probiotics are effective at preventing Clostridium difficile-associated diarrhea: A systematic review and meta-analysis","volume":"9","author":"Lau","year":"2016","journal-title":"Int. J. Gen. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/j.1572-0241.2006.00734.x","article-title":"Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome","volume":"101","author":"Whorwell","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.3748\/wjg.v18.i30.4012","article-title":"Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome","volume":"18","author":"Ducrotte","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/j.1365-2036.2011.04665.x","article-title":"Meta-analysis: Lactobacillus rhamnosus GG for abdominal pain-related functional gastrointestinal disorders in childhood","volume":"33","author":"Horvath","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_39","unstructured":"Guarner, F., Sanders, M.E., Szajewska, H., Cohen, H., Eliakim, R., Herrera-deGuise, C., Karakan, T., Merenstein, D., Piscoya, A., and Ramakrishna, B. (2017). Probiotics and prebiotics. World Gastroenterology Organisation Global Guidelines, World Gastroenterology Organisation."},{"key":"ref_40","first-page":"879151","article-title":"Is the gut microbiota a new factor contributing to Obesity and its Metabolic disorders","volume":"2012","author":"Harris","year":"2012","journal-title":"J. Obes."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/978-3-642-24716-3_11","article-title":"Intestinal microbiota and Obesity","volume":"209","author":"Blaut","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An Obesity-associated gut microbiome with increased capacity for Energy harvest","volume":"444","author":"Tumbaugh","year":"2006","journal-title":"Nature"},{"key":"ref_43","first-page":"1","article-title":"Mikrobiota jelitowa a zaburzenia metaboliczne i oty\u0142o\u015b\u0107\u2014Punkt widzenia internisty i dietetyka","volume":"8","author":"Ostrowska","year":"2016","journal-title":"Gastroenterol. Klin."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/MED.0b013e3280123119","article-title":"The role of peptide YY in integrative gut physiology and potential role in obesity","volume":"14","author":"Grudell","year":"2007","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/emmm.201100159","article-title":"Intestinal mucosal adherence and translocation of commensal bacteria at the early onset oftype 2 diabetes: Molecular mechanism and probiotic treatment","volume":"3","author":"Amar","year":"2011","journal-title":"EMBO Mol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1007\/s00125-007-0791-0","article-title":"Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia","volume":"50","author":"Cani","year":"2007","journal-title":"Diabetologia"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bbalip.2006.05.007","article-title":"Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice","volume":"1761","author":"Lee","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/j.1365-2672.2007.03336.x","article-title":"Antiobesity effect of trans-10,cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet-induced obese mice","volume":"103","author":"Lee","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1017\/S0007114507839006","article-title":"Effects ofmilk fermented by Lactobacillus gasseri SBT2055 on adipocyte size in rates","volume":"99","author":"Sato","year":"2008","journal-title":"Br. J. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00253-013-5252-8","article-title":"Effect of orally administered L fermentum NCIMB 5221 on markers of metabolic syndrome: An in vivo analysis using ZDF rats","volume":"98","author":"Saha","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1017\/S0007114507682907","article-title":"Administration of Lactobacillus evokes coordinated changes in the intestinal expression profile ofgenes regulating energy homeostasis and immune phenotype in mice","volume":"97","author":"Nerstedt","year":"2007","journal-title":"Br. J. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/ejcn.2010.19","article-title":"Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial","volume":"64","author":"Kadooka","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1017\/S0007114513001037","article-title":"Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controll trial","volume":"110","author":"Kadooka","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1017\/S0007114513003875","article-title":"Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women","volume":"111","author":"Sanchez","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.3945\/jn.115.214593","article-title":"Consumption of yogurt, low-fat milk, and other low-fat dairy products is associated with lower risk of metabolic syndrome incidence in an elderly Mediterranean population","volume":"145","author":"Babio","year":"2015","journal-title":"J. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Neyrinck, A.M., Possemiers, S., Druart, C., Van de Wiele, T., De Backer, F., Cani, P.D., Larondelle, Y., and Delzenne, N.M. (2011). Prebiotic effects of wheat arabinoxylan related to the increase in Bifidobacteria, Roseburia and Bacteroides\/Prevotella in diet-induced obese mice. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0020944"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1017\/S0007114511003163","article-title":"Prebiotic fibres dose-dependently increase satiety hormones and alter Bacteroidetes and Firmicutes in lean and obese JCR: LA-cprats","volume":"107","author":"Parnell","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.micpath.2012.05.007","article-title":"Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals","volume":"53","author":"Million","year":"2012","journal-title":"Microb. Pathog."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1473-3099(13)70179-8","article-title":"Related actions of probiotics and antibiotics on gut microbiota and weight modification","volume":"13","author":"Angelakis","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Alvarez-Arrano, V., and Martin-Pelaez, S. (2021). Effects of probiotics and synbiotics on weight loss in subjects with overweight or obesity: A systematic review. Nutrients, 13.","DOI":"10.3390\/nu13103627"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"175069","DOI":"10.1016\/j.ejphar.2022.175069","article-title":"Anti-obesity properties of probiotics; a considerable medical nutrition intervention: Findings from an umbrella meta-analysis","volume":"928","author":"Musazadeh","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_62","first-page":"5542626","article-title":"Probiotics can further reduce waist circumference in adults with morbid obesity after bariatric surgery: A systematic review and meta-analysis of randomized controlled trials","volume":"2021","author":"Zhang","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Niloufar Rasaei, N., Heidari, M., Esmaeili, F., Khosravi, S., Baeeri, M., Tabatabaei-Malazy, O., and Emamgholipour, S. (2024). The effects of prebiotic, probiotic or synbiotic supplementation on overweight\/obesity indicators: An umbrella review of the trials\u2019 meta-analyses. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1277921"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/oby.2005.117","article-title":"Oligo-fructose promotes satiety in rats fed a high-fat diet: Involvement of glucagon-like Peptide-1","volume":"13","author":"Cani","year":"2005","journal-title":"Obes. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1677\/joe.1.06100","article-title":"Involvement of endogenous glucagon-like peptide-1 (7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats","volume":"185","author":"Cani","year":"2005","journal-title":"J. Endocrinol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.clnu.2009.01.013","article-title":"Yacon syrup: Beneficial effects on obesity and insulin resistance in humans","volume":"28","author":"Genta","year":"2009","journal-title":"Clin. Nutr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/gut.2008.165886","article-title":"Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement ofgut permeability","volume":"58","author":"Cani","year":"2009","journal-title":"Gut"},{"key":"ref_68","first-page":"6688450","article-title":"Probiotics as a complementary therapy for management of obesity: A systematic review","volume":"2021","author":"Mohseni","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s12602-022-10037-3","article-title":"The effects of oral probiotic supplementation in postmenopausal women with overweight and obesity: A systematic review and meta-analysis of randomized controlled trials","volume":"15","author":"Li","year":"2022","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Perna, S., Ilyas, Z., Giacosa, A., Gasparri, C., Peroni, G., Faliva, M.A., Rigon, C., Naso, M., Riva, A., and Petrangolini, G. (2021). Is probiotic supplementation useful for the management of body weight and other anthropometric measures in adults affected by overweight and obesity with metabolic related diseases? A systematic review and meta-analysis. Nutrients, 13.","DOI":"10.3390\/nu13020666"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Mayta-Tovalino, F., Diaz-Arocutipa, C., Piscoya, A., and Hernandez, A.V. (2023). Effects of probiotics on intermediate cardiovascular outcomes in patients with overweight or obesity: A systematic review and meta-analysis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12072554"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1080\/10408398.2018.1545218","article-title":"Efficacy of synbiotic supplementation in obesity treatment: A systematic review and meta-analysis of clinical trials","volume":"60","author":"Hadi","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"8020","DOI":"10.3390\/nu7095380","article-title":"Lactose intolerance in adults: Biological mechanism and dietary management","volume":"7","author":"Deng","year":"2015","journal-title":"Nutrients"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1080\/10408398.2018.1425977","article-title":"The effects of probiotics in lactose intolerance: A systematic review","volume":"59","author":"Oak","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1002\/fsn3.2145","article-title":"The effect of yogurt fortified with Lactobacillus acidophilus and Bifidobacterium sp. probiotic in patients with lactose intolerance","volume":"9","author":"Masoumi","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1251S","DOI":"10.3945\/ajcn.113.073023","article-title":"Lactose digestion from yogurt: Mechanism and relevance","volume":"99","author":"Savaiano","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1542\/peds.2006-1721","article-title":"Committee on Nutrition. Lactose intolerance in infants, children, and adolescents","volume":"118","author":"Heyman","year":"2006","journal-title":"Pediatrics"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0140-6736(73)90862-3","article-title":"Recessive inheritance of adult-type lactose malabsorption","volume":"13","author":"Sahi","year":"1973","journal-title":"Lancet"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ng826","article-title":"Identification of a variant associated with adult-type hypolactasia","volume":"30","author":"Enattah","year":"2002","journal-title":"Nat. Genet."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/ajcn\/80.2.245","article-title":"Yogurt and gut function","volume":"80","author":"Adolfsson","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1159\/000007514","article-title":"Diet supplemented with yoghurt or milk fermented by Lactobacillus casei DN-114 001 stimulates growth and brush-border enzyme activities in mouse small intestine","volume":"59","author":"Thoreux","year":"1998","journal-title":"Digestion"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.3168\/jds.2022-22762","article-title":"Effects of probiotics administration on lactose intolerance in adulthood: A meta-analysis","volume":"106","author":"Ahn","year":"2023","journal-title":"J. Dairy Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1017\/S0022029921000625","article-title":"Fermented foods and probiotics: An approach to lactose intolerance","volume":"88","author":"Ibrahim","year":"2021","journal-title":"J. Dairy Res."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Aguilera, G., C\u00e1rcamo, C., Soto-Alarc\u00f3n, S., and Gotteland, M. (2021). Improvement in lactose tolerance in hypolactasic subjects consuming ice creams with high or low concentrations of Bifidobacterium bifidum 900791. Foods, 10.","DOI":"10.3390\/foods10102468"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12602-018-9507-7","article-title":"Use of a novel probiotic formulation to alleviate lactose intolerance symptoms\u2014A pilot study","volume":"12","author":"Levy","year":"2020","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Vitellio, P., Celano, G., Bonfrate, L., Gobbetti, M., Portincasa, P., and De Angelis, M. (2019). Effects of Bifidobacterium longum and Lactoibacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients, 11.","DOI":"10.3390\/nu11040886"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Leis, R., de Castro, M., de Lamas, C., and Couce, M.L. (2020). Effects of Prebiotic and Probiotic Supplementation on Lactase Deficiency and Lactose Intolerance: A Systematic Review of Controlled Trials. Nutrients, 2.","DOI":"10.3390\/nu12051487"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3945\/ajcn.115.123216","article-title":"Consumption of dairy foods and diabetes incidence: A dose-response meta-analysis of observational studies","volume":"103","author":"Gijsbers","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3945\/ajcn.111.014159","article-title":"Association between yogurt, milk, and cheese consumption and common carotid artery intima-media thickness and cardiovascular disease risk factors in elderly women","volume":"94","author":"Ivey","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.3945\/jn.111.143339","article-title":"A diet high in low-fat dairy products lowers diabetes risk in postmenopausal women","volume":"141","author":"Margolis","year":"2011","journal-title":"J. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/NNR.0b013e3181fa4dc6","article-title":"Probiotic yogurt effects on intestinal flora of patients with chronic liver disease","volume":"59","author":"Liu","year":"2010","journal-title":"Nurs. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1452S","DOI":"10.3945\/jn.117.248229","article-title":"Yogurt and diabetes: Overview of recent observational studies","volume":"147","author":"Babio","year":"2017","journal-title":"J. Nutr."},{"key":"ref_93","unstructured":"(2024, November 11). Available online: www.stat.gov.pl."},{"key":"ref_94","first-page":"190","article-title":"\u201cMikrobiota i jej zwi\u0105zek z cukrzyc\u0105 typu 2 i oty\u0142o\u015bci\u0105\u201d Szpital Miejski w Zabrzu, Katedra i Klinika Chor\u00f3b Wewn\u0119trznych, Diabetologii i Nefrologii, \u015al\u0105ski Uniwersytet Medyczny w Zabrzu","volume":"2","author":"Pokrzywnicka","year":"2016","journal-title":"Diabetol. Prakt."},{"key":"ref_95","unstructured":"Konturek, S. (2013). Fizjologia Cz\u0142owieka Podr\u0119cznik dla Student\u00f3w Medycyny, Edra Urban & Partner."},{"key":"ref_96","first-page":"358","article-title":"Insulinooporno\u015b\u0107 i stan przedcukrzycowy","volume":"5","author":"Stawerska","year":"2021","journal-title":"Lekarz POZ"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ecl.2012.11.008","article-title":"Integrating metabolism and longevity through insulin and IGF1 signaling","volume":"42","author":"Sadagurski","year":"2013","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Nowosad, K. (2021). Rola diety i Stylu \u017bycia w Leczeniu Insulinooporno\u015bci, Polskie Towarzystwo Przyrodnik\u00f3w im. Kopernika wydawnictwo KOSMOS.","DOI":"10.36921\/kos.2022_2801"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.17219\/acem\/109976","article-title":"Dietary support in insulin resistance: An overview of current scientific reports","volume":"28","year":"2019","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_100","first-page":"85","article-title":"Czy istniej\u0105 \u015brodowiskowe uwarunkowania insulinooporno\u015bci?","volume":"3","author":"Ostrowska","year":"2012","journal-title":"Forum Zaburze\u0144 Metab."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"106614","DOI":"10.1016\/j.phrs.2022.106614","article-title":"The effect of probiotic and synbiotic supplementation on appetite-regulating hormones and desire to eat: A systematic review and meta-analysis of clinical trials","volume":"187","author":"Noormohammadi","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_102","first-page":"897","article-title":"Rola leptyny w zaburzeniach od\u017cywiania si\u0119\u2014Wsp\u00f3\u0142czesne pogl\u0105dy","volume":"47","author":"Stachowicz","year":"2013","journal-title":"Psychiatr. Pol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bbrc.2012.12.121","article-title":"Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhancement of adiponectin production","volume":"431","author":"Kim","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1007\/s00520-020-05926-8","article-title":"Effects of synbiotic supplementation on serum adiponectin and inflammation status of overweight and obese breast cancer survivors: A randomized, triple-blind, placebo-controlled trial","volume":"29","author":"Zarrati","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1017\/S0007114514004097","article-title":"Probiotic supplementation prevents high-fat, overfeeding-induced insulin resistance in human subjects","volume":"113","author":"Hulston","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Elbere, I., Silamikelis, I., Dindune, I.I., Kalnina, I., Ustinova, M., Zaharenko, L., Silamikele, L., Rovite, V., Gudra, D., and Konrade, I. (2020). Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0241338"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Guo, X., Guo, J., He, Q., Li, H., Song, Y., and Zhang, H. (2014). Lactobacillus casei reduces susceptibility to type 2 diabetes via microbiota-mediated body chloride ion influx. Sci. Rep., 4.","DOI":"10.1038\/srep05654"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Peng, X., Xian, H., Ge, N., Hou, L., Tang, T., Xie, D., Gao, L., and Yue, J. (2024). Effect of probiotics on glycemic control and lipid profiles in patients with type 2 diabetes mellitus: Arandomized, double blind, controlled trial. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1440286"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Li, S., Liu, Z., Zhang, Q., Su, D., Wang, P., Li, Y., Shi, W., and Zhang, Q. (2024). The Antidiabetic Potential of Probiotics: A Review. Nutrients, 16.","DOI":"10.3390\/nu16152494"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Shen, X., Ma, C., Yang, Y., Liu, X., Wang, B., Wang, Y., Zhang, G., Bian, X., and Zhang, N. (2024). The Role and Mechanism of Probiotics Supplementation in Blood Glucose Regulation: A Review. Foods, 13.","DOI":"10.3390\/foods13172719"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Toejing, P., Khampithum, N., Sirilun, S., Chaiyasut, C., and Lailerd, N. (2021). Influence of Lactobacillus paracasei HII01 Supplementation on Glycemia and Inflammatory Biomarkers in Type 2 Diabetes: A Randomized Clinical Trial. Foods, 10.","DOI":"10.3390\/foods10071455"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1002\/jsfa.12267","article-title":"Lactobacillus paracasei IMC 502 ameliorates type 2 diabetes by mediating gut microbiota-SCFA-hormone\/inflammation pathway in mice","volume":"103","author":"Gu","year":"2023","journal-title":"J. Sci. Food Agric."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Wang, Y.M., Dilidaxi, D., Wu, Y.C., Sailike, J., Sun, X., and Nabi, X.H. (2020). Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db\/db mice. Biomed. Pharmacother., 125.","DOI":"10.1016\/j.biopha.2020.109914"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1039\/D1FO00698C","article-title":"Lactobacillus plantarum HAC01 ameliorates type 2 diabetes in high-fat diet and streptozotocin-induced diabetic mice in association with modulating the gut microbiota","volume":"12","author":"Lee","year":"2021","journal-title":"Food Funct."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s42770-022-00686-5","article-title":"Lactiplantibacillus plantarum Y15 alleviate type 2 diabetes in mice via modulating gut microbiota and regulating NF-\u03baB and insulin signaling pathway","volume":"53","author":"Liu","year":"2022","journal-title":"Braz. J. Microbiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"100093","DOI":"10.1016\/j.metop.2021.100093","article-title":"Probiotic and resveratrol normalize GLP-1 levels and oxidative stress in the intestine of diabetic rats","volume":"10","author":"Pegah","year":"2021","journal-title":"Metab. Open"},{"key":"ref_117","first-page":"543","article-title":"The effects of probiotic and synbiotic supplementation on inflammation, oxidative stress, and circulating adiponectin and leptin concentration in subjects with prediabetes and type 2 diabetes mellitus: A GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials","volume":"62","author":"Naseri","year":"2023","journal-title":"Eur. J. Nutr."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Zhao, J.Y., Wang, L.H., Cheng, S.S., Zhang, Y., Yang, M., Fang, R.X., Li, H.X., Man, C.X., and Jiang, Y.J. (2022). A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: Lactobacillus paracasei JY062 and Exopolysaccharide Isolated from Lactobacillus plantarum JY039. Nutrients, 14.","DOI":"10.3390\/nu14020377"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Xiao, R., Wang, L.L., Tian, P.J., Jin, X., Zhao, J.X., Zhang, H., Wang, G., and Zhu, M.M. (2023). The Effect of Probiotic Supplementation on Glucolipid Metabolism in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. Nutrients, 15.","DOI":"10.3390\/nu15143240"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41467-020-20313-x","article-title":"Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes","volume":"12","author":"Rodrigues","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Jiang, H.R., Cai, M.M., Shen, B.Y., Wang, Q., Zhang, T.C., and Zhou, X. (2022). Synbiotics and Gut Microbiota: New Perspectives in the Treatment of Type 2 Diabetes Mellitus. Foods, 11.","DOI":"10.3390\/foods11162438"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Gulnaz, A., Nadeem, J., Han, J.H., Lew, L.C., Son, J.D., Park, Y.H., Rather, I.A., and Hor, Y.Y. (2021). Lactobacillus sps in Reducing the Risk of Diabetes in High-Fat Diet-Induced Diabetic Mice by Modulating the Gut Microbiome and Inhibiting Key Digestive Enzymes Associated with Diabetes. Biology, 10.","DOI":"10.3390\/biology10040348"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"7938","DOI":"10.1039\/D1FO01571K","article-title":"Effect of Lactobacillus fermentum TKSN041 on improving streptozotocin-induced type 2 diabetes in rats","volume":"12","author":"Zhou","year":"2021","journal-title":"Food Funct."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1007\/s12602-021-09744-0","article-title":"Lactobacillus fermentum MCC2759 and MCC2760 Alleviate Inflammation and Intestinal Function in High-Fat Diet-Fed and Streptozotocin-Induced Diabetic Rats","volume":"13","author":"Archer","year":"2021","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/TIN.0000000000000219","article-title":"The Effect of Probiotic Supplementation on Glycemic Control in Women with Gestational Diabetes Mellitus A Systematic Review","volume":"35","author":"Koczarski","year":"2020","journal-title":"Top. Clin. Nutr."},{"key":"ref_126","first-page":"641","article-title":"Probiotics with anti-type 2 diabetes mellitus properties: Targets of polysaccharides from traditional Chinese medicine","volume":"20","author":"Wu","year":"2022","journal-title":"Chin. J. Nat. Med."},{"key":"ref_127","first-page":"88","article-title":"Rola probiotyk\u00f3w i prebiotyk\u00f3w w apoptozie przewodu pokarmowego","volume":"5","author":"Maciorkowska","year":"2010","journal-title":"Przegl\u0105d Gastroenterol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0031-3939(08)70292-0","article-title":"Probiotyki i prebiotyki w \u017cywieniu i leczeniu dzieci","volume":"83","author":"Cichy","year":"2008","journal-title":"Ped. Pol."},{"key":"ref_129","first-page":"34","article-title":"Wsp\u00f3\u0142czesne pogl\u0105dy na profilaktyczne i terapeutyczne zastosowanie probiotyk\u00f3w u dzieci","volume":"9","author":"Cichy","year":"2006","journal-title":"\u015awiat Med. Farm."},{"key":"ref_130","first-page":"90","article-title":"A human Lactobacillus strain (Lactobacillus casei sp. Strain GG) promotes recovery from acute diarrhoea in children","volume":"88","author":"Isolauri","year":"1991","journal-title":"Pediatrics"},{"key":"ref_131","first-page":"333","article-title":"Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis","volume":"20","author":"Majamaa","year":"1995","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_132","first-page":"410","article-title":"Lactobacillus reuteri effectively colonises GI tract and shortens acute diarrhoea in children","volume":"22","author":"Shornikova","year":"1996","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(94)91708-6","article-title":"Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and sheeding of rotavirus","volume":"344","author":"Saavedra","year":"1994","journal-title":"Lancet"},{"key":"ref_134","first-page":"96","article-title":"Probiotyki w zapobieganiu biegunce zwi\u0105zanej ze stosowaniem antybiotyk\u00f3w\u2014Aktualizacja metaanalizy bada\u0144 z randomizacj\u0105","volume":"10","author":"Szajewska","year":"2008","journal-title":"Pediatr. Wsp\u00f3\u0142cz."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1542\/peds.104.5.e64","article-title":"Prophylactic Lactobacillus GG reduces antibiotic-assosiated diarrhea in children with respiratory infections: A randomized study","volume":"104","author":"Arvola","year":"1999","journal-title":"Pediatrics"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0022-3476(99)70053-3","article-title":"Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children","volume":"135","author":"Vanderhoof","year":"1999","journal-title":"J. Pediatr."},{"key":"ref_137","first-page":"36","article-title":"Probiotyki a antybiotykoterapia u dzieci","volume":"5","author":"Roszak","year":"2007","journal-title":"\u015awiat Med. Farm."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1365-2036.2005.02356.x","article-title":"Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: A randomized double-blind placebo-controlled trial","volume":"21","author":"Kotowska","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000151300","article-title":"Bifidobacterium longum PL03, Lactobacillus rhamnosus KL53A and Lactobacillus plantarum PL02 in the prevention of antibiotic-associated diarrhoea in children: A randomized controlled pilot trial","volume":"78","author":"Szajewska","year":"2008","journal-title":"Digestion"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Chandrasekaran, P., Weiskirchen, S., and Weiskirchen, R. (2024). Effects of Probiotics on Gut Microbiota: An Overview. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25116022"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Ma, C., Zhang, C., Chen, D., Jiang, S., Shen, S., Huo, D., Huang, S., Zhai, Q., and Zhang, J. (2021). Probiotic consumption influences universal adaptive mutations in indigenous human and mouse gut microbiota. Commun. Biol., 4.","DOI":"10.1038\/s42003-021-02724-8"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.tifs.2019.11.022","article-title":"Interactions between probiotics and pathogenic microorganisms in hosts and foods: A review","volume":"95","author":"Khaneghah","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cca.2015.01.003","article-title":"The role of the gut microbiome in the healthy adult status","volume":"451","author":"Salvatore","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.gendis.2014.08.001","article-title":"Exploring gut microbes in human health and disease: Pushing the envelope","volume":"1","author":"Sun","year":"2014","journal-title":"Genes Dis."},{"key":"ref_145","first-page":"284","article-title":"Probiotics and their role in gastrointestinal cancer prevention and treatment: An overview","volume":"11","author":"Javanmard","year":"2018","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"ref_146","first-page":"262","article-title":"Bacterial overgrowth and diversification of microbiota in gastric cancer","volume":"3","author":"Wang","year":"2016","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_147","first-page":"2032","article-title":"The role of microbiota in the development of colorectal cancer","volume":"8","author":"Dai","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_148","first-page":"41","article-title":"Zastosowanie fitoterapii w leczeniu wrzodziej\u0105cego zapalenia jelita grubego","volume":"LII","author":"Ruszkowski","year":"2019","journal-title":"Bromatol. Chem. Toksykol."},{"key":"ref_149","first-page":"1098","article-title":"Szlak sygna\u0142owy Wnt i jego rola w regulacji metabolizmu kom\u00f3rki","volume":"67","year":"2013","journal-title":"Post\u0119py Hig. Med. Do\u015bwiadczalnej"},{"key":"ref_150","first-page":"529","article-title":"W\u0142a\u015bciwo\u015bci immunomodulacyjne i terapeutyczne drobnoustroj\u00f3w probiotycznych","volume":"3","author":"Fol","year":"2014","journal-title":"Probl. Hig. Epidemiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/01635581.2016.1158300","article-title":"The Potential Role of Probiotics in Cancer Prevention and Treatment","volume":"4","author":"Yu","year":"2016","journal-title":"Nutr. Cancer"},{"key":"ref_152","first-page":"541","article-title":"Probiotyki, prebiotyki i synbiotyki\u2014Charakterystyka i funkcje","volume":"3","author":"Mojka","year":"2014","journal-title":"Probl. Hig. Epidemiol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/19490976.2017.1290756","article-title":"Dietary fiber and prebiotics and the gastrointestinal microbiota","volume":"2","author":"Holscher","year":"2017","journal-title":"Gut Microbes"},{"key":"ref_154","first-page":"1","article-title":"Profilaktyka raka jelita grubego","volume":"8","author":"Siepsiak","year":"2015","journal-title":"Farm Wsp\u00f3\u0142."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(10)61543-7","article-title":"Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials","volume":"9754","author":"Rothwell","year":"2010","journal-title":"Lancet"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bpg.2016.02.009","article-title":"Probiotics, Prebiotics and Colorectal Cancer Prevention","volume":"1","author":"Ambalam","year":"2016","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_157","first-page":"1219","article-title":"Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice","volume":"8","author":"Feeney","year":"2001","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_158","first-page":"5","article-title":"Clostridium perfringens\u2014Znaczenie epidemiologiczne i diagnostyka zachorowa\u0144","volume":"75","author":"Kukier","year":"2019","journal-title":"Med. Weter."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00008469-200304000-00003","article-title":"Probiotic mixture decreases DNA adduct formation in colonic epithelium induced by the food mutagen 2-amino-9H-pyrido[2,3-b]indole in a human-flora associated mouse model","volume":"2","author":"Horie","year":"2003","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4149\/neo_2010_05_422","article-title":"The effect of probiotic microorganisms and bioactive compounds on chemically induced carcinogenesis in rats","volume":"5","author":"Bertkova","year":"2010","journal-title":"Neoplasma"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/ijc.25011","article-title":"The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition","volume":"4","author":"Ma","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1038\/sj.onc.1207361","article-title":"Identification and validation of an ERBB2 gene expression signature in breast cancers","volume":"23","author":"Bertucci","year":"2004","journal-title":"Oncogene"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.ijfoodmicro.2008.09.010","article-title":"The influence of Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp. shermanii JS on potentially carcinogenic bacterial activity in human colon","volume":"2","author":"Hatakka","year":"2008","journal-title":"Int. J. Food Microbiol."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Jacouton, E., Chain, F., Sokol, H., Langella, P., and Bermudez-Humaran, G.L. (2017). Probiotic Strain Lactobacillus casei BL23 Prevents Colitis-Associated Colorectal Cancer. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01553"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Deng, X., Yang, J., Zhang, Y., Chen, X., Wang, C., Suo, H., and Song, J. (2023). An Update on the Pivotal Roles of Probiotics, Their Components, and Metabolites in Preventing Colon Cancer. Foods, 12.","DOI":"10.3390\/foods12193706"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Budu, O., Banciu, C., Pinzaru, I., Sar\u0103u, C., Lighezan, D., \u0218oica, C., Dehelean, C., Dr\u0103ghici, G., Dolghi, A., and Prodea, A. (2022). A combination of two probiotics, Lactobacillus sporogenes and Clostridium butyricum, inhibits Colon Cancer Development: An In Vitro Study. Microorganisms, 10.","DOI":"10.3390\/microorganisms10091692"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Aindelis, G., Tiptiri-Kourpeti, A., Lampri, E., Spyridopoulou, K., Lamprianidou, E., Kotsianidis, I., Ypsilantis, P., Pappa, A., and Chlichlia, K. (2020). Immune responses raised in an experimental colon carcinoma model following oral administration of Lactobacillus casei. Cancers, 12.","DOI":"10.3390\/cancers12020368"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00394-021-02627-8","article-title":"Lactobacillus coryniformis MXJ32 administration ameliorates azoxymethane\/dextran sulfate sodium-induced colitis-associated colorectal cancer via reshaping intestinal microenvironment and alleviating inflammatory response","volume":"61","author":"Wang","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.21037\/jgo-20-573","article-title":"The inhibitory effects of probiotics on colon cancer cells: In vitro and in vivo studies","volume":"11","author":"Shang","year":"2020","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Janelle, A.C., Raad, Z.G., Joshua, M.U., Perez-Chanona, E., Sha, W., Tomkovich, S., M\u00fchlbauer, M., Fodor, A.A., and Jobin, C. (2013). VSL#3 probiotic modifies mucosal microbial composition but does not reduce colitis-associated colorectal cancer. Sci. Rep., 3.","DOI":"10.1038\/srep02868"},{"key":"ref_171","first-page":"18","article-title":"Chemopreventive Potential of Probiotics and Prebiotics","volume":"5","author":"Sunkata","year":"2014","journal-title":"Food Nutr. Sci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.fshw.2023.02.012","article-title":"Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota","volume":"12","author":"Wang","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_173","first-page":"334","article-title":"Ocena wp\u0142ywu bakterii probiotycznych na tolerancj\u0119 terapii eradykacyjnej zaka\u017ce\u0144 Helicobacterpylori u dzieci i m\u0142odzie\u017cy","volume":"81","author":"Mierzwa","year":"2006","journal-title":"Ped. Pol."},{"key":"ref_174","first-page":"53","article-title":"Rola probiotyk\u00f3w w zapobieganiu i leczeniu chor\u00f3b przewodu pokarmowego","volume":"7","author":"Szajewska","year":"2005","journal-title":"Pediatr. Wsp\u00f3\u0142cz."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/01.mcg.0000173855.77191.44","article-title":"Effects of a specially de- signed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: A pro- spective randomized double-blind study","volume":"39","author":"Sykora","year":"2005","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/j.1365-2036.2004.02274.x","article-title":"Bacillus clausi therapy to reduce side-effects of anti-Helicobacter pylori treatment: Randomiz- ded, double-blind, placebo controlled trial","volume":"20","author":"Nista","year":"2004","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_177","first-page":"6","article-title":"European Helicobacter and microbiota study group and concensus panel","volume":"66","author":"Malfertheiner","year":"2017","journal-title":"Management of Helicobacter pylori infection\u2014The Mastricht V\/Florence Consensus Report. Gut"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1038\/ajg.2014.202","article-title":"Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: Systematic review and meta-analysis","volume":"109","author":"Ford","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/apt.14539","article-title":"Systematic review: Probiotics in the management of lower gastrointestinal symptoms\u2014An updated evidence-based International consensus","volume":"47","author":"Hungin","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_180","first-page":"188","article-title":"Profilaktyka i leczenie raka \u017co\u0142\u0105dka\u2014Aktualny problem interdyscyplinarny","volume":"2","author":"Strzelec","year":"2018","journal-title":"Pol. Nurs."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/ijc.30700","article-title":"Gastric microbiota features associated with cancer risk factors and clinical outcomes: A pilot study in gastric cardia cancer patients from Shanxi, China","volume":"1","author":"Yu","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"68","DOI":"10.15557\/PiMR.2015.0005","article-title":"Zaka\u017cenie Helicobacter pylori. Diagnostyka i leczenie","volume":"1","author":"Dyrla","year":"2015","journal-title":"Pediatr. Med. Rodz."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Castano-Rodriquez, N., Goh, K.L., Fock, K.M., Hazel, M.M., and Nadeem, O.K. (2017). Dysbiosis of the microbiome in gastric cancer. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-16289-2"},{"key":"ref_184","first-page":"e3768","article-title":"Saccharomyces boulardii in Helicobacter pylori eradication in children: A randomized trial from Iran","volume":"1","author":"Namkin","year":"2016","journal-title":"Iran. J. Pediatr."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5223\/pghn.2015.18.1.17","article-title":"The efficiency of Saccharomyces boulardii CNCM I-745 in addition to standard Helicobacter pylori eradication treatment in children","volume":"1","author":"Bin","year":"2015","journal-title":"Pediatr. Gastroenterol. Hepatol. Nutr."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/apt.13214","article-title":"Systematic review and meta-analysis: Saccharomyces boulardii supplementation and eradication of Helicobacter pylori infection","volume":"12","author":"Szajewska","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2036.2006.03179.x","article-title":"Meta-analysis: The effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy","volume":"25","author":"Tong","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cimid.2019.02.010","article-title":"Are Probiotics Useful for Therapy of Helicobacter pylori Diseases?","volume":"64","author":"Eslami","year":"2019","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/1\/9\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:59:13Z","timestamp":1760115553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/1\/9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,24]]},"references-count":188,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["nu17010009"],"URL":"https:\/\/doi.org\/10.3390\/nu17010009","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,24]]}}}